Browsing by Author "Gurhan I."

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    The influence of ion implantation on cell attachment to glassy polymeric carbon
    (American Institute of Physics Inc., 2006) Zimmerman R.; Gurhan I.; Ozdal-Kurt F.; Sen B.H.; Rodrigues M.; Ila D.
    In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that near surface implantation of silver in Glassy Polymeric Carbon (GPC) can completely inhibit cell attachment on implanted areas while leaving adjacent areas unaffected. Patterned ion implantation permits precise control of tissue growth on medical applications of GPC. We have shown that silver ion implantation or argon ion assisted surface deposition of silver inhibits cell growth on GPC, a desirable improvement of current cardiac implants. © 2006 American Institute of Physics.
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    Patterning of cell attachment to biocompatible glassy polymeric carbon by silver ion implantation
    (Materials Research Society, 2006) Zimmerman R.L.; Gurhan I.; Ila D.; Ozdal-Kurt F.; Sen B.H.; Rodrigues M.
    Although Glassy Polymeric Carbon (GPC) is ideally suited for implants in the blood stream, tissue that normally forms around the moving parts of a GPC heart valve. There is concern that the tissue lose adhesion and create the condition for embolisms downstream. We have shown that silver ion implantation or argon ion assisted surface deposition of silver inhibits cell growth on GPC, a desirable improvement of current cardiac implants. In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that near surface implantation of silver in GPC can completely inhibit cell attachment on implanted areas while leaving adjacent areas unaffected. Patterned ion implantation permits precise control of tissue growth on medical applications of GPC. © 2006 Materials Research Society.
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    Investigation of cell growth on ion beam patterns on GPC surface
    (2009) Zimmerman R.; Muntele C.; Gurhan I.; Ozdal-Kurt F.; Sen B.H.; Rodrigues M.; Ila D.
    We have used implanted silver ions near the surface of Glassy Polymeric Carbon (GPC) to completely inhibit cell attachment and adhesion to GPC. The effect improves the safety and function of the GPC heart valve exposed to the blood stream. The strength, durability and low density make GPC a favored material for in vivo medical applications, including transcutaneous electrodes and replacement heart valves. However, the possible release of endothelial tissue that forms on the smooth surfaces of the GPC heart valve has the potential of creating an embolism. We have shown that L929 endothelial cells avoid silver implanted areas of GPC but attach and strongly adhere to areas close to silver implanted surfaces. Patterned ion implantation permits precise control of tissue growth on GPC and other biocompatible substrates. Cell growth inhibited by silver ion implanted patterns on an otherwise biocompatible substrate may be useful for in vitro studies of the way that cells sense and move away from inhospitable environments. © 2009.