Browsing by Author "Guclu, S"

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    Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus
    Gur, EB; Karadeniz, M; Genc, M; Eskicioglu, F; Yalcin, M; Hepyilmaz, I; Guclu, S
    Objective: To investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies. Subjects and methods: This study included 200 pregnant women. 25-hydroxyvitamin D-3 (25(OH)D-3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D-3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D-3 level in different MPV percentile (<= 50, 50-75, 75-90, >= 90 percentile) and MPV value in different 25(OH)D-3 level (<= 10, 10-20, >= 20 ng/mL) were calculated. Results: Low 25(OH)D-3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D-3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D-3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D-3 level in GMD group (p = 0.04). The optimal 25(OH)D-3 cut off point for predicting future cardiovascular risk was 10.4 ng/mL (area under curve (AUC) = 0.58). Conclusions: Vitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM.
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    The effect of vitamin D level in pregnancy on postpartum depression
    Gur, EB; Genc, M; Eskicioglu, F; Kurtulmus, S; Guclu, S
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    The relationship between uterine prolapse and premalignant endometrial pathology
    Genc, M; Celik, E; Eskicioglu, F; Gur, EB; Kurtulmus, S; Gulec, E; Guclu, S
    Objective: The aim of this study was to stress the importance of performing a thorough uterine assessment before selecting an organ sparing surgery in patients presenting with uterine prolapse and no other complaints. Materials and Methods: This study included a total of 111 participants who presented with pelvic organ prolapse and underwent hysterectomy for grades 3-4 uterine prolapse. The post-hysterectomy histopathology results were classified as benign (atrophic endometrium, proliferative or secretory endometrium) or patho-logic (endometrial hyperplasia, endometrial polyp, adenomyosis, myoma uteri, and endometrium carcinoma). Results: Of the 111 patients enrolled in this study, 23 (20.2%) had endometrial hyperplasia, eight (7.2%) had endometrial polyps, 30 (27%) had uterine fibroids, and 20 (18%) had adenomyosis. Conclusion: There may be premalignant lesions of the endometrium in both premenopausal and postmenopausal women presenting with uterine prolapse and no other symptoms. A chronic inflammatory process resulting from the extra-vaginal location of the uterus may play a role in the development of these lesions. Further studies are needed on this subject.
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    Mid-pregnancy vitamin D levels and postpartum depression
    Gur, EB; Gokduman, A; Turan, GA; Tatar, S; Hepyilmaz, I; Zengin, EB; Eskicioglu, F; Guclu, S
    Objectives: Postpartum depression (PPD) is a common disorder that affects 10-15% of postpartum women, and it can have negative effects on both the mother and newborn. Recent studies have suggested that low levels of vitamin D are associated with poor mood and depression. The aim of this prospective study was to evaluate a possible association between PPD and serum levels of 25-hydroxy vitamin D3 (25 (OH)D3), a reliable measurement of vitamin D, during mid-pregnancy. Study design: The source population consisted of all pregnant women between 24 and 28 gestational weeks from June 2012 to October 2012 at Bornova Health Research and Application Hospital, Sifa University. In order to better evaluate a possible effect between vitamin D levels and PPD, individuals with characteristics that put them at risk for developing PPD were excluded from the study. Serum 25 (OH)D3 levels were evaluated mid-pregnancy in the study group. Serum 25(OH)D3 concentrations <= 20 ng/mL (50 nmol/L) were classified as a mild deficiency and those <= 10 ng/mL (25 nmol/L) were classified as a severe deficiency. Pregnant subjects having complications during birth or with the newborn after delivery were excluded from the study. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess maternal PPD 1 week, 6 weeks, and 6 months after delivery. A Pearson correlation was used to measure the strength of the associations between the EPDS scores and vitamin D levels analyzed during the three time periods. A logistic regression analysis was used to determine the independent effects of vitamin D on PPD. Results: Six hundred and eighty-seven pregnant women were included in this study. After excluding women due to PPD risk factors (in two stages), 179 pregnant women were screened for vitamin D levels during mid-pregnancy and in the 6th month postpartum. Eleven percent of our study group had severe vitamin D deficiency and 40.3% had mild vitamin D deficiency. The frequency of PPD was 21.6% at the 1st week, 23.2% at 6th week, and 23.7% at the 6th month. There was a significant relationship between low 25 (OH)D3 levels in mid-pregnancy and high EPDS scores, which is indicative of PPD for all three follow-up periods (p = 0.003, p= 0.004 and p < 0.001, respectively). In addition, there was a significant negative correlation between vitamin D levels and EDPS at all three time points (r= -0.2, -0.2, -0.3, respectively). Conclusions: Vitamin D deficiency in mid-pregnancy may be a factor affecting the development of PPD. More extensive studies are required to be carried out on this subject. (C) 2014 Elsevier Ireland Ltd. All rights reserved.