Browsing by Author "Genç S."

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    Effect of transtympanic betamethasone delivery to the inner ear
    (Springer Verlag, 2016) Özel H.E.; Özdoğan F.; Gülşen Gürgen S.; Esen E.; Selçuk A.; Genç S.
    To investigate the effect of transtympanic betamethasone administration on hearing function with histologic correlation, rats were divided into three transtympanic treatment groups: isotonic saline (group I, n = 10), gentamicin (group II, n = 10) and betamethasone (group III, n = 10). Distortion product otoacoustic emission thresholds were compared on day 10. Also histological effects on cellular apoptosis in both the inner and outer hair cells in organ of Corti and spiral ganglion neurons were evaluated. Distortion product otoacoustic emission thresholds were comparable (p > 0.05) between group I and group III in all measurements. Distortion product otoacoustic emission thresholds of group II were significantly elevated in all measurements when compared with group I (p < 0.05) and group III (p < 0.05). In the Terminal deoxynucleotidyl transferase dUTP Nick End Labelling (TUNEL), Caspase-3, Caspase-8 and Caspase-9 staining method the amount of apoptotic cells in group II were significantly elevated in all measurements compared with group I (p < 0.05). In the TUNEL staining method the amount of apoptotic cells in Group III were significantly elevated compared with group I in both the organ of Corti and spiral ganglion neurons (p < 0.05). The overall histological results revealed that the severity of cellular apoptosis caused by betamethasone was somewhere between isotonic saline and gentamicin. Transtympanic betamethasone does not affect inner ear function as measured by distortion product otoacoustic emission responses, but some increase in cellular apoptosis in the organ of Corti and spiral ganglion neurons was observed. These findings suggest that transtympanic betamethasone may have mild ototoxic effects. Further studies are needed to obtain precise results for transtympanic application of betamethasone. © 2016, Springer-Verlag Berlin Heidelberg.
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    Comparison of the protective effects of intratympanic dexamethasone and methylprednisolone against cisplatin-induced ototoxicity
    (Cambridge University Press, 2016) Özel H.E.; Özdoʇan F.; Gürgen S.G.; Esen E.; Genç S.; Selçuk A.
    Objective: This study aimed to compare the efficacies of intratympanic dexamethasone and methylprednisolone in preventing in cisplatin-induced ototoxicity in rats. Methods: Experimental groups of rats (n = 8 each) received intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic dexamethasone, or intraperitoneal cisplatin and intratympanic methylprednisolone. Distortion product otoacoustic emission thresholds were compared on days 0 and 10 in all rats, and correlations between drug effects and changes in cochlear histology were evaluated. Results: Distortion product otoacoustic emission thresholds were comparable in groups III and IV (p > 0.05). Significant protection against cisplatin-induced ototoxicity was seen in groups III and IV compared with group II (p < 0.05). Dexamethasone and, to a lesser extent, methylprednisolone protected against cellular apoptosis in cisplatin-induced ototoxicity. Conclusion: Dexamethasone (and possibly methylprednisolone) may be clinically useful as an intratympanic chemopreventive agent to treat cisplatin ototoxicity. Future clinical studies should investigate the use of dexamethasone for this purpose in adult patients. © JLO (1984) Limited 2016.
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    Ginkgo biloba and lycopene are effective on cisplatin induced ototoxicity?
    (AVES İbrahim KARA, 2018) Esen E.; Özdoğan F.; Gürgen S.G.; Özel H.E.; Başer S.; Genç S.; Selçuk A.
    OBJECTIVE: The purpose of this study was to examine the anti-ototoxic impact of Ginkgo biloba extract and lycopene on the model of cisplatin-induced ototoxicity in rats. MATERIALS and METHODS: Thirty-two Wistar albino rats were examined with the distortion product otoacoustic emission (DPOAE) test (MADSEN Capella2; GN Otometrics, ICS Medical, Chicago USA), and they were randomly divided into four groups. Group 1 (n=8) was defined as the healthy control group. Cisplatin was given intraperitoneally as single dose of 12 mg/kg to group 2 (n=8), group 3 (n=8), and group 4 (n=8). Group 2 was determined as ototoxic control group. G. biloba extract (100 mg/kg) was given to group 3, and 20 mg/kg lycopene was given to group 4 with oro-gastric feeding tube daily for 10 days. DPOAE test was repeated on day 10 on all the groups. Finally, histopathological examination was performed. The study has been lead in agreement with the principles by the Institutional Animal Care and Use Committee Review Board at Kocaeli University Medical Center (KOÜ HADYEK- 1/9-14). The animals were treated in accordance with protocols approved by this committee. RESULTS: When DPOAE tests were compared, there was no significant difference in the four groups before the application (p>0.05). At the end of day 10, in groups 2 to 4, statistically significant changes were observed (p<0.05). According to the cisplatin group, a significant increase in the DP-grams on G. biloba and lycopene groups was observed (p<00.5). Corti organ and spiral ganglion neurons of groups 1, 3, and 4 were observed to have weak expression. Strong reactions were determined in organum spirale and some spiral ganglions of the cisplatin group. The striae vascularis damage on group 2 was found to be more significant more compared with groups 3 and 4. CONCLUSION: There is a protective effect of G. biloba and lycopene on cisplatin-dependent ototoxic rat model. © 2017 by The European Academy of Otology and Neurotology and The Politzer Society.
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    The Effect of Post-activation Performance Enhancement of Coincidence Anticipation Timing in Basketball Players
    (Springer Nature, 2023) Günay A.R.; Genç S.; Salman K.; Günay E.
    The aim of this study was to examine the effect of the post-activation performance enhancement (PAPE) method of coincidence anticipation timing in male basketball players. Seventeen male basketball players (mean age 20.17 years, height 1.87 m, weight 80.08 kg, training age 10.05 years) were included in the study. The study consists of two sessions. In the first session, after the participants were informed about the study and their consent was obtained, anthropometric measurements, coincidence anticipation timing (CAT) performances, and one-repetition maximum measurements were performed, respectively. Two days later, each participant performed five repetitions of back squats with 80% of one-repetition maximum (1RM) resistance after 20 min of general warm-up phases. Then, participants rested passively for 3 min. The CAT measurements of the participants were recorded after the rest period. Data were analyzed separately for CAT3 and CAT9 timing error scores in terms of pre-/post-PAPE. The results of the paired sample t-test showed that PAPE significantly decreased timing error scores on CAT 9 mph (p < 0.01). The same results were found for CAT 3 mph, and the Wilcoxon test result showed significantly decreased timing error scores after PAPE (p < 0.05). The findings showed that PAPE is an effective method for improving anticipation performance in sports such as basketball, where success is achieved through fast games. It can contribute positively to game-specific cognitive processes. © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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    The effects of resistance based postactivation performance enhancement on reaction time and change of direction in basketball players
    (Public Library of Science, 2025) Genç S.; Günay A.R.; Günay E.
    The aim of this study was to investigate the effect of post-activation performance enhancement (PAPE) intervention with 80% one repetition maximum (1RM) resistance on change of direction (COD) and reaction time (RT) in basketball players. This study sixteen male basketball players (mean age: 20.25 years, height: 1.88 m, weight: 80.75 kg, training age: 10.12 years) were included. For this study, participants attended 3 experimental sessions in the laboratory. Firstly, anthropometric measurements of the participants were taken, then RT and COD were familiarized respectively, and then 1RMs were determined. Then, the participants randomly completed the first and second sessions. In the first session, a 20-minute standard warm-up (Wup) was performed. After the participants rested passively for 3 minutes after the Wup, RT and COD tests were measured at 1-minute intervals, respectively. The results obtained were considered as the control condition. In the second session, participants rested passively for 3 minutes after performing the PAPE (80% of 1RM – 5 rep) protocol. After the rest period, participants performed RT and COD with a 1-minute interval, respectively. The data were analyzed separately for RT (visual, auditory, and mixed) and COD test results in terms of Wup and Wup+PAPE. At least 48 hours of rest was allowed between the first and second sessions to ensure that fatigue from the previous test session did not affect the results. Wilcoxon test results showed that PAPE significantly reduced visual RT (p < .005), mixed RT (p < 0.013), and COD (p < 0.001), but not auditory RT (p < 0.068). The findings showed that PAPE is an effective method to improve COD and RT performance in sports such as basketball, where success is achieved through fast-paced play. © 2025 Genç et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.