Browsing by Author "Gülle, S"
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Item Synthesis and Spectroscopic Studies of Phenanthroimidazole-Imine Derivatives and Evaluation of Their Antioxidant ActivityGülle, S; Erbas, SÇ; Uzel, AThe phenanthroimidazole derivatives are used in the drug industry in large scale. In this study four new phenanthroimidazole-imine derivatives were synthesized and their spectroscopic studies as well as their antioxidant behaviors were examined. Structural analyses were made by FT-IR, H-1-NMR, C-13-NMR, LC-MS spectroscopy techniques. UV-vis absorption and emission spectroscopy techniques have been used to determine the photophysical characteristics of four newly synthesized phenanthroimidazoles. The maximum absorption and emission wavelengths, molar extinction coefficients (epsilon), singlet energy levels (Es), Stokes' shift values (Delta lambda) of phenanthroimidazole-imine derivatives are given. Additionally, the antioxidant behavior of all compounds were investigated which the ascorbic acid used as standard molecule in present study.Item Construction of Hexahydropyrido[3,2-c]carbazole and Hexahydropyrrolo[3,2-c]carbazole Skeletons for the Synthesis of Related Indole AlkaloidsHizliates, CG; Gülle, SSynthesis of tetracyclic hexahydropyrido[3,2-[c] carbazoles (9a and 9b) and hexahydropyrrolo[3,2-[c]carbazoles (13a and 13b) structures was achieved via a new synthetic approach for the synthesis of related indole alkaloids such as deethylaspidospermidine and deethylibophyllidine. Hexahydropyrrolo[3,2-[c] carbazole structure was constructed for the first time starting from ethyl 4-[oxo-[cyclohexanecarboxylate in seven steps. Some tetrahydrocarbazole derivatives (4, 5, 6, 7, 11, and 12) were also synthesized.Item Investigation of spectroscopic and thermo-mechanical behaviors of different phenanthroimidazole-azo dyes in solvent and polymer mediumErbas, SÇ; Uregil, U; Gülle, S; Bastürk, SBThe aim of this study is the investigation of the interaction between dyes and polymers which have different polarities. Dye doped polymer films have larger application areas because of the fact that dye is more stable when doped in polymer compared to solvent medium. However, dye dispersion in the polymer medium affects both the spectroscopic and mechanical properties of the polymer. The polymer-dye interaction must be high for a good dispersion,. In this study, polypropylene with apolar character and polymethylmethacrylate with polar groups were chosen as a solid phase to examine polymer-dye interactions. The photophysical properties of phenanthroimidazole-azo compounds synthesized previously were examined with UV-visible and fluorescence spectroscopy techniques in tetrahydrofuran and two polymer media. Also, photostability tests of azo dyes in THF and polymer films were performed. Surface roughness characterizations of polymer films were carried out with AFM. Additionally, the viscoelastic behaviors of the polymethylmethacrylate and polypropylene films under sinusoidal vibrations at different temperatures were studied by dynamic mechanical analysis technique.Item A Selective Fluorescence Sensor for Fe (III) Based on Phenanthroimidazole Imine CompoundGülle, S; Erbas, SÇExperimental studies in the aqueous solution are crucial for the detection of metal cations in environmental and biological media. Polymer materials allow to work in aqueous media for fluorescent substances which are insoluble in water. Fluorescence sensor studies of the phenanthroimidazole imine compound (PI) synthesized previously by our group were performed in the polymer medium and the selective response to Fe (III) cation was obtained. The resulting sensor exhibited a selective fluorescence quenching effect to Fe (III). A logarithmic calibration graph was obtained in the range of 5.0 x 10(- 5) and 1.0 x 10(- 2) M. The interference effects of other ions besides Fe (III) have been examined and it has been observed that PI compound behaves selectively to Fe (III) ion in aqueous media. In addition, regeneration and reproducibility studies were carried out to determine the long-term usage of PI doped polymer film and reproducible results have been obtained for Fe (III) cation.Item Synthesis of Novel Phenanthroimidazole Based Beta-Diketone Compounds: Investigation of Their Spectroscopic Properties and Electrochemical CharacterizationGülle, S; Erbas, SÇ; Polatoglu, IIn this study, three new phenanthroimidazole based beta-biketone compounds containing different donor (methoxy and dodecyloxy) and acceptor (cyano) groups were synthesized. Spectroscopic and electrochemical properties of the synthesized compounds were studied. FTIR, 1H-NMR, 13C-NMR, and LC-MS/MS were carried out for the structural analyses of the phenanthroimidazole derivatives. UV-vis absorption and emission studies were also carried out in the solvents with different polarities. High molar absorption coefficients and high Stokes' shift values were observed. The photostability of these derivatives was measured in all the solvents used. These values suggest that the derivatives could be used in fluorescence imaging applications for various biological and analytical purposes. Furthermore, the potential use of these molecules as electron transfer mediators for the electrochemical behavior of biological material was investigated. All the curves were also simulated using the most suitable equivalent Randles circuit. The charge-transfer resistance values varied depending on the donor and acceptor groups in the synthesized molecules. The Nyquist plots were evaluated, and it was observed that these molecules exhibit different resistance to electron transfer. These synthesized molecules can potentially be used as electron transfer mediators in the electrochemical detection of biological analytes.Item Dinuclear N-heterocyclic carbene silver complexes: Synthesis, luminescence and catalytic studiesAtli, DD; Gülle, SA new dibenzimidazole compound (1) and three dibenzimidazolium salts (2a-2c) were prepared. Reactions of these salts with silver(I) oxide in methanol led to dinuclear N-heterocyclic carbene silver complexes (3a-3c). All of the compounds were characterized by H-1 NMR, C-13 NMR and elemental analyses. Molecular weights of the silver complexes were confirmed by MALDI-TOF mass spectrometry. Preliminary catalytic studies using all the silver complexes were performed on three-component coupling reaction of p-formaldehyde, piperidine and phenylacetylene. Complexes 3a and 3c exhibited good catalytic activities under neat conditions. The silver complexes showed luminescence properties in CH3CN at room temperature. (C) 2018 Elsevier B.V. All rights reserved.Item 3,9-Dimethyl-2,3-dihydrospiro[carbazole-1,2′-[1,3]dithiolan]-4(9H)-oneGülle, S; Delibas, NÇ; Ergün, Y; Hökelek, TThe title compound, C16H17NOS2, consists of a carbazole skeleton with methyl and dithiolane groups as substituents. In the indole ring system, the benzene and pyrrole rings are nearly coplanar, forming a dihedral angle of 1.02 (11)degrees. The cyclohexenone ring has a twisted conformation, while the dithiolane ring adopts an envelope conformation with one of the CH2 C atoms at the flap. In the crystal, weak C-H center dot center dot center dot O hydrogen bonds link the molecules into supramolecular chains nearly parallel to the c axis. These hydrogen bonds together with weak C-H center dot center dot center dot pi interactions link the molecules into a three-dimensional supramolecular network.Item Efficacy and Safety of CT-P13 as First- and Second-Line Treatment in Patients with Ankylosing SpondylitisUslu, S; Gülle, S; Sen, G; Capar, S; Senel, S; Dalkilic, E; Akar, S; Koca, SS; Tufan, A; Yazici, A; Yilmaz, S; Inanc, N; Birlik, M; Solmaz, D; Cefle, A; Goker, B; Direskeneli, H; Yolbas, S; Krogh, NS; Yilmaz, N; Erten, S; Bes, C; Gündüz, OS; Oztürk, MA; Haznedaroglu, S; Yavuz, S; Onen, F; Sari, IBackground/Objectives: CT-P13 is a biosimilar version of infliximab, a monoclonal antibody. In individuals with ankylosing spondylitis (AS), CT-P13 has been shown to be effective and to have a well-tolerated safety profile. The aim of this study was to evaluate the long-term drug persistence, safety, and efficacy of infliximab biosimilar CT-P13 in patients with AS undergoing first-line (1st-line) and later (>= 2nd-line) treatment in clinical practice. Methods: We performed an observational cohort study that included AS patients based on the biological drug database in the TURKBIO Registry between 2014 and 2021. The patients were divided into two groups: those receiving CT-P13 as first-line treatment or as a switch (>= 2nd-line) from another TNF inhibitor (TNFi). Standard disease activity metrics were used to assess the effectiveness of CT-P13, and drug retention rates were investigated. Results: There were 179 AS patients using CT-P13 (47.4% male, mean age: 42.9 +/- 11.3 years). Of these patients, 123 (68.7%) were receiving CT-P13 as a first-line treatment. The mean length of treatment was 3.5 years. CT-P13 drug retention rates in the general patient population were 58.6% and 48.2% in the first-line and >= second-line treatment, respectively, after 3 years of follow-up. The most common reason for CT-P13 treatment discontinuation was lack of efficacy. The first-line CT-P13 group had statistically substantially higher ASAS20/40 response rates at three and six months. Nonetheless, both groups' response rates at one year were comparable. Conclusions: In this real-world data analysis, AS patients who were TNFi na & iuml;ve (1st-line) and subsequently treated (>= 2nd-line) with CT-P13 showed encouraging drug retention rates with acceptable long-term effectiveness and safety.Item THE EFFICACY AND SAFETY OF ANTI-TNF A TREATMENT IN ANKYLOSING SPONDYLITIS PATIENTS WITH LATE ONSET COMPARED TO THOSE WITH ADULT ONSET; THE DATA FROM TURKBIO REGISTRYUslu, S; Can, G; Cefle, A; Yilmaz, S; Kocaer, SB; Inel, TY; Gülle, S; Koca, SS; Yolbas, S; Öztürk, MA; Senel, S; Inanc, N; Dalkiliç, E; Soysal, O; Tufan, A; Akar, S; Birlik, M; Sari, I; Akkoc, N; Onen, FItem Biological treatment in elderly and young patients with ankylosing spondylitis: TURKBIO real-life data resultsUslu, S; Gülle, S; Urak,Ö; Sen, G; Dalkiliç, E; Senel, S; Akar, S; Inanç, N; Cefle, A; Avsar, AK; Yolbas, S; Yilmaz, S; Gündüz, OS; Sari, I; Birlik, M; Akkoç, N; Önen, FObjectives: This study aims to investigate the effect of age on disease activity and biological treatment in patients with ankylosing spondylitis (AS). Patients and methods: A total of 811 AS patients registered in the TURKBIO registry database between 2011 and 2019 were categorized according to their age at the time of entry into the registry and assigned to one of two groups: young patients, defined as <60 years of age (n=610), and those aged >= 60 years (n=201) were recorded as elderly patients. Demographic, clinical, and laboratory characteristics, along with disease activity markers and other follow-up parameters, as well as current and prior treatments, were electronically recorded during each visit using open -source software. Results: The mean age of the elderly patients was 67 +/- 5.8 years, while the mean age of the younger patients was 49.2 +/- 10.9 years. Male predominance was lower in the older AS group compared to the younger AS group (p=0.002). During follow-up period, 397 patients (comprising 318 young and 79 elderly individuals) had a history of using at least one biological disease -modifying agent (bDMARD). There was no significant difference between the groups in terms of DMARD and bDMARD-use distributions. First tumor necrosis factor inhibitor (TNFi) retention rates were found to be similar in both groups over 10 years of follow-up. Adverse events were found to be similar in young (19.9%) and elderly (26.8%) AS patients. Conclusion: Research in the TURKBIO cohort reveals that both older and younger patients with AS exhibited similar disease activity levels with comparable treatment approaches. Moreover, the results of TNFi treatments in elderly patients were the same as those observed in younger patients, with no notable increase in safety concerns.Item The Efficacy and Safety of Anti-TNFα Treatment in Ankylosing Spondylitis Patients with Late Onset Compared to Those with Adult Onset; The Data from TURKBIO RegistryUslu, S; Can, G; Cefle, A; Yilmaz, S; Kocaer, SB; Inel, TY; Gülle, S; Koca, SS; Yolbas, S; Öztürk, MA; Senel, S; Inanc, N; Dalkiliç, E; Gunduz, O; Tufan, A; Akar, S; Birlik, M; Sari, I; Akkoç, N; Onen, FItem Synthesis of Cycloalk[b]indole Bearing Spiropiperidine DerivativesHizliates, CG; Gülle, S; Ergün, YThe novel heterocyclic compounds that have cycloalk[b]indole moiety bearing spiropiperidinone and spiropiperidinedione (3a, 3b, 3c, 5a, 5b, 8a, 8b, and 10a) were synthesized for the first time. The synthesis of spiropiperidinone and spiropiperidinedione structures was performed by a new method. These compounds are similar to sedative and hypnotic drugs such as methyprylon, glutethimide, and thalidomide.