Browsing by Author "Feray Aras"

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    Diagnostic and clinical value of F-18 FDG PET/CT in thoracic carcinoid tumors
    (2023) Feray Aras; CUMHUR MURAT TULAY
    Aim: To assess the correlation between standard uptake values (SUVmax, SUVmean) and Ki-67 in typical lung carcinoid (TC) tumors. Methods: Thirty-eight patients with thoracic masses sent for diagnosis and staging were included in the study. F-18 FDG PET / CT was applied to all patients before the operation. The patients were operated by thoracic surgery clinic. By determining different cut-off values (2.5 and 0.5), SUVmean and SUVmax values of the lesions from the curves drawn to the area of interest were calculated. Results: Thirty-eight patients were included in the study (18 women, 20 men). The average age of our patients was 45. Pathological diagnoses of all patients were determined as typical carcinoids. Eight of our patients had parenchymal lesions and twenty of them had endobronchial lesions. The average of the Ki-67 index was about 3-4% (range 1-10%). No recurrence or death was detected after resection in the 5-year follow-up period. SUVmean1 and SUVmean2 values were statistically significant when compared with SUVmax1 and SUVmax2 values (p <0.05). Conclusion: We think that the SUVmean and Ki-67 index may be an important prognostic indicator that identifies high-risk subgroups. It is thought that Ki-67 indices may correlate well with SUVmean values, and low cut-off values may be more suitable for diagnosis and prognosis in typical carcinoid tumors. SUVmean values can be used for lung carcinoid tumors and F-18 FDG PET/CT imaging is useful in the approach to carcinoid tumors of the lung before thoracic surgery.
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    Relationship between 99mTc-DTPA, 99mTc-DMSA and glomerular filtration rate by calculated γ - Camera method in kidney with unilateral renal scar
    (2024) Feray Aras
    Aim: To evaluate the relationship between renal abnormalities detected by 99mTc-Dimercaptosuccinic acid (99mTc-DMSA) scans and glomerular filtration rate estimated by γ-camera method using 99mTc-DTPA (Diethylene-triamine-pentaacetate dynamic renal scintigraphy) in patients with renal parenchymal scarring. Methods: We selected children who were followed up in our Pediatric Clinic for recurrent urinary tract infections and developed unilateral renal parenchymal scarring after these infections. We compared 99mTc- DMSA difference rates, glomerular filtration rate (GFR) calculated by γ -camera method and 99mTc-DTPA difference rates in the affected kidney. Results: Of the 23 patients, 14 (60.9%) were female and 9 (39.1%) were male. The mean age of the patients was 10.41 ± 4.49 years. In the comparison of 99mTc-DMSA scans and glomerular filtration rate calculated by γ -camera method using 99mTc-DTPA in the renal parenchymal scarring kidney, there was no significant difference in the Tc-99m-DTPA (%) difference rates between the scarring and non-scarring kidney (p=0.750). However, there was a significant decrease in GFR (ml/min) values in the scarring kidney compared to the non- scarring kidney (p=0.025). Conclusions: We found that GFR measurement provides earlier information than other methods in assessing renal function with DTPA and DMSA in patients with scarred kidneys, before irreversible loss of function occurs. GFR value is statistically more significant than DTPA and DMSA evaluation.