Browsing by Author "Ergür, BU"

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    Lipoic acid decreases peritoneal adhesion formation in a rat uterine scar model
    Micili, SC; Göker, A; Sayin, O; Akokay, P; Ergür, BU
    Objective: To investigate the effects of lipoic acid in the prevention of postoperative pelvic adhesions by a visual scoring system and immunohistochemistry in a rat uterine horn model with full thickness injury. Material and Methods: Twenty-eight female Wistar albino rats were randomised into four groups: uterine trauma control, 15 days and 30 days, and uterine trauma + lipoic acid, 15 days and 30 days. A full thickness defect was established by incising a segment of approximately 1.0 cm in length from each uterine horn, leaving the mesometrium intact. Extension and severity of the adhesions in each group were scored by a visual scoring system and evaluated immunohistochemically. Results: Adhesion scores were 2.00 +/- 0.81, 2.14 +/- 0.69 0.71 +/- 0.75, and 0.85 +/- 0.69 for extent and 2.28 +/- 0.48, 2.14 +/- 0.69, 0.85 +/- 0.69, and 1.14 +/- 0.69 for severity in Groups 1, 2, 3 and 4, respectively. Adhesion extent and severity were significantly less for groups treated by lipoic acid but no difference was observed between long and short administration. Both Vitronectin and u-PAR staining were significantly increased in treatment groups when compared to the control group. Conclusion: Lipoic acid was found to be effective in reducing postoperative adhesion formation in a rat model.