Browsing by Author "Gençoglan, G"

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    Ciliary body cysts in neurofibromatosis: A new coexistence?
    Emre, S; Palamar, M; Ulusoy, MO; Gençoglan, G
    Neurofibromatosis 1 (NF1) is an autosomal dominant, multisystem disorder that also effects the eye. Herein, we aimed to investigate the posterior iris surface and ciliary body morphology of NF1 patients by ultrasonic biomicroscopy (UB). Nine consecutive unrelated subjects with NF1, and as a control group 25 healthy subjects, were included in the study. All patients underwent ophthalmic examination including visual acuity testing, slit-lamp biomicroscopy, tonometry, gonioscopy (Schaffer classification), and dilated ophthalmoscopy, UB. Mean age was 35.1 +/- 16.2 (range, 11-57) and 34.5 +/- 15.6 (range, 9-60) for NF1 and control groups respectively ( > 0.05). Lisch nodules were present in 16 of 18 eyes (88.8%) in NF1 group. Fundoscopic examination of the control group and 15 eyes of NF1 (83.3%) patients was normal, whereas hypoplastic and tilted optic nerve were present in three eyes, and temporally-located bone-spicule-like lesions was present in one eye of the NF1 group. UB revealed ciliary body cyst in 77.7% (14/18) of the eyes among NF1 group, and 8% (4/50) among control group ( < 0.05). The mean size of the cysts were 520 +/- 191 mu (range, 220-860 mu) and 495 +/- 231 mu (range, 300-830 mu) at NF1 and control groups, respectively. Gonioscopic evaluation revealed that 55% of the NF1 patients have an unoccludable anterior chamber angle (Grade 3 or 4), 45% occludable angle (Grade 1 or 2), and 78% irregular pigment patches. However, occludable angle rate was just 4% in the control group, and none of the patients had irregular pigment patches. The coexistence of ciliary body cysts and NF1, and the effect of these cysts in the eye should be enlightened with further studies.
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    Pityriasis Rotunda
    Gençoglan, G; Karaarslan, IK; Kazandi, AC; Öztürk, G
    Pityriasis rotunda is a rare skin disease characterized by round or oval patches, localized mainly on the trunk, arms, and legs. The patches are usually lighter than the surrounding skin, but sometimes may be darker, and are covered by fine, adherent scales. It is very rare in caucasoids, common in Japanese and is also seen in South African blacks and West Indian black and Mediterrean area predominantly in Sardinia have been reported but it is seldom observed in Europe. We present the first two cases diagnosed from Turkey. There were well-demarcated circumscribed scaly plagues with a erythematous periphery and hypopigmented center on the trunk and proximal parts of upper limbs. Their skin phototype was III. Histopathologic examination revealed a moderate degree of compact hyperkeratosis without a granular layer. Complete clearing was observed with only emollients. (Turkderm 2010; 44: 99-101)
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    Azithromycin in the treatment of papulopustular rosacea
    Dereli, T; Inanir, I; Kilinç, I; Gençoglan, G
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    Investigation of effect of vitamin D receptor, calcium-sensing receptor and β-catenin on cutaneous squamous cell carcinoma
    Tugrul, B; Soylev, S; Temiz, P; Gençoglan, G
    Background: Cutaneous squamous cell carcinoma (cSCC) is a malignant and invasive tumor which is originated from epidermis with a high incidence among non-melanoma skin cancers. The aim of this study was to determine whether vitamin D receptor (VDR), calcium-sensing receptor (CaSR) and beta catenin (beta-catenin) proteins have an effect on cSCC. Materials and methods: VDR, CaSR and beta-catenin proteins in tissue samples of cSCC and control group were analyzed by immunohistochemistry (IHC) and Western blotting (WB) method. IHC findings were statistically evaluated. Results: IHC staining density of VDR and beta-catenin were higher in cSCC tissue samples than control. The difference between IHC staining density of VDR and beta-catenin in the patient and the control groups were statistically significant (p = 0.021, p = 0.021, respectively), but not for CaSR (p = 0.237). While the VDR and beta-catenin staining rates obtained by the IHC method could be supported by WB results, the WB bands for CaSR could not be shown. Conclusion: The findings suggest that VDR and beta-catenin may have an effect on the disease. Further research is required to better understand the role of VDR and beta-catenin together on cSCC.
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    Androphenotypic features in patients with coronary artery disease
    Gençoglan, G; Gülbasaran, F; Inanir, I; Tezcan, UK; Gündüz, K
    Objective: It has been a debate whether phenotypic features are associated with increased risk of coronary heart disease. Proposed explanations for this relation include biological aging, individual susceptibilities, and androgens which contribute to both the atherosclerotic process and dermatological signs. The results of the studies are inconsistent and most are not based on cardiovascular imaging techniques. Here, association between androphenotypic features and the risk and severity of coronary artery disease (CAD) in men is evaluated. Methods: This case-control study consists of 166 male patients with angiography-proven CAD and 160 age-gender-matched controls. Gensini score of angiograms (for severity of CAD) and phenotypic characteristics including androgenetic alopecia (AGA), thoracic hairiness (TH), hair graying a diagonal earlobe crease (DEC), and hairy ear (HE) were recorded. Men with well-established cardiovascular risk factors were excluded. Results: AGA, DEC, and HE were significantly more frequent in patients with CAD than controls (98.2% and 83.1% [P < 0.001], 61.4% and 23.8% [P < 0.001], 69.3% and 50.6% [P = 0.001], respectively). As the severity of AGA increased, the incidence of heart disease was increasing in patients. The presence of TH and AGA was found to be related to higher Gensini scores. Conclusion: The exact mechanism between these phenotypic features and CAD still remains to be elucidated. However, observation of visible aging signs is easy and inexpensive. AGA, HE, and DEC may be used as early screening tools for CAD.
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    Solid facial edema of acne
    Kilinç, I; Gençoglan, G; Inanir, I; Dereli, T
    Solid facial edema of acne is a rare persistent skin condition which occurs as a late complication of acne vulgaris. It is difficult to treat and isotretinoin seems to be the most effective agent. Here we present a 25-year-old man with a facial edema which arose after the complete remission of acne. Treatment with isotretinoin for 4 months was unsuccessful in this case.
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    Efficacy of 5% imiquimod cream in a patient with classic Kaposi sarcoma
    Gündüz, K; Günay, Ü; Inanir, I; Gençoglan, G; Temiz, P
    Background: The classic Kaposi sarcoma is most common in the Mediterranean population over 50 years of age and presents with reddish-brown papules and nodules particularly on the lower limbs. Treatment depends on the clinical presentation and extension of lesions. Imiquimod is as an immune response modifier with antiangiogenic activity. Main observations: We present a 74-year-old man with classic Kaposi sarcoma who had multiple, small, violaceous papules and nodules on the trunk and extremities with a history of 14 years. He complained particularly from plantar hyperkeratotic painful nodules. Treatment with imiquimod 5% cream under occlusion resulted with almost complete regression within 12 weeks. No local or systemic side effects were observed. Conclusions: Topical imiquimod was a safe and effective therapy in our patient with classic Kaposi sarcoma.
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    Psoriatic uveitis responding to adalimumab therapy
    Ermertcan, AT; Emre, S; Öztürk, F; Gençoglan, G; Gündüz, K
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    Pott's disease with scrofuloderma and psoas abscess misdiagnosed and treated as hidradenitis suppurativa
    Ermertcan, AT; Öztürk, F; Gençoglan, G; Inanir, I; Özkütük, N; Temiz, P
    A 29-year-old man with painless ulcers on the lumbar and inguinal regions associated with purulent discharge of 1.5 years' duration presented to our outpatient clinic. Dermatological examination revealed palpable nodules, discharging sinuses and scars on the left lumbar, gluteal and inguinal regions. According to the clinical, histopathological, scintigraphy, and magnetic resonance imaging findings as well as mycobacteriological examinations, the patient was diagnosed with Pott's disease with scrofuloderma and psoas abscess. Herein, we present an interesting case of Pott's disease with scrofuloderma and psoas abscess mistreated as hidradenitis suppurativa for a long time.
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    Sensitivity, predictive values, pretest--posttest probabilities, and likelihood ratios of presurgery clinical diagnosis of nonmelanoma skin cancers
    Ermertcan, AT; Öztürk, F; Gençoglan, G; Eskiizmir, G; Temiz, P; Horasan, GD
    Objective: This study aimed to compare clinical and histopathologic diagnoses of nonmelanoma skin cancers with regard to sensitivity, predictive values, pretest--posttest probabilities, and likelihood ratios. Methods: Two hundred nineteen patients with 241 nonmelanoma skin cancers were enrolled in this study. Of these patients, 49.4% were female and 50.6% were male. The mean age +/-+/- standard deviation (SD) was 63.66 +/-+/- 16.44 years for the female patients and 64.77 +/-+/- 14.88 years for the male patients. The mean duration of the lesions was 20.90 +/-+/- 32.95 months. One hundred forty-eight (61.5%) of the lesions were diagnosed as basal cell carcinoma (BCC) and 93 (38.5%) were diagnosed as squamous cell carcinoma (SCC) histopathologically. Results: Sensitivity, positive predictive value, and posttest probability were calculated as 75.96%, 87.77%, and 87.78% for BCC and 70.37%, 37.25%, and 37.20% for SCC, respectively. The correlation between clinical and histopathologic diagnoses was found to be higher in BCC. Conclusion: Knowledge of sensitivity, predictive values, likelihood ratios, and posttest probabilities may have implications for the management of skin cancers. To prevent unnecessary surgeries and achieve high diagnostic accuracies, multidisciplinary approaches are recommended.
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    Lentigo Malignant Melanoma Presenting with Cutaneous Horn
    Ermertcan, AT; Eskiizmir, G; Gençoglan, G; Günay, U; Kocabas, E; Temiz, P
    The authors have indicated no significant interest with commercial supporters.
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    Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose
    Eskiizmir, G; Gençoglan, G; Temiz, P; Hirçin, Z; Ermertcan, A
    The objective of the study was to investigate the effect of staged-surgery with permanent pathology on tumour recurrence of high-risk nonmelanoma skin cancers (NMSCs) of the nose and to determine the factors associated with subclinical spread and deep-margin involvement. Twenty-one patients who underwent staged-surgery with permanent pathology for high-risk NMSCs of the nose between 2007 and 2008 were prospectively followed-up for tumour recurrence. The incidence of tumour recurrence after staged-surgery with permanent pathology was 0%. A positive correlation between perineural involvement and subclinical spread (p = .012); and a statistically significant relationship between infiltrative type basal cell carcinoma (BCC) and deep-margin involvement (p = .033) was detected. Staged-surgery with permanent pathology is a reliable surgical method for complete excision of high-risk NMSCs of the nose and provides a significant decrease in tumour recurrence. Perineural involvement may cause subclinical spread, and infiltrative type BCC may invade deeper structures of the nose.
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    What is Your Diagnosis?
    Gençoglan, G
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    What is Your Diagnosis?
    Gençoglan, G
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    Lamellar Ichtyosis: Case Report
    Gündüz, K; Kayhan, TC; Gençoglan, G; Inanir, I; Temiz, P
    Introduction: Ichtyosiform dermatoses are a group of hereditary disorders characterized by excessive scaling on the skin. Lamellar ichtyosis is an autosomal recessive disorder. The clinical findings are seen at birth and become widespread and prominent in time; gray-brown scales are seen all over the body. Emollients and keratolytics containing salicylic acid or glycolic acid are used topically. Symptoms are improved significantly by acitretin usage. Case Report: Here we present a 5-year-old girl with lamellar ichtyosis. She was born in a collodion membrane. Besides the skin scales, ectropion and deformities of the nails and ears were observed. Significant clinical improvement was seen with acitretin (10 mg/day) therapy. Conclusion: Lamellar ichtyosis is a severe form of ichtyosiform dermatoses and topical agents may be insufficient. Systemic acitretin treatment improves the symptoms significantly but long term side effects limit its usage.
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    Halo angioma: A new clinical and dermoscopical description
    Kocabas, E; Gençoglan, G; Öztürk, F; Ermertcan, AT
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    What is Your Diagnosis?
    Gençoglan, G; Ermertcan, AT; Eskiizmir, G; Temiz, P