Browsing by Author "Günes, M"

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    Grouping of the companies in different scales by fuzzy cluster analysis operating in the Aegean region of KOSGEB (SMEs)
    Günes, M; Incekirik, A
    In recent academic researches and applications, fuzzy clustering theory is used to classify concepts which state uncertainty. In clustering studies, if there is an uncertainty in determining clusters or cluster memberships of some objects, it would be better to use fuzzy clustering approach. Furthermore, Fuzzy Clustering Analysis differ from other statistical analysis as flexible structure, more practical and not based on any assumption. As a result of that, modelling and even copying of many systems with the help of fuzzy systems have been caused considerable development in our lives as well as in scientific field. In this study, considering the all advantages of fuzzy clustering analysis, the companies operating in the Aegean region of KOSGEB with different scales are classified. The data obtained according to the criteria determined by KOSGEB are used. Classification is made by three different scales using fuzzy clustering methods. Fuzzy inference system has been created to provide convenience for applications of fuzzy modelling structure and fuzzy clustering algorithms. For classification analysis in this study were obtained a more flexible model. Also it is intended to provide opportunity of quick analysis and evaluation to researchers and practitioners through a software created using MATLAB.
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    Serum Levels of Trace Elements in Patients with Testicular Cancers
    Kaba, M; Pirinççi, N; Yüksel, MB; Geçit, I; Günes, M; Demir, M; Akkoyun, H; Demir, H
    Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9 +/- 11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4 +/- 10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20 degrees C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.
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    Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinoma
    Pirinççi, N; Kaba, M; Geçit, I; Günes, M; Yüksel, MB; Tanik, S; Arslan, A; Demir, H
    Objectives: Prolidase is a member of the matrix metalloproteinase family. It plays a vital role in collagen turnover, matrix remodeling, and cell growth. Reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, including cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. In our study, we aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal tumors and to evaluate their relationships with each other. Materials and Methods: A total of 37 male patients with renal cell cancer and with a mean age of 56.28 +/- 3.1 were included in the study. The control group comprising 36 male patients (mean age 56.31 +/- 2.9) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at -20 degrees C until they were used. Results: Serum prolidase activity and MDA levels were significantly higher in renal cancer patients than in controls (all, p < 0.05), while SOD, GSHPx, and GST levels were significantly lower (p < 0.05). Conclusion: Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer.
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    Serum adenosine deaminase, catalase and carbonic anhydrase activities in patients with bladder cancer
    Pirinççi, N; Geçit, I; Günes, M; Yüksel, MB; Kaba, M; Tanik, S; Demir, H; Aslan, M
    OBJECTIVES: The relationship between adenosine deaminase and various cancers has been investigated in several studies. However, serum adenosine deaminase activity and carbonic anhydrase and catalase activities in patients with bladder cancer have not previously been reported. Therefore, the aim of this study was to measure serum adenosine deaminase, carbonic anhydrase and catalase activities in patients with bladder cancer. MATERIALS AND METHODS: Forty patients with bladder cancer and 30 healthy controls were enrolled in the study. Serum adenosine deaminase, carbonic anhydrase and catalase activities were measured spectrophotometrically. RESULTS: Serum adenosine deaminase, carbonic anhydrase and catalase activities were significantly higher in patients with bladder cancer than controls (all significant, p < 0.001). CONCLUSIONS: These markers might be a potentially important finding as an additional diagnostic biochemical tool for bladder cancer.
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    Levels of Serum Trace Elements in Renal Cell Carcinoma Cases
    Pirinççi, N; Geçit, I; Günes, M; Kaba, M; Tanik, S; Yüksel, MB; Arslan, H; Demir, H
    Trace elements which are essential components of biological structures may also be toxic when present at levels above the amounts required for biological function. In our study, trace element levels were measured with furnace atomic absorption spectrophotometry in 33 newly diagnosed renal cell carcinoma cases (preoperative) and 32 healthy controls. When compared with the control group, it was found that the levels of cadmium (Cd), lead (Pb) were higher and the levels of zinc (Zn), iron (Fe) and manganese (Mn) were lower in the patient group. These changes may be important in the formation of renal cell carcinoma, a question which should be explored with postoperative comparative studies.