Browsing by Author "Erdoğan A."

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    Marine anticancer agents: An overview with a particular focus on their chemical classes
    (MDPI, 2020) Barreca M.; Spanò V.; Montalbano A.; Cueto M.; Díaz Marrero A.R.; Deniz I.; Erdoğan A.; Bilela L.L.; Moulin C.; Taffin-De-Givenchy E.; Spriano F.; Perale G.; Mehiri M.; Rotter A.; Thomas O.P.; Barraja P.; Gaudêncio S.P.; Bertoni F.
    The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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    A New Network for the Advancement of Marine Biotechnology in Europe and Beyond
    (Frontiers Media S.A., 2020) Rotter A.; Bacu A.; Barbier M.; Bertoni F.; Bones A.M.; Cancela M.L.; Carlsson J.; Carvalho M.F.; Cegłowska M.; Dalay M.C.; Dailianis T.; Deniz I.; Drakulovic D.; Dubnika A.; Einarsson H.; Erdoğan A.; Eroldoğan O.T.; Ezra D.; Fazi S.; FitzGerald R.J.; Gargan L.M.; Gaudêncio S.P.; Ivošević DeNardis N.; Joksimovic D.; Kataržytė M.; Kotta J.; Mandalakis M.; Matijošytė I.; Mazur-Marzec H.; Massa-Gallucci A.; Mehiri M.; Nielsen S.L.; Novoveská L.; Overlingė D.; Portman M.E.; Pyrc K.; Rebours C.; Reinsch T.; Reyes F.; Rinkevich B.; Robbens J.; Rudovica V.; Sabotič J.; Safarik I.; Talve S.; Tasdemir D.; Schneider X.T.; Thomas O.P.; Toruńska-Sitarz A.; Varese G.C.; Vasquez M.I.
    Marine organisms produce a vast diversity of metabolites with biological activities useful for humans, e.g., cytotoxic, antioxidant, anti-microbial, insecticidal, herbicidal, anticancer, pro-osteogenic and pro-regenerative, analgesic, anti-inflammatory, anti-coagulant, cholesterol-lowering, nutritional, photoprotective, horticultural or other beneficial properties. These metabolites could help satisfy the increasing demand for alternative sources of nutraceuticals, pharmaceuticals, cosmeceuticals, food, feed, and novel bio-based products. In addition, marine biomass itself can serve as the source material for the production of various bulk commodities (e.g., biofuels, bioplastics, biomaterials). The sustainable exploitation of marine bio-resources and the development of biomolecules and polymers are also known as the growing field of marine biotechnology. Up to now, over 35,000 natural products have been characterized from marine organisms, but many more are yet to be uncovered, as the vast diversity of biota in the marine systems remains largely unexplored. Since marine biotechnology is still in its infancy, there is a need to create effective, operational, inclusive, sustainable, transnational and transdisciplinary networks with a serious and ambitious commitment for knowledge transfer, training provision, dissemination of best practices and identification of the emerging technological trends through science communication activities. A collaborative (net)work is today compelling to provide innovative solutions and products that can be commercialized to contribute to the circular bioeconomy. This perspective article highlights the importance of establishing such collaborative frameworks using the example of Ocean4Biotech, an Action within the European Cooperation in Science and Technology (COST) that connects all and any stakeholders with an interest in marine biotechnology in Europe and beyond. © Copyright © 2020 Rotter, Bacu, Barbier, Bertoni, Bones, Cancela, Carlsson, Carvalho, Cegłowska, Dalay, Dailianis, Deniz, Drakulovic, Dubnika, Einarsson, Erdoğan, Eroldoğan, Ezra, Fazi, FitzGerald, Gargan, Gaudêncio, Ivošević DeNardis, Joksimovic, Kataržytė, Kotta, Mandalakis, Matijošytė, Mazur-Marzec, Massa-Gallucci, Mehiri, Nielsen, Novoveská, Overlingė, Portman, Pyrc, Rebours, Reinsch, Reyes, Rinkevich, Robbens, Rudovica, Sabotič, Safarik, Talve, Tasdemir, Schneider, Thomas, Toruńska-Sitarz, Varese and Vasquez.
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    Investigation of phenolic content in five different pine barks species grown in Turkey by HPLC-UV and LC-MS
    (Oxford University Press, 2021) Şeker M.E.; Çelik A.; Dost K.; Erdoğan A.
    Investigation of phenolic content from different pine bark species grown in Turkey was performed using a reversed-phase high pressure liquid chromatography with ultraviolet (RP-HPLC-UV) method. All phenolic constituents were separated in <26 min on reversed-phase C18 column with gradient mobile phase that consists of orthophosphoric acid, methanol and acetonitrile. Detections were made on an UV detector at 280 nm and at a flow rate of 1 mL/min. Samples were prepared according to Masqueller's conventional sample preparation method with slight modifications. To avoid the reduction in extraction efficiency the sample preparation step was carried out under argon atmosphere. The linearity of the method was between 0.9994 and 0.9999. The detection limits for the five phenolic constituents ranged from 0122 to 0.324 mg/L. Catechin and taxifolin were found in all pine barks at a concentration of 0.065 ± 0.002-1.454 ± 0.004 and 0.015 ± 0.001-23.164 ± 0.322 mg/g, respectively. Epicatechin was determined in four pine barks between 0.027 ± 0.001 and 0.076 ± 0.002 mg/g, ferulic acid in two pine barks between 0.010 ± 0.001 and 0.022 ± 0.001 mg/g and epicatechin gallate in only one of the pine barks at 0.025 ± 0.001 mg/g. Finally, the total amount of phenolic compounds and antioxidant capacities of the pine barks were found to be very high. © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com