Browsing by Author "Dogru Y."

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    The effect of 8-week different-intensity walking exercises on serum hepcidin, IL-6, and iron metabolism in pre-menopausal women
    (Akademiai Kiado ZRt., 2017) Buyukyazi G.; Ulman C.; Çelik A.; Çetinkaya C.; Sisman A.R.; Çimrin D.; Dogru Y.; Kaya D.
    Objective: Hepcidin may be an important mediator in exercise-induced iron deficiency. Despite the studies investigating acute exercise effects on hepcidin and markers of iron metabolism, we found no studies examining the chronic effects of walking exercises (WE) on hepcidin and markers of iron metabolism in premenopausal women. The chronic effects of two 8-week different-intensity WE on hepcidin, interleukin 6 (IL-6), and markers of iron metabolism in pre-menopausal women were examined. Methods: Exercise groups (EG) [moderate tempo walking group (MTWG), n = 11; brisk walking group (BWG), n = 11] walked 3 days/week, starting from 30 to 51 min. Control group (CG; n = 8) did not perform any exercises. BWG walked at ∼70%-75%; MTWG at ∼50%-55% of HRRmax. VO2max, hepcidin, IL-6, and iron metabolism markers were determined before and after the intervention. Results: VO2max increased in both EGs, favoring the BWG. Hepcidin increased in the BWG (p < 0.01) and CG (p < 0.05). IL-6 decreased in the BWG and the MTWG (p < 0.05; p < 0.01). While iron, ferritin, transferrin, and transferrin saturation levels did not change in any group, total iron binding capacity (p < 0.05), red blood cells (p < 0.05), and hematocrit (p < 0.01) increased only in the BWG. Conclusion: Both WE types may be useful to prevent inflammation. However, brisk walking is advisable due to the positive changes in VO2max and some iron metabolism parameters, which may contribute to prevent iron deficiency. The increase in hepcidin levels remains unclear and necessitates further studies. © 2017 Akadémiai Kiadó, Budapest.
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    Effects of eccentric exercise-induced delayed onset muscle soreness on endoplasmic reticulum stress-related markers; [Eksantrik egzersize bagli gecikmis kas agrisinin endoplazmik retikulum stresle iliskili belirteçler üzerindeki etkileri]
    (De Gruyter Open Ltd, 2021) Dogru Y.; Varol S.R.; Nalcakan G.R.; Akyuz M.; Tas M.; Ulman C.
    Short Communications: Apelin, pentraxin3 (PTX3), and interleukin6 (IL6) parameters are known as inflammation markers and found to be related to endoplasmic reticulum (ER) stress. The aimof the studywas to investigate the effect of eccentric exercise-induced delayed onset muscle soreness (DOMS) on ER stress-related markers in young athletes. Objectives and Methods: ER stress and DOMS-related blood markers, maximal strength level, and rate of perceived exertion using the visual analog scale (VAS) were assessed before, immediately after, 24, 48, and 72 h after the muscle damage protocol. Results: IL6 peaked 24 h after while creatine kinase and lactate dehydrogenase enzyme levels reached their peaks at 72 h after the protocol. The level of apelin continued to increase throughout the four measurements, and PTX3 peaked at 24 h, and then declined to the levels before the protocol but the differences were not significant. The significant decrease in the strength and the significant increase in VAS continued 48 h after the protocol. Conclusion: ER is activated and ER stress occurred, due to increases in IL6, PTX3 and apelin levels after the test protocol concluded that a single vigorous eccentric exercise should be avoided in harmful effect on health as parallel with Physical Activity Guidelines Open Access. 2020 Yeliz Dogru et al. © 2021 De Gruyter. All rights reserved.