Browsing by Author "Göksoy, D"

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    One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study
    Senisik, AM; Içhedef, Ç; Kilçar, AY; Uçar, E; Ari, K; Göksoy, D; Parlak, Y; Bilgin, BES; Teksöz, S
    This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [F-18]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 A degrees C for 30 min in a vial containing AO-GlyGly and [F-18]FDG solution. The radiolabeled product ([F-18]FDG-GlyGly) was obtained with 98.65 +/- 0.35% yield without any purification step which makes this method more attractive for F-18 radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [F-18]FDG tagged GlyGly in vivo.
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    Baseline SUV Range for Liver and Blood Pool in Patients Undergoing F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography
    Parlak, Y; Göksoy, D; Mütevelizade, G; Gümüser, G; Sayit, E
    Introduction: The aim of the study was to define the baseline SUVmax range in the liver and blood pool of patients undergoing fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging. Methods: Five hundred and thirty-one patients (264 females, 267 males; mean age: 59.6 dagger 13.4 years) who were admitted to our department for PET/CT imaging before treatment were included in the study. Patient preparation, acquisition parameters and reconstruction protocols were standardized for all patients prior to PET/CT imaging. The mean serum glucose levels and mean age of the patients were calculated. These patients were divided into 10 groups as esophagus, stomach, colon, rectum, larynx, lung, breast, endometrium, ovarian cancers and lymphoma. 2D region of interests were plotted to calculate the mean SUV values in the right lobe of the liver and the aortic arch for the blood pool. Results: Normal Gaussian distributions of mean SUV changes for liver and blood pool were obtained. Mean SUVmax and SUVmean values for liver were 2.73 +/- 0.22 and 2.34 +/- 0.16, respectively, and 1.80 +/- 0.2 and 1.57 +/- 0.14 for blood pool, respectively. Conclusion: It was concluded that the obtained SUV ranges may provide ease of application in the clinic in evaluating qualitative tumor response and comparing tumor/background ratios in cancer patients.
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    Radiation Exposure to Nuclear Medicine Staff Working with Tc99m Radiopharmaceutical
    Hizli, Y; Parlak, Y; Göksoy, D; Mütevelizade, G; Gümüser, G; Sayit, E
    Introduction: Nuclear medicine technologists are potentially exposed to ionizing radiations while performing a variety of tasks associated with nuclear medicine procedures. We measured the external radiation doses for staff members working with Tc-99m radiopharmaceuticals to assess the annual radiation doses. Methods: Radiation doses for a nuclear medicine physician, a technologist, a nurse, a radiopharmacist, and a cleaning staff were measured by digital dosimeters. We measured the radiation exposure of these five people every day for 1 month. The dosimeters were placed at the waist levels on the anterior surfaces of the bodies. Results: After correction of natural background doses, the mean 1-month radiation dose for the physician, technologist, nurse, radiopharmacist, and cleaning staff were determined as 102.37 +/- 15.16 mu Sv, 110.8 +/- 7.5 mu Sv, 84.67 +/- 8.2 mu Sv, 111.8 +/- 7.1 mu Sv, and 106.5 +/- 12.27 mu Sv, respectively. Discussion: This study showed that effective radiation doses for nuclear medicine department staff members were within the permissible level.