Browsing by Author "Erol A."

Now showing 1 - 13 of 13
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    Muscle-specific PPARβ/δ agonism may provide synergistic benefits with life style modifications
    (2007) Erol A.
    Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation of PPARβ/δ promotes fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. In muscle, PPARβ/δ appears to act as a central regulator of fatty acid catabolism. PPARβ/δ contents are increased in muscle during physiological situations such as physical exercise or long-term fasting, characterized by increased fatty acid oxidation. Targeted expression of an activated form of PPARβ/δ in skeletal muscle induces a switch to form increased numbers of type I muscle fibers resembling the fiber type transition by endurance training. Activation of PPARβ/δ also enhances mitochondrial capacity and fat oxidation in the skeletal muscle that resembles the effect of regular exercise. Therefore, it is hypothesized that muscle-specific PPARβ/δ agonists could be a key strategy to support the poor cardiorespiratory fitness associated with metabolic disorders. Copyright © 2007 Adnan Erol.
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    The functions of PPARs in aging and longevity
    (2007) Erol A.
    Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitivetranscription factors and their dyregulated activations seem to be major culprits for thesepathological processes. Drugs targeting PPARs activity are already in widespread clinical use;however, based on these concepts, this review highlights the understanding of the role ofPPARs in aging and indicates the necessary particular attention for the potential therapeuticuses of current PPAR agonists in age-associated diseases. Copyright © 2007 Adnan Erol.
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    Chylous ascites and chylothorax due to membranous nephropathy [2]
    (Dustri-Verlag Dr. Karl Feistle, 2007) Colak H.B.; Alici T.; Tekce H.; Öz D.; Erol A.; Aras F.; Kursat S.
    [No abstract available]
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    Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress
    (2007) Erol A.
    Several protective cellular mechanisms protect against the accumulation of reactive oxygen species (ROS) and the concomitant oxidative stress. Therefore, any reduction in glucose or fatty acid flux into cells leading to a decrease in the production of reducing equivalents would also lead to a decreased ROS production and protect cells against oxidative stress. In the presence of insulin, FOXO proteins are localized from the nucleus to the cytoplasm and degraded. An increase in cellular glucose uptake will lead to increased production of ROS. This in turn activates the stress-responsive Jun-N-terminal kinase (JNK), which promotes nuclear translocation of FOXO proteins, upregulating some important target genes including stress resistance. Consequently, insulin resistance should result in decreased cellular ROS production. For this reason, insulin resistance could be a physiological mechanism activated at the cellular level in response to conditions stimulating ROS production and leading to the prevention of oxidative stress, and extension of life. Concerning the whole organism, however, IR is a maladaptive process in the long term causing a diabetic state. © 2007 Wiley Periodicals, Inc.
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    JNK/FOXO may be key mechanistic pathway for the hormetic anti-aging
    (2007) Erol A.
    FOXO transcription factors and evolutionarily conserved c-jun N-terminal kinase (JNK) could hold the key to counteract hormetic anti-aging and common diseases. Hormesis is increasingly recognized as a mechanism underlying the beneficial anti-aging effects of certain genetic and environmental factors. Caloric restriction and exercise increase the resistance of organisms to stress and activate stress resistance pathways in cells in different tissues throughout the body by hormesis based mechanism. JNK triggers the relocalization of FOXO factors to the nucleus inducing the expression of FOXO dependent stress response and damage repairing genes. This adaptive response to stress stimuli may play an important role in regulating homeostasis at the organismal level and contribute to longevity.
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    Association of rhabdomyolysis and deep venous thrombosis as a rare complication of haloperidol treatment
    (2007) Erol A.; Karataş S.
    Background: Rhabdomyolysis is one of the reasons for acute renal failure. Deep vein thrombosis (DVT) refers to the formation of a thrombus within a deep vein, commonly in the thigh or calf. DVT may lead to pulmonary emboli that can be fatal. Haloperidol is an antipsychotic drug. It has a broad spectrum of side effects. There are examples of DVT and rhabdomyolysis associated with haloperidol use in literature. However, there is no case that reports these two complications together with use of haloperidol. Case Report: A 33 year old woman who was treated with haloperidol for her agitation and acute psychotic reaction had been admitted to University Hospital because of DVT, rhabdomyolysis and loss of consciousness. Elevations of serum creatine kinase, aspartat transaminase and lactate dehydrogenase concentrations were compatible with the diagnosis of the rhabdomyolysis. Physical findings of right leg swelling, warmth, erythema and tenderness; radiological finding of right femoral and inferior vein thrombosis at CT venography were consistent with DVT. All other reasons for these two conditions had been excluded in a long period of laboratory and clinical investigation. Conclusions: Along with the haloperidol therapy clinicians should be aware of rare complications like DVT and rhabdomyolysis. Patient, who was admitted to hospitals with rhabdomyolysis or DVT, should also be investigated about haloperidol use in differential diagnosis.
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    Effect of facial emotion recognition on subjective psychosocial functioning in bipolar patients
    (2013) Aydemir O.; Akkaya C.; Uykur B.; Erol A.
    [No abstract available]
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    JAK/STAT pathway interacts with intercellular cell adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) while prostate cancer stem cells form tumor spheroids
    (Zerbinis Publications, 2015) Duzagac F.; Inan S.; Simsek F.E.; Acikgoz E.; Guven U.; Khan S.A.; Rouhrazi H.; Oltulu F.; Aktug H.; Erol A.; Oktem G.
    Purpose: JAK/STAT is an evolutionarily conserved pathway and very important for second messenger system. This pathway is important in malignant transformation and accumulated evidence indicates that this pathway is involved in tumorigenesis and progression of several cancers. It was possible to assume that activation of JAK/STAT pathway is associated with increase in the expressions of ICAM-1 and VCAM-1. In this study we hypothesized that when cells were maintained as spheroids or monolayers, the structure of cancer stem cells (CSCs) could show differentiation when compared with non-CSCs. Methods: DU-145 human prostate cancer cells were cultured using the Ege University molecular embryology laboratory medium supplemented with 10% fetal bovine serum. Clusters of differentiation 133 (CD133)(+high)/CD44(+high) prostate CSCs were isolated from the DU145 cell line by using BD FACSAria. CD133+/CD44+ CSCs were cultured until confluent with 3% noble agar. The expression of these proteins in CSCs and non-CSCs was analyzed by immunohistochemistry. Results: Different expression profiles were observed in the conventional two-dimensional (2D) and three-dimensional (3D) experimental model system when CSCs and non-CSCs were compared. Human prostate CSCs exhibited intense ICAM-1 and VCAM-1 immunoreaction when compared with non-CSCs. These findings were supported by the fact that VCAM-1 on the surface of cancer cells binds to its counterreceptor, the a4fil integrin (also known as very-late antigen, VLA-4), on metastasis-associated macrophages, triggering VCAM-1-mediated activation of the phosphoinositide 3-kinase growth and survival pathway in cancer cells. Conclusions: The results of this study showed that changes in JAK/STAT pathway are related with adhesion molecules and could affect cancer progression.
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    Determining Self-Efficacy of Nurses Who Graduated From Distance Education Because of the COVID-19 Pandemic: A Multicenter Cross-Sectional Study
    (Slack Incorporated, 2023) Baysal E.; Çetin S.P.; Demirkol H.; Erol A.
    Background: The current literature states that distance education has caused a lack of professional skills, regression of existing professional skills (Kaya & Akin Isik, 2021; Kürtüncü & Kurt, 2020), a lack of self-confi-dence, and feelings of inadequacy among nursing students (George et al., 2020). The current study examined the professional self-efficacy of nurses who graduated from distance education because of the coronavirus disease 2019 pandemic. Method: This multicenter cross-sectional study was conducted between November 2020 and June 2022 with 164 nurses who graduated from distance education in 2020-2021 from three facul-ties of health sciences. Results: Professional self-effica-cy of the nurses was found to be above average. Male nurses and nurses who believed distance education had a negative impact on their professional skills had significantly higher professional self-efficacy. Some nurses reported that their professional theoretical knowledge was insufficient and defined the effect of distance education on their professional skills as relatively negative. Conclusion: Most of the nurses expressed that distance education had a negative effect on their professional self-efficacy and working life. © SLACK Incorporated.
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    Nurses’ Perceptions of Spirituality and Spiritual Care and Influencing Factors in Türkiye, Italy, and Albania: A Multicultural Study
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024) Baysal E.; Demirkol H.; Erol A.; Kaçmaz E.D.; Duka B.; Agolli B.; Stievano A.; Notarnicola I.
    The present study aimed to explore the perceptions of spirituality and spiritual care among nurses who work in three different countries with different cultures as well as the factors influencing their perception. This is a cross-sectional multicultural study conducted with a total of 1090 nurses from Türkiye, Albania, and Italy. Data were collected through the “Individual Information Form” and the “Spirituality and Spiritual Care Rating Scale”. Nurses’ mean score on the Spirituality and Spiritual Care Rating Scale was above average. It was also found that country, marital status, religious belief, Islamic religion, training for spiritual care, and using spiritual practices to cope with difficulties or illnesses influenced nurses’ perception of spirituality and spiritual care. It was concluded that nurses from the three countries associated spirituality and spiritual care with religion and that some personal characteristics influenced their perceptions of spiritual care. The results highlight the need for training in spiritual care to improve nurses’ perceptions and practices of spiritual care. © 2024 by the authors.