Browsing by Author "Guler Aksu G."

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    Novel inflammatory targets for immunotherapies in pediatric patients with trichotillomania
    (Elsevier GmbH, 2020) Kutuk M.O.; Tufan A.E.; Kilicaslan F.; Mutluer T.; Gokcen C.; Karadag M.; Yektas C.; Kandemir H.; Buber A.; Guler Aksu G.; Topal Z.; Giray A.; Celik F.; Acikbas U.; Kutuk O.
    Immune dysregulation may be important in the etiology of obsessive-compulsive and related disordersandbody-focusedrepetitivebehaviors, such as Trichotillomania (TTM). The role of inflammation and inflammatory markers in TTM has received relatively little attention. This study was aimed to determine the expression levels of inflammatory markers (i.e. IL-1β, IL-1α, IL-4, IL-6, IL-17, TNF-α and TGF-β) in peripheral blood mononuclear cells of children with TTM and healthy controls and to evaluate their association with clinical variables. Seventy-seven patients with TTM and 107 healthy controls were enrolled in the study. Peripheral blood was collected in standardized conditions. The mean age of patients and controls did not differ significantly (10.8 ± 4.4 and 12.0 ± 3.2 years; respectively). The majority of patients with TTM and controls were females (n = 55, 71.4 % and n = 55, 51.4 %; respectively); with a greater preponderance of females among TTM. Patients with TTM had significantly elevated expression levels of TNF-α, IL-6 and IL-17 compared to controls. However, the expression level of IL-4 was significantly reduced in TTM patients compared to controls. Accordingly, we found a pro-inflammatory state in TTM and those findings may suggest novel treatment options for TTM and further, cross-disciplinary studies focusing on neuro- inflammation in TTM conducted on larger samples are needed. © 2020 Elsevier GmbH
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    functional outcome in late adolescence/early adulthood of patients with autism spectrum disorder and its relationships with parental burnout and depression: A preliminary multi-center, cross-sectional study
    (Elsevier Ltd, 2023) Kutuk M.O.; Tufan A.E.; Kilicaslan F.; Vural P.; Gokcen C.; Alsen Guney S.; Kutuk B.; Ozyurt G.; Inal N.; Mutluer T.; Acikalin E.Y.; Ozer F.H.; Pamuk E.N.; Yesilmese S.C.; Karadag M.; Hangul Z.; Bilginer C.; Sahin N.; Bilac O.; Kandemir H.; Ercan E.S.; Eseroglu Soylemez T.; Acikel S.B.; Guler Aksu G.; Dag P.; Toros F.; Mutlu C.; Kardas O.; Kardas B.; Kizildag S.; Demirci E.; Ozmen S.; Sevicin L.; Karagoz Y.S.; Isik U.; Aktepe E.; Altun H.; Yektas Ç.; Polat Tuysuz B.; Buber A.; Cansiz M.A.; Ogutlu H.; Eray S.; Taner H.A.; Altintas E.; Kutuk O.
    The aim of this study is to determine the functioning of adults with autism spectrum disorders (ASDs) diagnosed in childhood and depression and burnout levels among their parents. A total of 261 adults with ASDs and their parents were recruited for the study. Both parents completed the Beck Depression and Maslach Burnout Inventories and reported the functioning of their adult offspring with ASDs. Only 5.4 % of our sample reported “good” or “very good” outcomes. The most common psychiatric comorbidities were intellectual disabilities and attention-deficit/hyperactivity disorder. Maternal burnout and depression scores were significantly elevated compared to those of fathers. There is an undeniable urgent need for more research to identify the needs of adults and families suffering from ASD. Modifications for those with ASD may have to be made for support in workplaces, achieving driving licenses, using public transportation and attendance at tertiary education. © 2023 The Authors