Browsing by Author "Ekmen, N"

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    Artificial intelligence-based personalized diet: A pilot clinical study for irritable bowel syndrome
    Karakan, T; Gundogdu, A; Alagözlü, H; Ekmen, N; Ozgul, S; Tunali, V; Hora, M; Beyazgul, D; Nalbantoglu, OU
    We enrolled consecutive IBS-M patients (n = 25) according to Rome IV criteria. Fecal samples were obtained from all patients twice (pre-and post-intervention) and high-throughput 16S rRNA sequencing was performed. Six weeks of personalized nutrition diet (n = 14) for group 1 and a standard IBS diet (n = 11) for group 2 were followed. AI-based diet was designed based on optimizing a personalized nutritional strategy by an algorithm regarding individual gut microbiome features. The IBS-SSS evaluation for pre- and post-intervention exhibited significant improvement (p < .02 and p < .001 for the standard IBS diet and personalized nutrition groups, respectively). While the IBS-SSS evaluation changed to moderate from severe in 78% (11 out of 14) of the personalized nutrition group, no such change was observed in the standard IBS diet group. A statistically significant increase in the Faecalibacterium genus was observed in the personalized nutrition group (p = .04). Bacteroides and putatively probiotic genus Propionibacterium were increased in the personalized nutrition group. The change (delta) values in IBS-SSS scores (before-after) in personalized nutrition and standard IBS diet groups are significantly higher in the personalized nutrition group. AI-based personalized microbiome modulation through diet significantly improves IBS-related symptoms in patients with IBS-M. Further large-scale, randomized placebo-controlled trials with long-term follow-up (durability) are needed.
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    Prevalence of Pancreatic Steatosis and Its Associated Factors in Turkey: A Nation-Wide Multicenter Study
    Sezgin, O; Yaras, S; Cindoruk, M; Kasap, E; Ünal, H; Köksal, AS; Yildirim, AE; Özseker, B; Oruç, N; Soytürk, M; Kaçar, S; Kaya, M; Irak, K; Gökden, Y; Koç, DO; Özdogan, O; Altintas, E; Ekmen, N; Saruç, M; Acar, S; Polat, M; Barutçu, S; Bengi, G; Gökbulut, V; Ünal, NG; Oguz, D
    Background/Aims: Pancreatic steatosis (PS) is a pathology associated with metabolic syndrome (MS), endocrin and exocrine disfunctions of the pancreas, and fatty liver. The data on the frequency of PS are very limited. We aimed to evaluate the frequency of PS detected by transabdominal ultrasonography (TAU) in gastroenterology clinics located in different geographical regions of Turkey and the factors associated with it. Materials and Methods: Volunteers were evaluated by TAU for PS and hepatosteatosis (HS), and its degree. Pancreatic stiffness was evaluated by ultrasonographic shear wave elastography (SWE). All demographic, physical, and biochemical parametres were measured. Results: A total of 1700 volunteers from 14 centers throughout Turkey were included in the study. Mean age was 48.03 +/- 20.86 years (56.9% female). Prevalance of PS was detected in 68.9%. In the PS group, age, body mass index (BMI), waist circumference, systolic blood pressure, fasting blood glucose (FBG), lipid levels, insulin resistance, diabetes mellitus, hypertension, MS frequency, and pancreatic SWE score were increasing, and fecal elastase level was decreasing in correlation with the degree of PS. The frequency of HS was 55.5%. Hepatosteatosis [odds ratio (OR): 9.472], increased age (OR: 1.02), and BMI (OR: 1.089) were independent risk factors for the occurrence of PS. Lean -PS rate was 11.8%. The lean -PS group was predominantly female and younger than non -lean PS. Also it has lower blood pressure, FBG, liver enzymes, lipid levels, and HS rates. Conclusion: The frequency of PS was found 68.9% in Turkey. Its relationship was determined with age, BMI, HS, MS (and its components), pancreatic stiffness, and fecal elastase level.
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    Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report
    Koç, DÖ; Bengi, G; Gül,Ö; Alahdab, YÖ; Altintas, E; Barutçu, S; Bilgiç, Y; Bostanci, B; Cindoruk, M; Çolakoglu, K; Duman, D; Ekmen, N; Eminler, AT; Gökden, Y; Günay, S; Hakim, GD; Irak, K; Kacar, S; Kalkan, IH; Kasap, E; Köksal, AS; Kuran, S; Oruç, N; Özdogan, O; Özseker, B; Parlak, E; Saruç, M; Sen, I; Sisman, G; Tozlu, M; Tunç, N; Ünal, NG; Ünal, HÜ; Yaras, S; Yildirim, AE; Soytürk, M; Oguz, D; Sezgin, O
    Acute pancreatitis (AP) is a clinical condition that arises acutely in the pancreas through various inflammatory pathways due to multiple causes. Turkish Society of Gastroenterology Pancreas Working Group developed comprehensive guidance statements regarding the management of AP that include its epidemiology, etiology, clinical presentation, diagnostic criteria, disease severity, treatment, prognosis, local and systemic complications. The statements were developed through literature review, deliberation, and consensus opinion. These statements were ultimately used to develop a conceptual framework for the multidisciplinary management of AP.