Browsing by Author "Göksel, G"
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Item Palliative Biliary Drainage Has No Effect on Survival in Pancreatic Cancer: Medical Oncology PerspectiveErdogan, AP; Ekinci, F; Yildirim, S; Özveren, A; Göksel, GPurpose Removal of obstructive jaundice in metastatic pancreatic cancer is an important part of palliative therapy. However, it is not known whether invasive procedures reduce cancer-related mortality. In this study, the effect of palliative biliary drainage on survival outcomes in pancreatic cancer patients was evaluated. Methods Patients diagnosed with pancreatic cancer and undergoing biliary drainage in two different centers between 2010 and 2019 were evaluated retrospectively. Results Biliary drainage was applied to 73 patients, constituting 20.6% of 355 patients included in the study. The median progression-free survival (PFS) of patients with biliary stent was 5 months, while the median PFS of patients without stenting was 5.5 months and the median overall survival (OS) was 11.1 and 11.5 months, respectively (p: 0.424, p: 0.802). Conclusions A positive effect of palliative biliary drainage on median PFS and OS could not be demonstrated in our study group. In pancreatic cancer, predictive markers are needed to select patients who can derive a survival benefit from biliary drainage.Item Level of COVID-19 fear in cancer patientsErdogan, AP; Ekinci, F; Acar, Ö; Göksel, GBackground Cancer patients are in the high-risk group of getting COVID-19 infection and experiencing a severe course. Anxiety of cancer patients about how they pass this pandemic process and how changes in the health system would influence their treatment has increased together with the COVID-19 pandemic. Influence of COVID-19 on psychology of cancer patients is also a subject needed to be investigated as well as its course and prognosis. Thus, it is aimed to measure fear levels of cancer patients by a validated scale. Patients accepting to fill in the validated Fear of COVID-19 (FCV-19S) scale were included in our study. Higher scores obtained from the scale means high level of COVID-19 fear was experienced. Results A total of 66.8% of 486 patients expressed that they are very afraid of coronavirus, and 66.3% expressed that they fear from losing their lives due to coronavirus. The level of fear in the patient group having adjuvant therapy has been found statistically to be significantly higher compared with groups having neoadjuvant and metastatic/palliative therapy (p: 0.004). Conclusions Because the increase of level of fear may lead to vital outcomes such as weakening of immune system, disturbance of treatment compliance, and worsening of prognosis, a psychological approach to cancer patients is compulsory in order to prevent fear of COVID-19 infection.Item Intestinal Ewing Sarcoma Misdiagnosed as an Adnexal Mass in a Young WomanHasdemir, PS; Aliyeva, A; Mavili, S; Göksel, GExtraosseous Ewing's sarcoma is an extremely rare tumor. In the literature, intestinal Ewing's sarcoma was reported in 20 cases, and omental Ewing's sarcoma was reported in only two cases. In this case report, we report a 23-year-old female who presented with the complaint of diffuse abdominal pain. Abdominal ultrasound and whole-body computed tomography revealed a mass starting from the adnexal area and extending between the intestinal loops. Serum levels of tumor markers were high. The serum levels of carbohydrate antigen-125 (CA-125) and carcinoembryonic antigen-19.9 (CA-19.9) were high (427.5 U/mL and 67.9 U/mL, respectively). Laparotomic exploration was performed with the preliminary diagnosis of an adnexal mass, and a mass originating from the small intestine meso and completely covered by the omentum was excised. Histological evaluation reported intestinal and omental origin of Ewing's sarcoma. This case highlights the importance of rare extraosseous Ewing's sarcoma, which should be included in the differential diagnosis of a young female with intra-abdominal mass.Item A Rare Case Report of Skin Metastasis in Gastric CancerSahin, M; Ekinci, F; Çelik, C; Temiz, P; Erdogan, AP; Göksel, GItem The effect of the gastrectomy on survival in patients with metastatic gastric cancer: a study of ASMOYazici, O; Özdemir, N; Duran, AO; Menekse, S; Ali, M; Sendur, N; Karaca, H; Göksel, G; Arpaci, E; Hacibekiroglu, I; Bilgetekin, I; Kaçan, T; Özkan, M; Aksoy, S; Aksoy, A; Çokmert, S; Uysal, M; Elkiran, ET; Çiçin, I; Büyükberber, S; Zengin, NAim: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. Patients & methods: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. Results: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p <= 0.001, p = 0.001 and p = 0.012, respectively). Conclusion: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.Item The Confusion Caused by the Fear of COVID 19 in the Future of Cancer PatientsEkinci, F; Ates, GA; Erdogan, AP; Çelik, C; Dirican, A; Göksel, GObjective: The centrality of events scale (CES) was formed to determine to what extent this localisation cancer disease was by fear of COVID-19 in cancer patients or how centralised the cognitive trauma was in this patient group.Materials and Methods: In the first paragraph of the short 7-item CES, it was written, Please think about the most stressful or traumatic event in your life, then 3 options were given. These and C) Other. After marking one of these options, the subjects were instructed to mark their level of agreement with the 7 items as stated by Berntsen and Rubin, and thus this section was the same as the original questionnaire. To be able to evaluate the questionnaire results taking the disease characteristics into account, a record was made of age, gender, treatment history (chemotherapy and radiotherapy), spread, local, metastatic).The questionnaires were administered to all the cancer patients who presented at the oncology clinic between 1 April and 1 October 2020.Results:This study was conducted to seek an answer to this question, and it was seen that of a total of 523 patients diagnosed with cancer, the vast majority (n:368, 70.4%) saw the most traumatic and stressful event of their life as cancer, with the response to option A on the questionnaire. The possibility of contracting COVID-19 was selected by 83 (15.9%) patients as the most stressful or traumatic event in their life. The option of C was marked by 72 (13.8%) patients. This showed that neither cancer nor fear of coronavirus infection was strong enough to replace the traumatic event experienced and centred in the identity of these 72 patients. These traumas of the patients were analyzed with the mean CES points. The highest points were obtained by those who marked option A, at 3.71, which was statistically significantly higher than the 3.29 points for B and 3.29 points for C (p:0.004).Conclusion:A trauma left in the past actually lives on in the cognitive memory and may even be established at the centre of the self and personal identity. Thus, by modifying the short 7-item CES, developed by Berntsen and Rubin to be an objective, measurable format, the results of this study demonstratated both the extent to which the possibility of contracting COVID-19 has started to be established in cancer patients and the unshakable but declining centrality of cancer in the traumatic past.