Browsing by Author "Dursun, I"

Now showing 1 - 11 of 11
  • No Thumbnail Available
    Item
    Pediatric kidney care experience after the 2023 Türkiye earthquake
    Bakkaloglu, SA; Delibas, A; Döven, SS; Taner, S; Yavuz, S; Erfidan, G; Vatansever, ED; Aynaci, F; Yílmaz, K; Tasdemir, M; Akaci, O; Akinci, N; Güven, S; Çiçek, N; Dursun, I; Kelesoglu, E; Sancaktar, M; Alaygut, D; Saygili, S; Yavascan, Ö; Yilmaz, A; Gülleroglu, K; Ertan, P; Demir, BK; Poyrazoglu, H; Pinarbasi, S; Gençler, A; Bastug, F; Günay, N; Çelegen, K; Noyan, A; Parmaksiz, G; Avci, B; Çayci, FS; Bayrakçi, U; Özlü, SG; Aksoy, ÖY; Yel, S; Inal, GA; Köse, S; Bayazit, AK; Atmis, B; Saribas, E; Çagli, Ç; Tabel, Y; Elmas, AT; Selçuk, SZ; Kiliç, BD; Kara, MA; Büyükçelik, M; Balat, A; Tiryaki, BD; Erdogdu, B; Aksu, B; Mahmudova, G; Dursun, H; Candan, C; Göknar, N; Mutlubas, F; Çamlar, SA; Basaran, C; Akbulut, BB; Düzova, A; Gülhan, B; Oruç, Ç; Peru, H; Alpay, H; Türkkan, ÖN; Gülmez, R; Çelakil, M; Dogan, K; Bilge, I; Pehlivanoglu, C; Büyükkaragöz, B; Leventoglu, E; Alpman, N; Zeybek, C; Tülpar, S; Gülsan, RYÇ; Kara, A; Gürgöze, MK; Önder, ENA; Atikel, YÖ; Pul, S; Sönmez, F; Yildiz, G; Akman, S; Elmaci, M; Küçük, N; Yüksel, S; Kavaz, A; Nalçacioglu, H; Alparslan, C; Dinçel, N; Elhan, AH; Sever, L
    Background. Two earthquakes on 6 February 2023 destroyed 10 cities in Turkiye. We report our experience with pediatric victims during these catastrophes, with a focus on crush syndrome related-acute kidney injury (Crush-AKI) and death. Method. Web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, and kidney and overall outcomes were recorded. Results. A total of 903 injured children (median age 11.62 years) were evaluated. Mean TUR was 13 h (interquartile range 32.5, max 240 h). Thirty-one of 32 patients with a TUR of >120 h survived. The patient who was rescued after 10 days survived. Two-thirds of the patients were given 50 mEq/L sodium bicarbonate in 0.45% sodium chloride solution on admission day. Fifty-eight percent of patients were given intravenous fluid (IVF) at a volume of 2000-3000 mL/m(2) body surface area (BSA), 40% at 3000-4000 mL/m(2) BSA and only 2% at >4000 mL/m(2) BSA. A total of 425 patients had surgeries, and 48 suffered from major bleeding. Amputations were recorded in 96 patients. Eighty-two and 66 patients required ventilator and inotropic support, respectively. Crush-AKI developed in 314 patients (36% of all patients). In all, 189 patients were dialyzed. Age >15 years, creatine phosphokinase (CK) >= 20 950 U/L, TUR >= 10 h and the first-day IVF volume <3000-4000 mL/m2 BSA were associated with Crush-AKI development. Twenty-two deaths were recorded, 20 of 22 occurring in patients with Crush-AKI and within the first 4 days of admission. All patients admitted after 7 days survived. Conclusions. These are the most extensive pediatric kidney disaster data obtained after an earthquake. Serum CK level was significantly associated with Crush-AKI at the levels of >20 950 U/L, but not with death. Adolescent age and initial IVF of less than 3000-4000 mL/m(2) BSA were also associated with Crush-AKI. Given that mildly injured victims can survive longer periods in the disaster field, we suggest uninterrupted rescue activity for at least 10 days.
  • No Thumbnail Available
    Item
    Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease
    Lerch, C; Shroff, R; Wan, M; Rees, L; Aitkenhead, H; Bulut, IK; Thurn, D; Bayazit, AK; Niemirska, A; Canpolat, N; Duzova, A; Azukaitis, K; Yilmaz, E; Yalcinkaya, F; Harambat, J; Kiyak, A; Alpay, H; Habbig, S; Zaloszyc, A; Soylemezoglu, O; Candan, C; Rosales, A; Melk, A; Querfeld, U; Leifheit-Nestler, M; Sander, A; Schaefer, F; Haffner, D; Cortina, G; Arbeiter, K; Dusek, J; Harambat, J; Ranchin, B; Fischbach, M; Zalosczyk, A; Querfeld, U; Habbig, S; Galiano, M; Büscher, R; Gimpel, C; Kemper, M; Melk, A; Thurn, D; Schaefer, F; Doyon, A; Wühl, E; Pohl, M; Wygoda, S; Jeck, N; Kranz, B; Wigger, M; Montini, G; Lugani, F; Testa, S; Vidal, E; Matteucci, C; Picca, S; Jankauskiene, A; Azukaitis, K; Zurowska, A; Drodz, D; Tkaczyk, M; Urasinski, T; Litwin, M; Niemirska, A; Szczepanska, M; Texeira, A; Peco-Antic, A; Bucher, B; Laube, G; Anarat, A; Bayazit, AK; Yalcinkaya, F; Basin, E; Cakar, N; Soylemezoglu, O; Duzova, A; Bilginer, Y; Erdogan, H; Donmez, O; Balat, A; Kiyak, A; Caliskan, S; Canpolat, N; Candan, C; Civilibal, M; Emre, S; Alpay, H; Ozcelik, G; Mir, S; Sözeri, B; Yavascan, O; Tabel, Y; Ertan, P; Yilmaz, E; Shroff, R; Prytula, A; Bachetta, J; Haffner, D; Klaus, G; Gessner, M; Schmitt, CP; Stabouli, S; Reusz, G; Verrina, E; Groothoff, J; Tondel, C; Gamero, MA; Petrosyan, E; Bakkaloglu, SA; Dursun, I; Shroff, R
    Background. We investigated the effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism, i.e. serum levels of fibroblast growth factor 23 (FGF23), Klotho, bone alkaline phosphatase (BAP) and sclerostin, in two cohorts with chronic kidney disease (CKD). Methods. In all, 80 vitamin D-deficient children were selected: 40 with mild to moderate CKD from the ERGO study, a randomized trial of ergocalciferol supplementation [ estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m(2)], and 40 with advanced CKD from the observational Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study (eGFR 24 mL/min/1.73 m2). In each study, vitamin D supplementation was started in 20 children and 20 matched children not receiving vitamin D served as controls. Measures were taken at baseline and after a median period of 8 months. Age- and gender-related standard deviation scores (SDSs) were calculated. Results. Before vitamin D supplementation, children in the ERGO study had normal FGF23 (median 0.31 SDS) and BAP (-0.10 SDS) but decreased Klotho and sclerostin (-0.77 and -1.04 SDS, respectively), whereas 4C patients had increased FGF23 (3.87 SDS), BAP (0.78 SDS) and sclerostin (0.76 SDS) but normal Klotho (-0.27 SDS) levels. Vitamin D supplementation further increased FGF23 in 4C but not in ERGO patients. Serum Klotho and sclerostin normalized with vitamin D supplementation in ERGO but remained unchanged in 4C patients. BAP levels were unchanged in all patients. In the total cohort, significant effects of vitamin D supplementation were noted for Klotho at eGFR 40-70 mL/min/1.73 m(2). Conclusions. Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD.
  • No Thumbnail Available
    Item
    Comparison of infants and children with urolithiasis: a large case series
    Bastug, F; Agbas, A; Tülpar, S; Yildirim, ZNY; Çiçek, N; Günay, N; Gemici, A; Çelik, B; Delebe, EÖÇ; Nalçacioglu, H; Yilmaz, A; Gökçe, I; Demircin, G; Hacihamdioglu, DÖ; Yilmaz, K; Atmis, B; Yilmaz, EK; Ertan, P; Dursun, I; Aksu, B; Akbulut, BB; Döven, SS; Öner, N; Yel, S; Elmaci, AM; Atikel, YÖ; Erfidan, G; Uysal, B; Biyikli, N; Yazicioglu, B; Küçük, N; Çomak, E; Sever, FL; Akil, I; Aksoy, Ö; Alpay, H
    We evaluated the demographic features, etiologic risk factors, treatment strategies, and outcome of the infants and children with urolithiasis (UL). A retrospective multicenter study was conducted including 23 Pediatric Nephrology centers in Turkey. The medical records of 2513 children with UL were reviewed. One thousand, three hundred and four boys and 1209 girls (1.1:1) were reported. The mean age at diagnosis was 39.5 +/- 35 months (0.4-231 months), and 1262 patients (50.2%) were in the first year of life (infants). Most of the cases with infantile UL were diagnosed incidentally. Microlithiasis (< 3 mm) was found in 794 patients (31.6%), and 64.5% of the patients with microlithiasis were infants. Stones were located in the pelvis-calyces in 63.2% (n: 1530) of the cases. The most common stone type was calcium oxalate (64.6%). Hypocitraturia was the most common metabolic risk factor (MRF) in children older than 12 months, but in infancy, hypercalciuria was more common. Fifty-five percent of the patients had received at least one medical treatment, mostly potassium citrate. At the end of a year's follow-up, most of the patients with microlithiasis (85%) showed spontaneous remission. The rate of spontaneous stone resolution in infants was higher than in children. Spontaneous remission rate was higher in cases with MRF ( - ) stones than in MRF ( +) stones. However, remission rate with medical treatment was higher in cases with MRF ( +) stones. This study represents the results of a large series of infants and children with UL and showed that there are several differences such as underlying metabolic and anatomic abnormalities, clinical course, and stone remission rates between infants and children with urinary stone disease.
  • No Thumbnail Available
    Item
    Hemolytic uremic syndrome outbreak in Turkey in 2011
    Ekinci, Z; Candan, C; Alpay, H; Canpolat, N; Akyüz, SG; Gündüz, Z; Dursun, I; Bek, K; Dursun, H; Isiyel, E; Öktem, F; Tabel, Y; Akil, I; Delibas, A; Gülleroglu, K; Akinci, N; Dinçel, N; Özkaya, O; Söylemezoglu, O
    The aim of this retrospective multicenter study was to define the epidemiological and clinical features and prognostic factors of the first diarrhea-related hemolytic uremic syndrome (D+HUS) outbreak in Turkey in 2011. All pediatric nephrology centers in Turkey were asked about D+HUS patients via e-mail. Seventy D+HUS patients (median age: 5.7 years) participated. The seasonal peak was around the 7th, 8th and 9th months with 44 cases, centered in the east Marmara region. No causative agent could be identified. The rate of neurological complications and mortality was 21.4% and 4.2%, respectively. Eculizumab was used in four cases. Two of them had severe neurological complications despite plasma exchange. Elevated polymorphonuclear leukocyte count during hospital admission was the predictor of both severe disease and poor outcome. Duration of prodrome was the predictor of poor outcome (p<0.05). In conclusion, the median age of the affected children was greater than in the previous reports, while clinical features and outcome were similar.
  • No Thumbnail Available
    Item
    A nationwide retrospective study in Turkish children with nephrocalcinosis
    Döven, SS; Tülpar, S; Bastug, F; Yildirim, ZNY; Yilmaz, EK; Çiçek, N; Küçük, N; Çomak, E; Yazicioglu, B; Nalcacioglu, H; Delibas, A; Uysal, B; Agbas, A; Gemici, A; Günay, N; Ertan, P; Biyikli, N; Hacihamdioglu, DO; Elmaci, AM; Atikel, YO; Delebe, EÖÇ; Sever, FL; Gökçe, I; Öner, N; Akman, S; Aksu, B; Atmis, B; Yel, S; Yilmaz, A; Çelik, B; Dursun, I; Alpay, H
    Background/aim: Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors, and follow-up results of patients with NC in Turkey. Materials and methods: Patients diagnosed with NC in the pediatric nephrology Department Units of 19 centers from all geographical regions of Turkey over a 10-year period (2010-2019) were included in the study. The medical records from the centers were reviewed and demographic data, admission complaints, medical history, systemic and genetic disorders, risk factors for NC, treatment details, and presence of NC after one-year follow-up, were recorded retrospectively. Results: The study sample included 195 patients (88 females, 107 males). The mean age at diagnosis was 39.44 +/- 47.25 (0.5-208) months; 82/190 patients (43.2%) were diagnosed incidentally; 46/195 patients (23.6%) had an underlying disease; idiopathic hypercalciuria was detected in 75/195 (38.4%) patients. The most common systemic diseases were distal renal tubular acidosis in 11/46 patients (23.9%), primary hyperoxaluria in 9/46 patients (19.6%) and Bartter syndrome in 7/46 patients (15.3%). After one year of follow-up, NC resolved in 56/159 patients (35.2%) and they all did not have an underlying systemic disease. Conclusion: The most common presentation of NC was incidental. Distal renal tubular acidosis and primary hyperoxaluria were the main systemic diseases leading to NC, while hypercalciuria was the most common metabolic risk factor. Nephrocalcinosis was found to remain in most of the patients at a one-year follow-up. It may resolve particularly in patients with no underlying systemic disease.
  • No Thumbnail Available
    Item
    AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY DISEASE IN CHILDREN: PRELIMINARY RESULTS OF A TURKISH NATIONAL, MULTICENTER STUDY
    Ozdogan, EB; Nalcacioglu, H; Alpay, H; Dursun, I; Bek, K; Demir, BK; Tekcan, D; Acikgoz, Y; Melek, E; Yazilitas, F; Bayram, MT; Yildirim, ZY; Gokce, I; Yilmaz, D; Tulpar, S; Isik, G; Ertan, P; Agbas, A; Aydog, O; Mutlubas, F; Bircan, Z; Cicek, N; Bayazit, AK; Soylu, A; Soyaltin, E; Celakil, ME; Yildiz, N
  • No Thumbnail Available
    Item
    Hemolytic uremic syndrome outbreak in Turkey in 2011
    Ekinci, Z; Candan, C; Alpay, H; Akyuz, SG; Gunduz, Z; Dursun, I; Caliskan, S; Canpolat, N; Bek, K; Dursun, H; Isiyel, E; Oktem, F; Tabel, Y; Akil, I; Delibas, A; Gulleroglu, K; Akinci, N; Dincel, N; Soylemezoglu, O
  • No Thumbnail Available
    Item
    Kidney disease profile and encountered problems during follow-up in Syrian refugee children: a multicenter retrospective study
    Balat, A; Kilic, BD; Aksu, B; Kara, MA; Buyukcelik, M; Agbas, A; Eroglu, FK; Gungor, T; Alaygut, D; Yildiz, N; Bastug, F; Atmis, B; Melek, E; Elmaci, M; Tulpar, S; Pehlivanoglu, C; Doven, SS; Comak, E; Tabel, Y; Gemici, A; Uysal, B; Ozzorlar, GS; Kuçuk, N; Delibas, A; Ozcelik, G; Goknar, N; Dursun, I; Ertan, P; Ozunan, IA; Sonmez, F
    Background Children are one of the most vulnerable groups in conflict zones, especially those with chronic diseases. This study aimed to investigate kidney disease profiles and problems during follow-up in a population of Syrian refugee children residing in Turkey. Methods Syrian refugee children aged between 0 and 18 years were included in the study. Demographic data, diagnosis, particular interventions due to nephrological problems, and problems encountered during follow-up were obtained from all participating pediatric nephrology centers. Results Data from 633 children from 22 pediatric nephrology centers were included. Mean age of the children was 94.8 +/- 61.7 months and 375 were male (59%). 57.7% had parental consanguinity and 23.3% had a close relative(s) with kidney disease. The most common kidney diseases were congenital anomalies of the kidney and urinary tract (CAKUT) (31.0%), glomerular disease (19.9%), chronic kidney disease (CKD) (14.8%), and urolithiasis (10.7%). Frequent reasons for CAKUT were nonobstructive hydronephrosis (23.0%), vesico-ureteral reflux (18.4%), and neurogenic bladder (15.8%). The most common etiology of glomerular diseases was nephrotic syndrome (69%). Ninety-four children had CKD, and 58 children were on chronic dialysis. Six children had kidney transplantation. Surgical intervention was performed on 111 patients. The language barrier, lack of medical records, and frequent disruptions in periodic follow-ups were the main problems noted. Conclusions CAKUT, glomerular disease, and CKD were highly prevalent in Syrian refugee children. Knowing the frequency of chronic diseases and the problems encountered in refugees would facilitate better treatment options and preventive measures.
  • No Thumbnail Available
    Item
    CLINICAL, EPIDEMIOLOGICAL AND PROGNOSTIC FEATURES OF CHILDREN WITH HEMOLYTIC UREMIC SYNDROME: MULTICENTER EXPERIENCE OF TURKEY
    Ertan, P; Bulut, IK; Guven, S; Cicek, N; Tulpar, S; Coskun, S; Donmez, O; Dusunsel, R; Serdaroglu, E; Bek, K; Kucuk, N; Akinci, N; Celakil, ME; Dursun, I; Yigit, G; Soylu, A; Bayram, MT; Bayrakci, US; Bakkaloglu, S; Ozdogan, EB; Koyun, M; Tufan, AK; Sonmez, F; Delibas, A; Tabel, Y; Ozkayin, N; Melek, E; Erdogan, H; Uysal, B; Bastug, F; Yavascan, O
  • No Thumbnail Available
    Item
    COVID-19 IN PEDIATRIC NEPHROLOGY CENTERS IN TURKEY
    Bakkaloglu, SA; Atikel, YÖ; LeventoGlu, E; Nalçacioglu, H; Dursun, I; PoyrazoGlu, H; Dursun, H; Yildirim, ZY; Yildiz, N; Aksoy, GK; Akman, S; Tasdemir, M; Bilge, I; Çelakil, M; Kiliç, BD; Selçuk, SZ; Canpolat, N; Çakici, EK; Özlü, SG; Tülpar, S; Yüksel, S; Atmis, B; Döven, SS; Taner, S; Ertan, P; Kavaz, A; Bayram, MT; Kalyoncu, M; GÜlleroGlu, K; Kabasakal, C; Demir, BK; Çiçek, RY; Dönmez, O; Kara, A; Yavascan, Ö; Özçelik, G; Yildirim, DG; Güler, MA; Sönmez, F; Topaloglu, R; Alpay, H
  • No Thumbnail Available
    Item
    COVID-19 in pediatric nephrology centers in Turkey
    Leventoglu, E; Özdemir Atikel, Y; Nalçacioglu, H; Dursun, I; Dursun, H; Yürük Yildirim, Z; Yildiz, N; Kaya Aksoy, G; Tasdemir, M; Çelakil, M; Demircioglu Kiliç, B; Zirhli Selçuk, S; Canpolat, N; Kargin Cakici, E; Özlü, SG; Tülpar, S; Yüksel, S; Atmis, B; Sürmeli Döven, S; Taner, S; Ertan, P; Kavaz, A; Torun Bayram, M; Kalyoncu, M; Gülleroglu, K; Kabasakal, C; Kasap Demir, B; Çiçek, RY; Bilge, I; Dönmez, O; Kara, A; Yavascan, Ö; Özçelik, G; Gezgin Yildirim, D; Güler, MA; Sönmez, F; Poyrazoglu, H; Akman, S; Topaloglu, R; Alpay, H; Bakkaloglu, SA
    Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients' susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage.