Browsing by Author "Göker A."
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Item Ectopic pregnancy following tubal sterilization(2009) Oruç S.; Karaer Ö.; Göker A.[No abstract available]Item Retrospective evaluation of the pregnant women consulted due to drug exposure during pregnancy; [Gebelikte İlaç Kullanimi Nedeni ile Başvuran Hastalarin Deǧerlendirilmesi](2012) Göker A.; Kadioǧlu Duman M.; Gürpinar T.; Muci E.; Yildirim Y.; Erköseoǧlu I.; Dikayak Ş.; Koyuncu F.M.Objective: Drug use in pregancy is a major obstetric issue due to the potential teratogenic effects. There are restricted studies about drug use during the first trimester in our country. The aim of this investigation is to evaluate pregnancies which applied to two reference hospitals of west and northeast of Turkey for drug use retrospectively and to initiate further studies in this field. Material and Methods: This study was performed at Obstetrics and Gynecology and Pharmacology deaprtments of Celal Bayar University Hospital (CBU) in Manisa and Trabzon Technical University Hospital (KTU) in Trabzon. Pregnancies who applied between 2005-2010 at any week of gestation with a history of drug use were retrospectively evaluated. Results: A total of 811 records were analysed. The most frequent drug used in Manisa and Trabzon was antidepressants (19%, 38.3%) and antibiotics (17.8%, 32.9%). Antiepileptics ranked third at CBU (11.7%) and analgesics at KTU (23.3%). When the most freqently used drug groups were compared there was a significant difference. Pregnant women used drugs of Food and Drug Administration group C 58.1%, D 23.2%, B 14.2% and X 4.5% while in Trabzon there was a drug use of 82.7% low risk, 11.6% intermediate, 4.7% noncategorised and 0.9% high risk groups. Conclusion: There is a common belief that antidepressants and antibiotics are harmful for the fetus. Patients are more susceptible to consult a doctor when these two groups are consumed during pregnancy. It is important to raise awareness about planned pregnancies and educate women about medications during a possible pregnancy. Questioning about pregnancy before prescibing drugs will lower the risk of teratogenity. Copyright © 2012 by Türkiye Klinikleri.Item Comparison of patient satisfaction between general and spinal anaesthesia in emergency caesarean deliveries; [Acil sezaryen operasyonlarında genel ve spinal anestezinin hasta memnuniyeti yönünden karşılaştırılması](AVES Ibrahim Kara, 2017) Açıkel A.; Öztürk T.; Göker A.; Hayran G.G.; Keleş G.T.Objective: Obstetric anaesthesia aims to deliver a healthy baby as well as render a comfortable operation for the mother. This study compared general and spinal anaesthesia in terms of the quality of recovery and patient satisfaction in women undergoing emergency caesarean deliveries. Methods: In total, 100 patients were enrolled in this prospective, single-blind, cross-sectional clinical study. Patients were divided into spinal (n=50) and general (n=50) anaesthesia groups. The recovery score, pain and satisfaction were evaluated by Quality of Recovery Score (QoR-40), Visual Analogue Scale (VAS) and Numeric Rating Scale (NRS) at 24 hours postoperatively. Results: The total QoR-40 scores were significantly higher and the total operation time was longer in the spinal anaesthesia group (median score: 194.5 vs. 179.0, p<0.001 and mean±SD: 69.0±13.3 vs. 62.7±13.4 minutes, p=0.02, respectively). There was no significant difference in VAS and NRS scores between the groups. Conclusion: Both spinal anaesthesia and general anaesthesia have advantages and disadvantages in terms of emergency caesarean deliveries. Spinal anaesthesia speeds up the recovery time and enables the mother to return to normal life earlier, while general anaesthesia has a short initiation time and does not affect patient satisfaction. © 2017 by Turkish Anaesthesiology and Intensive Care Society.Item Relation between foot pain and plantar pressure in pregnancy(Turkiye Klinikleri Journal of Medical Sciences, 2017) Varol T.; Göker A.; Cezayırlı E.; Özgür S.; Tuç Yücel A.Background/aim: Hormonal and structural changes that occur during pregnancy cause alterations in body biomechanics. These alterations reach their peak in the last trimester. Adaptive changes that appear in the foot result in pain in the foot and ankle. Pedobarography is a noninvasive measurement method that can be used to understand the origin of such pain. Materials and methods: One hundred and thirty-one pregnant women who did not have a foot or ankle problem prior to pregnancy volunteered to take part in the study. Pain was quantified by a visual analog scale (VAS). A cut-off value of 2.95 was taken to divide the subjects into two groups: Group 1 (n = 70) with VAS scores of <2.95 and Group 2 (n = 61) with VAS scores of ≥2.95. Plantar pressure measurements were taken by Tekscan HR Mat using midgait protocol. Results: Forces experienced by the total right foot area, right forefoot, and the midfoot for both feet were significantly higher in Group 2 (P < 0.05). Contact area was significantly larger in Group 2 (P < 0.05). Conclusion: Results indicate that presence and severity of foot pain during pregnancy are related to the force distribution along the foot, especially at midfoot and the contact area. © TÜBİTAK.Item Factors affecting readiness for discharge and perceived social support after childbirth(Blackwell Publishing Ltd, 2018) Yanıkkerem E.; Esmeray N.; Karakuş A.; Üstgörül S.; Baydar Ö.; Göker A.Aims and objectives: To evaluate the factors affecting readiness for discharge and perceived social support after childbirth. Background: Many women still die during and following pregnancy and childbirth. Both early and late discharges are conflicting issues in the world. Evaluation of the readiness for discharge in terms of patient safety, satisfaction, physical, emotional, psychological and social aspects is important. Design: Descriptive and cross-sectional study. Methods: The study was carried out with 610 women in the early postpartum period at two hospitals in Turkey between October 2014–March 2015 using Readiness for Hospital Discharge Scale–New Mother Form and Multidimensional Scale of perceived social support. Results: The mean scores for Readiness for Hospital Discharge Scale–New Mother Form and Multidimensional Scale of perceived social support were found as 163.5 (SD: 34.1) and 64.2 (SD: 18.8), respectively. Women who were discharged from Merkezefendi Hospital, women who had one child or one pregnancy and women or baby who experienced complication during or after birth had lower scores on Readiness for Hospital Discharge Scale–New Mother Form. Women who received information about the postpartum period had significantly higher scores on the total Readiness for Hospital Discharge Scale–New Mother Form than women did not (165.5 ± 33.8 vs 151.1 ± 36.1). Personal status, knowledge and total score of the Readiness for Hospital Discharge Scale–New Mother Form were significantly higher in women who were ready for discharge. Conclusions: Findings provide vital information that can inform nursing clinical practice, especially related to readiness for discharge protocols and developing strategies for women, who had low sociodemographic backgrounds, did not have any information about postpartum period and were not ready for discharge. Relevance to Clinical Practice: The mother and family face with postpartum difficulties on their own when early discharge takes place. Providing postpartum care services plays an important role for maternal–child health. © 2017 John Wiley & Sons LtdItem Effects of stem cells applications on oxidative stress and apoptosis during implantation(Wolters Kluwer Medknow Publications, 2018) Aydemir I.; Özkut M.M.; Firat F.; Gümürüdü A.; Sal D.H.; Erdoǧan K.; Göker A.; Tuǧlu M.I.Objective: To investigate the effects of bone marrow derived mesenchymal stem cell (BMSC) application into the rat endometrium on oxidative stress, cell proliferation and apoptosis. Methods: The female rats selected in estrous cycle were divided into three groups (saline, media and BMSC group). The intrauterine and intraperitoneal injections were performed using the saline (200 μL), culture media (200 μL) and 1×106 BMSCs/200 μL culture media, and then they were mated with male rats. On the 7th day of the pregnancy, uterine samples were harvested and dyed with heamatoxylin-eosin histochemically, anti-endothelial nitric oxide synthase and anti-inducible nitric oxide synthase, and anti-proliferating cell nuclear antigen immunohistochemically, with terminal deoxynucleotidyl transferas dUTP nick end labeling for apoptosis. The stainings were evaluated by H-score and the results were analyzed using one-way ANOVA test statistically. Results: It was found that BMSCs increased the endometrial thickness, endometrial epithelium thickness and number of endometrial glands compared to control and sham groups. The intrauterine BMSC application decreased both anti-endothelial nitric oxide synthase and anti-inducible nitric oxide synthase immunoreactivities and the number of apoptotic cells compared to the intraperitoneal applications whereas the immunoreactivity of proliferating cell nuclear antigen was increased. Conclusions: In current study, we define that stem cells do not cause any structural damages. Also they change the distribution of oxidative stress and cell proliferation marker. These findings support the reliability of stem cells in clinical use in the case of infertility. © 2018 by the Asian Pacific Journal of Reproduction. All rights reserved.Item Effects of physical and depressive symptoms on the sexual life of Turkish women in the climacteric period(Taylor and Francis Ltd, 2018) Yanikkerem E.; Göker A.; Çakır Ö.; Esmeray N.Objective: To assess the effects of physical and depressive symptoms on the sexual life of women in the climacteric period. Methods: This study was conducted with 572 women at a university hospital. The Beck Depression Inventory (BDI), Menopause Rating Scale (MRS) and Female Sexual Function Index (FSFI) were used to evaluate depressive symptoms, intensity of menopausal symptoms and sexual function. Results: Sexual dysfunction and depressive symptoms were determined in 86.4% and 54.9% of the women, respectively. In univariate analysis, women without health insurance, with low income, being married for longer than 21 years and being in menopause had low FSFI but high BDI and MRS scores. In multiple regression analysis, advanced age of women, women with low income, unemployed women, low educated women and their husbands and women with depressive symptoms had low FSFI scores. There was a negative relationship between total FSFI and MRS and BDI scores. Conclusion: Determination and treatment of sexual, emotional and physical problems in the climacteric period are very important for the improvement of the quality of life of women. © 2018 International Menopause Society.Item A comparative study for selectivity of micronuclei in cervical exfoliated cells on chronic boron effects(Wolters Kluwer Medknow Publications, 2019) Yildirim H.; Göker A.; Demirci H.; Güvenal T.; Korkmaz M.Background: Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer. Aims: This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on cervical cells. Settings and Design: The study population comprised women who were diagnosed to be human papillomavirus (HPV)-positive and had atypical squamous cells of undetermined significance (ASCUS) as cervical cytology in a cervical screening project. A total of 15 HPV-positive and 36 ASCUS patients were identified. Randomly selected 20 women were selected from boron-rich region (n = 10) and nonboron region (n = 10). Materials and Methods: Cervical swab specimens were dyed using Papanicolaou (PAP) and May-Grünwalds-Giemsa (MGG) techniques, and MN count in 1000 cells was performed. The results were statistically evaluated. Statistical Analysis Used: Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 13. Quantitative data were presented as mean ± standard deviation. MN test scoring was compared using Mann-Whitney U-test. Results: Boron content of urine was measured to be 3.02 ± 1.45 and 0.98 ± 0.42 mg/day in boron-rich and nonboron regions, respectively. When MN counts were compared according to PAP and MGG staining in HPV- and ASCUS-positive women, there was statistically no significant difference (P > 0.05). Disregarding regions, HPV/control and HPV/ASCUS cases stained with PAP and MGG had statistically significant difference in MN count (P < 0.05). Conclusion: These findings suggest that MGG and PAP staining gives similar results with regard to MN count. On the other hand, it has been shown again that HPV induces MN and causes genomic instability. © 2019 Medknow Publications. All rights reserved.Item Protective effect of alpha lipoic acid on 4-vinylcyclohexene diepoxide induced primary ovarian failure in female rats(Elsevier Ltd, 2020) Özel F.; Kiray M.; Göker A.; Aydemir S.; Mıcılı S.C.Objective: The effects of alpha lipoic acid (ALA) and its possible mechanisms in treating Primary ovarian failure (POF) model was studied with 4 vinylcyclohexene diepoxide (VCD). Material and methods: Rats were divided into 4 groups (n = 7) as Control, VCD, VCD + ALA and ALA. POF model was induced by applying VCD intraperitoneally and ALA was administered by oral gavage as 100 mg/day to the VCD + ALA and ALA groups. Results: At the end of 42 days, ovarian and uterine tissues were received. The number of primordial and primary follicles were increased and corpus luteum and cystic follicles were decreased in ovarian tissues in VCD + ALA group compared to VCD group. Caspase-3 immunoreactivity in follicular cells was decreased in VCD + ALA group compared to VCD group. eNOS immunoreactivity and eNOS levels were decreased in VCD group and increased in VCD + ALA group while iNOS immunoreactivity and iNOS levels were increased in VCD group, decreased in VCD + ALA group in ovary and uterine tissue. Plasma FSH and LH hormone levels were increased in the VCD but decreased in VCD + ALA group. Estradiol level decreased in the VCD group compared to the other groups. The MDA values were significantly increased in the VCD + ALA group compared to VCD group. In addition, the levels of GSH values were decreased in VCD + ALA group compared to VCD group. Conclusion: Alpha lipoic acid treatment of rats with VCD-induced POF had a beneficial effect on reducing ovarian damage by improving histological, immunohistochemical, hormone level and oxidative stress markers. Our results show that ALA is an effective treatment of VCD-induced POF rats. © 2020Item The effect of infertility-related distress and marital adjustment on sexual dysfunction in women: a mixed methods study(Routledge, 2025) Yanikkerem E.; Topsakal Ö.; Kuşçu N.K.; Göker A.; Uyar Y.To investigate the effects of infertility-related distress and marital adjustment on sexual dysfunction. The research was carried out in two stages using a mixed method, both quantitatively with 242 and qualitatively with 12 infertile women. Characteristics of women questionnaire, the Infertility Distress Scale, Marital Adjustment Test, Female Sexual Function Index, and semi-structured interview form were used for data collection. The study found that smoking, husband’s unemployment, and duration of wanting children led to an increase in infertility stress and decrease in marital harmony. Likewise, infertility treatment history, spouse’s unemployment, paying all treatment expenses personally, and concerns about adoption were found to affect sexual functions. In this study, women’s sexual functions were positively related to marital adjustment and negatively related to infertility stress. Qualitative data analysis identified four main themes: the implications of infertility, infertility on treatment, infertility on marriage, and infertility on sexuality. Women reported that their sex life suffered during diagnosis and treatment, with intercourse becoming a duty solely for conception, making them feel like robots. Health care providers should recognize the factors affecting women’s sexual lives in infertility clinics. © 2025 College of Sexual and Relationship Therapists.Item Investigation of the Effect of Counseling Given to Postpartum Women with the EX-PLISSIT Model on Sexual *(SAGE Publications Inc., 2025) Üstgörül S.; Yanıkkerem E.; Göker A.The aim of this study was to investigate the effect of counselling using the EX-PLISSIT model on sexual problems experienced by postpartum women. The study collected data from a sample of 1062 women who gave birth at a Public University Hospital in 2017, using the Arizona Sexual Experiences Scale and Golombok Rust Inventory of Sexual Satisfaction Scale. The study was conducted in two stages, with 189 women in the first stage and 150 women in the second stage. Women in the intervention group received sexual counselling based on the EX-PLISSIT model. A statistically significant difference was found in the education level of the women and the age and education level of their spouses. Pain was reported by 14.7% of women during the pre-pregnancy period, 12.0% during pregnancy, and 26.7% during the third month after delivery. A statistical difference was found between the intervention and control groups in the sub-dimension scores of the Golombok Rust Inventory of Sexual Satisfaction, including communication, satisfaction, avoidance, touch, vaginismus, and orgasm, as well as the Arizona Sexual Experiences Scale, including sexual desire, vaginal wetting/moisturizing, and satisfying orgasm. However, age, income status, marital age, marital type, marital adjustment, parity, and childbearing were not statistically significant differences between the intervention and control groups. The study found that counselling with EX-PLISSIT had a positive effect on both sexual dysfunction and the quality of sexual intercourse. © The Author(s) 2025.