Browsing by Author "Erdogan, MS"

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    Food-induced anaphylaxis in early childhood and factors associated with its severity
    Aydogan, M; Topal, E; Yakici, N; Acar, HC; Demirkale, ZH; Arga, M; Uysal, P; Aydemir, S; Simsek, IE; Tamay, Z; Cekic, S; Cavkaytar, O; Kaplan, F; Kiykim, A; Cogurlu, MT; Süleyman, A; Yücel, E; Akkelle, E; Hancioglu, G; Yasar, A; Tuncel, T; Nacaroglu, HT; Aydogmus, C; Güler, N; Cokugras, H; Sapan, N; Yüksel, H; Sancak, R; Erdogan, MS; Ozdemir, O; Ozdemir, C; Orhan, F
    Background: Several factors that increase the risk of severe food-induced anaphylaxis have been identified. Objective: We aimed to determine the demographic, etiologic, and clinical features of food-induced anaphylaxis in early childhood and also any other factors associated with severe anaphylaxis. Methods: We carried out a medical chart review of anaphylaxis cases from 16 pediatric allergy and immunology centers in Turkey. Results: The data of 227 patients with 266 food-induced anaphylaxis episodes were included in the study. The median (inter quartile range) age of the first anaphylaxis episode was 9 months (6-18 months); 160 of these patients were boys (70.5%). The anaphylaxis episodes were mild in 75 cases (28.2%), moderate in 154 cases (57.9%), and severe in 37 cases (13.9%). The most frequent food allergens involved were cow's milk (47.4%), nuts (16.7%), and hen's egg (15.8%). Epinephrine was administered in only 98 (36.8%) of these anaphylaxis episodes. A logistic regression analysis revealed two statistically significant factors that were independently associated with severe anaphylaxis: the presence of angioedema and hoarseness during the anaphylactic episode. Urticaria was observed less frequently in patients who developed hypotension. In addition, confusion and syncope were associated with 25.9- and 44.6-fold increases, respectively, in the risk of concomitant hypotension. Conclusion: Cow's milk, nuts, and hen's egg caused the majority of mild and moderate-to-severe anaphylaxis episodes. The presence of angioedema and hoarseness in any patient who presents with a history of food-induced anaphylaxis should alert clinicians that the reaction may be severe. In addition, the presence of confusion, syncope, or stridor probably indicates concomitant hypotension.
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    Effects of Ginkgo biloba on experimental rapid maxillary expansion model: a histomorphometric study
    Kara, MI; Altan, AB; Sezer, U; Erdogan, MS; Inan, S; Ozkut, M; Nalcaci, R
    Objective. We aimed to investigate the effect of systemic Ginkgo biloba in rapid maxillary expansion (RME). Study Design. We randomly divided 24 rats into 3 groups: expansion only (EO), expansion plus Ginkgo biloba (GB), and no expansion (NE). Expansion appliances were affixed to the maxillary incisors. After a 5-day expansion period, there was a consolidation period of 15 days, following which the rats were killed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries, the number and intensity of inflammatory cells, and new bone formation. Results. New bone formation, number of capillaries, and the ratio of inflammatory cells in maxillary sutures were higher in the GB group than in the other groups. Statistical analysis demonstrated that the GB group had more osteoblasts and osteoclasts than the other groups. Conclusions. GB may hasten new bone regeneration in RME and prevent relapse after RME. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:712-718)