Browsing by Author "Güzel E."

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    EVect of lisinopril on renal tissue damage in unilateral ureteral obstruction in rats
    (2012) Karabuga Ä.; Akbay K.; Turna B.; Vatansever H.S.; Altay B.; Güzel E.; Uluer E.T.; Ustun G.; Ekren F.; Nazli O.; Muftuoglu S.; Apaydin E.
    In this study, it was aimed to investigate apoptosis in renal injury and the eVect of lisinopril in rat model, which constitute unilateral ureteral obstruction. The retroperitoneal ureter was ligated with a 4.0 silk for the experimental model of ureteral obstruction in Wistar albino rats. Untreated group (n = 20) received no treatment. For the lisinopril-treated group (n = 20), 20 mg/kg/day of drug was given orally. Ultrastructural diVerences were analyzed using electron microscopic technique; apoptotic distribution was analyzed using the TUNEL method. After electron microscopic evaluation, on the 4th and 14th day in the untreated group, edema in the glomeruli, loss of microvillus and apoptotic cells in proximal tubule cells and sclerosis in the glomeruli were detected. On the 4th day in the lisinopril-treated group, the kidney was ultrastructurally normal and a less number of apoptotic cells were only observed on the 14th day. On light microscopic examination on the 4th and 14th day in the untreated group, while the glomeruli were normal in structure, the boundary of the proximal tubule was disrupted and some picnotic cells in both the proximal and collecting tubules were observed. In both 4th and 14th day of the lisinopril-treated group, kidney showed normal structure, although in some places picnotic cells in the collecting tubules were observed. In conclusion, lisinopril was eVective and it may prevent early renal damage in the direct obstruction model. © Springer-Verlag 2011.
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    Lung cancer from suspicion to treatment: An indicator of healthcare access in Turkey
    (Elsevier Ltd, 2023) Kızılırmak D.; Yılmaz Kaya Z.; Gökçimen G.; Havlucu Y.; Cengiz Özyurt B.; Gündoğuş B.; Esendağlı D.; Serez Kaya B.; Yılmam İ.; Aydemir Y.; Çolak M.; Afşin E.; Çetin N.; İdikut A.; Değirmenci C.; Oral Tapan Ö.; Gündüz Gürkan C.; Kocatürk C.İ.; Ömeroğlu Şimşek G.; Kalafat C.E.; Özgün Niksarlıoğlu E.Y.; Ergün Serdaroğlu M.; Karcıoğlu O.; Özyurt S.; Karahacıoğlu Madran E.; Yaprak Bayrak B.; Alasgarova Z.; Baydar Toprak O.; Yılmazel Uçar E.; Topal B.N.; Argun Barış S.; Guliyev E.; Güzel E.; Küçük S.; Ocaklı B.; Baran Ketencioğlu B.; Selçuk N.T.; Sarı Akyüz M.; Sercan Özgür E.; Yetkin N.A.; Çetinkaya P.D.; Deniz P.P.; Atlı S.; Çetindoğan H.; Karakaş F.G.; Yılmaz E.S.; Ergün D.; Ergün R.; Tulay C.M.; Ünsal M.; Demirkaya İ.; Marım F.; Kaya İ.; Demirdöğen E.; Görek Dilektaşlı A.; Ursavaş A.; Çelik P.
    Background: Lung cancer is the leading cause of cancer-related deaths worldwide. Before beginning lung cancer treatment, it is necessary to complete procedures such as suspecting lung cancer, obtaining a pathologic diagnosis, and staging. This study aimed to investigate the processes from suspicion of lung cancer to diagnosis, staging, and treatment initiation. Methods: The study was designed as a multicenter and cross-sectional study. Patients with lung cancer from various health institutions located in all geographic regions of Turkey were included in the study. The sociodemographic and clinical characteristics of the patients, the characteristics of the health institutions and geographic regions, and other variables of the lung cancer process were recorded. The time from suspicion of lung cancer to pathologic diagnosis, radiologic staging, and treatment initiation, as well as influencing factors, were investigated. Results: The study included 1410 patients from 29 different medical centers. The mean time from the initial suspicion of lung cancer to the pathologic diagnosis was 48.0 ± 52.6 days, 39.0 ± 52.7 days for radiologic staging, and 74.9 ± 65.5 days for treatment initiation. The residential areas with the most suspected lung cancer cases were highly developed socioeconomic zones. Primary healthcare services accounted for only 0.4% of patients with suspected lung cancer. The time to pathologic diagnosis was longer in the Marmara region, and the wait time for staging and treatment initiation was longer in Eastern and Southeastern Anatolia. Patients who presented to chest disease referral hospitals with peripheral lesions, those with early-stage disease, and those who were diagnosed surgically had significantly longer wait times. Conclusion: The time between pathologic diagnosis, staging, and treatment initiation in lung cancer was longer than expected. Increasing the role of primary healthcare services and distributing socioeconomic resources more equally will contribute to shortening the time to diagnosis and improve treatment processes for lung cancer. © 2023 Elsevier Ltd