Browsing by Author "Güzel A.B."

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    A Turkish Gynecologic Oncology Group study of fertility-sparing treatment for early-stage endometrial cancer
    (John Wiley and Sons Ltd, 2012) Dursun P.; Erkanli S.; Güzel A.B.; Gultekin M.; Tarhan N.C.; Altundag O.; Demirkiran F.; Beşe T.; Yildirim Y.; Bozdag G.; Yarali H.; Simsek T.; Ozcelik B.; Ortaç F.; Taskin S.; Guvenal T.; Ozgul N.; Haberal A.; Vardar M.A.; Dede M.; Yenen M.; Altintas A.; Arvas M.; Ayhan A.
    Objective: To analyze the results of fertility-sparing treatment of early-stage endometrial cancer (EC) in patients treated at Turkish gynecologic oncology centers, and to present a review of the literature. Methods: Thirteen healthcare centers in Turkey were contacted to determine if they were eligible to participate in the study. Centers that were eligible and agreed to participate were sent a database form to record the demographic characteristics, clinicopathologic findings, and follow-up results for their EC patients. Results: Eleven Turkish healthcare centers provided data on 43 EC patients. Mean duration of treatment was 5 months and mean follow-up was 49 months. In total, 35 (81.4%) patients were tumor free following primary progesterone therapy. Mean time from the end of progesterone therapy to pregnancy was 10.6 ± 4.3 months (range, 3-18 months). Two patients had tumor recurrence during follow-up. The pregnancy rate among the 31 women who actively sought pregnancy was 41.9% (n = 13). Conclusion: Conservative management of early-stage EC in women of reproductive age using oral progestins was effective and did not compromise oncological outcome. Pregnancy in the study patients was achieved spontaneously and artificially. © 2012 International Federation of Gynecology and Obstetrics.