Browsing by Author "Gümüs B."

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    Beneficial effects of testosterone undecanoate on the lipoprotein profiles in healthy elderly men. A placebo controlled study
    (International Heart Journal Association, 1997) Uyanik B.S.; Ari Z.; Gümüs B.; Ramazan Yiǧitoǧlu M.; Arslan T.
    Background and Methods. In order to assess the effects of testosterone undecanoate (TU; 120 mg/d orally for 2 months) on serum lipid, lipoprotein, and apolipoprotein levels in healthy elderly men, the placebo (PL) controlled study was performed on 37 elderly men, aged between 53 and 89 years. In all subjects venous blood samples were taken after an overnight (10 hours) fast and sera were stored -70°C until analysis. Results. In PL group, neither hormonal data nor lipid, lipoprotein, and apolipoprotein levels showed significant changes. After TU supplementation, serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and estradiol (E2) levels decreased from 198 ± 30.7 mg/dl to 174 ± 41.9 mg/dl (P < 0.05), from 111 ± 18.14 mg/dl to 87.9 ± 29.4 mg/dl (P < 0.01), and from 86.2 ± 16.9 pmol/l to 70.5 ± 18 pmol/l (P < 0.01), respectively. Statistically significant differences were not observed in the serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and apolipoprotein (apo)A-1 and apo B levels after TU treatment. The mean ratios TC/HDL-C and LDL-C/HDL-C as coronary risk factor criteria decreased significantly in the TU but not in the PL group. No obvious side effect was observed in those who took TU except for reported pyrosis in 2 of 17 elderly men. Conclusions. These data indicate that the increased serum levels of total testosterone (TT) produced by administration of TU, 120 mg/d orally for 2 months lead to supressed levels of TC and LDL-C and E2 but not significantly changed levels of TG, HDL-C, apo A-1 and apo B. Thus, we conclude that TU may be an effective drug for protecting coronary heart disease in healthy elderly men with lowered TT and FT levels. It may also have beneficial effects for sexual function and behavior.
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    Combination of transrectal and transvaginal ultrasound examinations in the diagnosis of female incontinence
    (1998) Lekili M.; Gümüs B.; Tarhan S.; Yorulmaz I.; Temeltas G.; Büyüksu C.
    Stress urinary incontinence is a common problem for women. We investigated the use of transvaginal and transrectal endosonography in the evaluation of women with stress urinary incontinence in comparison with lateral chain cystography. Twenty-four patients with clinically determined stress urinary incontinence were evaluated consequently with transvaginal and transrectal ultrasound and conventional lateral chain cystography. Posterior urethrovesical angle and urethral lengths were measured at rest and during Valsalva manoeuver. The results, compared with X-ray cystourethrography, enabled us to show the combination of transvaginal and transrectal ultrasonographic examinations may provide further information than transvaginal and transrectal procedure alone.
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    Effect of varicocele on testicular artery blood flow in men: Color doppler investigation
    (2003) Tarhan S.; Gümüs B.; Gündüz I.; Ayyildiz V.; Göktan C.
    Objective: Varicocele can be defined as an abnormal tortuosity and dilatation of the veins of the pampiniform plexus. Contradictory results have been obtained from experimental animal models and a few clinical human studies on testicular arterial blood flow in varicocele. The purpose of this study was to determine the changes in testicular arterial blood flow parameters in patients with varicocele. Material and Methods: A total of 62 patients with a clinical diagnosis of left varicocele and a scrotal vein with a diameter of ≥3 mm on color Doppler ultrasonography were included in the study. A total of 44 fertile normal male volunteers served as controls. Results: Median testicular arterial blood flow and median flow rate in milliliters per minute per 100 g of testicular tissue were found to be significantly decreased in the patient group compared to the control group: blood flow, 1.42 and 2.00 ml/min; flow rate, 9.63 and 12.35 ml/min/100 g, respectively (p < 0.05). Positive correlations were found between sperm concentration and left testicular artery blood flow (p < 0.05) and between left testicular volume and testicular artery blood flow (p < 0.05). Conclusions: Testicular arterial blood flow was found to be significantly decreased in men with varicocele. This may be a reflection of the impaired microcirculation. Following decreased testicular arterial blood flow, impaired spermatogenesis may result from defective energy metabolism in the microcirculatory bed.
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    Histopathological effects of sildenafil citrate on rat corpus cavernosum
    (Elsevier GmbH, 2004) Gümüs B.; Vatansever H.S.; Müezzinoǧlu T.; Müftüoǧluc S.; Kaymaz F.; Büyüksu C.
    Sildenafil citrate (Viagra) is widely used for the treatment of erectile dysfunction with various etiologies. The aim of the present study was the investigation of histopathological effects of sildenafil citrate on rat corpus cavernosum using light and electron microscopical techniques. Twenty male rats were divided into two groups. The first group (n = 10) was used as a control and the second group (n = 10) was treated with sildenafil citrate. Penile tissue was collected, fixed with formalin and embedded in paraffin for light microscopy, or fixed with gluteraldehyde and osmium tetroxide and embedded in Epon for electron microscopy. Light microscopical analysis showed that the corpus cavernosum was elongated and the number of blood vessels was increased. The amount of connective tissue in the penis was increased and dense collagen and smooth muscle fibers were observed in treated rats. Electron microscopical analysis showed that stromal structures of the corpus cavernosum (collagen fibers and number of cellular elements) were increased in treated rats. Fibroblasts showed signs of activation and the number of other stromaL cells was increased. Immature newly synthesized collagen fibers were observed and penetrated endothelial basement membranes. In addition, endothelial cells also showed signs of activation such as cytoplasmic granules in treated rats, whereas the surface area of blood vessels was increased and basement membranes were thickened. These histopathological changes due to treatment with sildenafil citrate indicate that prolonged use of sildenafil citrate may increase the risk of fibrosis in the penis. © 2003 Elsevier GmbH. All rights reserved.
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    Influence of the erectile dysfunction on quality of life accompanying diabetes mellitus: A longitudinal, controlled study; [Şeker hastaliǧina eşlik eden erektil disfonksiyonun yasam kalitesi üzerine etkileri: Longitudinal kontrollü bir çalişma]
    (2008) Okur M.; Gümüs B.; Üçer O.; Karatas T.C.; Özmen E.; Büyüksu C.
    Introduction: Erectile dysfunction (ED) is one of the most common complications of Diabetes Mellitus (DM) in males and has a negative impact on the quality of life (QoL). The number of studies related with this subject is limited in the literature. QoL was evaluated and compared in diabetic patients with and without ED. Materials and Methods: Patients with ED who applied to our outpatient clinics (Celal Bayar University, Medical Faculty, Department of Urology) were included in the study. We interviewed 82 patients with DM+ED, 85 patients with ED and 65 normal (control) male subjects. All men (study and control groups) were asked to fill the IIEF (International Index of Erectile Function), CES-D (Center of Epidemiological Studies-Depression), BAI (Beck Anxiety Inventory), PIED (Pyschological Impact of Erectile Dysfunction) forms. Sildenafil citrate was administered as a medical treatment. Same forms were asked to be filled again in the 3th, 6th, 9th months of the therapy. Results: We observed that QoL of the patients with DM+ED and ED were affected negatively. ED was worse in the DM group compared to others. Significant improvements were detected in both QoL and ED in 3th and 6th months of the therapy. Conclusion: Our data show that treatment of ED significantly improves QoL in the patients with DM therefore, presence of ED has to be assessed in the patients with DM.