Browsing by Author "Eserdag, M"

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    Trimetazidine May Protect the Myocardium during Cardiac Surgery
    Iskesen, I; Kurdal, AT; Eserdag, M; Cerrahoglu, M; Sirin, BH
    Background: Trimetazidine is an anti-ischemic agent with cardioprotective effects. The purpose of this double-blind, controlled, prospective randomized study was to investigate the possible effects of the preoperative use of trimetazidine on the biochemical markers of myocardial injury during open heart surgery and to determine if it has any myocardial protective effects. Methods: Thirty patients undergoing coronary artery bypass grafting surgery, received either trimetazidine (study group, n = 15) or not (control group, n = 15). Pretreatment began 2 weeks before the operation with trimetazidine (60 mg/day orally), and the control group received no medication. We measured the levels of serum creatine kinase (CK), CK isoenzyme MB (CK-MB), myoglobin, and troponin T in venous blood samples obtained before and after the operation to evaluate the effect of this drug against myocardial damage. We also took serial blood samples from the radial artery and the coronary sinus before the institution of cardiopulmonary bypass (CPB) and at 2 and 15 minutes after the removal of the cross-clamp to measure lactate levels and calculate the lactate extraction of the myocardium. Results: Postoperative levels of myoglobin, troponin T, CK, and CK-MB were significantly lower in the trimetazidine group than in the control group (P < .05). There was also a significant difference in the values for the lactate extraction calculation between the groups at minute 2 after the removal of the cross-clamp (P < .05). Conclusion: We conclude that pretreatment with trimetazidine has some beneficial effects in protecting the myocardium and decreasing myocardial injury during the cardioplegic arrest period in open heart surgery without affecting postoperative hemodynamics.
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    Subfascial endoscopic perforator surgery ameliorates the symptoms of chronic venous ulcer (C6) patiens
    Kurdal, AT; Cerrahoglu, M; Iskesen, I; Eserdag, M; Sirin, H
    Aim. Chronic venous insufficiency and the development of venous ulceration, as a result of this condition affects quality of life. In order to avoid skin changes and allow for quick remedy, subfacial endoscopic perforator surgery (SEPS) has been suggested and gained some popularity. The purpose of this study was to assess the healing rate of venous ulcers in patients undergoing SEPS. Methods. The SEPS procedure by using two ports was applied in 20 patients with active venous ulceration (CEAP-C6). The results were evaluated by Doppler findings, Venous Disability Score (VDS) and Venous Clinical Severity Score (VCSS) before and after the operation. Patients with prior deep vein thrombosis were excluded from this study. Results. The ulcers healed in all patients. Significant clinical improvement according to VDS and VCSS values was obtained in all patients after the procedures. There was no mortality or any other major complication during the follow up period. Conclusion. The advantages of using two-port, video-controlled SEPS procedure may provide freedom from the skin complications that can be seen after Linton operation with quick and sustainable ulcer healing. [Int Angiol 2010;29:70-4]
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    A rare cardiac tumor in childhood: right atrial myxoma
    Kurdal, AT; Eserdag, M; Iskesen, I; Sirin, BH
    Myxoma is a rare tumor in childhood and unlike left atrial localization is quite rare in right atrium. A 14-year-old male child presented with complains of exertional dyspnea and tachycardia. Transthoracic echocardiography revealed a huge myxoma in the right atrium, closing the inferior vena cava orifice and causing tricuspid stenosis. Cardiopulmonary bypass was started only with superior vena cava cannulation. Inferior vena cava cannulation was performed after cardiac arrest due to the embolic risk. The total resection was performed by right atriotomy.
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    Preoperative NT-proBNP Levels: A Reliable Parameter to Estimate Postoperative Atrial Fibrillation in Coronary Artery Bypass Patients
    Iskesen, I; Eserdag, M; Kurdal, AT; Cerrahoglu, M; Sirin, BH
    Background: Atrial fibrillation (AF) is one of the most common complications after coronary artery bypass grafting (CABG). This study was designed to evaluate whether the levels of preoperative and postoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) are predictors of postoperative paroxysmal atrial fibrillation in patients who undergo coronary artery bypass surgery. Methods: A total of 117 patients were prospectively evaluated for new-onset AF after coronary operation. Plasma NT-proBNP values in all patients were measured at five different time points. Results: AF occurred during the hospitalization period in 33 patients (28.2%). Significantly higher NT-proBNP levels in the preoperative examination were recorded in patients who developed AF postoperatively compared with patients without postoperative AF (329.36 +/- 82.93 vs. 230.67 +/- 59.93 pg/ml, p < 0.05). Although we detected some higher values in the other group of patients with AF (at T1, T2, T3, T4), the difference was not statistically significant compared to the normal rhythm group. Conclusion: The main finding of the current study is a positive correlation between high levels of preoperative NT-proBNP and the risk of new-onset AF after CABG surgery.