Browsing by Author "Günay, Ö"

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    The Effect of Dehydroepiandrosterone Sulfate on Oxidant Status, Copper and Zinc Levels in Hind Leg Muscle of the Rats Fed with High-Fat Diet
    Ari, Z; Ulman, C; Taneli, F; Isbilen, B; Uyanik, BS; Aldirmaz, H; Çelik, HT; Günay, Ö
    Obesity can be induced by a high fat diet. Dehydroepiandrosterone sulfate decreases body fat mass and have an antiatherogenic effect. The objective of our study was to investigate the high fat diet changes and the effect of dehydroepiandrosterone sulfate on the antioxidant status, zinc and copper levels in the rat hind leg muscle tissue. Thirty-seven female rats were divided into 4 groups. Group 1 ( control, n=11) were fed with standard rat chow, Group 2, 3 and 4 with high fat diet (65%) for five months. Dehydroepiandrosterone sulfate was administered as 1 mg/kg for group 3 (n=9) and as 10 mg/kg for group 4 (n=8) daily for seven days. The same amount of saline was injected to group 1 and 2 (n=9). After decapitation, right hind leg of the rat was collected and kept frozen. Muscle tissues were used for the determination of nitrotyrosine, myeloperoxidase activity, copper and zinc levels. As a conclusion, dehydroepiandrosterone sulfate significantly decreases the oxidant status parameters, tissue nitrotyrosine levels and myeloperoxiase activity in the rat hind leg muscle tissue on high fat diet, but did not have any effect on copper and zinc tissue levels. We believe that, further research is needed for investigation of the positive effects of DHEA-S on muscle metabolism.
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    Effects of physical exercise on quality of life, pulmonary function and symptom score in children with asthma
    Yüksel, H; Sögüt, A; Yilmaz, Ö; Günay, Ö; Tikiz, C; Dündar, P; Onur, E
    Objective: To evaluate the effects of regular exercise on asthma symptom score, quality of life and pulmonary function in asthmatic children. Materials and Methods: Thirty children with newly diagnosed mild-moderate asthma (mean age 9.8 +/- 1.78 years) were randomly allocated into exercise group (group 1) and control group (group 2). Both groups received inhaled fluticasone and montelukast treatment. Children in the exercise group were also included in an exercise training program. The program consisted of condition bicycle for one hour two times a week for 8 weeks. Pediatric Asthma Quality of Life Questionnaire (PAQLQ), a disease spesific quality of life questionnaire, and KINDL, a generic quality of life questionnaire, were used to assess health related quality of life in both groups. Spirometric tests were also performed and asthma symptom scores were recorded. Results: The degree of improvement in all scores of PAQLQ (total, activity, symptom, emotion) and symptom score in group 1 were significantly higher than those in group 2 in final evaluation, (p= 0.005, 0.000, 0.003, 0.009, respectively). Moreover, the scores of self-esteem and family subscales of KINDL in group 1 were significantly higher than those in group 2 (p=0.047, 0.030, respectively). Although insignificant, the degree of improvement in pulmonary function values (FEV1, FVC and FEV1/FVC) in group 1 were higher than those group 2. (Asthma Allergy Immunol 2009; 7: 58-65) Conclusion: Regular exercise added to conventional treatment in children with asthma significantly improves quality of life besides symptoms score.
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    The beneficial effects of physical exercise on antioxidant status in asthmatic children
    Onur, E; Kabaroglu, C; Günay, Ö; Var, A; Yilmaz, Ö; Dündar, P; Tikiz, C; Güvenç, Y; Yüksel, H
    Background: The pathogenesis of asthma involves both airway inflammation and an oxidant/antioxidant imbalance. It is demonstrated in asthmatic adults that exercise programmes improve lung function, a mechanism yet to be elucidated. The purpose of this study was to investigate the possible beneficial effects of physical exercise on antioxidant status in asthmatic children which may lead to ameliorated lung function. Methods: The study enrolled thirteen control and thirty asthmatic children. The asthmatic group was subdivided into two: the first group receiving only pharmacological treatment (n = 15) and the second receiving pharmacological treatment with exercise programme (n = 15) for 8 weeks. Blood samples were drawn from the subjects before and after treatment periods. As oxidant stress markers blood levels of malondialdehyde (MDA) and total nitric oxide (NO), and as antioxidant status, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) enzyme activities were assessed. Results: Before any treatment was initiated, MDA and NO levels in the asthmatic group were significantly higher than the controls (3.40 +/- 0.96 nmol/ml vs 2.46 +/- 0.58 nmol/nnl, and 12.53 +/- 2.10 vs 9.40 +/- 1.39 micromol/L, respectively). Both SOD (p=0.0001) and GSH-Px (p=0.023) activities were significantly lower in the asthmatic group. Pharmacological treatment and exercise programme together significantly improved lung performance and decreased the levels of oxidant stress markers, in concordance with a significantly increase in antioxidant enzyme activity measures when compared to the pharmacological treatment. Conclusion: Structured exercise programme in asthmatic children resulted in better lung function, which may be attributed to its effect on antioxidant status. (C) 2010 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.