Browsing by Author "Gul R."

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    Anaesthetic quality in children during inhalational induction and anaesthesia with sevoflurane or halothane; [COCUKLARDA SEVOFLURAN ILE HALOTANIN ANESTEZI KALITESI YONUNDEN KARSILASTIRILMASI]
    (1997) Erincler T.; Luleci N.; Gul R.; Erbuyun K.; Tutan A.
    Due to its low blood gas partition coefficient (0.69) and its neutral odor, sevoflurane (S) is suitable for inhalational induction of anaesthesia. At the moment halothane (H) is preferentially used for this purpose due to its non-irritating odor and the smoothness of anaesthetic action. However, experience is limited with the use of S in children. Therefore, we compared S and H in an open, randomized trial. 40 children (age 1-10, mean, 5.3 years, ASA class I and II) had anaesthesia induced without premedication (fresh gas flow 6 L/min, N2O/O2=65/35). Concentration of volatile anaesthetics was increased ever 3-5 breats (S: % 0.8....3.2 vol, H: % 0.4....1.6 vol). The ciliary reflex was tested until it disappeared. Airway reflexes and excitation were quantified using a score. Upon venipuncture, relaxation and intubation, anaesthesia was maintained with S (Fi: % 1.8 vol) or H (Fi: % 0.9 vol) in N2O/O2 (3 L/min) E(T)CO2 35-38 mmHg). Alfentanyl was supplemented in repeated doses of 10 μg/kg, ECG, NIBP, SpO2, Fi and Fet of CO2 and volatile anaesthetics were continuously recorded. At the end of surgery anaesthetics were terminated abruptly and fresh gas flow was increased to 6 L/min O2. Time to the first purposeful movement was registered. Time to possible discharge from the PACU was quantified using a modified Aldrete score. Data were analysed with 'Student's t' test or non-parametric tests as appropriate. Groups did not differ with respect to age, weight, sex, or type of surgery. It's concluded that sevoflurane is an alternative to halothane in pediatric inhalational anaesthesia, with a comparable, low incidence of airway irritation and smoothness of induction. Because of the significantly faster induction and recovery it seems superior to halothane.
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    Effects of sevoflurane on the cell division and levels of sister cromatid exchange; [Sevofluran hucre bolunmesi ve kardes kromatid degisimi duzeyleri uzerine etkisi]
    (1999) Solak M.; Erincler T.; Luleci E.; Gul R.; Luleci N.; Fistik T.; Tutan A.
    In this study, the mitotic index (MI) and Sister Cromatid Exchange (SCE) levels were investigated to identify the mutagenic and carcinogenic effects of sevoflurane (sevorane). The data of 20 patients in ASA I-II were studied. All of the patients received an anaesthesia induction with anaesthesia mask and 'tidal volume method. 8 % sevoflurane in 100 % oksigen was used to the induction of anaesthesia and 0.1 mg/kg vecuronium for neuromuscular block and intratracheal intubation. Anaesthesia continued with 2-2.5 sevoflurane, in 60 % N2O and 40 % O2 . Three mL venous blood samples taken before (as controls) 60 minutes, 24 hours and 5 days after the sevoflurane induction, were examined according to the periferic blood culture assay with conventional cytogenetic methods. On the metaphase plaques which obtained in this way, the levels of MI and SCE were examined. As a result, a significant decrease of MI has been found in the test objects at the first 60 minutes of sevoflurane anaesthesia compared to controls (p<0.001). But this depression was smaller after 24 hours (p<0.01) and reversible after 5 days (p>0.05). SCE increased significantly at the first 60 minutes of anaesthesia (p<0.001) was also smaller after 24 hours (p<0.01) and returned to normal levels after 5 days (p>0.05). As conclusion; It has been revealed the effects of sevoflurane on cellular replication and on DNA at the cellular level were repaired in a short period of time. Thus, it has been suggested that sevoflurane had no permanent effect on genetic material of healthy individuals.