Browsing by Author "Gürpinar T."

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    Interactions between herbal herbal products and drugs; [Bitkisel ürünler ile ilaçlar arasindaki etkileşimler]
    (2006) Gürpinar T.
    Recently, herbal products are being increasingly used worldwide as a part of alternative medicine. The possibility of their concomitant use with sentetic medicines has also increased. However, there are important interactions between herbal products- and drugs. Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effect of the drug. Further research is needed to confirm and assess the clinical significance of these interactions. Physicians must be alert for adverse effects and drug interactions associated with herbal remedies, and they should ask all patients about the use of these products.
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    The histologic evaluation of atorvastatin and melatonin treatment on oxidative stress and apoptosis of diabetic rat pancreas; [Atorvastatin ve melatonin tedavisinin diyabetik siçan pankreasinda oksidatif stres ve apoptozise etkilerinin histolojik incelemesi]
    (2010) Gürpinar T.; Nuran E.; Uysal N.; Barut T.; Tarakçi F.; Tuǧlu M.
    In the diabetic state, there is an enhanced oxidative stress due to excessive production of reactive oxygen compounds and decreased bioavailability of nitric oxide. Antioxidant treatment has been used to prevent oxidative damage in diabetes. The objective of the present study was to explore the effects of atorvastatin (AT) and melatonin (MLT) on oxidative stress in diabetic rat pancreas. We also assessed nitric oxide synthase (NOS) activity and apoptosis. Diabetes was induced by an alkylating agent steptozotocin (STZ, 55 mg/kg, IP). Six weeks later rats were divided into five groups: STZ-induced diabetic group received atorvastatin (STZ+AT), STZ-induced diabetic group received melatonin (STZ+MLT) and STZ-induced diabetic group received atorvastatin and melatonin (STZ+AT+MLT). The vehicle-treated non-diabetic (CT) and diabetic group (STZ-CT) served as normoglycemic and diabetic controls. AT was given 8 mg/kg orally and MLT was given 10 mg/kg/IP once a day for 2 weeks beginning from the sixth week. Pancreatic tissue was examined by immunohistochemical methods. Although no significant difference was observed with respect to antioxidant status, NOS activity was tended to be higher in the untreated diabetic rats than in the treated rats. We observed that AT and MLT treatment improved the histopathological changes including apoptosis and oxidative stress in diabetic pancreas.
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    Retrospective evaluation of the pregnant women consulted due to drug exposure during pregnancy; [Gebelikte İlaç Kullanimi Nedeni ile Başvuran Hastalarin Deǧerlendirilmesi]
    (2012) Göker A.; Kadioǧlu Duman M.; Gürpinar T.; Muci E.; Yildirim Y.; Erköseoǧlu I.; Dikayak Ş.; Koyuncu F.M.
    Objective: Drug use in pregancy is a major obstetric issue due to the potential teratogenic effects. There are restricted studies about drug use during the first trimester in our country. The aim of this investigation is to evaluate pregnancies which applied to two reference hospitals of west and northeast of Turkey for drug use retrospectively and to initiate further studies in this field. Material and Methods: This study was performed at Obstetrics and Gynecology and Pharmacology deaprtments of Celal Bayar University Hospital (CBU) in Manisa and Trabzon Technical University Hospital (KTU) in Trabzon. Pregnancies who applied between 2005-2010 at any week of gestation with a history of drug use were retrospectively evaluated. Results: A total of 811 records were analysed. The most frequent drug used in Manisa and Trabzon was antidepressants (19%, 38.3%) and antibiotics (17.8%, 32.9%). Antiepileptics ranked third at CBU (11.7%) and analgesics at KTU (23.3%). When the most freqently used drug groups were compared there was a significant difference. Pregnant women used drugs of Food and Drug Administration group C 58.1%, D 23.2%, B 14.2% and X 4.5% while in Trabzon there was a drug use of 82.7% low risk, 11.6% intermediate, 4.7% noncategorised and 0.9% high risk groups. Conclusion: There is a common belief that antidepressants and antibiotics are harmful for the fetus. Patients are more susceptible to consult a doctor when these two groups are consumed during pregnancy. It is important to raise awareness about planned pregnancies and educate women about medications during a possible pregnancy. Questioning about pregnancy before prescibing drugs will lower the risk of teratogenity. Copyright © 2012 by Türkiye Klinikleri.
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    The effects of the melatonin treatment on the oxidative stress and apoptosis in diabetic eye and brain
    (Hindawi Limited, 2012) Gürpinar T.; Ekerbiçer N.; Uysal N.; Barut T.; Tarakçi F.; Tuglu M.I.
    Oxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ,55mg/kg/i.p) in adult rats. MLT was given 10mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat. Copyright © 2012 Tuba Grpnar et al.
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    Investigation of in vitro antileishmanial activity of moxifloxacin, linezolid and caspofungin on Leishmania tropica promastigotes.
    (2013) Limoncu M.E.; Eraç B.; Gürpinar T.; Özbilgin A.; Balcioǧlu I.C.; Hoşgör-Limoncu M.
    This study aimed to evaluate the potential in vitro anti-leishmanial activities of moxifloxacin, linezolid and caspofungin against Leishmania tropica. In vitro effects of all agents were studied by using the microdilution method. For this purpose, serial dilutions of the aforementioned agents were prepared in concentrations between 4096 μg/mL-0.008 μg/mL. Afterwards, promastigotes incubated in suitable medium were counted with the hemocytometer and adjusted as having a last concentration of 2.5 x 10(6) cells/mL in wells containing medium+antibiotic or antifungal. After incubation live promastigotes were counted with the hemocytometer and inhibitor concentrations (IC(50)) were determined by comparing with the control that contained no antibiotics or antifungal. IC(50) values of moxiloxacin, linezolid and caspofungin were found as 194.7 μg/mL, 896 μg/mL and 235.7 μg/mL, respectively. As a result, moxifloxacin was found to be effective in lower concentrations than the other studied agents against L. tropica promastigotes.