Browsing by Author "Eren H."

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    Serum levels of trace elements in patients with prostate cancer
    (Asian Pacific Organization for Cancer Prevention, 2014) Kaba M.; Pirincci N.; Yuksel M.B.; Gecit I.; Gunes M.; Ozveren H.; Eren H.; Demir H.
    Background: Trace elements are major components of biological structures; however, excessive levels of these elements can be toxic. Materials and Methods: In the present study, serum levels of trace elements were measured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnace atomic absorption spectrophotometry. Results: It was found that there was an increase in serum levels of Co, Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostate cancer (p<0.05). Conclusions: These changes may be important in the pathogenesis of prostate cancers; however, further prospective studies are needed to identify relationships between prostate cancer and trace elements.
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    Antifibrogenic role of valproic acid in streptozotocin induced diabetic rat penis
    (Blackwell Publishing Ltd, 2016) Kutlu O.; Karaguzel E.; Gurgen S.G.; Okatan A.E.; Kutlu S.; Bayraktar C.; Kazaz I.O.; Eren H.
    We investigated the therapeutic effects of valproic acid (VPA) on erectile dysfunction and reducing penile fibrosis in streptozocin (STZ)-induced diabetic rats. Eighteen male rats were divided into three experimental groups (Control, STZ-DM, STZ-DM plus VPA) and diabetes was induced by transperitoneal single dose STZ. Eight weeks after, VPA and placebo treatments were given according to groups for 15 days. All rats were anesthetised for the measurement of in vivo erectile response to cavernous nerve stimulation. Afterward penes were evaluated histologically in terms of immune labelling scores of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1). Slides were also evaluated in terms of collagen/smooth muscle ratio and penile apoptosis. After the treatment with VPA, erectile responses were found as improved when compared with STZ-DM rats but not statistically meaningful. eNOS and VEGF immune expressions diminished in penile corpora of STZ-DM rats and improved with VPA treatment. VPA led to decrease in TGF-β1 expression and collagen content of diabetic rats' penes. Penile apoptosis was not diminished with VPA. In conclusion, VPA treatment seems to be effective for reducing penile fibrosis in diabetic rats and more prolonged treatment period may enhance erectile functions. © 2016 Blackwell Verlag GmbH.
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    Nation-wide analysis of the impact of Covid-19 pandemic on daily urology practice in Turkey
    (Blackwell Publishing Ltd, 2021) Bozkurt O.; Sen V.; Irer B.; Sagnak L.; Onal B.; Tanidir Y.; Karabay E.; Kaya C.; Ceyhan E.; Baser A.; Duran M.B.; Suer E.; Celen I.; Selvi I.; Ucer O.; Karakoc S.; Sarikaya E.; Ozden E.; Deger D.; Egriboyun S.; Ongun S.; Gurboga O.; Asutay M.K.; Kazaz I.O.; Yilmaz I.O.; Kisa E.; Demirkiran E.D.; Horsanali O.; Akarken I.; Kizer O.; Eren H.; Ucar M.; Cebeci O.O.; Kizilay F.; Comez K.; Mercimek M.N.; Ozkent M.S.; Izol V.; Gudeloglu A.; Ozturk B.; Akbaba K.T.; Polat S.; Gucuk A.; Ziyan A.; Selcuk B.; Akdeniz F.; Turgut H.; Sabuncu K.; Kaygisiz O.; Ersahin V.; Kahraman H.I.; Guzelsoy M.; Demir O.
    Objective: To present a nation-wide analysis of the workload of urology departments in Turkey week-by-week during Covid-19 pandemic. Methodology: The centres participating in the study were divided into three groups as tertiary referral centres, state hospitals and private practice hospitals. The number of outpatients, inpatients, daily interventions and urological surgeries were recorded prospectively between 9-March-2020 and 31-May-2020. All these variables were recorded for the same time interval of 2019 as well. The weekly change of the workload of urology during pandemic period was evaluated, also the workload of urology and the distributions of certain urological surgeries were compared between the pandemic period and the same time interval of the year 2019. Results: A total of 51 centres participated in the study. The number of outpatients, inpatients, urological surgeries and daily interventions were found to be dramatically decreased by the 3rd week of pandemics in state hospitals and tertiary referral centres; however, the daily urological practice were similar in private practice hospitals throughout the pandemic period. When the workload of urology in pandemic period and the same time interval of the year 2019 were compared, a huge decrease was observed in all variables during pandemic period. However, temporary measures like ureteral stenting, nephrostomy placement and percutaneous cystostomy have been found to increase during Covid-19 pandemic compared with normal life. Conclusions: Covid-19 pandemic significantly affected the routine daily urological practice likewise other subspecialties and priority was given to emergent and non-deferrable surgeries by urologists in concordance with published clinical guidelines. © 2020 John Wiley & Sons Ltd
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    Evaluation of Children with Ralstonia pickkettii Bacteraemia; [Ralstonia pickettii Bakteriyemili Çocuk Olguların Değerlendirilmesi]
    (AVES, 2023) Yeşil E.; Hacımustafaoğlu M.; Çelebi S.; Özer A.; Düzcan Kilimci D.; Eren H.; Özakın C.
    Objective: Ralstonia pickettii is an opportunistic pathogen that is often considered to be contaminant. It can cause infection due to colonisation in infusion solutions and disinfectants. Although rare, it can lead to noso-comial outbreaks, so this agent should not be ignored. In this study, it was aimed to evaluate the growth of R. pickettii in blood cultures taken in the pediatric wards of our hospital, to analyze the outbreaks by R. pickettii and to discuss the precautions to prevent the outbreaks. Material and Methods: Patients with Ralstonia picketti in blood cultures, who were admitted in the pediatric intensive care unit (PICU; n= 46, 81%), neonatal intensive care unit (n= 7, 12%) and other pediatric wards (n= 4, 7%) between February 2014 and December 2017 were included into the study. Patient’s data, the relation between the outbreaks and culture growths, and the sources and the prevention of potential outbreaks were evaluated. Recurrent growths were defined as a single episode. Results: Ralstonia pickettii detected in 57 different specimens in 38 different episodes in a total of 35 patients. Of the fifty-seven blood samples, 67% (n= 38) were peripheral blood cultures, 33% (n= 19) were catheter blood cultures and 74% of the samples lead to infection. Of the 38 ep-isodes, 63% (n= 24) were considered as infection and 37% (n= 14) was contamination. Median age of the patients were seven (0-180) months, and the major underlying comorbidity was congenital heart disease. Of 57 specimens with Raltstonia pickettii growth, 16 (28%) had only R. pick-ettii growth, and the remaining 41 (71%) cultured growths were polymi-crobial. Among these, the most common accompanying microorganisms were Stenotrophomonas maltophilia and Burkholderia species. Of 38 ep-isodes, 58% (n= 22) had a central venous catheter (CVC), of which 64% (n= 14) developed catheter-related bloodstream infection due to R. picket-tii. Eighty-one percent of the specimens were detected in the pediatric intensive care unit, and the outbreak situation was examined. Twenty-three (61%) of a total of 57 growths were associated with an outbreak of health-care-associated infection in three separate periods. Ralstonia pickettii was not detected in environment scans. Antibiogram features of the growths were similar and they were thought to be of the same isolate, no molec-ular study was applied. Three patients died within the first 30 days after the growth. Conclusion: Our study has the largest case series reported in a pediatric population in Türkiye and the world. The mortality rate due to R. pickettii was low. Eighty-one percent of the specimens were in the pediatric intensive care unit and 61% was associated with the outbreak. The importance of hospital infection control measures in preventing R. pickettii and similar outbreaks were emphasized. A limited number of studies have been conducted on this subject in Türkiye, and we believe that our study will contribute to the literature. © 2023, AVES. All rights reserved.