Browsing by Author "Guvenc G."

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    Does the anti-migraine drug rizatriptan affect early neural tube development in chick embryos?
    (Turkish Neurosurgical Society, 2019) Sayin M.; Gurgen G.S.; Sayin S.S.; Guvenc G.; Yuceer N.
    AIM: To investigate the impact of rizatriptan on neural tube development using early chick embryos as a model organism. MATERIAL and METHODS: A total of 36 pathogen-free Leghorn chicken eggs were selected and categorized in three groups: sham, therapeutic, and supra-therapeutic. After 24 hours, the eggs were opened and injected with sterile drugs, and then reclosed using plastic tape. After a period of 72 hours, the eggs were opened and assessed using the Hamburger-Hamilton chick embryology classification method. TUNEL staining was used to identify apoptosis, and hematoxylin-eosin staining was used to investigate neural tube closure. RESULTS: Treatment with rizatriptan significantly slowed down neural tube development. The supra-therapeutic group showed neural tube closure defects. CONCLUSION: Rizatriptan had a negative effect on neural tube closure. Further research is needed to identify a safe and effective drug for treating migraines during pregnancy. © 2019 Turkish Neurosurgical Society.