Browsing by Author "Genc, M"

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    Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus
    Gur, EB; Karadeniz, M; Genc, M; Eskicioglu, F; Yalcin, M; Hepyilmaz, I; Guclu, S
    Objective: To investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies. Subjects and methods: This study included 200 pregnant women. 25-hydroxyvitamin D-3 (25(OH)D-3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D-3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D-3 level in different MPV percentile (<= 50, 50-75, 75-90, >= 90 percentile) and MPV value in different 25(OH)D-3 level (<= 10, 10-20, >= 20 ng/mL) were calculated. Results: Low 25(OH)D-3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D-3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D-3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D-3 level in GMD group (p = 0.04). The optimal 25(OH)D-3 cut off point for predicting future cardiovascular risk was 10.4 ng/mL (area under curve (AUC) = 0.58). Conclusions: Vitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM.
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    The effect of vitamin D level in pregnancy on postpartum depression
    Gur, EB; Genc, M; Eskicioglu, F; Kurtulmus, S; Guclu, S
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    The relationship between uterine prolapse and premalignant endometrial pathology
    Genc, M; Celik, E; Eskicioglu, F; Gur, EB; Kurtulmus, S; Gulec, E; Guclu, S
    Objective: The aim of this study was to stress the importance of performing a thorough uterine assessment before selecting an organ sparing surgery in patients presenting with uterine prolapse and no other complaints. Materials and Methods: This study included a total of 111 participants who presented with pelvic organ prolapse and underwent hysterectomy for grades 3-4 uterine prolapse. The post-hysterectomy histopathology results were classified as benign (atrophic endometrium, proliferative or secretory endometrium) or patho-logic (endometrial hyperplasia, endometrial polyp, adenomyosis, myoma uteri, and endometrium carcinoma). Results: Of the 111 patients enrolled in this study, 23 (20.2%) had endometrial hyperplasia, eight (7.2%) had endometrial polyps, 30 (27%) had uterine fibroids, and 20 (18%) had adenomyosis. Conclusion: There may be premalignant lesions of the endometrium in both premenopausal and postmenopausal women presenting with uterine prolapse and no other symptoms. A chronic inflammatory process resulting from the extra-vaginal location of the uterus may play a role in the development of these lesions. Further studies are needed on this subject.