Browsing by Author "Ilhan H.A."

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    Cytotoxic and antitumor compounds from marine invertebrates
    (wiley, 2020) Ilhan H.A.; Pulat C.C.
    The marine environment covers a vast part of the biosphere's surface. Marine invertebrates, which include tunicates, sponges, bryozoans, and mollusks, represent the core of the known marine biodiversity, since there are more of them than all organisms in the sea. Recent advances in aquaculture, deep-sea collection techniques, biotechnology, and high-throughput screening methods allow the isolation of various cytotoxic and antitumor marine compounds with novel mechanisms of action. The phylum Porifera, commonly referred to as sponges, are frequently considered to be the simplest multicellular animals with great ecological, commercial, and biopharmaceutical importance. Cnidarians are well-known producers of secondary metabolites and complex mixtures of proteinaceous venoms used for defense. This chapter overviews some of the most promising bioactive compounds isolated from cnidarians. The phylum Mollusca represents the second-largest animal phylum on Earth with eight classes. They have evolved alternative defense strategies such as antibacterial, antifungal, and antiviral secondary metabolites to protect themselves. © 2020 John Wiley & Sons Ltd All rights reserved.
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    Gingival crevicular fluid galectin-3 and interleukin-1 beta levels in stage 3 periodontitis with grade B and C
    (Springer Science and Business Media Deutschland GmbH, 2023) Afacan B.; Ilhan H.A.; Köse T.; Emingil G.
    Objectives: This study aims to evaluate GCF Galectin-3 and Interleukin-1 beta (IL-β) levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in periodontal diseases. Materials and methods: A total of 80 systemically healthy and non-smoker individuals, 20 stage 3 grade C (S3GC) periodontitis 20 stage 3 grade B (S3GB) periodontitis, 20 gingivitis, and 20 periodontally healthy were enrolled. Clinical periodontal parameters were recorded and GCF Galectin-3 and IL-1β total amounts were measured by ELISA. Receiver operating characteristics curve was used for estimating the area under the curve (AUC). Results: Galectin-3 and IL-1β were detected in all participants. Both periodontitis groups had significantly higher GCF Galectin-3 total amounts than periodontally healthy controls (p <0.05). S3GC periodontitis group had also significantly higher GCF Galectin-3 levels than gingivitis group (p <0.05). GCF IL-1β levels in periodontitis groups were higher than gingivitis and periodontally healthy groups (p <0.05). Galectin-3 exhibited an AUC value of 0.89 with 95% sensitivity to discriminate S3GC periodontitis from periodontal health, an AUC value of 0.87 with 80% sensitivity to discriminate S3GC periodontitis versus gingivitis, while an AUC value of 0.85 with 95% sensitivity to discriminate S3GB periodontitis from healthy controls. Conclusions: GCF Galectin-3 levels are involved in the pathogenesis of periodontal diseases. Galectin-3 showed excellent diagnostic performances to discriminate S3GB and S3GC periodontitis from periodontal health and gingivitis. Clinical relevance: The present findings suggest that GCF Galectin-3 levels may be useful in the diagnosis of the periodontal diseases. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.