Browsing by Author "Icli, A"

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    Increased Mean Platelet Volume in Hypertrophic Cardiomyopathy
    Icli, A; Aksoy, F; Dogan, A; Arslan, A; Akcay, S; Yücel, H; Ersoy, I; Gorgulu, O
    Thromboembolic events may be seen in patients with hypertrophic cardiomyopathy (HCM). We investigated the mean platelet volume (MPV), an indicator of platelet activation in patients with HCM. This study included 112 patients with HCM, in which 40 were patients with hypertrophic obstructive cardiomyopathy (HOCM), and 106 were control participants. The MPV was significantly higher in patients with HCM than in controls (9.1 +/- 0.3 vs 7.9 +/- 0.3 fL, P = .01). In the subgroup analyses, MPV was also higher in patients with HOCM compared to those with hypertrophic nonobstructive cardiomyopathy (HNCM; 9.3 +/- 0.3 vs 9.0 +/- 0.2 fL, P = .01). Similarly, patients with HNCM had higher MPV values than controls (9.0 +/- 0.2 vs 7.9 +/- 0.3 fL, P = .01). The MPV was significantly and positively correlated with left ventricular outflow tract (LVOT) obstruction (r = .42, P = .001) and septal thickness (r =.62, P = .001). In linear regression analysis, MPV was independently associated only with septal thickness (beta = .07, 95% confidence interval: 0.04-0.09, P = .001). The MPV can be elevated in patients with HCM regardless of the obstruction of LVOT and may be associated with the severity of septal thickness.
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    Plasma lipoprotein(a) levels in patients with slow coronary flow
    Yucel, H; Dogan, A; Altinbas, A; Akcay, S; Icli, A; Ceyhan, BM
    Introduction: Slow coronary flow (SCF) is a microvascular disorder characterized by delayed opacification of coronary vessels with normal coronary angiogram. It may be due to endothelial dysfunction and diffuse atherosclerosis. Lipoprotein(a) [Lp(a)] is related to cardiovascular events. Plasma Lp(a) levels have not been studied previously in SCF patients. Aim: We investigated plasma Lp(a) and fibrinogen levels, and their relation to coronary flow rate in patients with SCE Material and methods: This cross-sectional study included 50 patients with SCF and 30 age- and sex-matched controls who had normal coronary arteries and normal flow. Coronary flow rates of patients and controls were counted with the thrombolysis in myocardial infarction (TIMI) frame count. Plasma Lp(a) and fibrinogen levels were measured in SCF patients and controls, with routine biochemical tests. Results: There were no significant differences between the two groups with respect to plasma Lp(a) (21 mg/dl vs. 14 mg/dl, p = 0.11) and fibrinogen (278 mg/dl vs. 291 mg/dl, p = 0.48) levels. The TIMI frame count was not correlated with plasma Lp(a) (r = 0.13, p = 0.25) or fibrinogen (r = -0.14, p = 0.28) levels. Conclusions: Our results show that there is no significant association between SCF and Lp(a) and fibrinogen levels.
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    Evaluation of the Apolipoprotein B R3500Q Gene Mutation in Nonvalvular Atrial Fibrillation with Ischemic Stroke in Turkish Population
    Icli, A; Erten, N; Sütcü, R; Akcay, S; Yasar, E; Yücel, H; Aksoy, F; Arslan, A