Browsing by Author "Goktalay, T"
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Item Omalizumab in patients with severe persistent asthma in real life setting in Manisa, TurkeyHavlucu, Y; Yorgancioglu, A; Kurhan, F; Özdemir, L; Coskun, S; Goktalay, T; Yilmaz, O; Celik, PItem Comparision of the original and simplified pulmonary embolism severity index according to predictive value for mortality and morbidityHavlucu, Y; Cetinkaya, C; Celik, P; Coskun, AS; Goktalay, T; Yorgancioglu, AItem Relation between COPD assessment testCAT™ and functional parameters and quality of life in COPD patientsErkan, S; Yorgancioglu, A; Havlucu, Y; Ozdemir, L; Goktalay, T; Sakar, A; Celik, PItem The attidude of the teachers working in Manisa City Center toward the practice of the law on prevention of hazards of tobacco products numbered 5727 and the rate of smoking cessation among teachersGoktalay, T; Havlucu, Y; Coskun, A; Baydur, H; Altiparmak, S; Gerceklioglu, G; Ozbey, S; Guzel, P; Yildiz, Y; Vurgun, N; Zongur, C; Bati, H; Gunay, T; Horasan, GItem Reliability and validity of a Turkish version of Leicester cough questionnaireGonen, NA; Havlucu, Y; Yorgancioglu, A; Goktalay, T; Coskun, AS; Celik, PItem Epidemiological changes of patients with lung cancer over YearsHavlucu, Y; Celik, P; Durmaz, F; Coskun, AS; Goktalay, T; Yorgancioglu, AItem Asthma control with omalizumab treatment in severe allergic asthma and severe non-allergic asthma patientsHavlucu, Y; Yorgancioglu, A; Kurhan, F; Goktalay, T; Coskun, AS; Celik, PItem The acute effects of cilazapril on pulmonary function tests and arterial blood gas changes in patients with pulmonary hypertensionTavli, T; Sekuri, C; Goktalay, T; Uyanik, BS; Ari, ZThe aim of the present study was to evaluate pulmonary function tests and arterial oxygen transport in patients with pulmonary hypertension due to congestive heart failure before and after cilazapril treatment. Thirty patients (16 men and 14 women, mean age, 65 18 years) with congestive heart failure and 30 healthy volunteers (20 men and 10 women, mean age 59 +/- 12 years, p > 0.05) were included in the study. All patients underwent evaluation of pulmonary function by spirometry and arterial blood gas analysis. Arterial oxygen saturation and arterial oxygen transport changed significantly after treatment (81 +/- 7 to 87 +/- 8 and 317 +/- 74 to 392 +/- 8, respectively). Forced expiration volume in 1 second, vital capacity and total lung capacity were increased after cilazapril treatment (2.55 +/- 0.7 to 2.61 +/- 0.8, 3.2 +/- 0.9 to 3.3 +/- 1.0 and 3.6 +/- 0.9 to 4.1 +/- 1.1, respectively p < 0.05). In conclusion, short-term cilazapril administration improved pulmonary function and arterial oxygen transport because it increased cardiac output, produced pulmonary vasodilatation, improved the pulmonary hemodynamics and removed interstitial fluid.Item Pulmonary infections in patients receiving treatment of tumor necrosis factor alpha antagonistsHavlucu, Y; Kurhan, F; Pirildar, T; Goktalay, T; Coskun, AS; Celik, P; Yorgancioglu, AItem Effectiveness of pulmonary rehabilitation initiated after exacerbation of Chronic Obstructive Pulmonary DiseaseGoktalay, T; Cerrahoglu, L; Havlucu, Y; Balci, N; Yorgancioglu, AItem Role of Bode Index in Predicting Participation in Structured Pulmonary Rehabilitation Programs With Ambulatory Follow-upGoktalay, T; Sari, S; Havlucu, Y; Kurhan, F; Coskun, A; Celik, P; Yorgancioglu, AItem Effect of High-Frequency Chest Wall Oscillation on Sputum Discharge in the Patiens With Bronchiectasis: Preliminary ResultsSari, S; Goktalay, T; Havlucu, Y; Yorgancioglu, A; Celik, P; Coskun, AItem Does high-frequency chest wall oscillation therapy have any impact on the infective exacerbations of chronic obstructive pulmonary disease? A randomized controlled single-blind studyGoktalay, T; Akdemir, SE; Alpaydin, AO; Coskun, AS; Celik, P; Yorgancioglu, AObjective: To investigate the impact of high-frequency chest wall oscillation in chronic obstructive pulmonary disease patients with infective exacerbation. Design: Clinical randomized controlled trial. Setting: Patients received high-frequency chest wall oscillation therapy at the Department of Pulmonology. Subjects: Stage III-IV chronic obstructive pulmonary disease patients hospitalized with acute infective exacerbation who had received high-frequency chest wall oscillation therapy were studied. Interventions: Patients were randomized into two groups, which were classified as I and II. All patients have been treated with bronchodilators, antibiotics, if necessary oxygen and patient education, as part of acute chronic obstructive pulmonary disease exacerbation protocol. Group II patients received additional high-frequency chest wall oscillation therapy. Main measures: Body mass index (B), forced expiratory volume in the first second (O), modified Medical Research Council dyspnea scale (D) and 6-minute walking test (E) (BODE) index, forced expiratory volume in the first second, dyspnea, exercise capacity, oxygenation parameters and hospitalization of duration were recorded at baseline and at three-days and five-days follow-up. Results: From April 2009 to July 2011, a total of 99 patients were assessed for eligibility, 50 patients were enrolled and randomized into two groups. A total of 50 (100%) patients (25 in Group I and 25 in Group II) were followed up for five days. Application of high-frequency chest wall oscillation therapy resulted in no significant advantage in all outcomes (p > 0.05). Mean (SD) baseline BODE index value in Group I was 7.72 (1.76), in Group II was 7.72(1.89) (p = 0.55). On the fifth-day assessment, mean (SD) BODE index value in Group I was 7.24 (1.83), in group II was 6.44 (2.46) (p = 0.18). Conclusions: The application of high-frequency chest wall oscillation therapy offers no additional advantages on infective exacerbations in chronic obstructive pulmonary disease.Item Effect of smoke-free legislation on smoking cessation rates in teachers in Manisa, TurkeyCoskun, AS; Goktalay, T; Havlucu, Y; Dinc, GObjective:This study investigated the attitudes of Turkish adults towards the ban on smoking in public areas and compared annual smoking cessation rates before (pre-2009) and after (post-2009) the ban became law, using data from a survey of teachers. Methods:A self-reported questionnaire was used to collect data from teachers in Manisa, Turkey. Annual smoking rates were calculated. Joinpoint regression analysis was used to identify when a significant change occurred in the annual smoking cessation rate. Results:Questionnaire response rate was 79.6% (579/727); 47.8% (277) of respondents were male. Smoking prevalence among men and women was 32.7% and 24.7%, respectively, and 97.3% of nonsmokers and 75.5% of current everyday smokers supported the law changes. Results of the Joinpoint analysis showed no significant change in annual smoking cessation rate between 2001-2002 and 2006-2007; but there were significant reductions in smoking rates between 2007-2008 and 2010-2011. Conclusions:Teachers in Turkey have a positive attitude to the law on smoking. The smoking cessation rate in teachers was significantly increased by changes in legislation.Item An Unusual Presentation of Bronchial RuptureGoktalay, T; Yaldiz, S; Alpaydin, AO; Goktan, C; Celik, PPersistent hydropneumothorax was diagnosed in a 62-year-old female with a history of blunt trauma, although she was treated with chest tube and closed underwater seal drainage. Computed tomography and fiberoptic bronchoscopy findings were consistent with fallen lung syndrome. Fiberoptic bronchoscopy also found a cavitary lesion at the right tracheobronchial angle. Forceps biopsy of the cavitary lesion indicated bronchogenic carcinoma. Our final diagnosis was tracheobronchial complete rupture and fallen lung syndrome secondary to malignancy.Item Varenicline disrupts prepulse inhibition only in high-inhibitory ratsGoktalay, T; Buyukuysal, S; Uslu, G; Coskun, AS; Yorgancioglu, A; Kayir, H; Uzbay, T; Goktalay, GVarenicline, a widely used smoking cessation drug, has partial agonistic activity at alpha 4 beta 2 nicotinic receptors, and full agonistic activity at alpha 7 nicotinic receptors. Thus it may interact with cognitive processes and may alleviate some of the cognitive disturbances observed in psychotic illnesses such as schizophrenia. We aimed to test the effects of varenicline on sensorimotor gating functioning, which is crucial for normal cognitive processes, especially for the integration of sensory and cognitive information processing and the execution of appropriate motor responses. Prepulse inhibition (PPI) of the acoustic startle reflex was used to test the sensorimotor gating functioning. First, the effects of varenicline and nicotine on rats having high or low baseline PPI levels were evaluated; then, varenicline was applied prior to apomorphine (0.5 mg/kg), and MK-801 (0.15 mg/kg), which are used as comparative models of PPI disruption. Varenicline (0.5-3 mg/kg) did not change PPI when given alone in naive animals. When rats were selected according to their baseline PPI values, varenicline (1 mg/kg) significantly decreased PPI in high-inhibitory (HI) but not in low inhibitory (LI) rats. Nicotine (1 mg/kg; tartrate salt) produced a similar activity in LI and HI groups. In combination experiments, varenicline did not reverse either apomorphine or the MK-801-induced disruption of PPI. These results demonstrate that the effects of both varenicline and nicotine on sensorimotor gating are influenced by the baseline PPI levels. Moreover, varenicline has no effect on apomorphine or the MK-801-induced disruption of PPI. (C) 2014 Elsevier Inc. All rights reserved.Item Investigation of sleep-related respiratory disorders in the young stroke patientsAk, AK; Saritas, A; Batum, M; Goktalay, T; Horasan, GD; Selcuki, D; Yilmaz, HItem A multicenter randomized trial for the effectiveness of structured discharge and follow-up protocol on readmission rate in COPD patients receiving LTOT/NIV: one-year interim analysis.Ergan, B; Goktalay, T; Ergun, P; Yilmaz, D; Ocakli, B; Gurgun, A; Demirci, N; Elverisli, F; Ucar, EY; Durmaz, A; Dilektasli, AG; Aksoy, E; Elmas, F; Kokturk, N; Aytekin, F; Akgun, M; Ozyilmaz, E; Cetinoglu, ED; Tuncay, EA; Tasbakan, S; Balbay, O; Demir, AU; Ergun, R; Savci, S; Karakurt, Z; Ekinci, B; Gemicioglu, B; Yorgancioglu, A