Browsing by Author "Gençoğlan G."

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    Investigation of effect of Vitamin D receptor, calcium-sensing receptor and β-catenin on cutaneous squamous cell carcinoma; [D vitamini reseptörü, kalsiyuma duyarlı reseptör ve β-katenin'in skuamöz hücreli deri kanseri üzerine etkisinin araştırılması]
    (De Gruyter, 2020) Tuğrul B.; Söylev S.; Temiz P.; Gençoğlan G.
    Background: Cutaneous squamous cell carcinoma (cSCC) is a malignant and invasive tumor which is originated from epidermis with a high incidence among non-melanoma skin cancers. The aim of this study was to determine whether vitamin D receptor (VDR), calcium-sensing receptor (CaSR) and beta catenin (β-catenin) proteins have an effect on cSCC. Materials and methods: VDR, CaSR and β-catenin proteins in tissue samples of cSCC and control group were analyzed by immunohistochemistry (IHC) and Western blotting (WB) method. IHC findings were statistically evaluated. Results: IHC staining density of VDR and β-catenin were higher in cSCC tissue samples than control. The difference between IHC staining density of VDR and β-catenin in the patient and the control groups were statistically significant (p = 0.021, p = 0.021, respectively), but not for CaSR (p = 0.237). While the VDR and β-catenin staining rates obtained by the IHC method could be supported by WB results, the WB bands for CaSR could not be shown. Conclusion: The findings suggest that VDR and β-catenin may have an effect on the disease. Further research is required to better understand the role of VDR and β-catenin together on cSCC. © 2020 De Gruyter. All rights reserved.
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    Prevalence of hirsutism in Turkey: Data of the dermatoendocrinology study group
    (John Wiley and Sons Inc, 2024) Cebeci Kahraman F.; Temiz S.A.; Erdoğan S.S.; Öztürk P.; Güven M.; Çelik H.A.; Tellal E.S.; Akbayrak A.; Selçuk L.B.; Akbulak Ö.; Emre S.; Gençoğlan G.; Ataseven A.; Kaya Erdoğan H.; Ertekin S.S.; Taşolar M.K.; An İ.; Öztürk M.; Karakuzu A.; Erdal S.A.; Solak S.S.; Albayrak H.; Cömert Özer E.; Bayramgürler D.; Özgöztaşı O.; Yulek T.; Aydoğan K.; Zindancı İ.; Çalıkoğlu E.; Kuş C.
    [No abstract available]