Browsing by Author "Eiwegger, T"

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    ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020)
    Bousquet, J; Jutel, M; Akdis, CA; Klimek, L; Pfaar, O; Nadeau, KC; Eiwegger, T; Bedbrook, A; Ansotegui, IJ; Anto, JM; Bachert, C; Bateman, ED; Bennoor, KS; Berghea, EC; Bergmann, KC; Blain, H; Bonini, M; Bosnic-Anticevich, S; Boulet, LP; Brussino, L; Buhl, R; Camargos, P; Canonica, GW; Cardona, V; Casale, T; Chinthrajah, S; Akdis, M; Chivato, T; Christoff, G; Cruz, AA; Czarlewski, W; Del Giacco, S; Du, H; El-Gamal, Y; Fokkens, WJ; Fonseca, JA; Gao, YD; Gaga, M; Gemicioglu, B; Gotua, M; Haahtela, T; Halpin, D; Hamelmann, E; Hoffmann-Sommergruber, K; Humbert, M; Ilina, N; Ivancevich, JC; Joos, G; Khaitov, M; Kirenga, B; Knol, EF; Ko, FW; Koskinen, S; Kowalski, ML; Kraxner, H; Kudlay, D; Kuna, P; Kupczyk, M; Kvedariene, V; Latiff, AAH; Le, LT; Levin, M; Larenas-Linnemann, D; Louis, R; Masjedi, MR; Melén, E; Mihaltan, F; Milenkovic, B; Mohammad, Y; Morais-Almeida, M; Mullol, J; Namazova, L; Neffen, H; Nunes, E; O'Byrne, P; O'Hehir, R; O'Mahony, L; Ohta, K; Okamoto, Y; Onorato, GL; Panzner, P; Papadopoulos, NG; Passalacqua, G; Patella, V; Pawankar, R; Pham-Thi, N; Pigearias, B; Popov, TA; Puggioni, F; Regateiro, FS; Rolla, G; Rottem, M; Samolinski, B; Sastre, J; Schwarze, J; Sheikh, A; Scichilone, N; Soto-Quiros, M; Soto-Martinez, M; Sova, M; Nicola, S; Stelmach, R; Suppli-Ulrik, C; Taborda-Barata, L; To, T; Tomazic, PV; Toppila-Salmi, S; Tsiligianni, I; Usmani, O; Valiulis, A; Ventura, MT; Viegi, G; Vontetsianos, T; Wang, DY; Williams, S; Wong, GWK; Yorgancioglu, A; Zernotti, M; Zidarn, M; Zuberbier, T; Agache, I
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    COVID-19 pandemic: Practical considerations on the organization of an allergy clinic-An EAACI/ARIA Position Paper
    Pfaar, O; Klimek, L; Jutel, M; Akdis, CA; Bousquet, J; Breiteneder, H; Chinthrajah, S; Diamant, Z; Eiwegger, T; Fokkens, WJ; Fritsch, HW; Nadeau, KC; O'Hehir, RE; O'Mahony, L; Rief, W; Sampath, V; Schedlowski, M; Torres, MJ; Traidl-Hoffmann, C; Wang, DY; Zhang, L; Bonini, M; Brehler, R; Brough, HA; Chivato, T; Del Giacco, SR; Dramburg, S; Gawlik, R; Gelincik, A; Hoffmann-Sommergruber, K; Hox, V; Knol, EF; Lauerma, A; Matricardi, PM; Mortz, CG; Ollert, M; Palomares, O; Riggioni, C; Schwarze, J; Skypala, I; Untersmayr, E; Walusiak-Skorupa, J; Ansotegui, IJ; Bachert, C; Bedbrook, A; Bosnic-Anticevich, S; Brussino, L; Canonica, GW; Cardona, V; Carreiro-Martins, P; Cruz, AA; Czarlewski, W; Fonseca, JA; Gotua, M; Haahtela, T; Ivancevich, JC; Kuna, P; Kvedariene, V; Larenas-Linnemann, DE; Latiff, AHA; Mäkelä, M; Morais-Almeida, M; Mullol, J; Naclerio, R; Ohta, K; Okamoto, Y; Onorato, GL; Papadopoulos, NG; Patella, V; Regateiro, FS; Samolinski, B; Suppli Ulrik, C; Toppila-Salmi, S; Valiulis, A; Ventura, MT; Yorgancioglu, A; Zuberbier, T; Agache, I
    BackgroundThe coronavirus disease 2019 (COVID-19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Allergists and other healthcare providers (HCPs) in the field of allergies and associated airway diseases are on the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics. MethodThe scientific information on COVID-19 was analysed by a literature search in MEDLINE, PubMed, the National and International Guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library, and the internet. ResultsBased on the diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations, and on previous experience, a panel of experts including clinicians, psychologists, IT experts, and basic scientists along with EAACI and the Allergic Rhinitis and its Impact on Asthma (ARIA) initiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies. ConclusionsThis international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients while ensuring the necessary safety measures in the current COVID-19 pandemic.
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    Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis
    Bousquet, J; Melén, E; Haahtela, T; Koppelman, GH; Togias, A; Valenta, R; Akdis, CA; Czarlewski, W; Rothenberg, M; Valiulis, A; Wickman, M; Akdis, M; Aguilar, D; Bedbrook, A; Bindslev-Jensen, C; Bosnic-Anticevich, S; Boulet, LP; Brightling, CE; Brussino, L; Burte, E; Bustamante, M; Canonica, GW; Cecchi, L; Celedon, JC; Loureiro, CC; Costa, E; Cruz, AA; Erhola, M; Gemicioglu, B; Fokkens, WJ; Garcia-Aymerich, J; Guerra, S; Heinrich, J; Ivancevich, JC; Keil, T; Klimek, L; Kuna, P; Kupczyk, M; Kvedariene, V; Larenas-Linnemann, DE; Lemonnier, N; Carlsen, KCL; Louis, R; Makela, M; Makris, M; Maurer, M; Momas, I; Morais-Almeida, M; Mullol, J; Naclerio, RN; Nadeau, K; Nadif, R; Niedoszytko, M; Okamoto, Y; Ollert, M; Papadopoulos, NG; Passalacqua, G; Patella, V; Pawankar, R; Pham-Thi, N; Pfaar, O; Regateiro, FS; Ring, J; Rouadi, PW; Samolinski, B; Sastre, J; Savouré, M; Scichilone, N; Shamji, MH; Sheikh, A; Siroux, V; Sousa-Pinto, B; Standl, M; Sunyer, J; Taborda-Barata, L; Toppila-Salmi, S; Torres, MJ; Tsiligianni, I; Valovirta, E; Vandenplas, O; Ventura, MT; Weiss, S; Yorgancioglu, A; Zhang, L; Latiff, AHA; Aberer, W; Agache, I; Al-Ahmad, M; Alobid, I; Ansotegui, IJ; Arshad, SH; Asayag, E; Barbara, C; Baharudin, A; Battur, L; Bennoor, KS; Berghea, EC; Bergmann, KC; Bernstein, D; Bewick, M; Blain, H; Bonini, M; Braido, F; Buhl, R; Bumbacea, RS; Bush, A; Calderon, M; Calvo-Gil, M; Camargos, P; Caraballo, L; Cardona, V; Carr, W; Carreiro-Martins, P; Casale, T; Sarabia, AMC; Chandrasekharan, R; Charpin, D; Chen, YZ; Cherrez-Ojeda, I; Chivato, T; Chkhartishvili, E; Christoff, G; Chu, DK; Cingi, C; de Sousa, JC; Corrigan, C; Custovic, A; D'Amato, G; Del Giacco, S; De Blay, F; Devillier, P; Didier, A; Teixeira, MD; Dokic, D; Douagui, H; Doulaptsi, M; Durham, S; Dykewicz, M; Eiwegger, T; El-Sayed, ZA; Emuzyte, R; Fiocchi, A; Fyhrquist, N; Gomez, RM; Gotua, M; Guzman, MA; Hagemann, J; Hamamah, S; Halken, S; Halpin, DMG; Hofmann, M; Hossny, E; Hrubisko, M; Irani, C; Ispayeva, Z; Jares, E; Jartti, T; Jassem, E; Julge, K; Just, J; Jutel, M; Kaidashev, I; Kalayci, O; Kalyoncu, AF; Kardas, P; Kirenga, B; Kraxner, H; Kull, I; Kulus, M; La Grutta, S; Lau, S; Thi, LL; Levin, M; Lipworth, B; Lourenço, O; Mahboub, B; Martinez-Infante, E; Matricardi, P; Miculinic, N; Migueres, N; Mihaltan, F; Mohammad, Y; Moniuszko, M; Montefort, S; Neffen, H; Nekam, K; Nunes, E; Tshipukane, DN; O'Hehir, R; Ogulur, I; Ohta, K; Okubo, K; Ouedraogo, S; Olze, H; Pali-Schöll, I; Palomares, O; Palosuo, K; Panaitescu, C; Panzner, P; Park, HS; Pitsios, C; Plavec, D; Popov, TA; Puggioni, F; Quirce, S; Recto, M; Repka-Ramirez, MS; Cordeiro, CR; Roche, N; Rodriguez-Gonzalez, M; Romantowski, J; Rosario, N; Rottem, M; Sagara, H; Serpa, FS; Sayah, Z; Scheire, S; Schmid-Grendelmeier, P; Sisul, JC; Sole, D; Soto-Martinez, M; Sova, M; Sperl, A; Spranger, O; Stelmach, R; Ulrik, CS; Thomas, M; To, T; Todo-Bom, A; Tomazic, PV; Urrutia-Pereira, M; Valentin-Rostan, M; Van Ganse, E; van Hage, M; Vasankari, T; Vichyanond, P; Viegi, G; Wallace, D; Wang, DY; Williams, S; Worm, M; Yiallouros, P; Yusuf, O; Zaitoun, F; Zernotti, M; Zidarn, M; Zuberbier, J; Fonseca, JA; Zuberbier, T; Anto, JM
    Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of one-airway-one-disease, coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the Epithelial Barrier Hypothesis. This review determined that the one-airway-one-disease concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme allergic (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.