Browsing by Author "Güvenal T."

Now showing 1 - 5 of 5
  • No Thumbnail Available
    Item
    Vaginal hysterectomy in a patient with 20 weeks' size uterus: A case report; [Yirmi hafta gebelik boyutunda i̇ri uterusta vaginal histerektomi: Olgu sunumu]
    (2008) Güvenal T.; Piçak A.; Kilçik M.A.; Yildiz Ç.
    Myoma uteri, one of the commonest benign tumor of uterus, is a common indication of hysterectomy. The most common operation performed in gynecology is hysterectomy. The 75-80 % of hysterectomies are performed abdominally. Vaginal hysterectomy is superior in terms of morbidity, duration of hospitalization, and cost effectivity. Although enlarged uteri (250 gr or size equal to 12 weeks gestation), considered by some to contraindicate the operation, we performed vaginal hysterectomy, bilateral salpingoopherectomy, and cystorectocele repair. Our case indicates that uterus enlargement is not a contraindication for vaginal hysterectomy. We consider that the ratio of vaginal approach will increase by the experience and the education.
  • No Thumbnail Available
    Item
    Vulvanin pri̇mer adenokarsi̇onomu
    (2009) Güvenal T.; Güvenal F.; Arici D.S.
    Primary adenocarcinoma of the vulva is extremely rare neoplasm. A 67-year-old woman with a tumoral mass involving the right vulva and vaginal wall were admitted. Biopsy revealed adenocarcinoma. No other primary lesion was found on clinical evaluation and extensive investigation. The patient was underwent a wide local excision and ipsilateral inguinal and retroperitoneal lymph node dissection. Final pathological diagnosis was primary adenocarcinoma of the vulva. The patient did not accept postoperative radiotherapy. Two years after the initial surgery, local recurren mass in right groin developed. The mass was removed by wide local exision. External radiotherapy was given as an adjuvant therapy. The patient was disease free 7 years after the initial operation.
  • No Thumbnail Available
    Item
    Outcomes of patients with gestational trophoblastic disease in an university hospital; [Bir üniversite hastanesinde gestasyonel trofoblastik hastalik olgularinin değerlendirilmesi]
    (Gunes Kitap Kirtasiye, 2014) Hasdemir P.S.; Özçakır H.T.; Koltan S.O.; Güvenal T.
    Aim: To investigate the clinicopathologic features and treatment procedures of the patients who diagnosed as Gestational Trophoblastic Disease (GTD). Methods: Thirty-four patients who pre-diagnosed as GTD between the years 2003-2013 included to this investigation. Descriptive and clinicopathologic features, treatment and follow-up results of the patients investigated retrospectively. Results: Totally 27 hydatiform mole (HM) (15 of them complete and 12 of them partial) and 7 non-metastatic gestational trophoblastic neoplasia (NM-GTN) case was found in 10 years period of time. The mean age of the patients was 331,37± 9,27 (16-52), the pregnancy rate was 2,7± 1,5 (0-7), parity rate was 1,13± 1,03 (0-4), the abortus and history of molar pregnancy rates were 0,35± 0,58 (0-2) ve 0,15± 0,44 (0-2), respectively. Three recurrences (8,8%) was seen in HM cases and two of them needed repeat curettage (R/C) and the other one needed hystetectomy and all the three cases survived. Single agent chemotheraphy was been successful in all the GTN cases. Conclusion: GTD is a curable condition with early diagnosis, adequate management and follow-up. Complications due to treatment should be kept in mind. © 2014, Gunes Kitap Kirtasiye. All rights reserved.
  • No Thumbnail Available
    Item
    A comparative study for selectivity of micronuclei in cervical exfoliated cells on chronic boron effects
    (Wolters Kluwer Medknow Publications, 2019) Yildirim H.; Göker A.; Demirci H.; Güvenal T.; Korkmaz M.
    Background: Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer. Aims: This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on cervical cells. Settings and Design: The study population comprised women who were diagnosed to be human papillomavirus (HPV)-positive and had atypical squamous cells of undetermined significance (ASCUS) as cervical cytology in a cervical screening project. A total of 15 HPV-positive and 36 ASCUS patients were identified. Randomly selected 20 women were selected from boron-rich region (n = 10) and nonboron region (n = 10). Materials and Methods: Cervical swab specimens were dyed using Papanicolaou (PAP) and May-Grünwalds-Giemsa (MGG) techniques, and MN count in 1000 cells was performed. The results were statistically evaluated. Statistical Analysis Used: Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 13. Quantitative data were presented as mean ± standard deviation. MN test scoring was compared using Mann-Whitney U-test. Results: Boron content of urine was measured to be 3.02 ± 1.45 and 0.98 ± 0.42 mg/day in boron-rich and nonboron regions, respectively. When MN counts were compared according to PAP and MGG staining in HPV- and ASCUS-positive women, there was statistically no significant difference (P > 0.05). Disregarding regions, HPV/control and HPV/ASCUS cases stained with PAP and MGG had statistically significant difference in MN count (P < 0.05). Conclusion: These findings suggest that MGG and PAP staining gives similar results with regard to MN count. On the other hand, it has been shown again that HPV induces MN and causes genomic instability. © 2019 Medknow Publications. All rights reserved.
  • No Thumbnail Available
    Item
    Management of gynecological cancers in the COVID-19 era: A survey from Turkey
    (Galenos, 2020) Altın D.; Yalçın İ.; Khatib G.; Keleşoğlu M.D.; Akgöl S.; Önder A.B.; Kahramanoğlu İ.; Güvenal T.; Topuz S.; Demirkıran F.
    Objective: This study aimed to investigate how gynecologic oncologists modified their patient management during Coronavirus disease-2019 (COVID-19) in Turkey. Material and Methods: An online survey was sent to gynecologic oncology specialists and fellows in Turkey. It included management questions about strategies for newly diagnosed or recurrent endometrial, cervical, ovarian and vulvar cancer during the pandemic. Participants were asked if treatment of these cancers can be delayed or not and, if yes, the duration of delay. Results: 32.9% of surgeons prescribed oral or intrauterine progesterone for early stage, low-grade endometrial cancer. Conversely, 65.7% and 45.7% of the most surgeons did not change their management for early stage high-grade and advanced stage endometrial cancers respectively, as they perform surgery. 58% and 67.1% of the surgeons continued to prefer standard surgical treatment for microinvasive and early stage cervical cancers, respectively. Radiotherapy was preferred administered with hypofractionated doses for locally advanced cervical cancer (57.1%). While 67.1% of surgeons operated early stage ovarian cancer patients, 50% administered neoadjuvant chemotherapy (NACT) to all advanced stage ovarian cancers and 50% administered more cycles of NACT in preference to interval debulking surgery. 93.7% of the surgeons responded that treatment should not be delayed beyond eight weeks. Conclusion: Most Turkish gynecologic oncologists modified their management of gynecologic cancers due to the COVID-19 pandemic. While chemotherapy was preferred for ovarian cancer, postponement of the surgery, with or without non-surgical options, was considered for early stage, low-grade endometrial cancer. Treatment of gynecologic cancers should be decided on a case by case basis, taking into account local COVID-19 infection rates and availability of health facilities. Prognosis is also an important consideration if delay is contemplated. Standard treatment and normal time-frames should be used if possible. If not, a postponement for a maximum of eight weeks or referral to another center were acceptable alternatives. © 2020 by the Turkish-German Gynecological Education and Research Foundation.