Browsing by Author "Erkin, Y"

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    Effects of octreotide and morphine on the clearance rate of indium-111-pentetreotide from the epidural space
    Aydin, Z; Sayit, E; Erkin, Y; Çapa, G; Ertay, Y; Sagiroglu, E; Durak, H
    In this study we aimed to evaluate the possible mechanisms by which somatostatin acts when given epidurally. Twenty male New Zealand rabbits were randomly separated into four groups and various drugs were administered via a caudal epidural catheter. Group 1 received a bolus of 3.7 MBq indium-111 (In-111)-pentetreotide, group 2 received 200 mu g octreotide and after 15 min a bolus of 3.7 MBq In-111-pentetreotide, group 3 received 0.1 mg morphine and after 15 min a bolus of 3.7 MBq In-111-pentetreotide, and group 4 received a bolus of 3.7 MBq technetium-99m (Tc-99(m))-diethylene triamine pentaacetic acid (DTPA). Dynamic images of 60 min' duration were obtained from the posterior projection. T-1/2 fast and T-1/2 total clearance half-times were calculated. When unlabelled octreotide was given to block somatostatin receptors, clearance of In-111-pentetreotide was found to be faster. Epidural morphine administration did not change the clearance rate of In-111-pentetreotide. All these findings are in favour of octreotide binding to its probable own specific receptors present in the epidural space. ((C) 2000 Lippincott William & Wilkins).
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    Penetration of amikacin into aqueous humor of rabbits
    Erkin, EF; Günenç, Ü; Öner, FH; Gelal, A; Erkin, Y; Güven, H
    Amikacin is an aminoglycoside antibiotic that has poor corneal penetration due to its hydrophilic properties. The purpose of this study was to compare and evaluate the penetration of amikacin sulfate into aqueous humor of the rabbit eye when applied by different routes and concentrations, namely 100 or 250 mg/ml topical fortified amikacin eye drops, 100 or 250 mg/ml amikacin-embedded soft contact lenses and 25 mg subconjunctival amikacin injection. One hour after application, amikacin was not detectable in any of the 100 mg/ml concentration groups. High levels of amikacin above the minimum inhibitory concentration for susceptible bacteria were detected when applied subconjunctivally and by 250 mg/ mi topical fortified routes. Topical fortified amikacin 250 mg/ml reached the highest value in the aqueous (p < 0.05). Our results point out the poor corneal penetration of amikacin in standard concentrations from the intact rabbit cornea and that subconjunctival injections might provide satisfactory penetration. Copyright (C) 2001 S. Karger AG, Basel.