Browsing by Author "Ece A."

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    Effects of passive exposure to tobacco, socioeconomic status and a family history of essential hypertension on lipid profiles in children
    (International Heart Journal Association, 1996) Işcan A.; Uyanik B.S.; Vurgun N.; Ece A.; Yiǧitoǧlu M.R.
    There is abundant evidence that the atherosclerotic process begins in childhood. Dyslipidemia is a major risk factor for atherosclerosis in adults and children. In the present study, we measured serum lipoprotein concentrations in 194 healthy children aged between 4 to 14 years. Children were grouped according to the socioeconomic status of the families, family history of essential hypertension and passive tobacco exposure. The values of total cholesterol, low density lipoprotein cholesterol and the ratio of total cholesterol/high density lipoprotein cholesterol in the low socioeconomic group were found to be significantly higher than the values obtained for the middle-high socioeconomic group. The values of total cholesterol, low density lipoprotein cholesterol, the ratio of total cholesterol/high density lipoprotein cholesterol and low density lipoprotein cholesterol/high density lipoprotein cholesterol in the passive smoker group were found to be significantly higher than those of the nonsmoker group. But, the socioeconomic level in the passive smoker group was found to be significantly lower than that of the nonsmoker group, and therefore, the impact of passive smoking on the serum lipids in children was related to socioeconomic status. A significant difference in terms of blood lipid fractions between the groups with and that without a family history of essential hypertension was not found. These results suggest that passive smoking and lower socioeconomic status are important risk factors for cardiovascular heart disease, while a positive family history of essential hypertension is not an important risk factor.
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    A comparative study of azithromycin, cephalexin and penicillin V for the treatment of streptococcal pharyngitis and tonsillitis in children; [COCUKLARDA STREPTOKOKSIK FARENJIT VE TONSILLIT TEDAVISINDE AZITROMISIN, SEFALEKSIN VE ORAL PENISILIN VNIN ETKINLIGININ KARSILASTIRILMASI]
    (1996) Ece A.; Iscan A.; Sengil A.Z.; Balkan C.; Cetinkaya Z.
    In this study, clinical and bacteriological efficacies of penicillin V were compared with those of azithromycin and cephalexin. Of 94 children who had group A beta hemolytic streptococcal (GABHS) pharyngitis/tonsillitis, 31 received a single daily. dose of azithromycin (10 mg/kg) for three days, 33 received cephalexin 40 mg/kg/day in three doses for 10 days, 30 received oral penicillin V 50.000 IU/kg for 10 days. At the end of the treatment, bacterial eradication was achieved in 91% of azithromycin-treated patients, 88% of cephalexin-treated patients and 83% of penicillin treated-patients (p > 0.05). Clinical cure rates were 94% in azithromycin group, 91% in cephalexin group and 90% in penicillin group (p > 0.05). At follow-up evaluation (day 30 ± 5) bacteriologic recurrence was observed in 4 patients of azithromycin-treated group (13%), in 6 of cephalexin treated group (18%) and in 6 of penicillin-treated group (20%). The results of this study indicate that oral penicillin V is clinically as effective as azithromycin and cephalexin in the treatment of GABHS pharyngotonsillitis.
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    The effect of cigarette smoking during pregnancy on cord blood lipid, lipoprotein and apolipoprotein levels
    (International Heart Journal Association, 1997) Işcan A.; Yiǧitoǧlu M.R.; Ece A.; Ari Z.; Akyildiz M.
    We examined the relationship between maternal smoking during pregnancy and serum lipid, lipoprotein and apolipoprotein levels in newborns. Serum concentrations of total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B and lipoprotein (a) were assesed in blood samples from 38 mothers who were smokers and their newborns obtained at delivery and compared to blood sample from 42 nonsmokers and their newborns. As compared with newborns of nonsmoker mothers, newborns of smoker mothers showed a lower mean level of high density lipoprotein cholesterol (21 versus 26 mg/dl, p < 0.01), a higher total cholesterol to high density lipoprotein cholesterol (4.7 versus 3.7, P < 0.01), a higher low density lipoprotein cholesterol to high density lipoprotein cholesterol ratios (3.2 versus 2.3, p < 0.05), a lower mean level of apolipoprotein A-1 (105 versus 129 mg/dl, p < 0.01) and a higher apolipoprotein B to apolipoprotein A-1 ratio (0.44 versus 0.3, p < 0.01). These paremeters were also different between smoker and nonsmoker mothers. There were no significant differences in TC, TG, LDL-C, Apo B and Lp (a) values between the two newborn groups. These data suggest that maternal smoking during pregnancy markedly affects lipid metabolism in the fetus.
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    Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia
    (Humana Press Inc., 1997) Ece A.; Uyanik B.S.; Işcan A.; Ertan P.; Yiǧitoǧlu M.R.
    In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged 1-14 yr and 64 healthy children as controls aged 1-14 yr were included the study. Serum copper levels were higher in children with IDA (189 ± 49 μg/dL) than those of controls (163 ± 37 μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 μg/dL) than those of control subjects (135 ± 56 μg/dL) (p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum zinc level in patients. It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment should be initiated with zinc.
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    Renal functions of enuretic and nonenuretic children: Hypernatriuria and kaliuresis as causes of nocturnal enuresis
    (Elsevier B.V., 1997) Vurgun N.; Gumus B.H.; Ece A.; Ari Z.; Tarhan S.; Yeter M.
    Objective: The aim of this study was to investigate the pathophysiologic cause(s) of primary nocturnal enuresis. Therefore, electrolyte concentrations of urine specimens were evaluated in the morning, and alterations compared between enuretics and nonenuretics. Methods and Patients: First morning urine specimens of 27 enuretics and 21 nonenuretic subjects fed the same diet were collected, and urinary electrolytes were measured. The urinary Ca/Cr ratio, tubular reabsorption of phosphorus (TRP) and fractional sodium (FE Na%) and potassium excretions (FE K%) were determined for patients and controls. Results: There was no significant difference in the Ca/Cr ratio and TRP between patients and controls, but enuretic patients had significantly higher FE Na% and FE K% values than controls (p < 0.001). There were significant positive correlations between FE Na% and (r = 0.81, p < 0.001) FE K% and the frequency of bedwetting, respectively, among enuretic patients (r = 0.54, p < 0.001). Conclusion: Since Na and K excretion of enuretic patients was higher than in nonenuretics, it can be concluded that there may be a benign hereditary and/or postural renal tubular handling disorder of Na and K in enuretic children.
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    Relationship between pinworm and urinary tract infections in young girls
    (Blackwell Munksgaard, 1999) Ok U.Z.; Ertan P.; Limoncu E.; Ece A.; Özbakkaloǧlu B.
    Urinary tract infection is particularly common in young girls and Enterobius vermicularis (pinworm) is one of the most prevalent worms found in children worldwide. Young girls, with or without urinary tract infection, were examined for pinworms in order to explore a possible relationship between these two problems. Of the 55 young girls with urinary tract infection, 20 (36.4%) had pinworm eggs in the perianal and/or perineal region monitored using the cellophane tape method, while 9 (16.4%) of 55 young girls who had never previously had a urinary tract infection were found to have Enterobius eggs in at least one of the cellophane tape tests, and the difference was found to be significant (p<0.05). These results suggested that urinary tract infections may be related to pinworms. When a urinary tract infection is diagnosed in young girls, cellulose tape should be applied to both the perianal and the perineal regions on at least three consecutive occasions.