Browsing by Author "Emre S."
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Item Human cataractous lens nucleus implanted in a sheep eye lens as a model for phacoemulsification training(2004) Kayikçioǧlu Ö.; Eǧrilmez S.; Emre S.; Erakgün T.We describe a realistic and inexpensive experimental cataract model for phacoemulsification training. After a capsulorhexis is performed, a deep cavity in the lens of an enucleated sheep eye is formed by phacoemulsification through a lateral incision. An undamaged human cataractous lens nucleus obtained by extracapsular cataract extraction is inserted in the preformed cavity, resting in the center of a cortex cushion. Phacoemulsification training is performed through a corneal tunnel incision. The experimental model is prepared with a human cataractous lens nucleus of the preferred hardness, simulating nuclear phacoemulsification in humans. © 2004 ASCRS and ESCRS.Item What is the importance of Demodex folliculorum in Behçet's disease?(2009) Emre S.; Aycan O.M.; Atambay M.; Bilak S.; Daldal N.; Karincaoglu Y.Demodex folliculorum is an obligate parasite and commonly detected in patients with immune system deprivation. This study is planned to document the Demodex folliculorum prevalence among patients with Behçet's disease (BD). The patients who referred to the ophthalmology clinic were included in the study. Fourty patients with BD and 131 patients with refractive errors without any ocular and systemic disease were included. For parasite detection, 3 eyelashes from each inferior eyelid were epilated. Standardized skin surface biopsy (SSSB) was performed for detection of parasite at cheeks of patients. Samples were prepared with Hoyer's solution and investigated under the light microscope. There were 15 female and 25 male in BD group and 61 female and 70 male patients ine control group. Mean ages were 37.62 and 38.38 for BD and control groups, respectively. Demodex folliculorum prevalence at eyelashes was 65% for BD and 10% for control group. SSSB of cheek revealed 7.5% positivity for BD and 10% for control group patients. Statistical analysis documented a significant difference for eyelashes (p < 0.05) which could not be detected for skin results. Investigation of Demodex folliculorum in BD may be useful, even in patients without any complaint, for the treatment of ocular and eyelid discomforts of these patients.Item Propolis prevents the effects of chronic alcohol intake on ocular tissues(2009) Emre S.; Yilmaz Z.; Öztürk F.; Emre M.H.Aim: This study is designed to investigate the protective effects of propolis in ocular tissues against chronic alcohol exposure. Material and Method: Wistar albino rats were used in this study. Rats were divided into 4 groups, and each group was fed a special liquid diet which contained an equal amount of calories. The control group was fed the liquid special diet without alcohol and propolis. We added propolis (150 mg/kg) to the diet of the second group. The diet of the third group contained alcohol, the concentration of which was increased progressively. The fourth group was fed a diet including propolis and alcohol. To counterbalance caloric intake, we decreased the amount of glucose in the special liquid diet for groups 3 and 4. At the end of 30 days, the animals were sacrificed and samples were kept at -80°C until evaluation. Specimens were investigated by light microscopy for morphology and morphometry. Results: In the histological investigation of ocular tissues, alcohol caused an increase in thickness of the cornea and corneal epithelium compared to the control group (p < 0.05). This incremental tendency was significantly reduced by propolis, and values were very close to those of the control group (p > 0.05). Alcohol did not cause any significant alteration of rat retinal thickness. Conclusion: This study showed that propolis is highly effective against corneal edema secondary to chronic alcohol intake. © 2009 S. Karger AG, Basel.Item Investigation of human papillomavirus and Epstein-Barr virus DNAs in pterygium tissue(Wichtig Editore s.r.l., 2009) Otlu B.; Emre S.; Turkcuoglu P.; Doganay S.; Durmaz R.Purpose. Recent studies postulated the presence of a probable relationship between pterygium and neoplasia. This study aimed to investigate the role of two oncogenic viruses, human papillomavirus (HPV) and Epstein-Barr virus (EBV), in the development of conjunctival pterygia. Methods. Polymerase chain reaction was used to identify the presence of HPV and EBV in 30 primary and 10 recurrent pterygia samples. Twenty conjunctival samples obtained from patients undergoing cataract surgeries were used as the control group. Patient groups had similar sex, race, and age distribution to eliminate bias. For exploration of HPV in groups, two different PCR methods (in-house PCR with two different primer sets and one real-time PCR method) were studied.The presence of EBV was shown by real-time PCR method. Results. HPV was identified in none of the pterygia and control group patients. However, EBV was detected in 3 out of 30 (10%) primary pterygia patients and in none of the recurrent pterygia and control patients. Conclusions. Up to now, HPV has been blamed as the major viral pathogen in the etiopathogenesis of pterygium. The current results suggest that EBV may also be involved in the pathogenesis of pterygium, but further larger studies with larger cohorts are required to confirm this hypothesis. © Wichtig Editore, 2009.Item Comparison of the protective effects of prostaglandin analogues in the ischemia and reperfusion model of rabbit eyes(2009) Emre S.; Gul M.; Ates B.; Esrefoglu M.; Koc B.; Erdogan A.; Yesilada E.This study was planned to investigate the neuroprotective potentials of three commercially available prostaglandin analogues (PGA), in the ischemia and reperfusion model (I/R). Thirty New Zealand rabbits were divided into 5 groups and except for the control group (non-ischemic, non-treated), 0.9% NaCl, bimatoprost, latanoprost, or travoprost were applied to both eyes of animals of the respective groups for 1 week. At the end of treatment, ischemia was induced in both eyes of the 4 treatment groups by anterior chamber irrigation of the animals for 60 min. Following 24 h reperfusion, the animals were sacrified. Enucleated eyes and retinal tissues were investigated by light microscopy, electron microscopy, immunohistochemicstry for retinal histopathology, intracellular and apoptotic cells and by retinal morphometry. Vitreous samples were biochemically investigated for probable role of reactive oxygen species, by measuring xanthine oxidase (XO) activity. Analysis of morphometric measurements and vitreous XO activity revealed significant differences between the PGA-treated groups and the NaCl-treated group (P<0.05). Similarly, apoptotic cell counts in different retinal layers showed that PGA-treated groups had fewer apoptotic cells in all retinal layers than the NaCl-treated ischemic group (P<0.05). PGA may have high protective potential for different retinal layers and cells. Biochemical analysis of vitreous showed that all PGAs decreased vitreous XO activity significantly compared to the NaCl-treated group (P<0.05). However we could not find any statistically significant differences among the analogues. PGAs may reduce the injury induced by I/R, through the inhibition of XO activity, and it seems that their effects are elicited through numerous pathways.Item Trabeculectomy combined with deep sclerectomy and scleral flap suture tension adjustment under an anterior chamber maintainer: A new modification of trabeculectomy(2010) Kayikcioglu O.R.; Emre S.; Kaya Z.The objective of this study was to investigate the efficacy and safety of trabeculectomy combined with deep sclerectomy in patients with primary open angled glaucoma (POAG) and to compare the results with those from conventional trabeculectomy. In the study 12 eyes of 10 patients operated with trabeculectomy combined with deep sclerectomy (Group I) and 16 eyes of 16 patients operated with conventional trabeculectomy surgery (Group II) were included. In the described form of combined deep sclerectomy with the trabeculectomy technique the superficial scleral flap was sutured with 10/0 monofilament, the number and tension of sutures were adjusted according to the outflow dynamics, under the scleral flap, of balanced salt solution (BSS) provided by an anterior chamber maintainer. In groups I and II all the patients were male POAG cases with mean ages of 60.0 ± 19.4 and 67.0 ± 7.1 years, respectively. The mean follow-up periods were 8.3 ± 3.5 months for group I and 16.6 ± 7.0 months for group II. Preoperative mean IOP were 29.7 ± 8.3 and 29.1 ± 12.8 mmHg mmHg, and averagetopical antiglaucomatous medications were 2.9 ± 0.7 and 2.7 ± 1.1 for groups I and II, respectively. Postoperatively mean IOP measurements were reduced in groups I and II to 10.5 ± 2.9 vs. 9.6 ± 4.8 mmHg at 1 week, 13.7 ± 5.6 vs. 16.0 ± 9.8 at 1st month, 12.3 ± 6.4 vs. 17.3 ± 8.0 at 3rd month, 11.0 ± 4.1 vs. 15.3 ± 5.8 at 6th month, 10.8 ± 1.6 vs. 16.1 ± 4.4 at 12th month, and 11.0 ± 1.0 vs. 16.7 ± 5.0 at 18th month. Statistical analysis revealed that mean postoperative IOP measurements for group I were significantly lower than for group II for all measurements except the first week (P<0.05). At 12th month, the complete (IOP<22 mmHg without medication) and qualified (IOP <22 mmHg with medication) success rates were 83.3 and 100% for group I and 63.6 and 90.9% for group II. Postoperatively at 12th month, the mean number of antiglaucoma medications had fallen to 0.0 ± 0.0 in group I and 0.81 ± 1.1 in group II. Trabeculectomy surgery combined with deep sclerectomy and suture adjustment under an anterior chamber maintainer provided sufficient IOP decrease and diffuse bleb morphology. This technique could be used as a safe method for management of glaucoma. © Springer Science+Business Media B.V. 2009.Item Corneal hysteresis, corneal resistance factor, and intraocular pressure measurement in patients with scleroderma using the reichert ocular response analyzer(2010) Emre S.; Kaykçoǧlu O.; Ateş H.; Çnar E.; Inceoǧlu N.; Yargucu F.; Prldar T.; Oksel F.PURPOSEItem Gain in visual acuity after cataract surgery improves postural stability and mobility(2011) Durmus B.; Emre S.; Cankaya C.; Baysal O.; Altay Z.Objectives: Vision plays an important role in postural stability. It has also been shown that visual information from the environment and visual cues significantly contribute to balance skills. The aim of this study was to investigate the effects of visual acuity on postural stability and mobility before and after cataract surgery. Methods: The study group was composed of 25 male and 11 female patients (age 57-84, mean 66.6±4.7) who had been operated for age-related cataract. Postural stability and mobility were assessed before and four weeks after the surgery by means of Biodex stability system (BSS), Tinetti, Time up and go (TUG) and Functional reach (FR) tests, as well as by gait analysis (gait velocity, step length, step width, cadence, stride length). Results: Postoperative visual acuity was significantly improved. Gait velocity and cadence increased significantly but step length, stride length, and step width did not change significantly. Postoperative improvement of Tinetti balance, TUG and FR tests were significant. Similarly, antero-posterior stability index (APSI), medio-lateral stability index (MLSI) and overall stability index (OSI) that were examined with BSS improved significantly after the cataract surgery. Conclusion: These results demonstrated that gain in visual acuity after cataract surgery improves the postural stability and mobility of patients.Item Ultrasound-assisted vitrectomy for late stage infectious endophthalmitis(2011) Kaykçoǧlu Ö.; Emre S.; Seymenoǧlu G.We described an ultrasound-assisted technique of pars plana vitrectomy in endophthalmitis cases with visualization problems of the retina related to the loss of ocular media clarity.We performed pars plana vitrectomy, assisted with a B-mode ultrasonography, on 5 eyes of 5 patients who were referred for late-stage postcataract endophthalmitis. After the implantation of a 6.0-mm infusion port and creation of another pars plana sclerostomy, a 20-gauge vitrectomy tip was visualized in the midvitreus cavity. Core vitrectomy was performed followed by intravitreal antibiotic injection at the end of the surgery without complication in all cases.The study group of 5 patients had a mean age of 73.6 ± 7.9 years. Preoperative visual acuity was light perception positive in 2 eyes and light perception negative in 3 eyes. We obtained satisfactory cosmetic results in all patients, controlled intraocular infection, and prevented evisceration; however, there was no change in visual acuity after surgery.In this preliminary study, we obtained acceptable results with ultrasound-assisted vitrectomy, which may help retinal surgeons to operate on cases with ocular media opacity. Copyright © 2011 by Lippincott Williams & Wilkins.Item Conducting polymers with benzothiadiazole and benzoselenadiazole units for biosensor applications(2011) Emre F.B.; Ekiz F.; Balan A.; Emre S.; Timur S.; Toppare L.Poly(4,7-di(2,3)-dihydrothienol[3,4-b][1,4]dioxin-5-yl-benzo[1,2,5] thiadiazole) (PBDT) and poly(4,7-di(2,3)-dihydrothienol[3,4-b][1,4]dioxin-5-yl- 2,1,3-benzoselenadiazole) (PESeE) were electrochemically deposited on graphite electrodes and used as immobilization matrices for biosensing studies. After electrochemical deposition of the polymeric matrices, glucose oxidase (GOx) was immobilized on the modified electrodes as the model enzyme. In the biosensing studies, the decrease in oxygen level as a result of enzymatic reaction was monitored at -0.7 V vs Ag/AgCl (3.0 M KCl) and correlated with substrate concentration. The biosensor was characterized in terms of several parameters such as operational and storage stabilities, kinetic parameters (Km and Imax) and surface morphologies. The biosensor was tested on real human blood serum samples. © 2011 Elsevier B.V. Al rights reserved.Item New treatment alternatives in the management of non-i̇nfectious i̇ntraocular i̇nflammations: Biologic agents; [Enfeksiyöz olmayan i̇ntraoküler i̇nflamasyonlarin kontrolünde yeni seçenekler: Biyolojik ajanlar](2011) Emre S.; Tutkun I.T.Conventional immunosuppressive agents have been traditionally used for the treatment of noninfectious uveitis. Recent developments in genetic engineering have made it possible to synthesize proteins that target specific molecules playing role in the inflammatory response. These agents are generally in protein structure and are named biologic agents. While there is limited experience with biologics in the field of ophthalmology, they are commonly used in other disciplines such as rheumatology and dermatology. Although considerable data have accumulated in the uveitis literature regarding the use of biologic agents, including mainly interferon, infliximab, and adalimumab, their use for this indication is still off-label. Moreover, there are certain precautions that have to be taken into account, as well as important safety issues associated with their use. The purpose of this paper is to present an updated comprehensive review of biologic agents that may be used for the treatment of refractory uveitis.Item Ciliary body cysts in neurofibromatosis: A new coexistence?(2012) Emre S.; Palamar M.; Ulusoy M.O.; Gençoǧlan G.Purpose: Neurofibromatosis 1 (NF1) is an autosomal dominant, multisystem disorder that also effects the eye. Herein, we aimed to investigate the posterior iris surface and ciliary body morphology of NF1 patients by ultrasonic biomicroscopy (UB). Materials & Methods: Nine consecutive unrelated subjects with NF1, and as a control group 25 healthy subjects, were included in the study. All patients underwent ophthalmic examination including visual acuity testing, slit-lamp biomicroscopy, tonometry, gonioscopy (Schaffer classification), and dilated ophthalmoscopy, UB. Results: Mean age was 35.1±16.2 (range, 11-57) and 34.5±15.6 (range, 9-60) for NF1 and control groups respectively (p<0.05). Lisch nodules were present in 16 of 18 eyes (88.8%) in NF1 group. Fundoscopic examination of the control group and 15 eyes of NF1 (83.3%) patients was normal, whereas hypoplastic and tilted optic nerve were present in three eyes, and temporally-located bone-spicule-like lesions was present in one eye of the NF1 group. UB revealed ciliary body cyst in 77.7% (14/18) of the eyes among NF1 group, and 8% (4/50) among control group (p<0.05). The mean size of the cysts were 520±191 μ (range, 220-860 μ) and 495± 231 μ (range, 300-830 μ) at NF1 and control groups, respectively. Gonioscopic evaluation revealed that 55% of the NF1 patients have an unoccludable anterior chamber angle (Grade 3 or 4), 45% occludable angle (Grade 1 or 2), and 78% irregular pigment patches. However, occludable angle rate was just 4% in the control group, and none of the patients had irregular pigment patches. Conclusion: The coexistence of ciliary body cysts and NF1, and the effect of these cysts in the eye should be enlightened with further studies. © Springer-Verlag 2011.Item Expression of nitric oxide synthase in primary and recurrent pterygium; [Primer ve tekrarlayan pteryjiumlarda nitrik oksid sentaz ekspresyonu](2012) Emre S.; Vatansever S.H.; Türköz E.; Kayikçioǧlu O.R.Purpose: The aim of this study was to investigate the expression of different nitric oxide synthases (NOSs) in primary and recurrent pterygia and to investigate the probable role of any nitric oxide synthase on pterygium recurrence. Materials and Method: Specimens of 40 primary pterygia and 10 recurrent pterygia excised during pterygium surgery were included in the study. Also, 15 normal conjunctiva of medial limbus obtained from patients free of pterygia and removed during other ophthalmologic surgeries formed the control group. Specimens were stained with hematoxylin and eosin for general histological and morphologic evaluation. The distribution of n-NOS, e-NOS and i-NOS were analyzed using indirect immunoperoxidase staining. Results: Histological evaluation of specimens revealed that the epithelium in primary and recurrent pterygia groups was thicker compared to that in the control group. Immunohistochemical analysis revealed that in both primary pterygium and control groups, immunoreactivity was positive for all NOSs in both epithelium and connective tissue. For recurrent pterygium group, NOS immunoreactivity could be detected moderately for n-NOS in the epithelium and weakly for e-NOS in both epithelium and connective tissue. However, in recurrent pterygium samples, i-NOS immunoreactivity was lacking in both epithelium and connective tissue. Discussion: These data are the first to demonstrate that NOS expression may differ between primary and recurrent pterygia. Meanwhile, continuous expression of n-NOS with suppression of i-NOS and e-NOS may be an important step in the recurrence process of pterygia.Item A patient with cystinosis presenting like bartter syndrome and review of literature(Brieflands, 2012) Ertan P.; Evrengul H.; Ozen S.; Emre S.Background: Nephropathic cystinosis is an autosomal recessively inherited metabolic disorder presenting with metabolic acidosis, Fanconi syndrome and renal failure. Case Presentation: We present a 6-year-old girl with severe growth failure, hyponatremia and hypokalemia. Her parents were 4th degree relatives. Two relatives were diagnosed as end stage renal failure. She also had persistant hypokalemic hypochloremic metabolic alkalosis. Her renal function was normal at presentation. She was thought to have Bartter syndrome with supporting findings of elevated levels of renin and aldosterone with normal blood pressure, and hyperplasia of juxtaglomerular apparatus. Her metabolic alkalosis did not resolve despite supportive treatment. At 6th month of follow-up proteinuria, glucosuria and deterioration of renal function developed. Diagnosis of cystinosis was made with slit lamp examination and leukocyte cystine levels. At 12th month of follow-up her metabolic alkalosis has converted to metabolic acidosis. Conclusion: In children presenting with persistant metabolic alkalosis, with family history of renal failure, and parental consanguinity, cystinosis should always be kept in mind as this disease is an important cause of end stage renal failure which may have features mimmicking Bartter syndrome. © 2012 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved.Item Genetic screening in adolescents with steroid-resistant nephrotic syndrome(Nature Publishing Group, 2013) Lipska B.S.; Iatropoulos P.; Maranta R.; Caridi G.; Ozaltin F.; Anarat A.; Balat A.; Gellermann J.; Trautmann A.; Erdogan O.; Saeed B.; Emre S.; Bogdanovic R.; Azocar M.; Balasz-Chmielewska I.; Benetti E.; Caliskan S.; Mir S.; Melk A.; Ertan P.; Baskin E.; Jardim H.; Davitaia T.; Wasilewska A.; Drozdz D.; Szczepanska M.; Jankauskiene A.; Higuita L.M.S.; Ardissino G.; Ozkaya O.; Kuzma-Mroczkowska E.; Soylemezoglu O.; Ranchin B.; Medynska A.; Tkaczyk M.; Peco-Antic A.; Akil I.; Jarmolinski T.; Firszt-Adamczyk A.; Dusek J.; Simonetti G.D.; Gok F.; Gheissari A.; Emma F.; Krmar R.T.; Fischbach M.; Printza N.; Simkova E.; Mele C.; Marco Ghiggeri G.; Schaefer F.Genetic screening paradigms for congenital and infantile nephrotic syndrome are well established; however, screening in adolescents has received only minor attention. To help rectify this, we analyzed an unselected adolescent cohort of the international PodoNet registry to develop a rational screening approach based on 227 patients with nonsyndromic steroid-resistant nephrotic syndrome aged 10-20 years. Of these, 21% had a positive family history. Autosomal dominant cases were screened for WT1, TRPC6, ACTN4, and INF2 mutations. All other patients had the NPHS2 gene screened, and WT1 was tested in sporadic cases. In addition, 40 sporadic cases had the entire coding region of INF2 tested. Of the autosomal recessive and the sporadic cases, 13 and 6%, respectively, were found to have podocin-associated nephrotic syndrome, and 56% of them were compound heterozygous for the nonneutral p.R229Q polymorphism. Four percent of the sporadic and 10% of the autosomal dominant cases had a mutation in WT1. Pathogenic INF2 mutations were found in 20% of the dominant but none of the sporadic cases. In a large cohort of adolescents including both familial and sporadic disease, NPHS2 mutations explained about 7% and WT1 4% of cases, whereas INF2 proved relevant only in autosomal dominant familial disease. Thus, screening of the entire coding sequence of NPHS2 and exons 8-9 of WT1 appears to be the most rational and cost-effective screening approach in sporadic juvenile steroid-resistant nephrotic syndrome. © 2013 International Society of Nephrology.Item Corneal biochemical features of patients with vernal keratoconjunctivitis(2013) Emre S.; Başer E.; Öztürk B.; Zorlu S.; Uzun O.; Gülhan C.Background: Vernal keratoconjunctivitis (VKC) is a chronic, bilateral, seasonally exacerbated, allergic inflammation of the ocular surface, involving bulbar and â or tarsal conjunctiva and cornea. The ocular response analyzer (ORA) measures corneal biomechanical properties in vivo by monitoring and analyzing the corneal behavior when its structure is submitted to a force induced by an air jet. This study was designed to examine corneal biomechanical properties and intraocular pressure in patients with VKC, and to compare with control eyes. Methods: ORA measurements were performed on the both eyes of 26 patients with VKC (group I) and 14 healthy children who served as the control group (group II). Corneal hysteresis (CH), corneal resistance factor (CRF) and intraocular pressure [Goldmann correlated (IOPg) and corneal compensated (IOPcc)] were recorded with ORA. Results: Mean age of patients with VKC and control groups were 11.3 ± 5.8 and 10.6 ± 1.9 years for groups I and II respectively. Mean (± SD) of the CH and CRF readings were 10.1 ± 1.6 versus 10.5 ±1.6 (p > 0.05) and 9.5 ± 1.7 versus 10.8 ± 1.7 mmHg (p < 0.05), in groups I and II respectively. Mean (± SD) of the IOPg and IOPcc recordings were 13.3 ±3.4 versus 16.6 ±3.6 mmHg (p < 0.05) and 14.3 ± 3.4 versus 16.9 ± 3.7 mmHg (p > 0.05) in groups I and II respectively. Statistical analysis revealed significant differences for CRF and IOPg between the study groups. Conclusion: The mean CRF and IOPg values of patients with VKC were lower than those of controls. According to the results of our study, one can conclude that corneal biomechanical property, CRF, could be different in VKC patients compared to normals. © 2012 Springer-Verlag.Item Influence of tamsulosin on the anterior segment parameters and central corneal thickness; [Tamsulosinin ön segment parametreleri ve santral kornea kali{dotless}nli{dotless}ǧi{dotless}na etkisi](Turkiye Klinikleri, 2014) Palamar M.; Emre S.; Turna B.; Yaǧci A.Objective: To investigate the effects of tamsulosin (α-1 adrenergic receptor antagonist) on the main numerical parameters of anterior segment using Pentacam rotating Scheimmpflug camera, and on biomechanical parameters using Reichert Ocular Response Analyser (ORA) in patients with benign prostate hyperplasia. Material and Methods: In addition to full eye examination [best corrected visual acuity, keratometry, intraocular pressure (IOP) measured with Goldmann applanation tonometry], Pentacam [central corneal thickness (CCT), anterior chamber depth, anterior chamber volume, anterior chamber angle, pupil diameter] and ORA (corneal hysteresis, corneal resistance factor, corneal compensated IOP, Goldmann correlated IOP) measurements of 30 eyes of 15 male patients were performed before and one month after tamsulosin therapy. Paired t-test and non-parametric Wilcoxon test were used for comparisons. Results: Mean age in the study group was 61.50±6.10 (range 47-69) years. After tamsulosin treatment, CCT increased and this increment was statistically significant (p=0.002). None of the other parameters that were evaluated showed statistically significant difference after tamsulosin use. Conclusion: Tamsulosin leads to significant increment in CCT. The effects of tamsulosin on CCT should be taken into consideration for proper clinical interpretation in patients using tamsulosin. © 2014 by Türkiye Klinikleri.Item Psoriatic uveitis responding to adalimumab therapy(Blackwell Publishing Ltd, 2014) Ermertcan A.T.; Emre S.; Öztürk F.; Gençoǧlan G.; Gündüz K.[No abstract available]Item Isokinetic evaluation of knee extensor/flexor muscle strength in Behcet's patients(Sociedade Portuguesa de Reumatologia, 2015) Durmus B.; Emre S.; Sahin N.; Karincaoglu Y.; Dogan E.; Baysal O.; Ersoy Y.; Altay Z.Background: Behçet's disease (BD) is an idiopathic, multisystemic, progressive disease. The purpose of this study is to compare the knee flexor and extensor isokinetic muscle strengths of Behcet's patients with that of healthy subjects. Methods: Twenty-five (13 male and 12 female) patients with BD and 25 (15 male and 10 female) healthy individuals were included in the study. Velocities of 90°/sec, 120°/sec, and 150°/sec were used for the isokinetic muscle strength testing. Patients with active inflammatory knee arthritis were excluded. Peak torque (Nm) and peak torque adjusted to body weight (%) were taken into consideration for comparison between study groups. Results: Compared to healthy controls, there was a statistically significant decrease in both the bilateral knee extensor and flexor muscle isokinetic peak torques (Nm) as well as the peak torques adjusted to body weight (%) at velocities of 90°/sec, 120°/sec and 150°/sec in patients with BD (p < 0.05). However, there was no significant difference in the agonist-antagonist ratio of the isokinetic peak torques of knee muscles between the two groups. Conclusion: In light of these findings, we have concluded that both knee flexor and extensor isokinetic muscle strengths are lower in BD. We therefore recommend careful monitoring of patients with BD in terms of muscle strength.Item Internalized stigma in psoriasis: A multicenter study(Blackwell Publishing Ltd, 2017) Alpsoy E.; Polat M.; FettahlıoGlu-Karaman B.; Karadag A.S.; Kartal-Durmazlar P.; YalCın B.; Emre S.; Didar-Balcı D.; Bilgic-Temel A.; Arca E.; Koca R.; Gunduz K.; Borlu M.; Ergun T.; Dogruk-Kacar S.; Cordan-Yazici A.; Dursun P.; Bilgic O.; Gunes-Bilgili S.; Sendur N.; Baysal O.; Halil-Yavuz I.; Yagcioglu G.; Yilmaz E.; Kavuzlu U.; Senol Y.Internalized stigma is the adoption of negative attitudes and stereotypes of the society regarding a person's illness. It causes decreased self-esteem and life-satisfaction, increased depression and suicidality, and difficulty in coping with the illness. The primary aim of this study was to investigate the internalized stigma state of psoriatic patients and to identify the factors influencing internalized stigma. The secondary aim was to identify the correlation of internalized stigma with quality of life and perceived health status. This multicentre, cross-sectional study comprised 1485 patients. There was a significant positive correlation between mean values of Psoriasis Internalized Stigma Scale (PISS) and Psoriasis Area and Severity Index, Body Surface Area, Dermatological Life Quality Index and General Health Questionnaire-12 (P < 0.001 in all). Lower percieved health score (P = 0.001), early onset psoriasis (P = 0.016), family history of psoriasis (P = 0.0034), being illiterate (P < 0.001) and lower income level (P < 0.001) were determinants of high PISS scores. Mean PISS values were higher in erythrodermic and generalized pustular psoriasis. Involvement of scalp, face, hand, genitalia and finger nails as well as arthropathic and inverse psoriasis were also related to significantly higher PISS scores (P = 0.001). Our findings imply that psoriatic patients experience high levels of internalized stigma which are associated with psoriasis severity, involvement of visible body parts, genital area, folds or joints, poorer quality of life, negative perceptions of general health and psychological illnesses. Therefore, internalized stigma may be one of the major factors responsible from psychosocial burden of the disease. © 2017 Japanese Dermatological Association