Browsing by Author "Ekici Z."

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    The effect of combination of sevoflurane and desflurane with fentanyl and remifentanil on different recovery scores in outpatient anesthesia; [Günübirlik Anestezide Sevofluran Veya Desfluran Ile Birlikte Fentanil ve Remifentanil Kombinasyonunun Farkli Derlenme Skorlari Ile Karşilaştirilmasi]
    (2005) Tezcan Keleş G.; Toprak V.; Ekici Z.; Tok D.
    We aim to compare sevoflurane and desflurane with fentanil and remifentanil in the operating room (OR-Phase-1) and post-anaesthesia care unit (PACU-Phase-2) by using Fast-Tract-Criteria (FTC) and Aldrete Criteria (AC) for ambulatory anesthesia. After obtaining approval from the Faculty Ethics Committee, 80 ASA I-II patients, aged 18-60 were randomly divided into four groups (n=20). Following standard anaesthesia induction, Group (S+F) received 1-3 % sevoflurane + 2 μg kg-1h-1 fentanyl, Group (S+R) received 1-3% sevoflurane + 0.25 μg kg-1h-1 remifentanil, Group (D+F) received 2-5 % desflurane + 2 μg kg-1h-1 fentanyl and Group (D+R) received 2-5% desflurane + 0.25 μg kg-1h-1 remifentanil in 60% N2O for anaesthesia management. Fifteen minutes before the end of the surgery, standard analgesic and anti-emetic medications were applied to all patients. Extubation times were recorded, FTC and AC were evaluated in the OR at the 5th and 10th minutes following extubation and in PACU at the 5th, 15th and 25th minutes. Pain and emesis were evaluated in the PACU. P<0.05 was considered significant. In phase 1 at the 10th min; Group (D+R) had a higher AC score than group (S+F) (p<0.05), in phase 2 at the 5th min; Group (D+R) had higher FTC and AC scores than the other groups (p<0.01 and p<0.05). In phase 2 at the 15th minute, Group (S+F) had a lower AC score than the other groups (p<0.05). In all patients, targeted discharge points were achieved at the 25th minute in PACU. In conclusion, both FTC and AC were applied easily in Phase 1 and Phase 2 to the four groups. The desflurane and remifentanil combination seems to be the most suitable for outpatient anesthesia.
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    Comparison of clinical effectiveness of thoracic epidural and intravenous patient-controlled analgesia for the treatment of rib fractures pain in intensive care unit; [Toraks travmali hastalarda intravenöz hasta kontrollü analjezi ile torakal epidural hasta kontrollü analjezinin klinik etkinliǧinin karşilaştirilmasi]
    (2007) Topçu I.; Ekici Z.; Sakarya M.
    BACKGROUND: The results of thoracic epidural and systemic patient controlled analgesia practice were evaluated retrospectively in patients with thoracic trauma. METHODS: Patients who were admitted to the intensive care unit between 1997 and 2003, with a diagnosis of multiple rib fractures related to thoracic trauma were evaluated retrospectively. Data were recorded from 49 patients who met the following criteria; three or more rib fractures, initiation of PCA with I.V. phentanyl or thoracic epidural analgesia with phentanyl and bupivacaine. RESULTS: There were no significant differences between the groups concerning injury severity score. APACHE II score (8.1±1.6 and 9.2±1.7) and the number of rib fractures (4±1.1 and 6.8±2.7) were higher in thoracic epidural analgesia group (p<0.05). Pain scores of patients who received thoracic epidural analgesia were significantly lower as from 6th hour during whole therapy (p<0.05). Length of intensive care unit stay (15.6±5.9 and 12.1±4.4 day) was found to be shorter in thoracic epidural analgesia group (p<0.05). There were no differences between the groups regarding mechanical ventilation requirement, pulmonary and cardiac complications. CONCLUSION: We suggest that the use of thoracic epidural analgesia with infusion of local anesthetics and opioids are more appropriate as they provide more effective analgesia and shorten length of intensive care unit stay in chest trauma patients with more than three rib fractures who require intensive care.
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    The effect of epidural and general anesthesia on newborn rectal temperature at elective cesarean section
    (Associacao Brasileira de Divulgacao Cientifica, 2009) Yentur E.A.; Topcu I.; Ekici Z.; Ozturk T.; Keles G.T.; Civi M.
    Both epidural and general anesthesia can impair thermoregulatory mechanisms during surgery. However, there is lack of information about the effects of different methods of anesthesia on newborn temperature. The purpose of this study was to determine whether there are differences in newborn rectal temperature related to type of anesthesia. Sixty-three pregnant women were randomly assigned to receive general or epidural anesthesia. Maternal core temperature was measured three times with a rectal probe just before anesthesia, at the beginning of surgery and at delivery. In addition, umbilical vein blood was sampled for pH. The rectal temperatures of the babies were recorded immediately after delivery, and Apgar scores were determined 1, 5, and 10 min after birth. The duration of anesthesia and the volume of intravenous fluid given during the procedure (833 ± 144 vs 420 ± 215 mL) were significantly higher in the epidural group than in the general anesthesia group (P < 0.0001). Maternal rectal temperatures were not different in both groups at all measurements. In contrast, newborn rectal temperatures were lower in the epidural anesthesia group than in the general anesthesia group (37.4 ± 0.3 vs 37.6 ± 0.3° C; P < 0.05) immediately after birth. Furthermore, the umbilical vein pH value (7.31 ± 0.05 vs 7.33 ± 0.01; P < 0.05) and Apgar scores at the 1st-min measurement (8.0 ± 0.9 vs 8.5 ± 0.7; P < 0.05) were lower in the epidural anesthesia group than in the general anesthesia group. Since epidural anesthesia requires more iv fluid infusion and a longer time for cesarean section, it involves a risk of a mild temperature reduction for the baby which, however, did not reach the limits of hypothermia.
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    Evaluation of piroxicam-β-cyclodextrin as a preemptive analgesic in functional endoscopic sinus surgery
    (Associacao Brasileira de Divulgacao Cientifica, 2010) Keleş G.T.; Topçu I.; Ekici Z.; Yentür A.
    The preemptive analgesic efficacy and adverse effects of preoperatively administered piroxicam-β-cyclodextrin for post-endoscopic sinus surgery pain was determined in a prospective, double-blind, randomized, clinical study. Seventy-five American Society of Anesthesiologists status I-II patients, aged 18-65 years, were divided into three groups with similar demographic characteristics: group 1 received 20 mg piroxicam-β-cyclodextrin, group 2 received 40 mg piroxicam-β-cyclodextrin and group 3 received placebo orally before induction of general anesthesia. A blinded observer recorded the incidence and severity of pain at admission to the post-anesthesia care unit (PACU), at 15, 30, and 45 min in the PACU, and 1, 2, 4, 6, and 24 h postoperatively. All patients received patient-controlled morphine analgesia during the postoperative period and consumption was recorded for 24 h. During the PACU period, mean visual analogue scale values were significantly lower in groups 1 and 2 compared to group 3 (P < 0.05). During the postoperative period, morphine consumption was 3.03 ± 2.54, 2.7 ± 2.8, and 5.56 ± 3.12 mg for each group, respectively (P < 0.05). As a side effect, bleeding was observed in groups 1 and 3, nausea and vomiting in all groups, and edema only in group 3. However, no significant differences were detected in any of the parameters analyzed, which also included epigastric pain, constipation/diarrhea and headache. Similar hematological test results were obtained for all groups. Preemptive administration of piroxicam-β-cyclodextrin effectively reduced analgesic consumption, and 40 mg of the drug was more effective than 20 mg piroxicam-β-cyclodextrin without side effects during the postoperative period.
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    Epidemiology and distribution of interstitial lung diseases in Turkey
    (2014) Musellim B.; Okumus G.; Uzaslan E.; Akgün M.; Cetinkaya E.; Turan O.; Akkoclu A.; Hazar A.; Kokturk N.; Calisir H.C.; Sever F.; Kiter G.; Celik G.; Bilgin S.; Kurutepe M.; Uzun O.; Tabak L.; Ozdemir O.; Turker H.; Ogus C.; Kiral N.; Ozkan M.; Yalniz E.; Camsari G.; Dogan T.; Yilmaz U.; Cildag O.; Yildiz F.; Hanta I.; Oztuna F.; Arik D.; Goktalay T.; Kanmaz D.; Yilmaz V.; Altiay G.; Komurcuoglu B.; Ozkan G.; Erbaycu A.; Dogrul M.I.; Ongen G.; Tuncay E.; Dabak G.; Sakar A.; Bircan A.; Uzel I.; Kalpaklioglu F.; Gülbay B; Bulbul Y.; Gulbanu H.; Havlucu Y.; Ekici Z.; Zamani A.; Caglayan B.; Kayacan O.; Dursunoglu N.
    Introduction: There is very few data on the epidemiological features of interstitial lung diseases (ILD) in the literature. These studies on this subject suffer from limited number of patients. Objective: The goal of this study was to evaluate the epidemiological features of ILD in Turkey. Methods: Fifty-four investigators, 31 centres in 19 cities from six regions of Turkey, participated in the study. Two thousand two hundred forty-five newly diagnosed patients (51.8% females), led by Turkish Thoracic Society Clinical Problems Study Group, enrolled in this prospective study. Results: The mean age was 51.8±16.7 years. The mean age among males was 50.5±18.6 years and 53.0±14.6 years among females (P<0.001). 23.8% of the cases had ILD with known causes, while 39.4% were in granulomatous group, 23.7% were idiopathic, and 4.4% were in the unclassified group. Overall, histopathologically confirmed diagnosis rate was 40.4%. Sarcoidosis was the most common disease (37%), whereas cases with idiopathic pulmonary fibrosis (IPF) constituted 19,9% of patients. 53% of the sarcoidosis patients were females, and the ratio reaches to 75% under 50 years of age (for this group, IPF ratio is %3). In contrast, sarcoidosis and IPF ratios were equal in males (25%). Sarcoidosis was 8% in men over 50, while IPF was %45. Conclusion: The overall incidence of ILD in Turkey was computed to be 25.8/100000. © 2013 John Wiley & Sons Ltd.