Browsing by Author "Ertan P."
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Item Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia(Humana Press Inc., 1997) Ece A.; Uyanik B.S.; Işcan A.; Ertan P.; Yiǧitoǧlu M.R.In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged 1-14 yr and 64 healthy children as controls aged 1-14 yr were included the study. Serum copper levels were higher in children with IDA (189 ± 49 μg/dL) than those of controls (163 ± 37 μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 μg/dL) than those of control subjects (135 ± 56 μg/dL) (p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum zinc level in patients. It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment should be initiated with zinc.Item Should children with infection be tested for lipid, lipoprotein and apolipoprotein?(1998) IŞĆn A.; YiŞitoŞl̈ R.; OnaǦ A.; Vurgun N.; Ari Z.; Ertan P.; Şengil A.Z.The lipid profile is known to alter in patients with infection, but there has not been a study of the apolipoprotein levels in serum of otherwise healthy children during infection. Lipids, lipoproteins, apolipoproteins A-l and B and lipoprotein (a) were evaluated prospectively in 31 consecutive children, aged4–15 years, who were admitted to the hospital with bacterial pharyngitis. The degree of dyslipidemia associated with bacterial pharyngitis was assessed using each child as his/her own control and by comparison with 79 healthy children who had not had an infection during the past 3 months. Serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A-l and apolipoprotein B levels were significantly decreased during the symptomatic phase of the disease, whereas the serum triglyceride level was slightly elevated. Serum lipoprotein (a) concentration did not change significantly. In conclusion, it is suggested that serum lipids, lipoproteins and apolipoproteins should not be assessed during infection because of the possible transient changes of these parameters during infection or inflammation. © 2017 Wiley. All rights reserved.Item Should children with infection be tested for lipid, lipoprotein and apolipoprotein?(1998) Işcan A.; Yiǧitoǧlu R.; Onaǧ A.; Vurgun N.; Ari Z.; Ertan P.; Şengil A.Z.The lipid profile is known to alter in patients with infection, but there has not been a study of the apolipoprotein levels in serum of otherwise healthy children during infection. Lipids, lipoproteins, apolipoproteins A-1 and B and lipoprotein (a) were evaluated prospectively in 31 consecutive children, aged 4-15 years, who were admitted to the hospital with bacterial pharyngitis. The degree of dyslipidemia associated with bacterial pharyngitis was assessed using each child as his/her own control and by comparison with 79 healthy children who had not had an infection during the past 3 months. Serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A-1 and apolipoprotein B levels were significantly decreased during the symptomatic phase of the disease, whereas the serum triglyceride level was slightly elevated. Serum lipoprotein (a) concentration did not change significantly. In conclusion, it is suggested that serum lipids, lipoproteins and apolipoproteins should not be assessed during infection because of the possible transient changes of these parameters during infection or inflammation.Item Relationship between pinworm and urinary tract infections in young girls(Blackwell Munksgaard, 1999) Ok U.Z.; Ertan P.; Limoncu E.; Ece A.; Özbakkaloǧlu B.Urinary tract infection is particularly common in young girls and Enterobius vermicularis (pinworm) is one of the most prevalent worms found in children worldwide. Young girls, with or without urinary tract infection, were examined for pinworms in order to explore a possible relationship between these two problems. Of the 55 young girls with urinary tract infection, 20 (36.4%) had pinworm eggs in the perianal and/or perineal region monitored using the cellophane tape method, while 9 (16.4%) of 55 young girls who had never previously had a urinary tract infection were found to have Enterobius eggs in at least one of the cellophane tape tests, and the difference was found to be significant (p<0.05). These results suggested that urinary tract infections may be related to pinworms. When a urinary tract infection is diagnosed in young girls, cellulose tape should be applied to both the perianal and the perineal regions on at least three consecutive occasions.Item Serological levels of zinc, copper and iron elements among Giardia lamblia infected children in turkey(2002) Ertan P.; Yereli K.; Kurt Ö.; Balcioǧlu I.C.; Onaǧ A.Background: Giardiasis, an intestinal protozoan infection caused by Giardia lamblia, is common in Turkey, especially among children aged between 2- and 14-years-old. Effects of giardiasis on serological levels of zinc, copper and iron elements were assessed in this study. Methods: A total of 45 children, aged between 2- and 14-years-old, who were admitted to the Pediatrics Department of Celal Bayar University Medical School with gastrointestinal complaints and diagnosed as having giardiasis by stool examinations in the Parasitology Department, were enrolled as the study group (SG). The control group (CG) consisted of 45 age-matched healthy children. Serological levels of zinc, copper and iron were measured by atomic absorption spectrophotometer in all samples. Results: As a result of the study, serum zinc levels were 67.43 ± 17.72 μg/dL and 145.20 ± 9.13 μg/dL, copper levels were 198.45 ± 39.14 μg/dL and 150 ± 21.14 μg/dL and iron levels were 87.98 ± 18.31 μg/dL and 160.45 ± 45.40 μg/dL, in SG and CG, respectively. When compared separately as SG and CG, there was a statistically significant difference between the serological levels of all these elements. Conclusion: These results revealed that giardiasis increased the serological levels of copper, like other infectious agents. However, zinc and iron levels decreased during giardiasis due to malabsorption.Item Serological prevalence of Helicobacter pylori in children with recurrent abdominal pain in Manisa region, Western Turkey(2002) Kasirga E.; Ertan P.; Tosun S.; Sanlidag T.; Tansug N.; Onag A.Objective: The purpose of this study was to evaluate the serological prevalence of Helicobacter pylori infection in asymptomatic and symptomatic (recurrent abdominal pain) children in Manisa region, Western Turkey. Design: To study the rate of infection by Helicobacter pylori in children, the prevalence of IgG antibodies to Helicobacter pylori was determined. Materials and Methods: Fifty-five symptomatic (25 boys and 30 girls) and one hundred sixty-four asymptomatic (82 boys and 82 girls) children between 3-15 years of age were tested for anti-Helicobacter pylori IgG. Serum samples collected were tested for IgG antibodies against Helicobacter pylori by enzyme-linked immunosorbent assay (ELISA) using commercial kits. Mean titers >20 U/ml were considered positive for specific IgG antibody. Results: The prevalence of anti-H. pylori IgG antibody was 65.5% in symptomatic and 35.4% in asymptomatic children. The seroprevalence was increased significantly with age in children with recurrent abdominal pain (chi-square= 18.09; p< 0.001). There was a significant difference in the appearance rate of IgG antibodies between asymptomatic and symptomatic children (chi-square= 15.22; p< 0.001). Conclusion: This study shows that Helicobacter pylori seropositivity is more common in children with recurrent abdominal pain than in asymptomatic children living in Manisa region, Western Turkey.Item Giardiasis treatment in Turkish children with a single dose of ornidazole(2002) Özbilgin A.; Ertan P.; Yereli K.; Tamay A.T.; Kurt Ö.; Degerli K.; Balcioglu I.C.; Ok Ü.Z.; Onag A.This study was designed to compare the treatment efficacy of single dose of ornidazole with 5 d treatments of ornidazole and metronidazole in children with giardiasis. 175 children, between 2 and 15 y old, whose stool samples were found to be positive for Giardia lamblia cysts and/or trophozoites by either saline-Lugol, formalin-ethyl acetate or trichrome staining, were enrolled in the study. Of these children, 105 were treated with a single dose of ornidazole: 35 with 30 mg/kg, 35 with 25 mg/kg and 35 with 20 mg/kg; 35 were treated with 25 mg/kg per day of ornidazole for 5 d in 2 doses and 35 children were treated with 20 mg/kg per day metronidazole for 7 d in 3 doses. All cases were examined on the 7th, 10th and 14th days after treatment by the same methods; clinical symptoms were also evaluated. Giardia lamblia was eradicated in 34 of 35 (97%), 34 of 35 (97%) and 33 of 35 (94%) patients treated with 30, 25 and 20 mg/kg single doses of ornidazole, respectively. Eradication was achieved in all 35 patients treated with 25 mg/kg per day ornidazole for 5 d and in 31 of 35 (89%) patients treated with metronidazole. There was no statistically significant difference among doses of ornidazole (p > 0.05); however, all ornidazole treatment regimens were significantly more effective than metronidazole treatment (p < 0.05). No important side-effects were detected in any patients and clinical symptoms disappeared in all. Single-dose ornidazole treatment could be considered as a proper and effective alternative method for the treatment of giardiasis in children.Item Serological prevalence of Toxoplasma Gondii infection in children aged 1 month to 5 years in Manisa region, Western Turkey(2002) Yereli K.; Kasirga E.; Kilimcioglu A.; Ertan P.; Tamay A.T.; Özbilgin A.Objective: Toxoplasmosis is a protozoan infection caused by Toxoplasma gondii. Toxoplasma gondii infections are generally asymptomatic in immunocompetent cases. However, congenital toxoplasmosis may easily occur when seronegative women are being primarily infected during pregnancy. Routine serological testing is the only way of detecting toxoplasma antibodies in patients without any symptoms of toxoplasmosis. Design: In this study, seroprevalence rates according to age groups were determined in children living in Manisa region, Turkey. Materials and Methods: Sera were analyzed by indirect fluorescent antibody (IFA) and enzyme linked immunoassay (ELISA) methods. Results: Of the 200 children, 9 (4.5%) had only IgG, 2 (1.0%) had only IgM and 2 (1.0%) had both IgG and IgM types toxoplasma antibodies. Conclusion: The results of our study indicate that in Manisa region, Turkey, the antibody presence was increased with age and the overall toxoplasma antibody prevalence was 6.5% among children in the first five years of life.Item Incidence of giardiasis among siblings in Turkey(2003) Balcioglu I.C.; Limoncu E.; Ertan P.; Yereli K.; Özbilgin A.; Onag A.Background: Giardiasis, a common infection among children, is caused by a flagellated protozoan called Giardia lamblia. It is well known to be contagious in common living places. This is an epidemiologic study investigating the incidence of giardiasis among the siblings of patients with giardiasis living in the same household. Methods: Stool samples of 50 patients with a G. lamblia positive sibling in the same household, and 50 patients with a G. lamblia negative sibling in the same household, were examined for giardiasis by saline-Lugol, formalin-ethyl acetate concentration and trichrome staining methods. Other causes of diarrhea were excluded by microbiologic laboratory tests. Results: Thirty-eight per cent of siblings of G. lamblia positive patients and 8% of siblings of G. lamblia negative children were found to be positive for G. lamblia cysts and/or trophozoites. The differences between the groups were statistically significant (P < 0.001). Conclusion: The results suggested that the examination of G. lamblia among the siblings of patients with giardiasis both in the same age group and living in the same household should be considered.Item Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole(Blackwell Publishing Ltd., 2003) Girginkardeşler N.; Coşkun Ş.; Cüneyt Balcioǧlu I.; Ertan P.; Ok Ü.Z.Objective. To evaluate the pathogenicity of Dientamoeba fragilis by comparing it with Giardia lamblia and to investigate the effect of a single dose of secnidazole in dientamoebiasis. Methods. Stool samples of 400 patients, admitted to the Department of Parasitology, Celal Bayar University, were examined by direct wet mount, formalin-ethyl acetate concentration and trichrome staining methods on three consecutive days. All cases positive for D. fragilis were treated with a single dose of secnidazole, 30 mg/kg for children, and 2 g for adults. On the seventh and fourteenth days, at the end of the treatment, stool samples were examined by the same methods, and clinical symptoms were again evaluated. Results. D. fragilis and G. lamblia were detected in 35 (8.8%) and 34 (8.5%) cases, respectively. The most frequent symptoms were found to be abdominal pain and diarrhea in both infections. D. fragilis was eradicated in 34 (97.1%) patients with a single dose of secnidazole, but a second dose was necessary in one patient. Clinical symptoms disappeared in 27 (77.1%) and decreased in eight (22.9%) cases, after eradication. Conclusions. These data suggested that D. fragilis is as prevalent and pathogenic as G. lamblia, and secnidazole seems to be highly effective in achieving parasitologic and clinical cure. To our knowledge, this is the first report of secnidazole being used in the treatment of dientamoebiasis.Item Children with recurrent abdominal pain in Manisa Region, Western Turkey: An evaluation of serological prevalence of Helicobacter Pylori(2003) Kasirga E.; Ertan P.; Tosun S.; Sanhdag T.; Tansug N.; Onag A.Objective- To evaluate the serological prevalence of Helicobacter Pylori infection in asymptomatic and symptomatic children with recurrent abdominal pain. Design- A cohort was used to study the rate of infection by Helicobacter Pylori in children, the prevalence of IgG antibodies to Helicobacter Pylori was determined. Setting- Manisa region, Western Turkey. Materials and Methods- Fifty-five symptomatic (25 boys and 30 girls) and one hundred sixty-four asymptomatic (82 boys and 82 girls) children between 3-15 years of age were tested for anti-Helicobacter pylori IgG. Serum samples collected were tested for IgG antibodies against Helicobacter pylori by enzyme-linked immunosorbent assay using commercial kits. Mean titers >20 U/ml were considered positive for specific IgG antibody. Result- The prevalence of anti-H. pylori IgG antibody was 65.5% in symptomatic and 35.4% in asymptomatic children. The seroprevalence was increased significantly with age in children and recurrent abdominal pain (chi-square = 18.09; p<0.001). There was a significant difference in the appearance rate of IgG antibodies between asymptomatic and symptomatic children (chi-square = 15.22; p<0.001). Conclusion- This study shows that Helicobacter pylori seropositivity is more common in children with recurrent abdominal pain than in asymptomatic children living in Manisa region, Western Turkey.Item Evidence against the fecal-oral route of transmission for Helicobacter pylori infection in childhood(2003) Tosun S.Y.; Kasirga E.; Ertan P.; Aksu S.Background: Acquisition of Helicobacter pylori (H. pylori) occurs mainly in childhood. However, little is known about the mode of transmission. In such developing countries as Turkey, where the hygienic situation facilitates the transmission of hepatitis A virus (HAV), infection with HAV is mainly transmitted via the enteral route. Therefore, it seemed advisable to evaluate the role of fecal-oral transmission in the spread of H. pylori. Material/Methods: Blood samples taken from healthy children (n = 90) 2-16 years old were studied for anti-H. pylori and anti-hepatitis A antibodies by enzyme immunoassay. Results: Of the 90 children, 33.3% were seropositive for both H. pylori and HAV, 33.3% were seronegative for both, 8.9% were seropositive for H. pylori only, and 24.4% were seropositive for HAV only. The percentage of seropositive children increased with age for H. pylori and HAV. There was no significant relationship in seroprevalence between H. pylori and HAV when analyzed by logistic regression analysis (p 0.178). Conclusions: This study suggests that the seropositivity rates of H. pylori and HAV increase with age, while the fecal-oral route may not be an important mode of transmission for H. pylori in children living in western Anatolia, in the Manisa region.Item Albendazole as an alternative therapeutic agent for childhood giardiasis in Turkey(Blackwell Publishing Ltd, 2004) Yereli K.; Balcioĝlu I.C.; Ertan P.; Limoncu E.; Onaĝ A.The efficacy of albendazole for the treatment of giardiasis has been indicated by previous in-vitro and in-vivo studies. In order to compare the therapeutic efficacy of albendazole and metronidazole, 107 Giardia-positive children (aged 3-15 years), diagnosed by three consecutive positive stool examinations, were enrolled in the study. Of these children, 52 were given a single daily dose of albendazole 10 mg/kg for 5 days, and 55 were given metronidazole 20 mg/kg daily in three doses for 7 days. Parasite eradication was achieved in 47 (90.4%) of 52 children treated with albendazole and 49 (89.1%) of 55 children treated with metronidazole (p > 0.05). These results suggest that albendazole is an effective treatment option for childhood giardiasis. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.Item Effect of alarm treatment on bladder storage capacities in monosymptomatic nocturnal enuresis(2004) Taneli C.; Ertan P.; Taneli F.; Genç A.; Günsar C.; Sencan A.; Mir E.; Onag A.Objective: Despite a great number of studies, very little is known about the mechanism of action of enuresis alarm systems. Nevertheless, as a result of this treatment many children are able firstly to wake up before urination occurs and then, in time, to sleep through the night without voiding. The aim of this study was to investigate the effect of enuresis alarms on bladder storage capacities. Material and Methods: A total of 28 children aged >7 years who were not polyuric but who voided once every night, slept alone in their own bedroom and who were willing, along with their family members, to cooperate were recruited. Patients were asked to record their urine output using a frequency/volume chart for two consecutive days. After these records and the results of physical and laboratory examinations were taken into consideration, treatment was instituted with the bell-and-pad (alarm) system for a period of 12 weeks. At the end of this period, patients were asked to complete another frequency/volume chart. Results: The pre- and post-treatment maximum functional bladder capacity was 178.35 ± 87.86 ml and 243.03 ± 102.84 ml, respectively and the pre- and post-treatment mean day-time bladder capacity was 111.11 ± 45.87 and 148.445 ± 7.68 ml. Both of these differences were statistically significant (p < 0.0001 and <0.0001, respectively). The maximum nocturnal bladder capacity was found to be increased from 177.85 ± 84.95 to 255.25 ± 124.52 ml after treatment (p < 0.0001). Conclusion: Treatment with the alarm system for a period of 12 weeks was seen to be associated with a significant increase in bladder storage capacities (maximum nocturnal bladder capacity, maximum functional bladder capacity and mean day-time bladder capacity).Item Changes in seroprevalence of hepatitis A in children and adolescents in Manisa, Turkey(2004) Tosun S.; Ertan P.; Kasirga E.; Atman Ü.Background: Hepatitis A virus (HAV), being an enteric transmitting virus wide world, occurs mostly in children of developing countries. However, the virus has recently been seen in adolescents and young adults worldwide. The aim of the present study was to evaluate the seroprevalence of the HAV infection in children and adolescents in Manisa, Turkey, and to verify whether the increased incidence of HAV infection in other parts of the world and Turkey generally is also true for the area of Manisa. Methods: The authors studied blood samples of 1395 adolescents and children aged between 6 months and 17 years from the Manisa area in order to evaluate the existence of anti-HAV antibodies using micro-ELISA test. Results: Total seropositivity was 44.6% while age related values were as followed: 6-23 months, 47.8%; 2-6 years, 23.7%; 7-10 years, 43.4%; 11-14 years, 52.4%; and 15-17 years, 76.6%. These results suggest that the seropositivity increases significantly among children at school age and also increases parallel to age. Conclusions: According to these results, the authors concluded that there has been a shift of seropositivity from children to adolescents especially in families with an average or high socio-economical level.Item Correlation of quality of life with clinical parameters and eosinophilic cation protein levels in children with allergic rhinoconjunctivitis(2008) Yuksel H.; Yilmaz O.; Sogut A.; Ertan P.; Onur E.Background: Systemic and mucosal roles of eosinophils in the pathogenesis of allergic rhinoconjunctivitis (AR) are known. The aim of this study was to investigate the relationship of clinical parameters and quality of life with eosinophilic cationic protein (ECP) in grass pollen-sensitive children with seasonal AR. Methods: This study included 31 children with AR and 18 healthy controls aged between 5 and 15 years. ECP levels in nasal lavage fluid and serum were measured. AR symptom scores were calculated and the pediatric rhinoconjunctivitis quality of life questionnaire (PRQLQ) was filled in for all patients. Results: Mean serum and nasal ECP levels (ng/ml) were significantly higher in the patient group (p < 0.05 for both). In the AR group, the mean clinical symptom score was 7.3 ± 2.2, while the total PRQLQ score, activity limitation, symptoms and emotional function domains were 2.5 ± 0.9, 3.0 ± 1.1, 2.5 ± 1.2 and 2.6 ± 1.1, respectively. The total clinical symptom score and disease duration showed a significant correlation with the total PRQLQ score (p = 0.00 and 0.003, respectively). However, neither nasal lavage nor serum ECP levels were significantly correlated with symptom score, duration of disease, PRQLQ total score or domains (p > 0.05 for all). Conclusion: These results may indicate the absence of a correlation between clinical status and quality of life and levels of ECP in tissues with allergic inflammation. Copyright © 2008 S. Karger AG.Item Sleep quality and depression-anxiety in mothers of children with two chronic respiratory diseases: Asthma and cystic fibrosis(2008) Yilmaz O.; Sogut A.; Gulle S.; Can D.; Ertan P.; Yuksel H.Background: Sleep quality and psychological well being of parents are expected to be influenced by the child's health and disease status. The aim of this study was to compare sleep quality and depression-anxiety parameters in mothers of children with cystic fibrosis (CF) asthma and healthy controls. Methods: The study included mothers of 62 children with asthma, 21 children with CF and 35 healthy children. All mothers filled in the Pittsburgh Sleep Quality Index (PSQI) questionnaire and hospital anxiety depression scale (HADS). Results: Comparison of the three groups with Kruskall Wallis analysis demonstrated that subjective sleep, sleep efficiency and total PSQI scores were significantly different between the groups (p = 0.02, p = 0.01 and p = 0.04 respectively). Comparisons of the groups in pairs with Mann Whitney U test with Bonferroni correction revealed that subjective sleep quality scores in mothers of children with asthma were significantly higher than the ones in the control group (1.0 ± 0.9 vs 0.6 ± 0.7, p = 0.015). The other PSQI scores as well as the anxiety and depression scores were higher in CF and asthma groups when compared to the control group but did not reach statistical significance. Anxiety and depression scores were significantly correlated with PSQI total score in CF (rho = 0.54 and 0.49 respectively) and asthma groups (rho = 0.45 and 0.60 respectively) but not in the control group. Conclusion: In conclusion, presence of a chronic respiratory disease in a child may be associated with disturbed sleep quality and increased depression and anxiety in mothers. © 2008 European Cystic Fibrosis Society.Item Common viral etiologies of community acquired lower respiratory tract infections in young children and their relationship with long term complications; [Küçük çocuklarda toplum kökenli viral alt solunum yolu enfeksiyonu etkenlerinin sιklιǧι ve uzun dönem komplikasyonu ile ilişkileri](2008) Yüksel H.; Yilmaz Ö.; Akçali S.; Söǧüt A.; Yilmaz Çiftdoǧan D.; Urk V.; Ertan P.; Şanlidaǧ T.Viral lower respiratory tract infections (LRTIs) and their late complications are important causes of morbidity and mortality in childhood. The aims of this study were the detection of viral agents that cause community-acquired LRTIs in young children and investigation of the relationship between viral etiology and bronchiolitis obliterans (BO) which is one of the late complications of LRTIs. A total of 151 children (86 male, 65 female; mean age: 2.9 ± 1.9 years) who were diagnosed to have LRTIs between the period of 2002-2004, at Pediatric Allergy and Pulmonology Department of a University Hospital in Manisa (located in the Aegean region of Turkey) were included to the study. The presence of respiratory viruses [respiratory syncytial virus (RSV), influenza virus type A and B, parainfluenza virus types 1, 2 and 3, adenovirus] in the nasopharyngeal aspirate specimens collected from children have been searched by direct fluorescence antibody test (Biotrin, Ireland). Respiratory viruses were detected in 25.2% (38/151) of the patients with LRTIs, while this rate was 46.8% (22/47) for 2002 period, 13.3% (8/60) for 2003 period and 18.2% (8/44) for 2004 period. RSV and adenoviruses both detected with a frequency of 31.5% (n= 12/38); were the most common agents encountered, and followed by parainfluenza (10/38, 26.3%) and influenza (9/38, 23.6%) viruses. Postinfectious BO have been diagnosed in 7.3% (11/151) of the patients; seven in 2002, one in 2003 and three in 2004 periods. Viral etiology were present in all of the patients who developed BO in 2002, while viral infection was detected in one of the patients who developed BO in 2003-2004 periods. Adenoviruses were the most frequently detected agents (n= 5) in BO cases with viral etology (n= 8). Viral agents were found positive in 72.7% (8/ 11) and 21.4% (30/140) of the patients with and without BO development, respectively, and this difference was found statistically significant (p= 0.02). Besides, BO development was detected in 21.1% (8/38) and 2.6% (3/113) of LRTI patients with and without viral etiology, respectively, and this difference was also significant (p< 0.05). In conclusion, the long term follow-up is important in young children with viral LRTIS for the early diagnosis of complications. Thus the identification of viruses might aid in estimation of prognosis.Item Relationship of sleep quality and quality of life in children with monosymptomatic enuresis(2009) Ertan P.; Yilmaz O.; Caglayan M.; Sogut A.; Aslan S.; Yuksel H.Background: Health-related quality of life (QoL) in children with monosymptomatic nocturnal enuresis might be influenced by impaired quality of sleep. The aim of this study was to evaluate possible deteriorations in QoL and sleep quality and the association between these parameters in children with monosymptomatic nocturnal enuresis. Methods: The study consisted of 44 children with monosymptomatic nocturnal enuresis and 27 healthy controls aged 6-15 years. KINDL QoL and Pittsburgh Sleep Quality Index (PSQI) were applied to all children. Results: Mean total KINDL scores in enuresis and control groups were 65.1 ± 11.0 vs. 67.4 ± 13.7, respectively (P = 0.44). PSQI scores were not significantly different between the groups (P > 0.05l). In the enuresis group, age showed significant negative correlation with self-esteem domain of KINDL (r = -0.39, P = 0.01) and positive correlation with sleep duration sub-score of the PSQI (r = 0.37, P = 0.03). Duration of enuresis showed significantly negative correlation with total KINDL score and self-esteem domain (r = -0.32 and r = -0.39, P = 0.04 and P = 0.01, respectively). There was significant correlation between physical well-being sub-score of KINDL with daytime dysfunction and total scores of PSQI (r = -0.53, P = 0.001 and r = -0.41, P = 0.02, respectively). Daytime dysfunction sub-score of PSQI was significantly correlated with friends sub-score of KINDL (r = -0.33, P = 0.04). Conclusions: As age of the child and duration of enuresis increase, self-esteem domain of QoL worsens. Moreover, there is a significant correlation of physical well-being and friends domains of QoL score and total and daytime dysfunction scores of PSQI. These findings necessitate global evaluation of QoL and sleep quality in children with monosymptomatic nocturnal enuresis to increase efficacy of health care. © 2009 Blackwell Publishing Ltd.Item Rapidly progressive glomerulonephritis in a child with Henoch-Schönlein Vasculitis and familial Mediterranean fever(2009) Sozeri B.; Mir S.; Ertan P.; Kara O.D.; Sen S.Henoch-Schonlein Vasculitis (HSV) is systemic small vessel vasculitis involving the skin, kidney, joints, and gastrointestinal tract. The proportion of patients reported to have renal involvement varies between 20% and 80%. Rapidly progressive glomerulonephritis (RPGN)is rare syndrome in children, characterized by clinical features of glomerulonephritis (GN) and rapid loss of renal function. We present a severe kidney involvement in a 14 year old boy with HSV in who is carring MEFV mutation. A 14 year old boy had developed sudden onset of palpable purpuric rash on his extensor surfaces of lower extremities. He had elevated an erythrocyte sedimentation rate (ESR) (45 mm/h), C-reactive protein (3.74 mg/dl), serum urea 66 mg/dl, serum creatinine 1.8 mg/dl. Also, he had hypocomplementemia. Antinuclear antibody, anti ds DNA, antineutrophil cytoplasmic antibody, anticardiolipine antibodies were negative. Urinalysis revealed macroscopic hematuria and proteinuria with a 24-h urinary protein excretion of 55 mg/m2/h. The renal biopsy specimen showed crescentic and necrotizing glomerulonephritis. He had also M694V/E148Q compound heterozygote mutation. Clinical symptoms and renal failure resolved with intermittant hemodialysis and medical therapy. © 2009 Sozeri et al; licensee BioMed Central Ltd.