MCBÜ Açıkerişim Sistemi :: Browsing by Author "Ersoy B."

Browsing by Author "Ersoy B."

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Mental health of both child and parents plays a larger role in the health-related quality of life of obese and overweight children
(Walter de Gruyter GmbH, 1985) Kızılay D.Ö.; Sapmaz Ş.Y.; Şen S.; Özkan Y.; Özyurt B.C.; Ersoy B.
Aims: A decrease in health-related quality of life (HRQOL) measures among obese (OB) and overweight (OW) children has been shown in several studies, but knowledge about the variables affecting HRQOL impairments is missing. The aim of this study was to evaluate the relationship between HRQOL and sociodemographic characteristics, anthropometric measurements, metabolic parameters, mental symptoms and parental attitudes in a sample of OB/OW children. Methods: Eighty-six OB/OW children, aged between 9 and 17 years, participated in the study. We performed sociodemographic questioning, anthropometric examinations and laboratory evaluations of the participants. HRQOL was assessed using the Pediatric Quality-of-Life Inventory (PedsQL), and levels of anxiety and depressive symptoms were measured using the Screen for Child Anxiety-Related Disorders (SCARED) questionnaire and the Children’s Depression Inventory (CDI), respectively. Parental attitudes were assessed with the Parental Attitude Research Instrument (PARI) questionnaire. Results: A statistically significant relationship was found between total scores of CDI and SCARED answered by children and the total and subscale scores of PedsQL. Scores of total quality of life subscale, physical functionality and emotional functionality subscales were significantly lower in children with a family history of mental illness. No relationship was found between PedsQL subscales, anthropometric and metabolic parameters. Conclusions: Emotional problems and parental psychological distress are important factors in models of HRQOL in the OB/OW pediatric population. © 1985 Walter de Gruyter GmbH. All rights reserved.
The concentration of insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in maternal sera during pregnancy with normal and growth retarded fetuses; [Normal ve yetersiz fetal gelisim gosteren gebelerde gebelik suresince serum insulin benzeri buyume faktoru-1 (IGF-1) ve insulin benzeri buyume faktoru baglayici protein-3 (IGFBP-3) konsantrasyonlari]
(2000) Lacin S.; Oruc S.; Kuscu K.; Ersoy B.; Tansug N.; Uyanik B.S.; Yildirim Y.; Koyuncu F.
Objective: To determine the concentrations of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in maternal sera of pregnancies with normal and growth retarded fetuses and investigate the relationship between these substances and fetal growth. Materials and Methods: Blood samples of 148 pregnant women were collected at 14-16 and 30-31 weeks and during delivery. Also cord blood samples were obtained during delivery. For the determination of IGF-1 and IGFBP-3, double-sided IRMA method was used. Infants were divided into two groups as normal and growth retarded fetuses based upon their patterns of growth using the percentile curves and the serum levels were compared. Correlation analysis and Mann-Whitney U test were used as statistical calculations. Results: Both IGF-1 and IGFBP-3 levels increased while approaching term in all pregnant women. In growth retarded cases, maternal IGF-1 levels were found to be significantly lower than pregnancies with normal fetuses (p< 0.005), but maternal IGFBP-3 levels were not different between two groups. IGF-1 levels in cord blood during delivery were not different while IGFBP-3 levels were significantly higher in growth retarded fetuses. Conclusion: Our study did not support the hypothesis that fetal growth retardation is due to IGF-1 deficiency. High binding protein levels may cause a relative free IGF-1 deficiency, but the levels of binding protein is probably secondary to metabolic changes or placental insufficiency. Low levels of IGF-1 and high levels of binding proteins implies the necessity of further investigation of placental transfer.
Increased transaminase levels coexistent with pseudo-obstruction; [Çölyak hastaliǧinda transaminaz yüksekliǧi ile psödo-obstrüksiyonun birlikteliǧi]
(2003) Polat M.; Kasirga E.; Ersoy B.; Abay I.; Onaǧ A.
Celiac disease is an intestinal reaction towards gluten which causes a defect in the digestive system. Although celiac disease presents with typical malabsorption symptoms, it can also cause atypical gastrointestinal system symptoms (discomfort). Among case reports in the literature related with atypical celiac disease, there has been no celiac disease case who presented with pseudo-obstruction and increased liver enzymes. In this paper, we report a nine-year-old celiac patient who presented with pseudo-obstruction symptoms and increased aminotransferase level.
Effects of different socioeconomic conditions on menarche in Turkish female students
(Elsevier Ireland Ltd, 2004) Ersoy B.; Balkan C.; Gunay T.; Onag A.; Egemen A.
Purpose: The aim of this study was to determine the age at menarche, the menarcheal features, and the association between menarcheal age and socioeconomic status in an urban area in Turkey. In addition, we tried to assess whether there is a relationship between age at menarche and body composition. Methods: We asked some questions about menarche of 1017 female adolescent students in the high schools of Manisa region. Height and weight were measured. The body mass index (BMI; kg/m2) was used as an index of relative weight. Adolescent girls were grouped into three socioeconomic status according to the educational and occupational levels of their parents. The age at menarche and the menarcheal pattern were evaluated according to the socioeconomic status. Results: The ages of girls involved in the study ranged between 14 and 18 years, with a mean of 15.7±1.1 years. Although the menarcheal age was found to be lower in girls with higher socioeconomic status, there was no significant difference between the three different socioeconomic status. In all of the three groups, menarche was more common in summer and fall than in spring and winter. Although the mother was an important source of knowledge in all groups, it was significantly more important in the group with high socioeconomic status. Adolescent girls with low socioeconomic status had fewer premenstrual complaints. However, there was no significant difference between the groups. We found an inverse correlation between menarcheal age and postmenarcheal weight and the BMI (r=-0.14, p=0.000). However, there was no correlation between menarcheal age and postmenarcheal height. Conclusion: These results indicate that as the social status differences decrease, the difference observed in menarcheal age and pattern disappears in urban areas of developing countries. Menarcheal age may be an indicator of socioeconomic development. It does not influence postmenarcheal height; however, as menarcheal age decreases, BMI increases. © 2003 Elsevier Ireland Ltd. All rights reserved.
Myelofibrosis associated with severe vitamin D deficiency rickets
(Cambridge Medical Publications, 2005) Balkan C.; Ersoy B.; Nese N.
Myelofibrosis is a rare disorder in childhood. In this report, we present the case of a 6-month-old infant with myelofibrosis due to severe vitamin D deficiency rickets. The characteristic clinical and laboratory findings of myelofibrosis improved rapidly after vitamin D therapy. In developing countries, nutritional rickets is still an important health problem. Rickets is not only a skeletal system-related disorder, it is also a systemic disorder. Rickets should be considered, therefore, as one of the conditions that can lead to severe haematological disorders in infants.
The factors affecting the relation between the menarcheal age of mother and daughter
(2005) Ersoy B.; Balkan C.; Gunay T.; Egemen A.
Background: Menarche is one of the most important biologic signals in the life of a woman. Menarche is a biological variable which has a significant genotypic component in girls. In recent years, many studies reporting the earlier onset of menarche owing to the improvement of socio-economic conditions have been published. Design: We asked some questions about menarche to 1017 female students studying in the high schools of Manisa region in order to determine the menarcheal age and the correlation of menarcheal age between the mothers and daughters in our region. Results: The mean age at menarche for the girls was 12.82 ± 1.07 years and for the mothers was 13.6 ± 1.39 years. The mean menarcheal age of the mothers was higher than the mean menarcheal age of the girls (P < 0.001). This difference persisted independent of the socio-economic status, nutritional state and physical activity of the girls. There was a significant correlation between the menarcheal age of the girls and their mothers (r = 0.262, P < 0.001). This correlation existed in all the girls with different socio-economic status, nutritional state and physical activity. However, this correlation disappeared in girls with body mass index (BMI) > 25 (r = 0.04, P = 0.813). In girls with BMI < 25, there was a correlation between the menarcheal age of the girls and mothers (r = 0.282, P < 0.001). Conclusion: These results suggest that the menarche occurs earlier in the daughters than their mothers. The correlation between the menarcheal age of the girls and their mothers persists under all circumstances except in obesity. The mother's menarcheal age is a good predictor of the daughter's menarcheal age in non-obese girls and the BMI is an important factor. © 2005 Blackwell Publishing Ltd.
The role of platelet-activating factor in pathogenesis of type 1 diabetes [1]
(American Diabetes Association Inc., 2005) Ersoy B.; Hüseyinov A.; Darcan Ş.
[No abstract available]
Bone mineral density in girls and boys at different pubertal stages: Relation with gonadal steroids, bone formation markers, and growth parameters
(2005) Yilmaz D.; Ersoy B.; Bilgin E.; Gümüşer G.; Onur E.; Pinar E.D.
Puberty has a key role in bone development. During puberty, several nutritional and hormonal factors play a major role in this process. The aim of this study was to determine the changes in areal bone mineral density (BMD), gonadal steroids, bone formation markers, and growth parameters in healthy Turkish pubertal girls and boys at different pubertal stages. In additional, we aimed to detect the relationship between BMD, sex steroids, and growth parameters, and to reveal the most important determinant of BMD in the pubertal period. BMD of the lumbar spine and total body was performed by dual-energy X-ray absorptiometry (Lunar DPX series) in 174 healthy pubertal children (91 girls, 83 boys), aged 11-15 years. Height and weight were measured. Pubertal stages were assesed. Bone formation markers and gonadal steroids were measured. BMD values significantly increased until stage IV in girls. In boys, BMD values also increased during puberty (P < 0.05), but it was significantly higher in stage IV compared with that in other pubertal stages (P < 0.01). Testosterone levels increased until stage IV in both sexes, particularly in boys. Estrogen levels significantly increased during puberty in girls, whereas it was significantly higher at stage IV in boys (P < 0.001). Bone-specific alkaline phosphatase (BAP) level was higher in early and midpuberty, and decreased in late puberty in girls (P < 0.001). BAP level was higher in stage IV in boys. Osteocalcin level was shown not to change significantly in pubertal stages. There was a modest correlation between BMD values and estrogen and testosterone levels in boys. In girls, there was a correlation between BMD values and estrogen levels only (P < 0.05). Weight was significantly associated with BMD in both sexes (P < 0.05). Estrogen had a significant influence on BMD in boys and girls. In conclusion, bone mass increased throughout puberty in both sexes. Peak bone mass was not achieved in girls, but was obtained at stage IV in boys. Bone formation markers were good predictors of bone mass in girls, but not in boys. Estrogen level made the greatest contribution to bone mineral acquisition in boys and girls. The achievement of peak bone mass was sustained by estrogen in boys. The major independent determinant of BMD in both sexes was weight. © Springer-Verlag 2005.
Changes in growth pattern, body composition and biochemical markers of growth after adenotonsillectomy in prepubertal children
(2005) Ersoy B.; Yücetürk A.V.; Taneli F.; Ürk V.; Uyanik B.S.
Objective: Adenotonsillar hypertrophy (ATH) is associated with growth interruption during childhood. The aim of this study was to determine the changes in growth, body composition and biochemical markers associated with growth following adenotonsillectomy (A&T) in prepubertal children. Study design: Twenty-eight children aged 3-10 years (mean age 73.90 ± 20.97 months) with ATH were followed up for 1 year after A&T. During the same period of time, 20 healthy children of similar ages (mean age 73.7 ± 18.2 months) were followed up too. Methods: Height, weight as well as insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were measured during the preoperative period, 6 months and 1 year after surgery. Results: Height and weight of the patient group significantly increased during the first year after A&T (p < 0.01). Increase in height standard deviation score (SDS) during the first postoperative year reflected a true acceleration of growth (p = 0.04). Height and weight of patients were not significantly below those of their healthy peers at the preoperative measurement. Height velocity of the patients (p = 0.118), which was similar to that of their healthy peers in the first 6 months postoperatively, was significantly higher at the end of the second 6-month period after the operation (p = 0.048). IGF-1 levels of the patient group, which were significantly lower than those of the controls preoperatively (p < 0.001), increased to similar levels 1 year after the operation. IGFBP-3 levels of the patient group increased significantly after postoperative sixth month (p = 0.002). Conclusion: Although children with ATH do not have significant growth retardation, their growth rate is slower. Increase in weight and IGF-1 levels followed by the increase in height leads to an acceleration in growth rate after A&T. These results have led to the conclusion that either the levels or effect of growth hormone (GH) increase following A&T. © 2005 Elsevier Ireland Ltd. All rights reserved.
Interaction of two public health problems in Turkish schoolchildren: Nutritional deficiencies and goitre
(2006) Ersoy B.; Günes H.S.; Gunay T.; Yilmaz O.; Kasirga E.; Egemen A.
Objective: The aim of the present study was to determine the interaction of and association between frequency of goitre detected by palpation, nutritional status evaluated by anthropometric indices and socio-economic status in school-aged children. Subjects: One thousand and eighteen prepubertal and pubertal children (aged 6-14 years) attending primary schools in an urban area were included in this study. Design and setting: All subjects were evaluated for the presence of goitre and nutritional status. Thyroid size was assessed using the World Health Organization's (WHO) palpation system (1960). Severity of protein-energy malnutrition (PEM) was based on WHO criteria. Children were grouped into four categories of socio-economic status. Results: Eight per cent of children were detected to have goitre by palpation. Body mass index and weight-for-height were significantly lower in children who had palpable goitre than in children who did not have goitre (P < 0.05). Frequencies of having palpable goitre and being stunted and underweight were especially higher in children with very low socio-economic status (P = 0.016, 0.01 and 0.01, respectively). Frequency of being stunted, underweight and wasted in children with palpable goitre did not change significantly according to socio-economic status (P > 0.05). In logistic regression analyses, the most important factor in detection of palpable goitre was socio-economic status (B = 0.517, P = 0.004). Fathers' education and occupation were found to be most significant (P = 0.031 and 0.020, respectively). Conclusion: Children detected to have palpable goitre were thinner. However, nutritional disorders were not more frequent among children with palpable goitre compared with children without goitre. Goitre and nutritional deficiencies were more common in children with lower socio-economic status but the frequency of nutritional disorders in children with palpable goitre did not change according to socio-economic status. © The Authors 2006.
Diabetic ketoacidosis presenting with pneumomediastinum
(2007) Ersoy B.; Polat M.; Coşkun Ş.
[No abstract available]
Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young
(2007) Ellard S.; Thomas K.; Edghill E.L.; Owens M.; Ambye L.; Cropper J.; Little J.; Strachan M.; Stride A.; Ersoy B.; Eiberg H.; Pedersen O.; Shepherd M.H.; Hansen T.; Harries L.W.; Hattersley A.T.
Aims/hypothesis: Heterozygous mutations of glucokinase (GCK) and hepatocyte nuclear factor-1 alpha (HNF1A; also known as hepatic transcription factor 1 [TCF1]) genes are the most common cause of MODY. Genomic deletions of the HNF1B (also known as TCF2) gene have recently been shown to account for one third of mutations causing renal cysts and diabetes syndrome. We investigated the prevalence of partial and whole gene deletions in UK patients meeting clinical criteria for GCK or HNF-1α/-4α MODY and in whom no mutation had been identified by sequence analysis. Methods: A multiplex ligation-dependent probe amplification (MLPA) assay was developed using synthetic oligonucleotide probes for 30 exons of the GCK, HNF1A and HNF4A genes. Partial or whole gene deletions were identified in 1/29 (3.5%) probands using the GCK MLPA assay and 4/60 (6.7%) of probands using the HNF1A/-4A MLPA assay. Four different deletions were detected: GCK exon 2, HNF1A exon 1, HNF1A exons 2 to 10 and HNF1A exons 1 to 10. An additional Danish pedigree with evidence of linkage to HNF1A had a deletion of exons 2 to 10. Testing other family members confirmed co-segregation of the deletion mutations with diabetes in the pedigrees. Conclusions/interpretation: Large deletions encompassing whole exons can cause GCK or HNF-1α MODY and will not be detected by sequencing. Gene dosage assays, such as MLPA, are a useful adjunct to sequence analysis when a diagnosis of MODY is strongly suspected. © 2007 Springer-Verlag.
Prognostic value of initial antithrombin levels in neonatal sepsis
(2007) Ersoy B.; Nehir H.; Altinoz S.; Yilmaz O.; Dundar P.E.; Aydogan A.
Objectives: We determined whether initial antithrombin (AT) levels help in diagnosis and prognosis of neonatal sepsis. Methods: Sepsis was diagnosed according to clinical and laboratory findings and positive culture results in 34 of the 54 newborns who presented to the hospital with suspected sepsis. Between AT levels and hematological parameters (fibrinogen levels, prothrombin time (PT), activated partial thromboplastin time (aPTT) and liver function tests), these were correlated each other and with outcome of the babies. Results: Initial AT and fibrinogen levels were significantly lower in newborns with sepsis compared to control (P<0.05). Initial AT levels were lower in the ones who developed disseminated intravascular coagulation (DIC) compared to those without DIC (P <0.05). Initial AT levels were significantly lower in newborns who died as compared to survivors (P <0.05). Sensitivity of AT was highest at 15 mg/dL for prognosis in neonatal sepsis (sensitivity:92.3%, specificity:61.9%, positive predictive value : 61.9%, negative predictive value: 61.9%). Conclusion: Lower initial AT levels in neonatal sepsis are associated with a severe disease and increased mortality. It may be useful in predicting clinical outcome in neonatal sepsis.
Doppler ultrasonography imaging of hemodynamic alteration of retrobulbar circulation in type 1 diabetic children and adolescents without retinopathy
(2008) Yilmaz Ovali G.; Ersoy B.; Tuncyurek O.; Urk V.; Ozkol M.; Ozhan B.; Baser E.; Pabuscu Y.
Aim: We aimed to investigate the retrobulbar blood circulation using Colour Doppler Imaging (CDI) in type 1 diabetic children and adolescents who had no diabetic retinopathy and to compare the results with their healthy peers. Methods: Forty-nine patients with type 1 diabetes mellitus with no retinopathy on fundoscopic examination were included in the study. Forty-nine healthy children were defined as the control group. Central retinal artery (CRA), ophthalmic artery (OA) and posterior ciliary artery (PCA) were examined with Doppler US bilaterally. Peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive indices (RI) for each artery were recorded. Results: Blood flow velocity of the OA was significantly different in diabetic patients (p < 0.05). EDV of the OA was significantly higher (p = 0.011) and RI was significantly lower (p = 0.027) in patients with diabetes duration of longer than 5 years. RI of the CRA was significantly higher in patients who had higher microalbuminuria levels (p = 0.016). Conclusion: EDV of the OA increases and RI of the OA decreases in diabetes duration longer 5 years. Raised AER increases RI of the CRA. These findings may be the initial changes in the arterial circulation before vascular rigidity develops. © 2007 Elsevier Ireland Ltd. All rights reserved.
Borderline phyllodes tumor of the breast in an adolescent girl; [Adölesan kiz olguda memenin "Borderline" fillodes tümörü Olgu Sunumu]
(2008) Genç A.; Yilmaz Ö.; Özgüven A.A.; Ersoy B.; Aygören R.; Kandiloǧlu A.R.; Taneli C.
Phyllodes tumor (PT) is a tumor similar to fibroadenoma, that can reach to enormous sizes. It consistic less than 1 % of all breast neoplasms. Here, a 13 years old female patient is reported due to its rarity. She presented with a mass in the right breast which showed hard consistency and fixation to the thoracic wall by palpation and caused retraction of the nipple. Tomography revealed a solid mass with the diameter of approximately 11 cm. Patient was operated with the presumptive diagnosis of PT or breast carcinoma and the mass was totally excised together with its capsule. Pathologic examination showed 6 mitotic cells in each field, medium cellularity and slight atypia. It was accepted as a borderline tumor but no recurrence or metastasis was observed within postoperative 5 months. As for conclusion, PT should be considered in rapidly expanding masses of breast that present with enormous size.
Interactions of thyroid hormones; Insulin-like growth factor-1 (IGF-1), igf binding proteins, and nutritional anthropometric parameters in school children with goiter detected by palpation
(2009) Ersoy B.; Gunes H.S.; Uyanik B.S.; Taneli F.; Gunay T.
Aim: In the present study we evaluated anthropometric indices, serum thyroid hormones, insulin-like growth factor-1 (IGF-1) and IGF- binding proteins (IGFBPs) levels, in children who has palpable goiter at endemic population. We aimed to 1) compare children with palpable goiter with healthy peers, 2) detect interaction of anthropometric indices, serum thyroid hormones, IGF-1 and IGFBPs parameters in both groups 3) evaluate the effects of their nutritional status to these parameters. Subjects and Methods: We performed goiter palpation to 1018 child and found goiter at 81 child. Seventy-three pubertal children were included in this study. Seventy-five healthy children were defined as the control group. Weight and height of all children were measured. Thyroid hormone levels, IGF-1, IGFBP-3, and IGFBP-1 were assessed in both groups. Results: Height and weight SDS were significantly lower in children who had goiter by palpation than healthy peers (p<0.05). Free T4 (FT4) levels were significantly higher in control group than children with palpable goiter (p<0.05). IGF-1 level and IGF-1 SDS were significantly lower in children with palpable goiter (p<0.001), IGFBP3 and IGFBP1 levels were not significantly different between the two groups (p>0.05). Serum IGF-1 and IGFBP-3 levels were significantly lower (p<0.05) in underweight children with goiter than normal weight group. In the presence of goiter, IGF-1 levels were lower (B: 0.97, 95% CI: 0.960.98, p<0.001). Conclusion: In endemic areas, children with palpable goiter were shorter and thinner than the healthy peers. Thyroid hormones were between the reference ranges. In children with palpable goiter, IGF-1 levels were lower and IGFBP-3 and IGFBP-1 levels were not different from the healthy control group. However, at the presence of goiter IGF-1 levels decrease. This decrease can be the result of insufficient nutrition and result in short stature and weakness than their healthy peers. © Georg Thieme Verlag KG Stuttgart, New York.
Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3
(Baishideng Publishing Group Co, 2009) Ersoy B.; Ozbilgin K.; Kasirga E.; Inan S.; Coskun S.; Tuglu I.
AIM: To evaluate the effects of growth hormone (GH) on the histology of small intestines which might be related to the role of insulin like growth factor (IGF)-I, IGF-binding protein 3 (IGFBP-3) and its receptors. METHODS: Twelve week-old adult male Wistar albino rats were divided into two groups. The study group ( n = 10), received recombinant human growth hormone (rGH) at a dose of 2 mg/kg per day subcutaneously for 14 d and the control group ( n = 10) received physiologic serum. Paraffin sections of jejunum were stained with periodic acid shift (PAS) and hematoxylin and eosin (HE) for light microscopy. They were also examined for IGF-I, IGFBP-3 and IGF-receptor immunoreactivities. Staining intensity was graded semi-quantitatively using the HSCORE. RESULTS: Goblet cells and the cells in crypt epithelia were significantly increased in the study group compared to that of the control group. We have demonstrated an increase of IGF-I and IGFBP-3 immunoreactivities in surface epithelium of the small intestine by GH application. IGF-I receptor immunoreactivities of crypt, villous columnar cells, enteroendocrine cells and muscularis mucosae were also more strongly positive in the study group compared to those of in the control group. CONCLUSION: These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine. The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I. © 2009 The WJG Press and Baishideng. All rights reserved.
Factors affecting carotid intima media thickness predicts early atherosclerosis in overweight and obese adolescents
(2010) Ozguven I.; Ersoy B.; Ozguven A.; Ozkol M.; Onur E.
Objective: Aims of this study were to compare serum leptin levels, atherosclerotic markers and carotid intima media thickness (IMT) among the overweight, obese and normal weight healthy adolescents and to investigate the association of carotid IMT with leptin and atherosclerotic markers in adolescence. Methods: Seventy obese-overweight adolescents (27 of them obese, 43 of them overweight) and 72 two normal weight adolescents aged 14-18 years were included in this study. Leptin and homocysteine levels and lipid profiles were determined and carotid IMT were measured in all adolescents. Subjects were evaluated as obese-overweight and normal weight and obese, overweight and normal weight. Results: Carotid IMT was significantly different among the overweight adolescents, obese adolescents and the control group (p < 0.001). Leptin levels were significantly higher in obese-overweight adolescents compared to the control group (p < 0.001). Apolipoprotein (Apo) B levels were significantly higher in obese adolescents than the overweight ones and the control group (p < 0.016). There were significantly positive correlations of carotid IMT with leptin, homocysteine and Apo B levels (p < 0.05, r = 0.33, 0.28, 021, respectively). The factors associated with carotid IMT were leptin and ApoB levels (β = 0.632, p < 0.04, β = 0.264, p = 0.019, respectively). Conclusion: Subclinical atherosclerosis determined by carotid IMT begins in overweight adolescents. Elevated leptin and Apo B levels are independent predictors of subclinical atherosclerosis. Leptin resistance, which is related to subclinical atherosclerosis, also begins in overweight adolescents. High Apo B levels, which promote development of atherosclerosis are more prominent in obese adolescents than other groups. For these reasons, all necessary precautions should be taken in overweight adolescents to prevent atherosclerosis as well as in obese adolescents. © 2009 Asian Oceanian Association for the Study of Obesity.
A patient with Bartter syndrome accompanying severe growth hormone deficiency and focal segmental glomerulosclerosis
(2010) Akil I.; Ozen S.; Kandiloglu A.R.; Ersoy B.
Bartter syndrome is a rare autosomal recessive, salt-losing disorder characterized by hypokalemic hypochloremic metabolic alkalosis. A 10-year-old boy had severe growth retardation (height standard deviation score - 8.15). He had a thin, triangular face, prominent ears and forehead, and big eyes. Megacystis, bilateral hydroureteronephrosis, and residual urine were detected in ultrasonography, but there was no vesicoureteral reflux. Lumbosacral magnetic resonance (MR) showed posterior disc bulging at L4-5. Serum sodium and chloride levels were normal, but mild hypokalemia was overlooked initially. During follow-up, hypokalemic hypochloremic metabolic alkalosis developed, with high urinary chloride and potassium excretion (52 and 43 mEq/L, respectively). The patient, with renal salt loss, was thought to have classic Bartter syndrome due to absence of nephrocalcinosis, presence of persistent hypercalciuria and sensorineural deafness, and presence of relatively mild clinical and laboratory findings, except polyuria initially. The child was treated with indomethacin, spironolactone, and oral potassium in addition to growth hormone (GH). During treatment, he had considerable increase in weight and height compared with the period of GH therapy only. We present this case because, although growth retardation is a major feature of Bartter syndrome, associated GH deficiency is rarely reported in the literature. Diagnosis of Bartter syndrome was made later, as our patient was followed for megacystis and megaureter secondary to the neurogenic bladder and GH deficiency initially; and proteinuria associated with focal segmental glomerulosclerosis responded to treatment for Bartter syndrome.
The effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages
(2010) Taneli F.; Ersoy B.; Özhan B.; Çalkan M.; Yilmaz Ö.; Dinç G.; Genç A.; Taneli C.
Objectives: The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages. Design and methods: Eighty adolescent boys were grouped (n=20) as; Group1: obese-Tanner2, Group2: non-obese-Tanner2, Group3: obese-Tanner4, Group4: non-obese-Tanner4. Serum INSL3, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, estradiol, sex hormone binding globulin, inhibin B and leptin levels were assessed in all groups. Results: INSL3 levels were significantly lower in obese adolescents compared to non-obese boys (p=0.003, Tanner2) and (p=0.031, Tanner4). There was a negative correlation between INSL3 and leptin (r=-0.468, p=0.001). The negative correlation between INSL3 and BMISDS indicates that pubertal obesity leads to Leydig cell impairment. Conclusions: This study demonstrated for the first time in the literature that obesity effects testicular Leydig cell function starting from Tanner stage 2. © 2010.

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