Browsing by Author "Eskicioğlu F."

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    Evaluation of the effects of different anesthetic techniques on neonatal bilirubin levels
    (Aras Part Medical International Press, 2014) Eskicioğlu F.; Ozlem S.; Bilgili G.; Baytur Y.
    Objectives: The aim of the present study was to determine whether different anesthetic techniques applied for vaginal delivery and cesarean section affect neonatal bilirubin levels in the first 24 hours of life.; Materials and Methods: A total of 511 neonates delivered by vaginal route or cesarean section were included in the study. The neonates were classified according to method of delivery and anesthetic agents as group A (cesarean section/general anesthesia with sevoflurane), group B (cesarean section/ spinal anesthesia with bupivacaine hydrochloride), group C (vaginal delivery with episiotomy/local anesthesia with prilocaine hydrochloride) and group D (vaginal delivery/ no anesthesia). The levels of neonatal serum bilirubin in the groups were compared.; Results: There was no difference between group A and group B in terms of neonatal bilirubin levels (p = 0.98). Depending on the use of prilocaine hydrochloride as local anesthetic agent in the vaginal delivery, there was no significant difference between the groups C and D, in terms of the neonatal bilirubin levels (p = 0.99). The serum levels of bilirubin in cesarean section groups were significantly higher than those of the vaginal delivery groups (p<0.001).; Conclusion: Prilocaine hydrochloride used for episiotomy did not exert any effects on neonatal hyperbilirubinemia. However, cesarean section with sevoflurane and bupivacaine hydrochloride seemed to result in increased bilirubin levels. © 2014 / PMCARAS . All rights reserved.
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    The efficacy of complete blood count parameters in the diagnosis of tubal ectopic pregnancy
    (Studio K Krzysztof Molenda, 2014) Eskicioğlu F.; Özdemir A.T.; Turan G.A.; Gür E.B.; Kasap E.; Genç M.
    Objective: Ectopic pregnancy (EP) is the major cause of maternal morbidity and is responsible for maternal mortality in the first trimester. In order to reduce undesirable results, it is necessary to find rapid and accurate, non-surgical diagnostic tests for EP. The goal of the study was to investigate the differences in complete blood count parameters between tubal EPs and healthy pregnancies in be used in the diagnosis of ectopic pregnancy. Study design: White blood cell (WBC), neutrophil, monocyte, lymphocyte, platelet (PLT) counts, mean PLT volume (MPV) and PLT distribution width (PDW) levels in the complete blood count samples have been obtained from subjects with diagnosed tubal EP (n=78; study group) and women with healthy intrauterine gestations (n=79; control group). Statistical comparisons between groups were performed using the t test. Results: PDW levels were found to be significantly higher in the control group than EP (p<0.001). However, no differences between the study and control groups with regard to PLT and MPV levels were observed. WBC levels were found to be significantly higher in the EP group as compared to controls (p<0.001). When leukocyte differentials were compared, monocyte counts in the EP group were significantly higher than in controls (p=0.005). No statistically significant differences in neutrophil and lymphocyte values were observed in either group. Conclusion: PDW as an indicator of PLT activation is lower in tubal EP than intrauterine pregnancy so, possibly, endometrial invasion in the intrauterine pregnancy needs more PLT activation. Monocyte counts are higher in tubal EP, indicating that monocyte activation in the pathophysiology of EP could be effective in the formation of tubal motility and microenvironment regulation. © Polskie Towarzystwo Ginekologiczne.
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    Montelukast is effective in preventing of ovarian hyperstimulation syndrome; an experimental study
    (Studio K Krzysztof Molenda, 2015) Eskicioğlu F.; Turan G.A.; Sivrikoz O.N.; Cengiz H.; Akan Z.; Şahin N.; Yilmaz O.; Yeşil H.; Vatansever S.
    Objectives: To determine the efficacy of montelukast in comparison with cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in rats. Material and methods: An experimental OHSS model was formed in 35 female Wistar rats. Rats (22 days old) were randomized into 5 groups, each containing 7 animals. The control group received no therapy; the mild OHSS group was administered pregnant mare serum gonadotropin (PMSG) 10 IU for 4 days, hCG 10 IU on the 5th day; the severe OHSS group received PMSG 10 IU for 4 days, hCG 30 IU on the 5th day. The montelukast group: received montelukast 10 mg/kg/day and the cabergoline group was administered cabergoline 100μg/kg/day via oral gavage for 6 days (days 22-27), in addition to those of severe OHSS. All groups were sacrificed on 28th day. Body weight, ovarian diameter and weight, vascular permeability, vascular endothelial growth factor (VEGF), semiquantitative VEGF receptor-1, and VEGF receptor-2 (VEGFR-2) immunohistochemistry were evaluated. Results: Ovarian diameter and VEGF expression were significantly lower in the montelukast and cabergoline groups than in the severe OHSS group. While montelukast was more effective in limiting vascular permeability in the severe OHSS, cabergoline was superior to montelukast with respect to the limiting effect on increased body weight and VEGFR-2 expression. Conclusions: The VEGF/VEGFR-2 interaction plays an important role in OHSS pathogenesis. Montelukast limits VEGF expression, and cabergoline reduces both VEGF and VEGFR-2 expressions; they are both effective therapies for the prevention of severe OHSS.
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    Montelukast is effective in preventing of ovarian hyperstimulation syndrome; an experimental study
    (Studio K Krzysztof Molenda, 2015) Eskicioğlu F.; Turan G.A.; Sivrikoz O.N.; Cengiz H.; Akan Z.; Sahin N.; Yilmaz O.; Yesil H.; Vatansever S.
    Objectives: To determine the efficacy of montelukast in comparison with cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in rats. Material and methods: An experimental OHSS model was formed in 35 female Wistar rats. Rats (22 days old) were randomized into 5 groups, each containing 7 animals. The control group received no therapy; the mild OHSS group was administered pregnant mare serum gonadotropin (PMSG) 10 IU for 4 days, hCG 10 IU on the 5th day; the severe OHSS group received PMSG 10 IU for 4 days, hCG 30 IU on the 5th day. The montelukast group: received montelukast 10 mg/kg/day and the cabergoline group was administered cabergoline 100μg/kg/day via oral gavage for 6 days (days 22-27), in addition to those of severe OHSS. All groups were sacrificed on 28th day. Body weight, ovarian diameter and weight, vascular permeability, vascular endothelial growth factor (VEGF), semiquantitative VEGF receptor-1, and VEGF receptor-2 (VEGFR-2) immunohistochemistry were evaluated. Results: Ovarian diameter and VEGF expression were significantly lower in the montelukast and cabergoline groups than in the severe OHSS group. While montelukast was more effective in limiting vascular permeability in the severe OHSS, cabergoline was superior to montelukast with respect to the limiting effect on increased body weight and VEGFR-2 expression. Conclusions: The VEGF/VEGFR-2 interaction plays an important role in OHSS pathogenesis. Montelukast limits VEGF expression, and cabergoline reduces both VEGF and VEGFR-2 expressions; they are both effective therapies for the prevention of severe OHSS. © Polskie Towarzystwo Ginekologiczne.
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    Carotid intima-media thickness in postmenopausal women is associated with an endometrial thickness greater than 5 mm
    (Studio K Krzysztof Molenda, 2016) Eskicioğlu F.; Eskicioğlu M.S.; Özdemir A.T.; Özyurt B.
    Aim: The aim of this study was to investigate the relationship between ultrasonographic carotid intima-media thickness (C-IMT) and visceral fat thickness (VFT) and an endometrial thickness (ET) of more than 5 mm in postmenopausal women. Methods: C-IMT, VFT, and ET measurements were performed in 63 postmenopausal women using ultrasonography. The relationships between ultrasonographic data and demographic data, anthropometric measurements, such as waist circumference, metabolic syndrome parameters, and insulin resistance were examined. Moreover, the role of VFT and C-IMT in predicting an ET of more than 5 mm was investigated. Results: Only the C-IMT was higher in the ultrasonographic measurements of women with an ET >5 mm (p =0.03). Insulin resistance was also significantly higher in these women (p = 0.03). ET showed a positive correlation with VFT and body mass index (BMI) (r = 0.286, p = 0.02 and r = 0.249, p = 0.04), and C-IMT showed a positive correlation with age, pregnancy, parity, and time since menopause (p<0.05). Multivariate analysis showed that high-C-IMT levels were associated with an ET >5 mm (p = 0.04).Conclusions: There was a positive correlation between the ultrasonographic measures of VFT and ET, and high- C-IMT levels were independently associated with an ET>5 mm. Thus, C-IMT may be a predictor of pathologic ET in the postmenopausal period.
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    The association of HLA-G and immune markers in recurrent miscarriages
    (Taylor and Francis Ltd, 2016) Eskicioğlu F.; Özdemir A.T.; Özdemir R.B.; Turan G.A.; Akan Z.; Hasdemir S.P.
    Objective: To determine role of human leukocyte antigen (HLA)-G, CD8, CD16, CD56, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α for recurrent miscarriages in feto–maternal interface. Method: Chorion and decidua samples were obtained from 11 women with unwanted pregnancies (healthy pregnancy, HP) and 10 women with missed abortion diagnosis after at least two pregnancy losses (recurrent miscarriage, RM). In addition, endometrial tissues were obtained from 10 non-pregnant women (NonP). The expressions of markers were evaluated using the Western blot analysis. The values obtained between different groups were compared. Results: The highest protein expression of CD56 was found in the HP compared to NonP and RM. Meanwhile, the lowest protein expression of CD16 was observed in the NonP compared to HP and RM. The HLA-G expression exhibited the highest level in HP; however, there was no statistically significant difference between groups. CD8 and IFNγ expressions were lowest in the NonP group; however, TNF-α was highest in the RM group. Conclusions: The CD56 expression of uterine NK cells may be an indicator of a HP. However, not statistically significant, the increased expression of CD16, CD8, and also significantly increased expression of TNF may be associated with the predominant cytotoxic activity in the maternal immune system in patients with RM. Although there was no change in the expression of HLA-G, this finding may mean that the maternal immune system is unresponsive to HLA-G-mediated immunosuppressive signals originating from the fetus in these cases. © 2015 Taylor & Francis.