Browsing by Author "Goksel, T"

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    High dose rate endobronchial brachytherapy in the management of lung cancer: Response and toxicity evaluation in 158 patients
    Ozkok, S; Karakoyun-Celik, O; Goksel, T; Mogulkoc, N; Yalman, D; Gok, G; Bolukbasi, Y
    The aim of this study was to evaluate the symptomatic and endoscopic responses as well as the toxicities in 158 patients with endobronchial. lung cancer treated with high dose rate endobronchial. brachytherapy (HDR-EB). Forty-three patients with stage III NSCLC were treated with 60 Gy external beam radiotherapy (ERT) and three applications of 5 Gy each of HDR-EB (group A). Seventy-four patients who did not receive previous RT were treated with 30Gy ERT and two applications of 7.5 Gy HDR-EB with palliative intent (group B). Forty-one patients with recurrent tumor who were irradiated previously were treated with three applications of 7.5 Gy HDR-EB, with palliative intent (group C). In group A, bronchoscopic complete (CR) and overall response rates (ORR) were 67% and 86%, respectively. Symptomatic improvement was obtained in 58% of patients with cough, 77% of patients with dyspnea and 100% of patients with hemoptysis. Two and 5-year survival rates were 25.5% and 9.5%, respectively and the median survival time (MST) was 11 months. In group B, the bronchoscopic CR and ORR were 39% and 77%, respectively and 28% and 72% in group C. The symptomatic response rates were 57% and 55% for cough, 90% and 78% for dyspnea and 94% and 77% for hemoptysis, with a MST of 7 and 6 months in Groups B and C, respectively. Eighteen patients (11%) died of fatal hemoptysis (FH) with the median time to this event of 7 months. Treatment intent (p < 0.001), totat BED (p < 0.001) and the number of HDR-EB fractions (p < 0.001) were significant prognostic factors for FH. HDR-EB provides effective palliation in relieving the symptoms of patients with enclobronchial lung cancer, however, there is a risk of developing FH that is associated with a high BED and multiple HDR-EB applications. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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    The Assessment of the Effect of Changes in Lung Cancer Follow-up Period on the Quality of Life Using EQ-5D Questionnaire and Follow Data (AKAYAK-1 Multicenter Project)
    Erbaycu, AE; Goksel, T; Eser, E; Gursul, KK; Basarik, B; Oz, A; Celik, P; Ediz, EC; Hatipoglu, O; Yayla, BA; Baser, S; Baydur, H
    The EURO-QOL (EQ-5D), a generic quality of life measure, is a self-report scale. The aim was to study the reliability, validity and feasibility of the Turkish version of the EQ-5D as an instrument to evaluate quality of life in lung cancer patients in Turkish society. A prospective cohort study carried out within the framework of the multicenter Lung Cancer Association Project which was conducted in collaboration with Turkish Thoracic Society, Lung and Pleural Malignancies working group and Health and Quality of Life Society. A total of 266 patients were included in the study with a mean age of 61.3 years. 75,9% of the patients had chemotherapy alone; 9% received sequential chemotherapy and radiotherapy, 8,6% were given concurrent chemotherapy and radiotherapy, and 6,4% of them received radical radiotherapy alone. EQ-5D score measures at the moment of diagnosis were found to be moderately reliable while measures at the 3rd chemotherapy cycle, 5th chemotherapy cycle and after the radiotherapy were highly reliable. The items of the EQ-5D were found to be consistent among themselves. EQ-5D Visual Analogue Scale scores at diagnosis, the 3rd cycle, the 5th cycle and following radiotherapy were assessed to be correlated with each other. EQ-5D scale was found to be valid as it meets the conditions of 6 fit indices in our study design. The psychometric properties of the Turkish version of the EQ-5D questionnaire is a valid and reliable scale for patients with lung cancer in Turkey and it can be safely used in clinical practices.
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    The assessment of the effect of changes in lung cancer follow-up period to the quality of life by using EQ-5D questionnaire and follow data (the project of AKAYAK-1)
    Gursul, KK; Erbaycu, AE; Goksel, T; Eser, E; Basarik, B; Oz, A; Celik, P; Ediz, EC; Hatipoglu, O; Yayla, BA; Baser, S; Baydur, H
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