Browsing by Author "Gumus B."
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Item The addition of metoclopramide to the PCA with tramadol; [Tramadol ile yapilan PCA'ya metoklopramid eklenmesi](1998) Luleci N.; Erincler T.; Tekin I.; Gumus B.; Erbuyun K.; Tutan A.Nausea and vomiting is a major problem during opioid administrations. In PCA (Patient Controlled Analgesia), sufficient analgesia can be obtained with smaller doses of opioids but nause and vomiting may still a great problem. Addition of antiemetics to opioids in PCA applications is not studied adequately. In this study we added metoclopramide to tramadol hydrochloride (TH) TH for PCA and evaluated its effects on the nausea and vomiting. 36 patients in ASA I-III, were allocated randomly into two groups (each had 18 patients) to receive patient-controlled analgesia with either TH and metoclopramide combination or with TH alone. Bolus doses of TH 20 mg (limited to 200 mg in four hours) alone used in the first and combined with metoclopramide 5 mg in the second group were used with a lockout time of 15 min. During the first 24 h. after surgery the VAS scores and side effects were recorded. The patients in metoclopramide group have significantly lower PAC scores (p<0.05). As a result nausea and vomiting can be reduced by addition of metoclopramide to TH in PCA. The same method maybe used also with of other opioids.Item Histopathologic effect of chronic use of sildenafil citrate on the choroid & retina in male rats(2003) Vatansever H.S.; Kayikcioglu O.; Gumus B.Background & objectives: Sildenafil citrate is an oral medication used to treat male impotence by the inhibition of phosphodiesterase-5 in the corpus cavernosum and subsequent facilitation of penile erection. Though the ocular side effects of sildenafil have been reported, no information is available on the histopathologic effects of chronic use of sildenafil citrate on the ocular vasculature. The present study was undertaken to study the histopathologic effects of chronic use of sildenafil on the retina and choroid of male rats. Methods: Twelve adult male Wistar rats were used in the study. Six of them were given 8 mg/kg/day sildenafil citrate orally on alternate days, the other six rats were used as control. The animals were sacrificed after 4 wk of treatment, and the eyes were fixed in 10 per cent formalin solution and sectioned after embedding in paraffin. Sections were cut, stained with haematoxylin-eosin (HE) or periodic acid Schiff (PAS) and examined under light microscope. The choroidal capillary diameter was also measured. Results: The choroidal capillaries were more dilated in the sildenafil citrate treated group (mean capillary diameter 3.44 ± 1.68 μm versus the control of 1.78±1.36 μm, P<0.001). The retinal layers and their configuration were unchanged in both the groups. Interpretation & conclusion: Chronic use of sildenafil citrate can cause dilatation and congestion in the choroidal vasculature of male rats.Item Doppler sonographic findings in testicular microlithiasis(Brazilian Society of Urology, 2008) Serter S.; Orguc S.; Gumus B.; Ayyildiz V.; Pabucsu Y.Objective: The aim of this prospective study was to compare the resistive index (RI) values, which is a parameter of testicular parenchymal perfusion, in testicular microlithiasis (TM) cases and normal cases. Materials and Methods: 2179 Volunteers, all healthy men (17-42 years of age) from the Annual Army'Reserve Oflicer Training Corps training camp were included in the study. A screening scrotal ultrasound was performed and all men diagnosed, with TM underwent a scrotal Doppler ultrasonography scan (US). US examinations were performed for subjects with TM and without TM as a control group and Rl was determined. Results: 53 men with TM were identified in the 2179 US. Spectral Doppler examination was applied to 50 randomly selected cases (100 testicles) without TM and 92 testicles with TM, 39 cases (78 testicles) with bilateral and 14 cases with unilateral involvement. However, 48 normal testicles (17 bilateral and 14 unilateral) and 47 testicles with TM (15 bilateral and 17 unilateral, 10 of which were cases with bilateral TM) where flow from the centripetal artery could be obtained and analyzed were included in the statistical analysis for resistive indices. There was no significant difference regarding the RI and spectral examinations between subjects with and without TM. An interesting finding was the twinkling artifact observed in three cases. Conclusion: Microliths did not alter the RI values and thus had no influence on testicular perfusion on Doppler US examination.Item Impact of nasal polyposis on erectile dysfunction(2011) Gunhan K.; Zeren F.; Uz U.; Gumus B.; Unlu H.Background: Our male patients with chronic rhinosinusitis with nasal polyposis (NP) declare a better sexual function after functional endoscopic sinus surgery (FESS) with polypectomy. This study was planned to conduct the first prospective, controlled trial evaluating the possible relation between erectile dysfunction (ED) and NP by subjective and objective parameters. Methods: Thirty-three male patients with NP and thirty randomly selected male control subjects were evaluated. All subjects underwent assessments of nasal endoscopy, rhinomanometry, body mass index (BMI), Epworth Sleepiness Scale, full in-laboratory polysomnograpy and serum levels of glucose, thyroid hormones, lipid profile, and testosterone. ED was evaluated by the erectile function domain of the International Index of Erectile Function (IIEF-EF) subjectively and nocturnal penile tumescence (NPT) objectively. The NP group was reassessed 6 months after FESS. Results: The mean age, BMI, and laboratory tests of the patients and the control subjects had no significant difference. The well-recognized risk factors for ED were eliminated. Preoperative evaluation of the patients revealed that ED was present in 34 and 24% of the patients by IIEF-EF and NPT, respectively, which was significantly higher than the control group (p = 0.009 and p = 0.018, respectively). There was a significant improvement of ED in the assessment of IIEF-EF and NPT postoperatively (p = 0.014 and p = 0.037, respectively). Conclusion: ED was determined in a high percentage of patients with NP and significantly ameliorated after FESS. NP might present a risk factor in the development of ED. Copyright © 2011, OceanSide Publications, Inc.Item Long-term effect of microsurgical inguinal varicocelectomy on testicular blood flow(2011) Tarhan S.; Ucer O.; Sahin M.O.; Gumus B.We aimed to investigate the long-term effect of microsurgical inguinal varicocelectomy on testicular blood flow using color Doppler sonography (CDS) in this observational study. A total of 30 patients clinically diagnosed with left varicocele who underwent a microsurgical inguinal varicocelectomy were examined 3 times with CDS for testicular blood flow parameters, first before, then 3 months after, and finally 6 months after the operation. CDS values of testicular blood flow (peak systolic velocity, end diastolic velocity, resistive index, and pulsatility index) were measured from testicular, capsular, and intratesticular arteries. We also evaluated preoperative and postoperative semen parameters. The mean values of blood flow velocities in the left testicular artery (peak systolic and end diastolic) increased and resistance indices (resistive and pulsatility) in the left capsular and intratesticular arteries decreased significantly after surgery (P < .05). No significant difference was detected between the preoperative and postoperative blood flow parameters in the right testicular, capsular, or intratesticular arteries (P < .05). In the semen analysis run 3 months after the operations, statistically significant increases were found in sperm concentration (P < .001), morphology percentage (P < .001), and total motile sperm concentration (P = .009). The increase in blood flow velocity in the testicular artery and the decrease in resistive and pulsatility indices in the capsular and intratesticular branches of the artery may be strong indicators of an increase in testicular arterial blood flow into the testicular tissue. Our data show that a significant improvement occurs in testicular blood supply and sperm parameters after microsurgical inguinal varicocelectomy. Copyright © American Society of Andrology.Item A unique case of bilateral synchronous testicular tumor with concomitant bilateral diffuse intratubular germ cell neoplasia: Testis sparing surgery and local radiotherapy(S. Karger AG, 2012) Yuksel M.B.; Gumus B.; Özbek E.; Nese N.Synchronous bilateral testicular germ cell tumors (TGCTs) are seen in exteremely rare cases. Although there is still no standard therapy for bilateral TGCTs, bilateral orchiectomy is recommended as the gold standard treatment. Nevertheless, it has some long-term problems, such as infertility and psychosocial difficulties, and thus some clinicians prefer to perform testis-sparing surgery in appropriate cases. We reviewed the first case of bilateral synchronous TGCT with concomittant bilateral diffuse intratubular germ cell neoplasia in a young single patient, who was treated by a left radical orchiectomy and right testis sparing-surgery with following local radiotherapy to the right residual testicular tissue with previous semen cryopreservation to maintain the ability to father children. We supposed that testis-sparing surgery can be a feasible therapeutic alternative to radical orchiectomy in patients with bilateral TGCTs in terms of improving the quality of life and continuing fertility and normal hormonal status with no medications. However, while the long-term effects are not yet known, this type of treatment should be perpormed in carefully selected cases with longlife expectancy. © 2012 S. Karger AG, Basel.Item Analysis of radiofrequency ablation of small renal tumors in patients at high anesthetic and surgical risk: Urologist experience with follow-up results in the initial six months(Asian Pacific Organization for Cancer Prevention, 2013) Yuksel M.B.; Karakose A.; Gumus B.; Tarhan S.; Atesci Y.Z.; Akan Z.Background: To evaluate the results of various types of radiofrequency ablation (RFA) treatment of renal tumors in patients with excessive anesthetic and surgical risk. Materials and Methods: Data for RFA performed in in high risk patients were retrospectively evaluated. Other RFA applications in patients with no anesthetic and/or surgical risk were excluded. RFA was by ultrasound or CT guided percutaneous (USG/CT-PRFA) and retroperitoneally or transperitoneally laparoscopic (R/T-LRFA) techniques under general or local anethesia. Follow-up data of enhanced CT or MRI after 1, 3 and 6 months were analysed for twelve RFA applications. Results: The RFA applications included 4 (40%) left-sided, 5 (50%) right-sided and 1 (10%) bilaterally RFA (simultaneously 1 right and 2 left). The localizations of tumors were 2 (16.6%) upper, 5 (41.6%) mid and 5 (41.6%) lower pole. The RFA applications included 9 (75%) USG-PRFA, 1 (8.3%) CT-PRFA, 1 (8.3%) T-LRFA and 1 (8.3%) R-LRFA. The mean age was 65.3±8.5 (52-76) years. The mean tumor size was 29.6±6.08 (15-40) mm. No complications related to the RFA were encountered in any of the cases. Failure (residual tumour) was determined in 8.3% (1/12) of USG-RFA application. The success rate was thus 91.7% (11/12). Other 1st, 3rd and 6th months follow-up data revealed no residua and recurrence. Conclusions: RFA application appears to be safe as a less invasive and effective treatment modality in selected cases of small renal tumors in individuals with excessive anesthetic and also surgical risk.Item A rare complication of prolonged bisphosphonate treatment: The osteonecrosis of jaw in a patient with metastatic prostate cancer(2013) Yuksel M.B.; Gumus B.; Borazan S.; Muezzinoglu T.Bisphosphonates are frequently used for the treatment of bone metastases. We described a 71 years old male with the previous diagnosis of bone metastatic prostate cancer and who underwent hormonotherapy combined with zolendronic acid treatment during 7.5 years and presented the complaints of severe jaw pain and inability of chewing. It was determined that the findings of increased PSA with osteonecrotic area on jaw at radiological imaging. He was urgently diagnosed with the diagnosis of osteonecrosis of jaw related to the long-term zolendronic acid treatment. Bisphosphonate treatment was stopped, and he was treated with conservative treatment, and the disorder was improved by this management. This unclear disorder is required more detailed studies on the terms of ethiology, treatment style, follow-up at the treatment period, and management of complications with the aim of applying these agents more safely.Item The comparison of short term results of transobturatour tape and single incision midurethral sling procedures(Aras Part Medical International Press, 2013) Yuksel M.B.; Kose O.; Karakose A.; Gorgel S.N.; Yılmaz Y.; Gumus B.Objectives: We aimed to evaluate the efficacy of transobturatortape (TOT) and single incision mini sling (SIMS) procedures in the treatment of stress urinary incontinence (SUI).; Materials and Methods: The data of 32 patients who underwent TOT(Promedon®) or SIMS (Ophira®) operations related to SUI between January 2010 - August 2012 were retrospectively evaluated. The sample divided in two groups according to the operation type. The demographical features, preoperative, perioperative, and postoperative data were analysed and compared between two groups to evaluate the efficacy of the operations in SUI. All patients were assessed with a detailed history, physcical examination, cough test, Q-tip test, ultrasonography, postvoiding residual measurement, cystometry and UDI-6, IIQ-7 questionares. Postoperatively, the patients without any incontinence on cough test or sistometry were defined as the success.; Results: The parameters of age, menapousal status, number of vaginal delivery, and body mass index were similar in two groups. The mean operation time was significantly shorter in SIMS group (16±3 vs 27±5, p<0.05). Postoperative succes was not different between two groups (88% , %80 respectively, p>0.05). Postoperative UDI-6 and IIQ-7 scores were 3.5 ± 3.4 vs 3.8 ± 4.8 and 4.4 ± 4.2 vs 5.1 ± 5,6 respectively, and they were similar (p>0.05 in both). In addition, the improvement in these scores were not statistically significant between two groups (p> 0.05 in both).; Conclusion: SIMS procedure is safe and as effective as TOT with shorter operation time in the surgical teratment of female SUI. © 2014 / PMCARAS. All rights reserved.Item The role of stem/progenitor cells and wnt/β-catenin signaling pathway in the patients with prostate cancer(Edizioni Minerva Medica, 2014) Vatansever H.S.; Gumus B.; Aydogdu O.; Sivrikoz O.N.; Türkôz-Uluer E.; Kivanç M.; Ateşçi Y.Z.; Bugdayci H.Aim: The aim of this paper was to investigate the possible effect of cancer stem cells (CSCs) and relationship with Wnt/β-catenin signaling pathway progressing of prostate cancer. Methods: Thirty men with a pathological diagnosis of benign prostate hyperplasia (BPH) (group 1, N.=10), prostate cancer with a gleason score of ≤6 (group 2, N.=10), and prostate cancer with a gleason score of >6 (group 3, N.=10) were included in the study. The patients' groups were compared in terms of immunoreactivity strength of prostatic stem/progenitor cell surface markers including CD133 and CD117. We also compared the immunoreactivity of Wnt7a, a part of Wnt signaling pathway which has a potential role in the progression of several cancers including prostate cancer. The immunoreactivity of Frizzled 6 (Fzd 6) which is the receptor of Wnt family was also evaluated in all groups. Results: Immunohistochemical analyses demonstrated that although CD 133 immunoreactivity was positive in all groups, immunoreactivity was significantly stronger in group 3 when compared to other groups. While CD117 immunoreactivity was negative in group 1 and 2, it was positive in group 3. Wnt7a immunoreactivity was weak in all groups and Fzd 6 immunoreactivity was stronger in group 1 and 3 when compared to group 2. Conclusion: Our findings demonstrated that CSCs and Wnt signaling pathway have a potential role in the development and progression of prostate cancer.Item The analysis of the efficacy and safety of transobturator sling operation by using an adjustable sling device in the treatment of stress urinary incontinence(Aras Part Medical International Press, 2014) Temeltas G.; Yuksel M.B.; Tatlı V.; Gumus B.Objectives: We aimed to evaluate the safety and efficacy of a transobturator sling (TOT) procedure by using an adjustable TOT device in the treatment of stress urinary incontinence (SUI).; Materials and Methods: The data of 89 patients who had the diagnosis of SUI and underwent TOT operation by using an adjustable MUS device of SAFYRE t plus (Promedon®) between June 2005-November 2012, were retrospectively evaluated. The pateints were evaluted by the parametres of physical examination, stress test, ultrasonography, uroflowmetry, residual urine measurement, cystometry, subjective incontinence scoring (VASi), patients' satisfaction scoring (VASs), and ICQ-SF questionare. The preoperative, perioperative, and postoperative collected data were statistically analysed to determine the efficacy and safety of TOT application by using SAFYRE t plus.; Results: The mean age, account of parity, and body mass index was 55.3±10.1, 2.34 ± 1.43, and 24.97 ± 3.7, respectively. While the pre- and postoperative results of stress test, VASi, and ICIQ-SF scores were significantly different (P=0.00 in all), the pre- and postoperative results of Qmax and PVR account were similar (P= 0.84, P= 0.79, respectively). The severity of subjective incontinence (VASi score) significantly improved after the operation. The mean VASs score at postoperative 12th month was 7.75±1.11. The subjective and objective cure rates were %89.9 (80/89) and %78.6 (70/89), respectively.; Conclusion: The TOT operation by using SAFYRE t plus, which was an adjustable sling device, seemed to be an efficient, reasonably safe, minimally invasive treatment alternative for the surgical management SUI in women. © 2014 / PMCARAS . All rights reserved.Item Can cancer detection rate increase when transrectal biopsies were taken from the laterally?(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Karakose A.; Yuksel M.B.; Pirincci N.; Gorgel S.N.; Atesci Y.Z.; Gumus B.Acording to general opinion when biopsy is taken from the prostate’s lateral peripheral zone. More cancer is seen. In our study, the incidence of cancer in the lateral peripheral zone biopsies was investigated. In our study, 93 patients were analyzed retrospectively transrectal prostate biopsy. 12 core biopsies were taken from each patient. Medial peripheral zone (MPZ) and lateral peripheral zone (LPZ) biopsies compared the detection of prostate cancer. The average age of the patients was 67.2±10.3. Total PSA value in patients was found as 13.7 ng/mL. Prostate cancer was detected at the rate of 22.5% (21 patients) in 93 patients. 3 patients (14.3%) had prostate cancer in MPZ and 8 patients (38%) had prostate cancer in LPZ. Prostate cancer was detected at MPZ and LPZ at the rate of 47.7% (10 patients) in patients. Prostate cancer was more commonly detected in LPZ (p<0.05). Prostate biopsies of the LPZ biopsies more commonly cancer is seen. We believe it will increase the capture rate for prostate cancer if a sufficient number of biopsies were taken from the LPZ. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item The effect of antibiotherapy on high serum PSA levels(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Karakose A.; Yuksel M.B.; Pirincci N.; Gorgel S.N.; Atesci Y.Z.; Gumus B.This study investigated the effect of antibiotics in patients with PSA value high than 4 ng/mL on tPSA, fPSA and fPSA/tPSA ratio without missing cancer and avoiding unnecessary biopsies. A total of 96 patients were included into the study with detected high level than 4 ng/mL serum PSA. Patients were divided into 2 groups according to the high level of PSA value. Group 1 included 49 patients with PSA level between 4-10 ng/mL. Group 2 included 47 patients with PSA level higher than 10 ng/mL. Patients were treated with Ciprofloxacin (500mg b.i.d.) orally for 2 weeks. All patients' PSA levels were evaluated and analyzed before and after antibiotic treatment. Statistical analyses were performed with SPSS version 18. A p value <0.05 was considered as significant. The mean age was 61.6 ±5.7 (51-75) years in group 1 and 63.1 ±8.7 (55-74) years in group 2. Suspicious DRE findings were significantly high in group 2. The mean tPSA values were 6.82±0.42 and 5.93±0.36 before and after antibiotic treatment in group 1 respectively. There was no significant differences in tPSA value before and after antibiotic treatment in group 1. The mean tPSA values were 32.53±8.23 and 11.72±5.61 before and after antibiotic treatment in group 2 respectively. The mean tPSA value decreased significantly after antibiotic treatment in group 2. Prostate cancer was detected in 32 patients after TRUS guided prostate biopsy. Prostate cancer was identified in 13 patients in group 1 and 19 patients in group 2. Antibiotic treatment in patients with PSA levels higher than 10 ng/mL is effective on prostate biopsy decision and antibiotic treatment can prevent unnecessary prostate biopsies. © 2015 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item The long-term results of temporary urethral stent placement for the treatment of recurrent bulbar urethral stricture disease(Brazilian Society of Urology, 2016) Temeltas G.; Ucer O.; Yuksel M.B.; Gumus B.; Tatli V.; Muezzinoglu T.Aim: To evaluate the long term outcomes of temporary urethral stent placement for the treatment of recurrent bulbar urethral stricture. Materials and Methods: Twenty-eight patients who underwent temporary polymer coated urethral stent placement due to recurrent bulbar urethral stricture between 2010 and 2014 were enrolled in the study. The long term outcomes of the patients were analyzed. Results: The mean age of the patients was 62.3±6.4 (44-81). The overall clinical success was achieved in 18 (64.2%) of the 28 patients at a median (range) follow-up of 29 (7-46) months. No patient reported discomfort at the stent site. Stone formation was observed at the urethral stent implantation area only in one patient. Stenosis occurred in the distal end of the stents in two patients and took place in bulbar urethra in seven patients after removed the stents. The mean maximum urine flow rates were 6.24±2.81mL/sec and 19.12±4.31mL/sec before and at 3 months after the procedure, respectively. Conclusion: In this study, the success rate of temporary urethral stent placement has remained at 64.2% at a median follow-up of 29 months. Therefore, our outcomes have not achieved desired success rate for the standard treatment of recurrent bulbar urethral stricture.Item Comparison of pain, quality of life, lower urinary tract symptoms and sexual function between flexible and rigid cystoscopy in follow-up male patients with non muscle invasive bladder cancer: A randomized controlled cross section single blind study(John Wiley and Sons Inc, 2021) Ucer O.; Temeltas G.; Gumus B.; Muezzinoglu T.Objectives: To compare pain, quality of life (QoL), sexual function and lower urinary tract symptoms (LUTS) between rigid (RC) and flexible cystoscopy (FC). Methods: Forty-one patients who were planned control cystoscopies were enrolled the study. At the first cystoscopy, 20 patients (Group 1) and other 21 patients (Group 2) were performed by flexible (15.5 Fr) and rigid cystoscope (15.5 Fr), respectively. At the second cystoscopies, the patients in group 1 and group 2 were performed by rigid and flexible cystosacope, respectively. In all the patients, pain was measured with visual pain scale (VPS) shortly after cystoscopy. Also, SF, QoL and LUTS were assessed by IIEF, SF-36 and MLUTS forms, respectively. Results: While 22 of the patients preferred FC, the other 19 preferred RC (P > 0.05). There were no statistical differences between VPS, IIEF, SF-36 and MLUTS scores of the two groups. In multivariate analysis regarding the quality of life, although sexual function, pain and cystoscopy type did not affect QoL, voiding symptoms affected independently QoL. After both cystoscopy type, IIEF, SF-36 and MLUTS scores did not change statistically. Conclusion: The results showed that the effects on pain, sexual function, QoL and LUTS of RC and FC were similar. In general, cystoscopy did not affect negatively on QoL, sexual function and LUTS of the patients. © 2020 John Wiley & Sons LtdItem Comparison stone-free rate and effects on quality of life of percutaneous nephrolithotomy and retrograde intrarenal surgery for treatment of renal pelvis stone (2-4cm): A prospective controlled study(Lippincott Williams and Wilkins, 2022) Ucer O.; Erbatu O.; Albaz A.C.; Temeltas G.; Gumus B.; Muezzinoglu T.Objectives: The aim of our study was to compare the effects on quality of life (QoL) and stone-free rate (SFR) of percutaneous nephrolithotomy (PNL) and retrograde intrarenal surgery (RIRS) in patients with renal stones 2-4cm. Materials and methods: A total of 102 patients with renal pelvis stones were enrolled in this prospective controlled study, of which 52 were performed RIRS and 50 with PNL. The QoL was evaluated by using Short From-36 pre- and post-operatively. Also, the surgical data of all patients during and after the operations were compared between the 2 groups. Results: The mean age, body mass index, stone size and density of the patients in the 2 groups were statistically similar (p>0.05). The SFR of PNL and RIRS were found 94% (47/50) and 73% (38/52), respectively (p<0.01). There were no statistically differences between operation times, minor complication rates and Short From-36 scores of the 2 groups. Hospitalization times were 1.13± 0.34days for RIRS and 2.9±5.7days for PNL (p<0.05). While the blood transfusion rate of PNL group was 8% (4/50), none patient was made blood transfusion in RIRS. Conclusions: The results of our study show that the blood transfusion rates and hospitalization times of RIRS group are significantly lower than PNL for management of renal pelvis stone 2-4cm. Despite these advantages of RIRS, the SFR is significantly lower than PNL for these stones. The effects on QoL of the both interventions before and after surgery were similar. © 2022 S. Karger AG. All rights reserved.Item The Relationship of Testicular Sonoelastography with Gonadotropin Hormone Levels and Sperm Parameters(Wolters Kluwer Medknow Publications, 2023) Bozkurt Y.; Gumus B.; Ozbay M.; Duzgun F.; Taneli F.; Kurutep S.Background: Elastography is a non-invasive medical imaging technique that helps determine the stiffness of organs and other structures in our body. In this study, we investigated the effectiveness of elastography in the diagnosis of infertility. Aim: In this study, we aimed to examine the relationship between testicular elastography and hormonal parameters and sperm parameters. Patients and Methods: The study included 136 patients, 272 testicles were examined, and the mean age of the study participants was 30.1 years. Testicular tissue stiffness was measured by scrotal ultrasonographic shear wave elastography. Gonadotropin and testosterone hormones were measured from blood samples. Spermiogram parameters were studied manually. Results: The control group included 66 patients, and the varicocele group consisted of 70 patients. Testicular stiffness degrees of the control group were measured as 4.29 kPa for the right testis and 4.23 kPa for the left testis. The varicocele group was divided into grades 1, 2, and 3 according to physical examination. In group 1 (grade 1), the right testis was 4.07 ± 1.24 kPa and the left testis was 3.77 ± 0.98 kPa. In group 2 (grade 2), the right testis was 4.31 ± 1.40 kPa and the left testis was 3.98 ± 0.93 kPa. In group 3 (grade 3), the right testis was 4.73 ± 1.50 kPa and the left testis was 3.99 ± 1.68 kPa. Hormone and sperm parameters were not statistically significant when comparing the control and varicocele groups. There was no statistical significance between the testicular tissue stiffness degrees of the control and varicocele groups. Hormone and spermiogram findings were also similar in groups. Conclusion: It is known that varicocele leads to histological tissue changes in the testes. These changes result in tissue softness and loss while affecting sperm parameters and testosterone levels in a negative way. Before varicocele surgery, there is a need for new imaging methods with more sensitivity that can detect tissue changes in the testes. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.