Browsing by Author "Ermete M."

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    Preoperative staging of rectal carcinoma by endorectal ultrasonography
    (2000) Can M.; Dural T.; Aydede H.; Ermete M.; Guney S.
    Purpose: To evaluate the efficacy and accuracy of endorectal ultrasonography (EUS) in detecting preoperatively rectal wall invasion and nodal involvement in patients with rectal carcinoma. Materials and methods: EUS was applied to 27 patients prediagnosed as having rectal carcinoma by using a 7.5 MHz endorectal transducers with water bag. Sonographic evaluation consisted of estimation of tumour invasion into the rectal wall and adjacent lymph node involvement. All of the patients were operated on with curative intend and the sonographic stage was compared with the postoperative pathologic stage. Results: The accuracy rates of EUS compared with the postoperative pathologic staging were 81%, 70.3% and 59.3% in determining wall invasion, nodal involvement and overall tumour stage, respectively. The most frequent factor leading to false-positive results was the abnormally reactive-hyperplastic lymph nodes which were hypoechoic and larger than 5 mm in diameter. Conclusion: It is concluded that EUS is a moderately reliable imaging method for local tumour staging, mainly due to its relatively high rate of nodal imaging failure.
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    Col IV and Fn Distribution in Prostatic Adenocarcinoma and Correlation of 67LR, MMP-9 and TIMP-1 Expression with Gleason Score
    (2003) Işisaǧ A.; Neşe N.; Ermete M.; Lekili M.; Ayhan S.; Kandiloǧlu A.R.
    OBJECTIVE: To assess the immunoreactivity of 5 proteins related to basement membrane (BM) and extracellular matrix in order to investigate whether any of them correlates with differentiation of prostatic adenocarcinoma (PAc). Two of these markers are collagen type IV (Col IV), the collagenous component of basement membrane, and fibronectin (Fn), an adhesion protein in extracellular matrix. Others are matrix metalloproteinase-9 (MMP-9), a type IV collagenase, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), which has a high affinity for MMP-9, and 67-kd laminin receptor (67LR), which belongs to the non-integrin laminin binding receptor family. STUDY DESIGN: Forty-three PAc cases with Gleason scores ranging between 5 and 10 and 10 benign prostatic hyperplasia (BPH) cases, the control group, were included in the study. Formalin-fixed and paraffin-embedded tissue slides from each case were immunostained with the avidin-biotin-peroxidase method. Immunoreactivity was determined by means of a scoring system similar to the Gleason scoring system. RESULTS: Overexpression of Col IV, Fn, 67LR and MMP-9 was detected in PAc as compared with BPH, whereas no difference was determined in TIMP-1 expression. Among these, only 67LR correlated statistically with Gleason score. CONCLUSION: Expression of 67LR in tumor cells was significantly increased in parallel to tumor grade. This may be useful in microscopic evaluation of PAc.
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    Small cell Carcinomas of the bladder highly express somatostatin receptor type 2A: Impact on prognosis and treatment-a multicenter study of urooncology society, Turkey
    (Lippincott Williams and Wilkins, 2016) Nese N.; Kumbaraci B.S.; Baydar D.E.; Kilicaslan I.; Sari A.A.; Sen S.; Gonul I.I.; Kankaya D.; Ozluk Y.; Ermete M.; Ozagari A.; Bal N.; Kiremitci S.; Yildiz K.; Tuna B.; Sen N.; Yorukoglu K.
    Small cell carcinoma (SmCC) is a rare and aggressive neuroendocrine carcinoma of the bladder. Neuroendocrine carcinomas expressing somatostatin receptors (SSTR) in other viscera such as lung, pancreas, and gastrointestinal system respond to therapy with somatostatin analogs. In the present study, expressions of SSTRs 1 to 5 including type 2A are investigated by immunohistochemistry (IHC) and their relationship with clinicopathologic factors was evaluated. Hundred primary bladder SmCC cases were collected from 12 centers in Turkey. Forty-three cases were pure SmCC. Other cases had mostly papillary urothelial carcinoma as a second component. The percentage of the SmCC component ranged from 5% to 100%. SSTR-2A expression was membranous, whereas the other receptors showed cytoplasmic staining. The percentages of positive cases for SSTR-1, SSTR-2A, SSTR-3, SSTR-4, and SSTR-5 were 4% (3/75), 61.4% (54/88), 2.4% (2/84), 24.4% (20/82), and 6.25% (5/80), respectively. The percentage of SmCC component was positively correlated with the percentage of SSTR-2A expression (P=0.003) while negatively correlated with patient age (P=0.032). SSTR-2A expression was correlated with survival as a bad prognostic factor (P=0.018). SSTR-1, SSTR-3, SSTR-4, and SSTR-5 expressions did not show any statistical significance with any parameter. In conclusion, although the limited number of cases with adequate term follow-up, SSTR-2A expression could be a prognostic factor and somatostatin analogs therapeutic candidate for SmCCs of the bladder as these tumors show high percentage of SSTR-2A expression. © 2016 Wolters Kluwer Health, Inc. All rights reserved.