Browsing by Author "Gur, EB"

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    Mid-pregnancy vitamin D levels and postpartum depression
    Gur, EB; Gokduman, A; Turan, GA; Tatar, S; Hepyilmaz, I; Zengin, EB; Eskicioglu, F; Guclu, S
    Objectives: Postpartum depression (PPD) is a common disorder that affects 10-15% of postpartum women, and it can have negative effects on both the mother and newborn. Recent studies have suggested that low levels of vitamin D are associated with poor mood and depression. The aim of this prospective study was to evaluate a possible association between PPD and serum levels of 25-hydroxy vitamin D3 (25 (OH)D3), a reliable measurement of vitamin D, during mid-pregnancy. Study design: The source population consisted of all pregnant women between 24 and 28 gestational weeks from June 2012 to October 2012 at Bornova Health Research and Application Hospital, Sifa University. In order to better evaluate a possible effect between vitamin D levels and PPD, individuals with characteristics that put them at risk for developing PPD were excluded from the study. Serum 25 (OH)D3 levels were evaluated mid-pregnancy in the study group. Serum 25(OH)D3 concentrations <= 20 ng/mL (50 nmol/L) were classified as a mild deficiency and those <= 10 ng/mL (25 nmol/L) were classified as a severe deficiency. Pregnant subjects having complications during birth or with the newborn after delivery were excluded from the study. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess maternal PPD 1 week, 6 weeks, and 6 months after delivery. A Pearson correlation was used to measure the strength of the associations between the EPDS scores and vitamin D levels analyzed during the three time periods. A logistic regression analysis was used to determine the independent effects of vitamin D on PPD. Results: Six hundred and eighty-seven pregnant women were included in this study. After excluding women due to PPD risk factors (in two stages), 179 pregnant women were screened for vitamin D levels during mid-pregnancy and in the 6th month postpartum. Eleven percent of our study group had severe vitamin D deficiency and 40.3% had mild vitamin D deficiency. The frequency of PPD was 21.6% at the 1st week, 23.2% at 6th week, and 23.7% at the 6th month. There was a significant relationship between low 25 (OH)D3 levels in mid-pregnancy and high EPDS scores, which is indicative of PPD for all three follow-up periods (p = 0.003, p= 0.004 and p < 0.001, respectively). In addition, there was a significant negative correlation between vitamin D levels and EDPS at all three time points (r= -0.2, -0.2, -0.3, respectively). Conclusions: Vitamin D deficiency in mid-pregnancy may be a factor affecting the development of PPD. More extensive studies are required to be carried out on this subject. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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    Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus
    Gur, EB; Karadeniz, M; Genc, M; Eskicioglu, F; Yalcin, M; Hepyilmaz, I; Guclu, S
    Objective: To investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies. Subjects and methods: This study included 200 pregnant women. 25-hydroxyvitamin D-3 (25(OH)D-3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D-3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D-3 level in different MPV percentile (<= 50, 50-75, 75-90, >= 90 percentile) and MPV value in different 25(OH)D-3 level (<= 10, 10-20, >= 20 ng/mL) were calculated. Results: Low 25(OH)D-3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D-3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D-3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D-3 level in GMD group (p = 0.04). The optimal 25(OH)D-3 cut off point for predicting future cardiovascular risk was 10.4 ng/mL (area under curve (AUC) = 0.58). Conclusions: Vitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM.
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    Diagnostic Modalities in Premature Rupture of Membranes
    Eskicioglu, F; Gur, EB
    Objectives: Rupture of membranes prior to the onset of labor is known as Premature Rupture of Membranes ( PROM). Early and correct diagnosis is crucial in order to prevent fetal and maternal risks that can be life threatening. We aimed to investigate the diagnostic ability of the tests in PROM. Materials and Methods: Nitrazine test, fern test, amnio-dye test, biochemical tests (insulin-like growth factor binding protein-1 and placental alpha microglobulin-1) were evaluated in terms of effectiveness in diagnosis of PROM. Results: A gold standard method has not yet been defined in PROM. Diagnostic tests (nitrazine test, fern test, Insulin-like Growth Factor Binding Protein-1 IGFBP-1 and Placental Alpha Microglobulin-1 PAMG-1) should be used when the diagnosis is not certain following history, examination with sterile speculum and ultrasonography evaluation. Conclusion: IGFBP-1 and PAMG-1 are tests based on bedside immunochromatographic method. Especially, PAMG-1 comes into prominence with its high sensitivity and specificity.
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    Prophylactic vitamin D supplementation in ovarian hyperstimulation syndrome: an animal study (vol 292, pg 421, 2015)
    Turan, GA; Eskicioglu, F; Sivrikoz, ON; Cengiz, H; Gur, EB; Tatar, S; Sahin, N; Yilmaz, O
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    Prophylactic vitamin D supplementation in ovarian hyperstimulation syndrome: an animal study
    Turan, GA; Eskicioglu, F; Sivrikoz, ON; Cengiz, H; Gur, EB; Tatar, S; Sahin, N; Yilmaz, O
    To investigate the effect of vitamin D in ovarian hyperstimulation syndrome (OHSS). In this animal study, 28 immature female Wistar rats were divided into four groups: group 1 (control); group 2 (ovarian stimulation); group 3 (OHSS group); group 4 (OHSS + vitamin D group). All groups were killed 48 h after hCG administration and were compared in terms of vascular permeability, ovarian weight, ovarian diameter, vascular endothelial growth factor (VEGF) expression (immunohistochemistry) in ovarian tissue and pigment epithelium-derived factor (PEDF) level in the serum (ELISA test) with the Kruskal-Wallis and Mann-Whitney U tests. VEGF expression in the vitamin D group was similar to that in the OHSS group. However, the PEDF level was significantly higher in the vitamin D group (p = 0.013). Prophylactic vitamin D supplementation is not sufficiently effective in preventing OHSS. Vitamin D effectively increases PEDF, which has an opposing effect on VEGF, which plays a key role in OHSS. Thus, the protective effect of Vitamin D on OHSS should be investigated with a vitamin D deficient model in the study group.
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    Myo-inositol is a promising treatment for the prevention of ovarian hyperstimulation syndrome (OHSS): an animal study (vol 292, pg 1163, 2015)
    Turan, GA; Eskicioglu, F; Sivrikoz, ON; Cengiz, H; Adakan, S; Gur, EB; Tatar, S; Sahin, N; Yilmaz, O
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    The effect of vitamin D level in pregnancy on postpartum depression
    Gur, EB; Genc, M; Eskicioglu, F; Kurtulmus, S; Guclu, S
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    The relationship between uterine prolapse and premalignant endometrial pathology
    Genc, M; Celik, E; Eskicioglu, F; Gur, EB; Kurtulmus, S; Gulec, E; Guclu, S
    Objective: The aim of this study was to stress the importance of performing a thorough uterine assessment before selecting an organ sparing surgery in patients presenting with uterine prolapse and no other complaints. Materials and Methods: This study included a total of 111 participants who presented with pelvic organ prolapse and underwent hysterectomy for grades 3-4 uterine prolapse. The post-hysterectomy histopathology results were classified as benign (atrophic endometrium, proliferative or secretory endometrium) or patho-logic (endometrial hyperplasia, endometrial polyp, adenomyosis, myoma uteri, and endometrium carcinoma). Results: Of the 111 patients enrolled in this study, 23 (20.2%) had endometrial hyperplasia, eight (7.2%) had endometrial polyps, 30 (27%) had uterine fibroids, and 20 (18%) had adenomyosis. Conclusion: There may be premalignant lesions of the endometrium in both premenopausal and postmenopausal women presenting with uterine prolapse and no other symptoms. A chronic inflammatory process resulting from the extra-vaginal location of the uterus may play a role in the development of these lesions. Further studies are needed on this subject.