Browsing by Author "Gunes S."

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    Association of intra-tumoral tumour-infiltrating lymphocytes and neutrophil-to-lymphocyte ratio is an independent prognostic factor in non-small cell lung cancer
    (Blackwell Publishing Ltd, 2017) Dirican N.; Karakaya Y.A.; Gunes S.; Daloglu F.T.; Dirican A.
    Background: Studies suggest that tumour-infiltrating lymphocytes (TILs) and inflammation markers have independent roles in non-small cell lung cancer (NSCLC), but the relationship between the two pronostic factors remains unclear. In this study, we investigated TILs and inflammation markers in with patients advanced stage NSCLC and assessed the association of their levels with prognosis. Materials and Methods: TILs were evaluated by immunohistochemical staining for cluster of differentiation 3 (CD3) and cluster of differentiation 5 (CD5) and by hematoxylin and eosin staining for non-specific lymphocyte. We investigated the localisation pattern of TILs in advanced stage NSCLC. We divided all cases into two groups: TILs-high and TILs-low groups, by 75th percentile of the population of. In our study, inflammation markers were assessed by C-reactive protein (CRP) and the neutrophil-to-lymphocyte ratio (NLR). Results: The results showed that the presence of intra-tumoral high CD3+ and low CD5+ were an independent prognostic factor for overall survival (respectively, P = 0.022 and P = 0.025). Moreover, the high NLR and serum high CRP levels were associated with poor survival (respectively, P = 0.008; P = 0.027). In multi-variate survival analysis, the high CD3+, low CD5+, high NLR, tumour node metastasis (TNM) stage, depth of tumour invasion and lymph node metastasis remained independent prognostic factors (respectively, P = 0.018, P = 0.020, P = 0.024, P = 0.038, P = 0.020 and P = 0.047).The high NLR was detected negative correlation with intra-tumoral CD3+ and positive correlation with intra-tumoral CD5+ (respectively, r = −0.623, P = 0.012; r = 0.628, P = 0.028). Conclusions: This study is first report demonstrating the prognostic value of intra-tumoral low CD5+ with NSCLC. Increased CD3+ and low CD5+ was observed in patients with poor prognosis; the two molecules were correlated with NLR, suggesting that inflammation might be used as improve therapeutic efficacy to immunotherapy for advanced NSCLC. © 2015 John Wiley & Sons Ltd
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    Prevalence of Childhood Affective disorders in Turkey: An epidemiological study
    (Elsevier B.V., 2018) Karacetin G.; Arman A.R.; Fis N.P.; Demirci E.; Ozmen S.; Hesapcioglu S.T.; Oztop D.; Tufan A.E.; Tural U.; Aktepe E.; Aksu H.; Ardic U.A.; Basgul S.; Bilac O.; Coskun M.; Celik G.G.; Demirkaya S.K.; Dursun O.B.; Durukan I.; Fidan T.; Gencoglan S.; Gokcen C.; Gokten E.S.; Gorker I.; Gormez V.; Gundogdu O.Y.; Gurkan C.K.; Herguner S.; Kandemir H.; Kilic B.G.; Kilincaslan A.; Mutluer T.; Nasiroglu S.; Ozcan O.O.; Ozturk M.; Sapmaz S.Y.; Suren S.; Sahin N.; Tahiroglu A.Y.; Toros F.; Unal F.; Vural P.; Yazici I.P.; Yazici K.U.; Yildirim V.; Yulaf Y.; Yuce M.; Yuksel T.; Akdemir D.; Altun H.; Ayik B.; Bilgic A.; Bozkurt O.H.; Cakir E.D.; Ceri V.; Demir N.U.; Dinc G.; Irmak M.Y.; Karaman D.; Kinik M.F.; Mazlum B.; Memik N.C.; Ozdemir D.F.; Sinir H.; Tasdelen B.I.; Taskin B.; Ugur C.; Uran P.; Uysal T.; Uneri O.S.; Yilmaz S.; Yilmaz S.S.; Acikel B.; Aktas H.; Alaca R.; Alic B.G.; Almbaidheen M.; Ari F.P.; Aslan C.; Atabay E.; Ay M.G.; Aydemir H.; Ayranci G.; Babadagi Z.; Bayar H.; Bayhan P.C.; Bayram O.; Bektas N.D.; Berberoglu K.K.; Bostan R.; Cakan Y.; Canli M.A.; Cansiz M.A.; Ceylan C.; Coskun N.; Coskun S.; Demir I.; Demir N.; Demirdogen E.Y.; Dogan B.; Donmez Y.E.; Donder F.; Efe A.; Eray S.; Erbilgin S.; Erden S.; Ersoy E.G.; Eseroglu T.; Firat S.K.; Gok E.E.; Goksoy S.C.; Guler G.; Gules Z.; Gunay G.; Gunes S.; Gunes A.; Guven G.; Horozcu H.; Irmak A.; Isik U.; Kahraman O.; Kalayci B.M.; Karaaslan U.; Karadag M.; Kilic H.T.; Kilicaslan F.; Kinay D.; Koc E.B.; Kocael O.; Mutlu R.K.; San Z.; Nalbant K.; Okumus N.; Ozbek F.; Ozdemir F.A.; Ozdemir H.; Ozgur B.G.; Ozkan S.; Ozyurt E.Y.; Polat B.; Polat H.; Sekmen E.; Sertcelik M.; Sevgen F.H.; Sevince O.; Shamkhalova U.; Suleyman F.; Simsek N.E.; Tanir Y.; Tekden M.; Temtek S.; Topal M.; Topal Z.; Turk T.; Ucar H.N.; Ucar F.; Uygun D.; Uzun N.; Vatansever Z.; Yazgili N.G.; Yildiz D.M.; Yildiz N.; Ercan E.S.
    Aim: To determine the prevalence of affective disorders in Turkey among a representative sample of Turkish population. Methods: This study was conducted as a part of the “The Epidemiology of Childhood Psychopathology in Turkey” (EPICPAT-T) Study, which was designed by the Turkish Association of Child and Adolescent Mental Health. The inclusion criterion was being a student between the second and fourth grades in the schools assigned as study centers. The assessment tools used were the K-SADS-PL, and a sociodemographic form that was designed by the authors. Impairment was assessed via a 3 point-Likert type scale independently rated by a parent and a teacher. Results: A total of 5842 participants were included in the analyses. The prevalence of affective disorders was 2.5 % without considering impairment and 1.6 % when impairment was taken into account. In our sample, the diagnosis of bipolar disorder was lacking, thus depressive disorders constituted all the cases. Among depressive disorders with impairment, major depressive disorder (MDD) (prevalence of 1.06%) was the most common, followed by dysthymia (prevalence of 0.2%), adjustment disorder with depressive features (prevalence of 0.17%), and depressive disorder-NOS (prevalence of 0.14%). There were no statistically significant gender differences for depression. Maternal psychopathology and paternal physical illness were predictors of affective disorders with pervasive impairment. Conclusion: MDD was the most common depressive disorder among Turkish children in this nationwide epidemiological study. This highlights the severe nature of depression and the importance of early interventions. Populations with maternal psychopathology and paternal physical illness may be the most appropriate targets for interventions to prevent and treat depression in children and adolescents. © 2018