Browsing by Author "Esen, E"
Now showing 1 - 17 of 17
Results Per Page
Sort Options
Item Comparison of the protective effects of intratympanic dexamethasone and methylprednisolone against cisplatin-induced ototoxicityÖzel, HE; Özdogan, F; Gürgen, SG; Esen, E; Genç, S; Selçuk, AObjective: This study aimed to compare the efficacies of intratympanic dexamethasone and methylprednisolone in preventing in cisplatin-induced ototoxicity in rats. Methods: Experimental groups of rats (n = 8 each) received intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic dexamethasone, or intraperitoneal cisplatin and intratympanic methylprednisolone. Distortion product otoacoustic emission thresholds were compared on days 0 and 10 in all rats, and correlations between drug effects and changes in cochlear histology were evaluated. Results: Distortion product otoacoustic emission thresholds were comparable in groups III and IV (p > 0.05). Significant protection against cisplatin-induced ototoxicity was seen in groups III and IV compared with group II (p < 0.05). Dexamethasone and, to a lesser extent, methylprednisolone protected against cellular apoptosis in cisplatin-induced ototoxicity. Conclusion: Dexamethasone (and possibly methylprednisolone) may be clinically useful as an intratympanic chemopreventive agent to treat cisplatin ototoxicity. Future clinical studies should investigate the use of dexamethasone for this purpose in adult patients.Item Periosteal adventitia is a valuable bone graft alternative (vol 36, pg 341, 2013)Gemalmaz, HC; Bolukbasi, S; Esen, E; Erdogan, D; Gürgen, SG; Bardakci, YItem How aware are college students of sexual harassment and assault in Turkey?Siyez, DM; Belkis, O; Esen, EThe aim of this study is to examine college students' views on sexual harassment and assault. Semi-structured interviews were conducted with 135 students (51.1% of women and 48.9% of men) from a state university in Turkey. Participants ages ranged from 18 to 27 (M = 21.69 years, SD = 2.49). Findings obtained from the content analysis show that the participants were not able to define sexual harassment and assault accurately and that their definitions included stereotypes regarding sexual harassment and assault. Other findings of the study show that participants had low awareness of online sexual harassment and did not have enough information about appropriate reporting avenues. According to these findings, there is a need for comprehensive prevention and education initiatives to raise awareness of this issue among Turkish college students.Practice impact statementEmerging adulthood (ages 18-24) is a particularly risky time for perpetration of sexual violence. This study draws attention to need for awareness raising among Turkish college students of the nature and risks for sexual violence. It is also important for professionals working with college students and university administrators to have in-depth information on students' experiences of sexual assault, and preferred reporting avenues, to ensure there are tailored interventions and responses to support victims.Item Adverse effects of endocrine therapy in breast cancer: single institute experienceSert, F; Ozsaran, Z; Esen, E; Alanyali, S; Sert, I; Haydaoglu, A; Aras, AAim of the study: The main purpose of this study is to assess the known adverse effects of adjuvant endocrine therapy for non-metastatic breast cancer patients and to present our single center experience with light of literature. Material and methods: The breast cancer patients treated with adjuvant radiotherapy in Medical School of Ege University between January 2007 and December 2009 were evaluated for this trial after obtaining their acceptance. Vital findings, bone mineral densitometry, endometrium thickness measured with trans-vaginal ultrasonography, biochemical results including liver function tests and blood lipid profile (total cholesterol, HDL, LDL, VLDL, triglyceride) were recorded for each controls. Socio-demographic data, financial statuses, medical history, co-morbid diseases were obtained from first controls. Patients were followed without any local recurrence and distant metastases until June 2011. Results: Endometrium thickness was not seen in AI using patients. As compared with tamoxifen group, lack of thickness in AI group was statistically significant (p = 0.000). When compared the values before AI, the number of patients who had osteoporosis was gradually increasing. The decrease was seen in the number of patients with osteopenia. The number of patients with normal lipid profile was gradually increasing up to the second evaluation for tamoxifen group (p = = 0.000). On the other hand, the number of patients with hyperlipidemia was increasing for AIs group in follow-up period statistically (p = 0.006). Conclusions: With the aid of careful patient follow and effective disease management strategies, the negative effect over the QoL can be minimized and also the greatest benefit from endocrine therapy can be obtained.Item Reproductive System Augmented Reality Application for Sexual Health ClassesBaran, B; Kaptanoglu, SN; Esen, E; Siyez, DMThis study aims to evaluate a reproductive systems augmented reality (AR) application for use in sexual health education. AR material included learner interactivity and a 3D video. Sixteen counselor candidates voluntarily registered to the sexual health class. A Reproductive Systems Questionnaire and an AR interview form were used to collect data. The participants were evaluated with a pretest, post-test and retention test. A significant improvement from pretest to post-test indicated that the AR application enhanced participants' knowledge of reproductive organs and their positions. Participants learned more about female reproductive systems than male reproductive systems.Item Ginkgo biloba and Lycopene are Effective on Cisplatin Induced Ototoxicity?Esen, E; Özdogan, F; Gurgen, SG; Özel, HE; Baser, S; Genc, S; Selçuk, AOBJECTIVE: The purpose of this study was to examine the anti-ototoxic impact of Ginkgo biloba extract and lycopene on the model of cisplatin-induced ototoxicity in rats. MATERIALS and METHODS: Thirty-two Wistar albino rats were examined with the distortion product otoacoustic emission (DPOAE) test (MADSEN Capella2; GN Otometrics, ICS Medical, Chicago USA), and they were randomly divided into four groups. Group 1 (n=8) was defined as the healthy control group. Cisplatin was given intraperitoneally as single dose of 12 mg/kg to group 2 (n=8), group 3 (n=8), and group 4 (n=8). Group 2 was determined as ototoxic control group. G. biloba extract (100 mg/kg) was given to group 3, and 20 mg/kg lycopene was given to group 4 with orogastric feeding tube daily for 10 days. DPOAE test was repeated on day 10 on all the groups. Finally, histopathological examination was performed. The study has been lead in agreement with the principles by the Institutional Animal Care and Use Committee Review Board at Kocaeli University Medical Center (KOU HADYEK-1/9-14). The animals were treated in accordance with protocols approved by this committee. RESULTS: When DPOAE tests were compared, there was no significant difference in the four groups before the application (p>0.05). At the end of day 10, in groups 2 to 4, statistically significant changes were observed (p<0.05). According to the cisplatin group, a significant increase in the DP-grams on G. biloba and lycopene groups was observed (p<00.5). Corti organ and spiral ganglion neurons of groups 1, 3, and 4 were observed to have weak expression. Strong reactions were determined in organum spirale and some spiral ganglions of the cisplatin group. The striae vascularis damage on group 2 was found to be more significant more compared with groups 3 and 4. CONCLUSION: There is a protective effect of G. biloba and lycopene on cisplatin-dependent ototoxic rat model.Item Effect of Sexual Health Education Programme on 9th Grade Students' Sexual Health Knowledge and AttitudeEsen, E; Siyez, DMIn this study, the effect of sexual health education program on the 9th grade high school students' sexual health knowledge levels and attitude towards sexual health have been investigated. Pretest - posttest - follow up test control group quasi experimental design has been used in the research. Sexual health knowledge and attitude inventory was used for measuring high school students' sexual health knowledge levels and attitudes toward sexual health. Sexual health education program for high school which is composed of 14 sessions were applied on the experimental group 60 minutes in a week. On the other hand, control group has not been provided any treatment. Mixed Design (one between and one within factor) Repeated Measures ANOVA was employed to the pre-test, posttest and follow up test scores of experiment and control group subjects. Results indicated that, sexual health education program employed to the treatment group has positive effect on sexual health knowledge levels and attitude towards sexual health of 9th grade students.Item Effects of infertility prevention programme on college studentsÖztürk, B; Siyez, DM; Esen, E; Kagnici, YWhen the risk factors causing infertility are examined in detail, most appear preventable. Primary prevention studies are considered among the most effective ways of reducing risk factors. This study aimed to determine the effects of an infertility prevention psycho-education programme on university students' infertility knowledge and attitudes. The psycho-education programme consisted of ten 90-minute sessions. The study employed a Solomon four-group experimental design with random assignment. Participants (n = 52) were university students enrolled in an Education programme in a state university in the west of Turkey. The groups were similar in terms of socio-demographic characteristics and infertility-related risky behaviours. To determine the effect of the intervention and its impact on infertility knowledge and attitudes, the researchers performed a two-way ANOVA. The results of the analyses showed that the infertility prevention psycho-education programme had a significant positive effect on participants' infertility knowledge and attitudes, free from the psycho-education programme's pre-post-test sensitivity.Item Development of the Attitudes toward Infertility Scale (ATIS): validity and reliability studySiyez, DM; Esen, E; Baran, B; Seymenler, S; Kagnici, DY; Siyez, EPurpose: The purpose of the study was to develop both a valid and reliable scale to determine the attitudes of university students towards infertility. Materials and Methods: This study was conducted in two phases, Study 1 (n = 443) and Study 2 (n = 309), with university students. Item analysis, exploratory factor analysis, discriminant validity, and internal reliability were calculated in Study 1. Confirmatory factor analysis and internal reliability were calculated in Study 2. Results: The result of exploratory factor analysis showed that the scale has a single factor structure with 12 items and confirmatory factor analysis indicated a good fit of the model for Attitudes Toward Infertility Scale. Cronbach's alpha coefficients were.85 and.83 for two studies. Conclusion: The findings of this study demonstrate that the Attitudes toward Infertility Scale is a reliable and valid instrument.Item Development of wellness scale for emerging adults: Validity and reliability studySiyez, DM; Esen, E; Seymenler, S; Öztürk, BConceptualizing wellness requires a systematic assessment with reliable, valid and accurate measurements. The purpose of the study is to develop both a valid and reliable scale to evaluate the wellness of emerging adults. This research is composed of three separate studies. In the first study, item pool was generated and content validity was evaluated. In the second study (n = 343), factor structure with exploratory factor analysis (EFA), convergent validity and internal reliability of the Wellness Scale for Emerging Adults (WSEA) were investigated. In the third study (n = 357), the factor structure of WSEA was determined by EFA and it was tested by confirmatory factor analysis (CFA) in a different sample. EFA results showed that WSEA had a single-factor structure and CFA results indicated that single-factor structure model showed acceptable fit. In addition, the internal consistency reliability coefficient of WSEA was calculated in the third study. Cronbach's alpha was calculated as .81 and .82, respectively in the second and third studies. The findings demonstrate that WSEA is a reliable and valid instrument.Item Investigating university students' attitudes towards infertility in terms of socio-demographic variablesSiyez, DM; Seymenler, S; Kagnici, Y; Esen, E; Siyez, E; Baran, BBACKGROUND Despite the development of medical interventions, being infertile is still deemed a shameful and humiliating experience and perceived as a failure. The aim of the study was to investigate university students' attitudes towards infertility in terms of socio-demographic variables and risky behaviors in Turkey. PARTICIPANTS AND PROCEDURE It was a cross-sectional study with a self-administered scale. A total of 9693 university students (5002 female, 4691 male) from 12 statistical regions of Turkey participated in the study. RESULTS According to the findings of the study, 26.99% of the Turkish university students believed that lives of couples without a child are incomplete. 49.00% stated that they would not marry again if their partner was infertile, and 70.05% did not agree that women who do not have a child are faulty. Like the limited studies done before, male students reported more negative attitudes towards infertility than female students. Students who received sexual health education and knew someone infertile in their social network had more positive attitudes. CONCLUSIONS The results of the study indicated that university students' attitudes towards infertility are relatively positive. Gender differences in attitudes towards infertility indicate that psycho-education programs about infertility including gender role issues can be developed and applied for Turkish university students.Item Attitudes of the Turkish University Students and Staff Toward Sexual Harassment and Assault: Preliminary Psychometric EvaluationSiyez, DM; Ercan, GS; Esen, E; Soylu, Y; Baran, B; Firuzan, E; Belkis, Ö; Sezer, TD; Güney, ME; Ergönen, AT; Günay, T; Tezcan, S; Öztürk, BThe aim of this study was to develop a scale to measure the attitudes of the university academic and administrative staff and students toward sexual harassment and assault, and examine its psychometric properties. After the development of the item pool and examination of the content validity of the intended items, Exploratory Factor Analysis (EFA) and parallel analysis was conducted and Cronbach's alpha reliability coefficient was calculated collecting data from 150 participants (54.7% of female and 45.3% of male) for the initial version (comprised of 12 items) of the Attitudes Toward Sexual Harassment and Assault Scale (ATSHAS). In the second phase, Confirmatory Factor Analysis (CFA) was conducted with 354 participants (54% of female and 46% of male) for the revised version (10 items) of the ATSHAS. Additionally, Cronbach's alpha reliability coefficient was calculated with second sample. After developing the item pool, the completion of the first phase of the study took 5 months, and the second phase took 4 months. The final version of the ATSHAS consisting of nine items demonstrated sufficient psychometric properties for measuring attitudes toward sexual harassment and assault in the university environment.Item Effect of transtympanic betamethasone delivery to the inner earÖzel, HE; Özdogan, F; Gürgen, SG; Esen, E; Selçuk, A; Genç, STo investigate the effect of transtympanic betamethasone administration on hearing function with histologic correlation, rats were divided into three transtympanic treatment groups: isotonic saline (group I, n = 10), gentamicin (group II, n = 10) and betamethasone (group III, n = 10). Distortion product otoacoustic emission thresholds were compared on day 10. Also histological effects on cellular apoptosis in both the inner and outer hair cells in organ of Corti and spiral ganglion neurons were evaluated. Distortion product otoacoustic emission thresholds were comparable (p > 0.05) between group I and group III in all measurements. Distortion product otoacoustic emission thresholds of group II were significantly elevated in all measurements when compared with group I (p < 0.05) and group III (p < 0.05). In the Terminal deoxynucleotidyl transferase dUTP Nick End Labelling (TUNEL), Caspase-3, Caspase-8 and Caspase-9 staining method the amount of apoptotic cells in group II were significantly elevated in all measurements compared with group I (p < 0.05). In the TUNEL staining method the amount of apoptotic cells in Group III were significantly elevated compared with group I in both the organ of Corti and spiral ganglion neurons (p < 0.05). The overall histological results revealed that the severity of cellular apoptosis caused by betamethasone was somewhere between isotonic saline and gentamicin. Transtympanic betamethasone does not affect inner ear function as measured by distortion product otoacoustic emission responses, but some increase in cellular apoptosis in the organ of Corti and spiral ganglion neurons was observed. These findings suggest that transtympanic betamethasone may have mild ototoxic effects. Further studies are needed to obtain precise results for transtympanic application of betamethasone.Item The My Children's Future Scale: Construct validity, measurement invariance, and reliability in a Turkish sampleEsen, EThe My Children's Future Scale (MCFS) measures the support provided by parents for their children's careers. The aim of this study was to adapt the MCFS to Turkish and examine its psychometric characteristics in a study conducted in the Turkish context. Participants consisted of 280 parents (190 mothers and 90 fathers). The factor structure of the MCFS and measurement invariance across parent gender were examined. The unidimensional factor structure was confirmed and the scale was invariant across parent gender. In addition, the reliability of the MCFS was assessed for internal consistency and test-retest reliability. Cronbach's alpha and McDonald's omega coefficients were calculated as .87, and test-retest reliability coefficient as .83. Our findings suggested that the Turkish form of the MCFS can be considered a valid and reliable data collection tool for use in Turkey to measure the support provided by parents for their children's careers.Item Predictors of self-reported sexually transmitted infections among Turkish university studentsGülsoy, SS; Siyez, E; Esen, E; Baran, B; Siyez, DMBackground and aimSexually transmitted infections (STIs) are among the most crucial health problems that sexually active university students may encounter. This study aims to identify the predictors of self-reported STIs among university students. MethodsStudy participants were 2,241 individuals who reported having had sexual intercourse among a cohort of 9,693 students surveyed from 21 Turkish universities. The age of participants ranged from 17 years to 28 years. ResultsThe Chi-Square Automatic Interaction Detection (CHAID) analysis indicated that gender was the main predictor of self-reported STI. Also, number of partners and substance use were found as predictor variables for males. Finally, the classification accuracy of the CHAID model was found to be 95.3% within the sample. ConclusionsThe present findings shed light on risk factors for STI acquisition, suggesting possible directions for tailoring future preventive interventions.Item Investigating knowledge levels of university students about infertilitySiyez, DM; Seymenler, S; Esen, E; Siyez, E; Kagnici, Y; Baran, B; Öztürk, BObjective: The aim of this study was to determine the knowledge levels of university students about infertility and investigate the differences in knowledge levels according to sociodemographic variables and some lifestyle factors. Material and methods: The sample of the study consisted of 9693 undergraduate students (5002 females, 4691 males) from 12 regions. Regions were determined according to Statistical Region Units Classification-1 criteria. Infertility Knowledge Test (IKT) was used as a data collection tool. Results: It was found that university students' IKT scores significantly differed according to gender (p<0.01); age (p<0.05); body mass index (p<0.05); reproductive health education status (p<0.001), presence of infertile individuals around (p<0.001); having sexual intercourse (p<0.001); smoking (p<0.001) and alcohol consumption frequency (p<0.05). Conclusion: University students' lack of knowledge about family planning, effects of age and sexual intercourse timing on infertility was remarkable. However, it was determined that the knowledge level of infertility risk factors related to substance use and body mass index was high. It is believed that increasing the level of knowledge about infertility among individuals will positively effect their awareness of risk factors and facilitate their search for timely medical assistance. Sexual health education can be effective in increasing university students' knowledge of infertility.Item Turkish Guideline for Diagnosis and Treatment of Allergic Rhinitis (ART)Ecevit, MC; Özcan, M; Can, IH; Tatar, EC; Özer, S; Esen, E; Atan, D; Göde, S; Elsurer, C; Eryilmaz, A; Coskun, BU; Yazici, ZM; Dinç, ME; Ozdogan, F; Gunhan, K; Bilal, N; Korkut, AY; Kasapoglu, F; Türk, B; Server, EA; Çelebi, ÖÖ; Simsek, T; Kum, RO; Adali, MK; Eren, E; Aslier, NGY; Bayindir, T; Çetin, AC; Göker, AE; Güvenç, IA; Köseoglu, S; Özler, GS; Sahin, E; Yilmaz, AS; Güne, C; Yildirim, GA; Öca, B; Durmusoglu, M; Kantekin, Y; Özmen, S; Kubat, GO; Sanal, SK; Altuntas, EE; Selçuk, A; Yazici, H; Baklaci, D; Yaylaci, A; Hanci, D; Dogan, S; Fidan, V; Uygur, K; Keles, N; Cingi, C; Topuz, B; Çanakçioglu, S; Önerci, MObject: To prepare a national guideline for Oto-rhinolaryngologist who treat allergic rhinitis patients Methods: The study was conducted by three authors, namely the writing support team. The support team made the study plan, determined the writing instructions, chose the subgroups including the advisory committee, the advisors for authors and the authors. A workshop was organized at the very beginning to explain the details of the study to the team. Advisors took the chance to meet their coworkers in their subgroups and determined the main headings and subheadings of the guideline, together with the authors. After key words were determined by the authors, literature search was done in various databases. The authors keep in touch with the advisors and the advisors with the advisory committee and the support group at every stage of the study. National and International published articles as well as the abstracts of unpublished studies, imperatively presented in National Congresses, were included in this guideline. Only Guideline and meta-analyses published in last seven years (2013- 2017) and randomized controlled studies published in last two years (2015- 2017) were included. After all work was completed by the subgroups, support team brought all work together and edited the article. Results: A detailed guideline about all aspects of allergic rhinitis was created. Conclusion: The authors believe that this guideline will enable a compact and up-to-date information on allergic rhinitis to healthcare professionals. This guideline is the first in the field of Otolaryngology in Turkey. It should be updated at regular intervals.