Browsing by Author "Duman, Y"

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    Comparison of the radiopharmaceutical potentials of dithizone radiolabeled with 131I and with 99mTc
    Ünak, T; Yildirim, Y; Avcibasi, U; Biber, Z; Duman, Y; Ünak, P
    In this study, dithizone (diphenylthiocarbazone) has been separately radiolabeled with I-131 and with Tc-99m for preliminarily testing their radiopharmaceutical potentials on male albino rabbits. I-131-dithizone and Tc-99m-dithizone were intravenously injected to rabbits via their ear veins after anesthetizing with a mixture of Alfazyne and Alfamine (Serva) to determine their dynamic and static statuses in the metabolism. Also, Tc-99m as pertechnetate and I-131 as iodate were administered to rabbits as controls. Dynamic and static scintigrams were obtained using a gamma camera (Diacan Instruments). Dynamic scintigrams were obtained over the first half hour with frames of 1 minute following the administrations of the labeled compounds. Static images were obtained from posterior projection at different time intervals up to about 3 hours following the administration of the radiolabeled compounds. Tc-99m-dithizone was significantly uptaken by the pancreas in contrast to free Tc-99m. In the case of I-131-dithizone, the distribution of I-131 activity in the metabolism was clearly different than the case of free (131)stopI and the uptake of I-131-dithizone at the pancreas zone was also significant. These preliminary tests have clearly indicated that especially Tc-99m-dithizone has a significant potential to be used as a pancreatic radiopharmaceutical.
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    Preliminary tests of the radiopharmaceutical potential of N-(2,6-diisopropylphenyl)-N'-(4-pyridyl)-perylene-3,4,9,10-tetracarboxylic diimide radiolabeled with 131I
    Avcibasi, U; Dinçalp, H; Ünak, T; Yildirim, Y; Avcibasi, N; Duman, Y; Içli, S
    Perylene diimide derivatives are one of the G-quadruplex DNA interactive agents which are thought to be useful in application of cancer treatment Starting from this consideration, N-(2,6-diisopropylphenyl)-N'-(4-pyridyl)-perylene-3,4,9,10-tetracarboxylic diimide (PYPER) was synthesized, radioiodinated with I-131, and its radiopharmaceutical potentials were tested on a male Albino rabbit and male Albino Wistar rats. This compound was successfully radioiodinated with I-131 with a radioiodination yield of about 100%. Scintigraphic imaging with the radiiodinated compound (I-131-PYPER) was performed on a rabbit. Static images were obtained from posterior projection using a Diacan gamma camera at several time intervals. The scintigrams clearly showed that the radioiodinated compound was not quickly cleared from the metabolism, accumulating in the stomach over about 30 minutes. The clearance time of this compound was considerably longer than 5 hours. The results obtained in this study agreed with that of the biodistribution studies and indicated that I-131-PYPER might be used as a scintigraphic agent for examining stomach diseases.