Browsing by Author "Eskiizmir G."
Now showing 1 - 20 of 67
Results Per Page
Sort Options
Item Pleomorphic adenoma originated from the inferior nasal turbinate(Elsevier Ireland Ltd, 2003) Unlu H.H.; Celik O.; Demir M.A.; Eskiizmir G.Although pleomorphic adenoma is the most common benign neoplasm of the salivary glands, it has also been reported to be present in the neck, ear, mediastinum, external nose and nasal cavity. Intranasal localization of this lesion is very rare and mainly originates from the nasal septum. From wherever the lesion originates, the main treatment modality should be surgical. We presented a very rare case of intranasal pleomorphic adenoma originated from the inferior nasal turbinate. Due to the expansile nature of the lesion, a midfacial degloving approach was preferred. © 2003 Elsevier Ireland Ltd. All rights reserved.Item The management of glottic and supraglottic cancers of the larynx in relation to neck metastasis.(2003) Yücetürk A.V.; Celik O.; Eskiizmir G.OBJECTIVES: We evaluated the management of glottic and supraglottic laryngeal cancers in relation to neck metastasis. PATIENTS AND METHODS: Fifty-two patients (51 males, 1 female; mean age 59.2 years; range 27 to 82 years) underwent surgery for primary laryngeal cancers. Preoperative and postoperative TNM classification and staging were made according to the AJCC 1997 criteria. The mean follow-up period was 39.4 months (range 6 to 74 months). RESULTS: The tumors were glottic in 31 patients and supraglottic in 21 patients. Laryngectomies were partial in 34 patients and total in 18 patients. All the patients with supraglottic tumors and those with glottic T2-4 tumors underwent neck dissection, as well. Radiotherapy was administered to 22 patients with established N2 or N3 tumors. Clinical assessment was in agreement with the pathological result in 63.5%; 13.5% and 23.1% of cases were underdiagnosed and overdiagnosed, respectively. The rates of neck metastasis were 0% in T1, 25% in T2, 75% in T3, and 66.7% in T4 supraglottic tumors. The corresponding rates for glottic cancers were 0%, 16.7%, 28.6%, and 60%, respectively. The overall rate of N+ tumors was 28.9%. Four patients (7.7%) developed local, two patients (3.9%) developed regional recurrences. Mortality occurred in eight patients (15.4%) due to following causes: laryngeal recurrence (T4N2, T4N2, T3N1), regional recurrence (T4N2), a second primary malignancy in one patient, and other causes in three patients. Five- and two-year disease-specific survival rates (Kaplan-Meier analysis) were 90.7%, and overall survival rates were 73.7% and 87.3%, respectively. CONCLUSION: Neck metastasis and advanced stage of the tumor were the most effective prognostic factors.Item Effect of thermal energy produced by drilling on the facial nerve: Histopathologic evaluation in guinea pigs(2005) Aslan A.; Vatansever H.S.; Aslan G.G.; Eskiizmir G.; Giray G.The effect of thermal energy due to drilling around the facial nerve canal on the facial nerve was histopathologically evaluated in four guinea pigs. The bony canal of the facial nerve was drilled using a 3-mm diamond burr for one minute. The temperature changes on the facial nerve canal were noted before and after dissection. The temporal bones of the animals were histopathologically examined under light microscopy using haematoxylin & eosin (H&E) and solochrome cyanine staining for myelin, and immunohistochemical staining for neuronal nitric oxide synthase (nNOS). Compared to the control group, it was observed with H&E staining that there was oedema among the axonal fibres and with solochrome cyanine staining that the thickness of the myelin fibres was decreased, and that the severity and extent of nNOS activity was decreased in the axonal fibres. It was concluded that a temperature increase on the facial canal may potentially lead to inflammation of the nerve, and may also cause deterioration of nerve conduction to some extent.Item Assessment of symptomatic patients after endoscopic sinus surgery with special reference to the frontal sinus: Comparative radiologic analysis(2006) Unlu H.H.; Eskiizmir G.; Tarhan S.; Ovali G.Y.Purpose: To reveal the role of potential risk factors in frontal recess dissection (FRD), middle turbinate resection (MTR), sinonasal polyposis, and extension of disease in postoperative frontal sinus opacification by determining radiologic changes after endoscopic sinus surgery (ESS) in symptomatic cases using computed tomography (CT). Study Design: Retrospective analysis of prospectively collected data from symptomatic patients after ESS. Methods: Postoperative CT scans were taken in all symptomatic patients during their least symptomatic period or after maximal medical therapy. The radiologic findings of each sinus were compared, and the outcome of ESS was statistically evaluated. Furthermore, FRD, MTR, sinonasal polyposis, and extension of disease were analyzed for postoperative frontal sinus opacification. Results: In our study, 101 sinuses of 61 symptomatic patients were examined. A significant improvement in opacification in all sinuses was detected postoperatively. Multivariate analysis of all potential risk factors revealed that postoperative frontal sinus opacification was affected only by sinonasal polyposis (odds ratio [OR] 3.32; 95% confidence interval [CI] 1.04-10.58) and extension of disease (OR 16.93; 95% CI 4.33-66.23). Conclusions: Our study revealed that surgical procedures such as FRD and/or MTR may not directly affect postoperative frontal sinus opacification. On the contrary, sinonasal polyposis and extension of disease seemed to be the main risk factors of this issue.Item Herpes zoster oticus associated with varicella zoster virus encephalitis(2009) Eskiizmir G.; Uz U.; Taşkiran E.; Ürdü H.Ramsay-Hunt syndrome, herpes zoster oticus (HZ0), derived its name from James Ramsay Hunt, who first described it in 1907. It is classically characterized by acute peripheral facial paralysis, herpetic eruptions on the auricle, and vestibulocochlear dysfunction due to the reactivation of varicella zoster virus (VZV). In this Case Report, the authors describe an HZO patient with simultaneous VZV encephalitis. To date, only eight cases of HZO associated with VZV encephalitis have been reported in the English literature. Therefore, the authors discuss all the aspects of this rare entity, including clinical examination, radiological evaluation, laboratory evaluation, and treatment options. © 2009 The American Laryngological, Rhinological and Otological Society, Inc.Item Is there a vicious cycle between obstructive sleep apnea and laryngopharyngeal reflux disease?(2009) Eskiizmir G.; Kezirian E.Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder which is mainly characterized by the repetitive episodes of obstructive apneas and/or hypopneas. It is associated with daytime sleepiness, decrements in quality of life, cardiovascular and cerebrovascular diseases and endocrine disturbances. In addition, there is a high prevalence of gastric reflux (including both gastroesophageal reflux and laryngopharyngeal reflux diseases) in patients with OSA. However, the mechanism underlying this association has not been completely established. Herein, we hypothesize that there is a vicious cycle between OSA and laryngopharyngeal reflux disease. Increased respiratory efforts in OSA generate more-negative intrathoracic pressure, contributing to reflux of gastric contents, which in turn creates inflammation and sensory deficits in the laryngeal and pharyngeal tissues that contributes to progression of OSA through both inflammatory and neuromuscular pathways. © 2009 Elsevier Ltd.Item The imbalance of enzymatic antioxidants in cholesteatoma(2009) Eskiizmir G.; Yuceturk A.V.; Onur E.; Var A.; Temiz P.Conclusion. Depletion of enzymatic antioxidants was observed in cholesteatoma. However, a relationship between activity of enzymatic antioxidants and the extent of bone erosion was not found. Objectives. To measure the level of major enzymatic antioxidants in cholesteatoma, and to investigate the relationship between the level of enzymatic antioxidants and the extent of bone erosion. Patients and methods. The cholesteatoma and skin samples were obtained during otologic surgeries. All cases were grouped according to the number of bone erosion sites. Samples were examined biochemically and the levels of enzymatic antioxidants were measured. The results were analyzed statistically. Results. Thirteen patients were included in the study. The mean level of superoxide dismutase in cholesteatoma and skin was 45.87 U/mg and 71.04 U/mg, respectively. When the catalase level was evaluated, the mean level was 5.04 U/g in cholesteatoma and 11.62 U/g in skin. The mean level of glutathione peroxidase in cholesteatoma and skin was 12.13 IU/g and 236.74 IU/g, respectively. All the results of cholesteatoma and skin samples were compared through non-parametric tests and statistically significant differences were found. However, a statistically significant difference between the levels of enzymatic antioxidants and the extent of bone erosion was not observed.Item A practical method for designing paramedian forehead flap: A preliminary report; [Paramedian alın flebi tasarımıs i̇çin pratik bir method: Önçalışma](Turkiye Klinikleri, 2010) Eskiizmir G.; Hirçin Z.; Halis Ünlü H.Objective: The paramedian forehead flap (PFF) is an interpolated flap which provides excellent aesthetic and functional results in the reconstruction of extensive nasal defects. The key elements for a PFF is the blood supply (supratrochlear artery and vein) and wideness of the pedicle. Herein, we offer a practical and reliable method for the design of PFF and discuss the effectiveness of this surgical method. Material and Methods: The harvestment of PFF was started by the identification of the potential area of the supratrochlear artery and vein. The medial canthal vertical line (MCVL) and transverse axis of the superior orbital rim (SOR) were marked as "primary lines", which were used as reference. Thereafter, the lateral borders of the potential area were metered 7 mm medial and lateral to MSVL and marked as the "secondary lines". The pedicle of the PFF was formed by using "secondary lines" and SOR. Finally, PFF was harvested and anchored to the defect area. Results: Six cases who had large nasal defects due to skin cancer were included into the study. All the PFFs were designed and successfully harvested according to this surgical method. None of the cases had flap failure or major complications. Conclusion: The surgical method for the design of PFF is easy, reliable and anatomically based, and it facilitates a relatively narrow pedicle without jeopardizing the blood supply. © 2010 by Türkiye Klinikleri.Item Asymmetric nasal bone trim: A surgical technique for the deviated nose with/without minimal hump deformity(2010) Ünlü H.H.; Eskiizmir G.[No abstract available]Item What is your diagnosis?; [Taniniz nedir?](2010) Gençoǧlan G.; Ermertcan A.T.; Eskiizmir G.; Temiz P.[No abstract available]Item Lingual tonsillectomy for the management of persistent obstructive sleep apnea after adenotonsillectomy in children(2010) Eskiizmir G.[No abstract available]Item Sensitivity, predictive values, pretest-posttest probabilities, and likelihood ratios of presurgery clinical diagnosis of nonmelanoma skin cancers(2011) Ermertcan A.T.; Öztürk F.; Gençoǧlan G.; Eskiizmir G.; Temiz P.; Horasan G.D.Background: The precision of clinical diagnosis of skin tumors is not commonly measured and, therefore, very little is known about the diagnostic ability of clinicians. Objective: This study aimed to compare clinical and histopathologic diagnoses of nonmelanoma skin cancers with regard to sensitivity, predictive values, pretest-posttest probabilities, and likelihood ratios. Methods: Two hundred nineteen patients with 241 nonmelanoma skin cancers were enrolled in this study. Of these patients, 49.4% were female and 50.6% were male. The mean age ± standard deviation (SD) was 63.66±16.44 years for the female patients and 64.77±14.88 years for the male patients. The mean duration of the lesions was 20.90±32.95 months. One hundred forty-eight (61.5%) of the lesions were diagnosed as basal cell carcinoma (BCC) and 93 (38.5%) were diagnosed as squamous cell carcinoma (SCC) histopathologically. Results: Sensitivity, positive predictive value, and posttest probability were calculated as 75.96%, 87.77%, and 87.78% for BCC and 70.37%, 37.25%, and 37.20% for SCC, respectively. The correlation between clinical and histopathologic diagnoses was found to be higher in BCC. Conclusion: Knowledge of sensitivity, predictive values, likelihood ratios, and posttest probabilities may have implications for the management of skin cancers. To prevent unnecessary surgeries and achieve high diagnostic accuracies, multidisciplinary approaches are recommended. © 2011 Informa Healthcare USA, Inc.Item The histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats(2011) Cingi C.; Eskiizmir G.; Burukoǧlu D.; Erdoǧmuş N.; Ural A.; Ünlü H.Background: Rhinosinusitis is a common disorder and its treatment includes a variety of topical and systemic drugs. This study was designed to determine the histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats. Methods: Sixty rats were randomly allocated into 3 test and 2 control groups, each of which consisted of 12 animals. The rhinosinusitis model was induced using intranasal application of platelet-activating factor. In test groups, the animals were separated into groups: (1) rhinosinusitis- antibiotherapy, (2) rhinosinusitis-thymoquinone, (3) rhinosinusitis-combination therapy. The positive and negative control groups were defined: rhinosinusitis group without any treatment and the group without rhinosinusitis, respectively. The histopathological features (vascular congestion, inflammation, and epithelial injury) in nasal respiratory and olfactory mucosa of animals were examined and graded according to their severity. A quantitative and statistical analysis of histopathological features was performed. Results: All histopathological features showed statistically significant differences between negative and positive control groups, respectively. Conversely, neither the group with rhinosinusitis-antibiotherapy nor the group with rhinosinusitis- thymoquinone had a statistically significant difference with the negative control group. Moreover, none of the histopathological features showed a statistically significant difference, when the group with rhinosinusitis- antibiotherapy and the group with rhinosinusitis-thymoquinone were compared. A statistically significant difference was not determined when the group with rhinosinusitiscombination therapy was compared with the group with rhinosinusitis-thymoquinone. The histopathological features did not show a statistically significant difference between the group with combination therapy and the negative control Conclusion: Thymoquinone is a promising bioactive agent for the treatment of rhinosinusitis, and its histopathological effect is as equivalent as an antibiotic. Copyright © 2011, OceanSide Publications, Inc.Item Angiokeratoma circumscriptum of the tongue(2011) Eskiizmir G.; Gencoglan G.; Temiz P.; Ermertcan A.T.Angiokeratoma circumscriptum of the tongue is a rare mucocutaneous vascular disorder. To date, only three cases of angiokeratoma circumscriptum of the tongue have been reported in the English literature. In this article, a case with angiokeratoma circumscriptum of the tongue was presented, and all the aspects of this clinical entity including clinical evaluation, differential diagnosis, histopathological features, and treatment modalities were discussed. © 2011 Informa Healthcare USA, Inc.Item The importance of metric view for photodocumentation of facial reconstructive surgery: A single blinded survey(2011) Eskiizmir G.; Özyurt B.Photodocumentation is an essential part of dermatooncology and reconstructive surgery. The purpose of this study is to suggest an imaging technique named metric view (photograph of the lesion with a surgical ruler) and to assess the accuracy of different views. Frontal, close-up and metric views were taken from the lesions of ten different cases. All the photographs were showed to 30 medical professionals and a prediction about the size of the lesion was requested individually. The relationship between the prediction values for three views and the exact size of the lesions were statistically analysed. The precise prediction of the exact size was only achieved in metric view of one case. In addition, the most approximate prediction values were obtained in metric views. The statistical analysis demonstrated that there was no statistically significant difference between the prediction values for metric view and exact size of the lesions in half of the cases. In contrast, statistically significant differences were detected in almost all of the prediction values for frontal and close-up views. Frontal and close-up views are not adequate to represent the size of the lesions. Metric view may enable a rational solution for a better representation. © 2010 Springer-Verlag.Item Acute spiral ganglion cell degeneration following acoustic overstimulation: An experimental study(2011) Eskiizmir G.; Yücetürk A.V.; Inan S.; Gürgen S.G.Background: To evaluate acoustic overstimulation-induced spiral ganglion cell (SGC) degeneration, and determine the relationship between the duration of acoustic overstimulation and rate of SGC degeneration. Methods: Fifteen guinea pigs were randomized equally to 4 experimental groups, which were exposed to different durations (7.5, 15, 30 and 60 min) of acoustic overstimulation (120 dB at 4 kHz), and a control group. Every bulla was examined histopathologically and immunohistochemically. A quantitative and statistical analysis of acidophilic and TUNEL-positive SGCs was performed. Results: In the control group, 2.1% of SGCs were acidophilic and no TUNEL-positive SGC was detected. In contrast, a statistically significant number of acidophilic (p = 0.000) and TUNEL-positive SGCs (p = 0.002) was determined in the experimental groups. Moreover, a positive correlation between the duration of acoustic overstimulation and acidophilic SGCs (p = 0.000), and a statistically significant relationship between the duration of acoustic overstimulation and TUNEL-positive SGCs (p = 0.000) were demonstrated. Conclusion: Acoustic overstimulation may induce acute SGC degeneration. A positive correlation was determined between the duration of acoustic overstimulation and rate of degenerated SGCs. Copyright © 2010 S. Karger AG, Basel.Item [Our experience in nasal reconstruction with local nasal and regional flaps].; [Nazal rekonstrüksiyonda lokal nazal ve bölgesel flep uygulamalarimiz.](2011) Eskiizmir G.; Hirçin H.Z.; Celik O.; Unlü H.In this study, we evaluated the patients, who underwent nasal reconstruction with local nasal or regional flaps and compared our approach with the algorithms of nasal reconstruction in literature. Twenty-seven patients (15 males, 12 females; mean age 68.7 years; range 42 to 86 years) who underwent nasal reconstruction with local nasal or regional flaps due to excision of skin cancers on the nose, between November 2007 and December 2009 were included in this study. The demographic data (age, sex and occupation), the location, histopathologic type, subtype and size of the tumor, the size and thickness of the defect area, the reconstruction technique and complications were recorded. All patients were photo-documented pre-, intra- and postoperatively, and were followed up at regular intervals. Basal cell carcinoma was detected in 23 patients and squamous cell carcinoma was detected in four patients. The tumors were most frequently located on the nasal dorsum (n=8, 29%) and the side walls (n=6, 22%). The tumor size was >15 mm in 14 (52%) patients. The size of the nasal defect was >20 mm in 18 (66%) patients. Reconstruction was performed with local nasal flaps in 10 patients and with regional flaps in 17 patients. The surgical flaps for nasal reconstruction should be selected individually. The ideal technique of nasal reconstruction should be determined based on the location, size, and thickness of the nasal defects, the preferences of the patients and the surgeon's experience.Item A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects(2011) Eskiizmir G.; Hirçin Z.; Özyurt B.; Ünlü H.Background: Oxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects. Methods: The study population comprised thirty healthy adults. All subjects underwent active anterior rhinomanometry (AARhm) and acoustic rhinometry (AR) tests following the application of oxymetazoline, xylometazoline, or placebo (physiological saline). The change in nasal resistance, nasal airflow, and different cross-sectional areas (CSAs) of the nasal cavity in the subjects were examined for each solution separately. The measurements were obtained over a 1-h period (baseline and 1, 15, 30, and 60 min post-dosing). All results were analyzed using the Kruskal-Wallis test and the Mann-Whitney U test. Results: A total of 6,300 measurements of AARhm and AR were obtained. The application of placebo did not cause a statistically significant change in nasal resistance, nasal airflow, and CSAs (CSA1, 2, and 3, respectively) of the nasal cavity. In contrast, statistically significant changes in nasal resistance (inspiration p=0.000 and p= 0.004; expiration p=0.000 and p=0.000), nasal airflow (inspiration p=0.000 and p= 0.004; expiration p=0.000 and p=0.000), and CSAs of the nasal cavity (CSA2 p=0.000 and p=0.000, CSA3 p=0.000 and p=0.00), with the exception of CSA1 (p= 0.982 and p=0.994), were obtained after the application of oxymetazoline and xylometazoline. A comparison of oxymetazoline and xylometazoline based on nasal resistance, nasal airflow, and CSAs of the nasal cavity demonstrated no statistically significant difference, except for CSA3. Conclusion: Oxymetazoline and xylometazoline are fast-acting and potent topical decongestants that have similar decongestive effects. © 2010 Springer-Verlag.Item Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose(2011) Eskiizmir G.; Gençoǧlan G.; Temiz P.; Hirçin Z.; Ermertcan A.The objective of the study was to investigate the effect of staged-surgery with permanent pathology on tumour recurrence of high-risk nonmelanoma skin cancers (NMSCs) of the nose and to determine the factors associated with subclinical spread and deep-margin involvement. Twenty-one patients who underwent staged-surgery with permanent pathology for high-risk NMSCs of the nose between 2007 and 2008 were prospectively followed-up for tumour recurrence. The incidence of tumour recurrence after staged-surgery with permanent pathology was 0%. A positive correlation between perineural involvement and subclinical spread (p = .012); and a statistically significant relationship between infiltrative type basal cell carcinoma (BCC) and deep-margin involvement (p = .033) was detected. Staged-surgery with permanent pathology is a reliable surgical method for complete excision of high-risk NMSCs of the nose and provides a significant decrease in tumour recurrence. Perineural involvement may cause subclinical spread, and infiltrative type BCC may invade deeper structures of the nose. © 2010 Springer-Verlag.Item New modification of cephalic resection of lateral crus in endonasal rhinoplasty(2012) Cingi C.; Eskiizmir G.; Toros S.Z.A successful rhinoplasty mainly depends on maintaining adequate nasal tip projection and achieving the desired tip refinement. In endonasal rhinoplasty, the surgeon canmodify the tip anatomy while still preserving the key structural support mechanisms. Herein, we describe a new modification of retrograde technique for the resection of the cephalic margin of the lateral crus in endonasal rhinoplasty in which a combined resection of the cephalic margin of the lateral crus and its underlying mucoperichondrium are performed. Copyright © 2012 by Mutaz B. Habal, MD.