Browsing by Author "Gündüz, A"

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    Mrs. Dalloway Revised: The Sense of Change and Disillusionment
    Çetinkaya, EB; Gündüz, A; Uygur, MA
    Mrs. Dalloway (1925) by Virginia Woolf is an acknowledged modernist novel which includes the sense of change and disillusionment as modernist elements. Woolf provides readers with illustrations of characters highlighting illusional reality and disillusionment throughout the novel. Although Clarissa Dalloway is not depicted as a disillusioned character within previous studies, both Clarissa Dalloway and Septimus Warren Smith represent disillusioned individuals in a modernist society. Thus, the aim of this article is to analyze the sense of change and disillusionment in Mrs. Dalloway via examining Clarissa Dalloway and Septimus Warren Smith as disillusioned characters who share similarities. To this end, the issues of social approval, marriage, war and trust towards institutions as products of civilization are discussed within the scope of this article.
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    The relationship between oxidative stress and apoptosis of histopathological changes in the ovary made by mad honey containing grayanotoxin
    Sarsmaz, HY; Gürgen, SG; Cansu, A; Türkmen, S; Gündüz, A
    The purpose of this study is to determine the effects of grayanotoxin in mad honey on ovarian tissue folliculogenesis in terms of cell death and nitric oxide expression. Three groups of 18 female Sprague-Dawley rats were formed. The first group received mad honey (80 mg/kg), the second group received normal honey (80 mg/kg), and the third group was the control. The first and second groups received normal and mad honey by oral gavage for 30 days before being sacrificed under anesthesia. Caspase 3 immunostaining showed a moderate to strong response, particularly in the mad honey group. In the mad honey group, immunostaining for caspase 8 and caspase 9 revealed a moderate immunoreaction in the granulosa cells of the Graaf follicles. The majority of Graaf follicles exhibited TUNEL positive in the mad honey group. The iNOS immunoreaction revealed a high level of expression in the mad honey group. In all three groups, eNOS immunostaining showed weak reactivity. According to the findings of apoptotic and nitric oxide marker expression, it was determined that mad honey may result in an increase in follicular atresia in ovarian follicles when compared to normal honey and control groups.